Blar i Institutt for klinisk og molekylær medisin på tittel
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A European multicentre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts
(Journal article; Peer reviewed, 2019)Polymerase chain reaction (PCR) detection has become the gold standard for diagnosis and typing of enterovirus (EV) and human parechovirus (HPeV) infections. Its effectiveness depends critically on using the appropriate ... -
A Functional Polymorphism C-509T in TGFβ-1 Promoter Contributes to Susceptibility and Prognosis of Lone Atrial Fibrillation in Chinese Population
(Journal article; Peer reviewed, 2014)Transforming growth factor-β1 (TGF-β1) is an important mediator of atrial fibrosis and atrial fibrillation (AF). But the involved genetic mechanism is unknown. Herein, the TGF-β1 C-509T polymorphism (rs1800469) was genotyped ... -
A high precision method for quantitative measurements of reactive oxygen species in frozen biopsies
(Journal article; Peer reviewed, 2014)Objective: An electron paramagnetic resonance (EPR) technique using the spin probe cyclic hydroxylamine 1-hydroxy-3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine (CMH) was introduced as a versatile method for high ... -
A high-throughput drug combination screen of targeted small molecule inhibitors in cancer cell lines
(Journal article; Peer reviewed, 2019)While there is a high interest in drug combinations in cancer therapy, openly accessible datasets for drug combination responses are sparse. Here we present a dataset comprising 171 pairwise combinations of 19 individual ... -
A longitudinal study of associations between psychiatric symptoms and disorders and cerebral gray matter volumes in adolescents born very preterm
(Journal article; Peer reviewed, 2017)Background:Being born preterm with very low birthweight (VLBW≤1500 g) poses a risk for cortical andsubcortical gray matter (GM) abnormalities, as well as for having more psychiatric problems during childhood andadolescence ... -
A manually curated ChIP-seq benchmark demonstrates room for improvement in current peak-finder programs
(Journal article; Peer reviewed, 2011)Chromatin immunoprecipitation (ChIP) followed by high throughput sequencing (ChIP-seq) is rapidly becoming the method of choice for discovering cell-specific transcription factor binding locations genome wide. By aligning ... -
A massive parallel sequencing workflow for diagnostic genetic testing of mismatch repair genes
(Journal article; Peer reviewed, 2014)The purpose of this study was to develop a massive parallel sequencing (MPS) workflow for diagnostic analysis of mismatch repair (MMR) genes using the GS Junior system (Roche). A pathogenic variant in one of four MMR genes, ... -
A method to assess obstetric outcomes using the 10-Group Classification System: A quantitative descriptive study
(Journal article; Peer reviewed, 2017)Objectives Internationally, the 10-Group Classification System (TGCS) has been used to report caesarean section rates, but analysis of other outcomes is also recommended. We now aim to present the TGCS as a method to assess ... -
A new approach to the study of middle cerebral artery occlusion in the rat using magnetic resonance techniques
(Dissertations at the Faculty of Medicine, 0805-7680; 200, Doctoral thesis, 2001) -
A novel antimycobacterial compound acts as an intracellular iron chelator
(Journal article; Peer reviewed, 2015)Efficient iron acquisition is crucial for the pathogenesis of Mycobacterium tuberculosis. Mycobacterial iron uptake and metabolism are therefore attractive targets for antitubercular drug development. Resistance mutations ... -
A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA
(Journal article; Peer reviewed, 2011)Recently, 5-hydroxymethylcytosine (5hmC) was identified in mammalian genomic DNA. The biological role of this modification remains unclear; however, identifying the genomic location of this modified base will assist in ... -
A novel non-canonical Wnt signature for prostate cancer aggressiveness
(Journal article; Peer reviewed, 2016)Activation of the Canonical Wnt pathway (CWP) has been linked to advanced and metastatic prostate cancer, whereas the Wnt5a-induced non-canonical Wnt pathway (NCWP) has been associated with both good and poor prognosis. A ... -
A Novel Photosensitizer for PET-Imaging and Cancer Treatment —In vitro studies (AY-27 cells)
(Master thesis, 2021) -
A Novel Truncated Form of Nephronectin Is Present in Small Extracellular Vesicles Isolated from 66cl4 Cells
(Journal article; Peer reviewed, 2019)Extracellular vesicles are emerging as biomarkers in breast cancer. Our recent report suggested that an intracellular granular staining pattern of the extracellular matrix protein nephronectin (NPNT) in breast tumor sections ... -
A PET/MRI study towards finding the optimal [18F]Fluciclovine PET protocol for detection and characterisation of primary prostate cancer.
(Journal article; Peer reviewed, 2016)Purpose: [18F]Fluciclovine PET imaging shows promise for the assessment of prostate cancer. The purpose of this PET/MRI study is to optimise the PET imaging protocol for detection and characterisation of primary prostate ... -
A Preoperative Multimarker Approach to Evaluate Acute Kidney Injury After Cardiac Surgery.
(Journal article; Peer reviewed, 2016)Objective To investigate whether a multimarker strategy combining preoperative biomarkers representing distinct pathophysiologic pathways enhances preoperative risk assessment of acute kidney injury after cardiac surgery ... -
A property-based analysis of human transcription factors
(Journal article; Peer reviewed, 2015)Background Transcription factors are essential proteins for regulating gene expression. This regulation depends upon specific features of the transcription factors, including how they interact with DNA, how they interact ... -
A prospective multicenter register study exploring health-related quality of life in women with Sjøgren's syndrome during pregnancy
(Master thesis, 2024)Sammendrag Introduksjon: Det er gjort få studier på helserelatert livskvalitet hos kvinner med Sjøgren's syndrom (SS) under svangerskap og gravide kvinner med SS anses som risikosvangerskap, med økt risiko for uheldige ... -
A prospective multicenter register study exploring health-related quality of life in women with Sjøgren's syndrome during pregnancy.
(Master thesis, 2024)Sammendrag Introduksjon: Det er gjort få studier på helserelatert livskvalitet hos kvinner med Sjøgren's syndrom (SS) under svangerskap og gravide kvinner med SS anses som risikosvangerskap, med økt risiko for uheldige ... -
A prospective study examining cachexia predictors in patients with incurable cancer
(Journal article; Peer reviewed, 2019)Background Early intervention against cachexia necessitates a predictive model. The aims of this study were to identify predictors of cachexia development and to create and evaluate accuracy of a predictive model based ...