Browsing Institutt for klinisk og molekylær medisin by Title
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Intraperitoneal and subcutaneous glucagon delivery in anaesthetized pigs: effects on circulating glucagon and glucose levels
(Journal article; Peer reviewed, 2020)Glucagon is a pancreatic hormone and increases the blood glucose levels. It may be incorporated in a dual hormone artificial pancreas, a device to automatically and continuously control blood glucose levels of individuals ... -
The intraperitoneal artificial pancreas: glucose sensing and glucagon delivery
(Doctoral theses at NTNU;2020:267, Doctoral thesis, 2020)Norsk sammendrag Diabetes er en gruppe sykdommer som globalt rammer millioner av mennesker. Denne avhandlingen fokuserer på diabetes mellitus type 1 som kjennetegnes av ingen, eller veldig liten, produksjon av insulin. ... -
Intraperitoneal insulin administration - superior choice for an artificial pancreas?
(Doctoral theses at NTNU;2021:334, Doctoral thesis, 2021)The main focus of this thesis is to explore the intraperitoneal (IP) cavity as the location for insulin administration. We hypothesized that IP insulin administration is more physiologic as it mimics endogenous insulin ... -
Intraperitoneal insulin administration in pigs: Effect on circulating insulin and glucose levels
(Peer reviewed; Journal article, 2021)Introduction The effect of intraperitoneal insulin infusion has limited evidence in the literature. Therefore, the aim of the study was to investigate the pharmacokinetics and pharmacodynamics of different intraperitoneal ... -
Intraperitoneal, subcutaneous and intravenous glucagon delivery and subsequent glucose response in rats: A randomized controlled crossover trial
(Journal article; Peer reviewed, 2018)Objective Hypoglycemia is a frequent and potentially dangerous event among patients with diabetes mellitus type 1. Subcutaneous glucagon is an emergency treatment to counteract severe hypoglycemia. The effect of intraperitoneal ... -
Intrauterine blood transfusions at the National Center for Fetal Medicine in Norway, 1988–2007
(Master thesis, 2009) -
Intravenous Iron Treatment in the Prevention of Iron Deficiency and Anaemia After Roux-en-Y Gastric Bypass
(Peer reviewed; Journal article, 2020)Background Iron absorption is disturbed after Roux-en-Y gastric bypass (RYGB) and iron deficiency with or without anaemia affects almost half of all patients. Intravenous iron is an option when per oral iron is insufficient ... -
Invasive lobular breast cancer: The prognostic impact of histopathological grade, E-cadherin and molecular subtypes
(Peer reviewed; Journal article, 2015)Aims The aim of this study was to compare breast cancer specific survival (BCSS) for invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) and, further, to evaluate critically the prognostic value of ... -
Invasive properties of cancer - a treatment target?: In vitro studies in human prostate cancer cell lines
(Doktoravhandlinger ved NTNU, 1503-8181; 2006:215, Doctoral thesis, 2007) -
Investigating a novel function of Ogg1 and Mutyh DNA glycosylases in memory formation
(Master thesis, 2021)Abstract The capacity to form and store new memories is one of the most important cognitive ability that characterizes the human brain. At the same time, is one of the brain faculties most affected by neurodegenerative ... -
Investigating iPSC derived macrophages as a model to study Mtb infection compared to alveolar macrophages, monocyte derived macrophages and THP-1 macrophages
(Master thesis, 2022)Mycobacterium tuberculosis (Mtb) er fortsatt et omfattende folkehelseproblem for en stor del av verdens utviklingsland, og forårsaker mer enn 1,5 millioner dødsfall årlig. Imidlertid forblir mange aspekter av interaksjonene ... -
Investigating novel biomarkers of immune activation and modulation in the context of sedentary behaviour: a multicentre prospective ischemic stroke cohort study
(Peer reviewed; Journal article, 2021)Background Sedentary behaviour is associated with disease, but the molecular mechanisms are not understood. Valid biomarkers with predictive and explanatory properties are required. Therefore, we have investigated traditional ... -
Investigating optimal β-cell-preserving treatment in latent autoimmune diabetes in adults: Results from a 21-month randomized trial
(Peer reviewed; Journal article, 2019)Aims To compare outcomes of glucagon‐stimulated C‐peptide tests (GSCTs) in people with latent autoimmune diabetes in adults (LADA) after a 21‐month intervention with either insulin or the dipeptidyl peptidase‐4 inhibitor ... -
Investigating survival, quality of life and cognition in PROton versus photon therapy for IDH- mutated diffuse grade 2 and 3 GLIOmas (PRO-GLIO): a randomised controlled trial in Norway and Sweden
(Peer reviewed; Journal article, 2023)Abstract Introduction The use of proton therapy increases globally despite a lack of randomised controlled trials demonstrating its efficacy and safety. Proton therapy enables sparing of non-neoplastic tissue from ... -
Investigating the anti-tumoural effect of novel therapeutics in cell lines generated from patient-derived glioblastoma organoids
(Master thesis, 2024)Glioblastom (GBM) er klassifisert som en grad 4 hjernesvulst og er beryktet for sin aggressive og diffuse vekst. Etter diagnose har kreften en median overlevelse på under 15 måneder. Betydelige utfordringer oppstår på grunn ... -
Investigating the causal effect of smoking on hay fever and asthma: A Mendelian randomization meta-analysis in the CARTA consortium
(Journal article; Peer reviewed, 2017)Observational studies on smoking and risk of hay fever and asthma have shown inconsistent results. However, observational studies may be biased by confounding and reverse causation. Mendelian randomization uses genetic ... -
Investigating the effect of sex and ketosis on weight-loss-induced changes in appetite
(Peer reviewed; Journal article, 2019)Background Diet-induced weight loss (WL) is usually accompanied by increased appetite, a response that seems to be absent when ketogenic diets are used. It remains unknown if sex modulates the appetite suppressant effect ... -
Investigating the immunomodulatory effects of SARS-CoV-2 proteins ORF3a, ORF6 and ORF9b on the inflammatory response of human lung epithelial cells
(Master thesis, 2022)The COVID-19 pandemic has taken an unprecedented number of lives and brought incredibly high social costs across the globe. The disease severity is associated with a strong innate immune dysregulation characterised by low ... -
Investigating the missing data mechanism in quality of life outcomes: a comparison of approaches
(Journal article; Peer reviewed, 2009)Background: Missing data is classified as missing completely at random (MCAR), missing at random (MAR) or missing not at random (MNAR). Knowing the mechanism is useful in identifying the most appropriate analysis. The ... -
Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium
(Journal article; Peer reviewed, 2014)Objectives: To investigate whether associations of smoking with depression and anxiety are likely to be causal, using a Mendelian randomisation approach. Design: Mendelian randomisation meta-analyses using a genetic ...