Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 1678-1697 av 3434
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Inherited Genetic Mutations and Polymorphisms in Malignant Mesothelioma: A Comprehensive Review
(Peer reviewed; Journal article, 2020)Malignant mesothelioma (MM) is mainly caused by air-born asbestos but genetic susceptibility is also suspected to be a risk factor. Recent studies suggest an increasing number of candidate genes that may predispose to MM ... -
Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model of Escherichia coli sepsis
(Journal article; Peer reviewed, 2017)Bacterial sepsis triggers robust activation of the complement system with subsequent generation of anaphylatoxins (C3a, C5a) and the terminal complement complex (TCC) that together contribute to organ failure and death. ... -
Inhibition of CYP2D6 mediated drug metabolism in vitro by Aloe vera juice
(Master thesis, 2009) -
Inhibition of Cytosolic Phospholipase A2α Induces Apoptosis in Multiple Myeloma Cells
(Peer reviewed; Journal article, 2021)Cytosolic phospholipase A2α (cPLA2α) is the rate-limiting enzyme in releasing arachidonic acid and biosynthesis of its derivative eicosanoids. Thus, the catalytic activity of cPLA2α plays an important role in cellular ... -
Inhibition of O-GlcNAc transferase activates tumor-suppressor gene expression in tamoxifen-resistant breast cancer cells
(Peer reviewed; Journal article, 2020)In this study, we probed the importance of O-GlcNAc transferase (OGT) activity for the survival of tamoxifen-sensitive (TamS) and tamoxifen-resistant (TamR) breast cancer cells. Tamoxifen is an antagonist of estrogen ... -
Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT
(Journal article; Peer reviewed, 2017)PKR is a cellular kinase involved in the regulation of the integrative stress response (ISR) and pro-inflammatory pathways. Two N-terminal dsRNA Binding Domains (DRBD) are required for activation of PKR, by interaction ... -
Initial characterization of tumor heterogeneity in a syngeneic breast cancer model
(Master thesis, 2015)Breast cancer is the most common cancer in women and the main reason of cancer death in the less developed countries. Metastasis is the leading cause of death in breast cancer patients. Due to the complexity of this cascade, ... -
Initial experience with positron emission tomography/computed tomography in addition to computed tomography and magnetic resonance imaging in preoperative risk assessment of endometrial cancer patients
(Peer reviewed; Journal article, 2021)Objective: Improved preoperative evaluation of lymph node status could potentially replace lymphadenectomy in women with endometrial cancer. PET/CT was routinely implemented in the preoperative workup of endometrial cancer ... -
Initial management and survival of patients with primary metastatic bladder cancer before the immunotherapy era: a population-based study from Norway
(Peer reviewed; Journal article, 2023)Before immunotherapy became part of the management of metastatic bladder cancer (mBC), systemic anti-cancer treatment comprised primarily of platinum-based chemotherapy. The objective of this study was to describe the ... -
Initial refinement of data from video-based single-cell tracking
(Peer reviewed; Journal article, 2023)Background Video recording of cells offers a straightforward way to gain valuable information from their response to treatments. An indispensable step in obtaining such information involves tracking individual cells from ... -
Innate antiviral immunity: Mechanisms of the RIG-Imediated response
(Doktoravhandlinger ved NTNU, 1503-8181; 2011:274, Doctoral thesis, 2011) -
Innate Immune Responses in Colonic Mucosa During Inflammatory Bowel Disease - Effects of TLR3 Signaling
(Doktoravhandlinger ved NTNU, 1503-8181; 2014:118, Doctoral thesis, 2014) -
Innate immune responses to human metapneumovirus - Exploring cellular models and molecular mechanisms of interferon regulation and action
(Doctoral theses at NTNU;2020:101, Doctoral thesis, 2020)Luftveisinfeksjoner forårsaket av virus og bakterier er et betydelig folkehelseproblem. Særlig for barn, gamle mennesker og personer med lungesykdom eller svekket immunsystem kan disse infeksjonene være livstruende. For ... -
Innate immune signalling genetics of pain, cognitive dysfunction and sickness symptoms in cancer pain patients treated with transdermal fentanyl
(Peer reviewed; Journal article, 2015)Common adverse symptoms of cancer and chemotherapy are a major health burden; chief among these is pain, with opioids including transdermal fentanyl the mainstay of treatment. Innate immune activation has been implicated ... -
Innføring av multidose i e-resept, og utfordringer når tre legemiddellister blir til en.
(Master thesis, 2020)Uoverensstemmelser mellom legemiddellistene fra fastlegen, apotek og hjemmetjeneste har vært et hyppig forekommende problem. Siden alle tre aktørene tar vurderinger basert på egen legemiddelliste risikerer man at behandling ... -
Innvandrerkvinners erfaringer i møte med jordmor under fødsel; En systematisk litteraturstudie med metaentografisk analyse av kvalitativ metode
(Master thesis, 2022)Tittel: Innvandrerkvinners erfaringer med å møte jordmor i fødsel. En systematisk litteraturstudie. Hensikt: Formålet med studien er å få innsikt i innvandrerkvinners erfaring med fødsel. Studien forsøker også å bidra til ... -
Insight to Functional Conformation and Noncovalent Interactions of Protein-Protein Assembly Using MALDI Mass Spectrometry
(Peer reviewed; Journal article, 2020)Noncovalent interactions are the keys to the structural organization of biomolecule e.g., proteins, glycans, lipids in the process of molecular recognition processes e.g., enzyme-substrate, antigen-antibody. Protein ... -
Insomnia symptoms and risk of bloodstream infections: prospective data from the prospective population-based Nord-Trøndelag Health Study (HUNT), Norway
(Journal article; Peer reviewed, 2022) -
Intake of non-nutritive sweeteners is associated with an unhealthy lifestyle: a cross-sectional study in subjects with morbid obesity
(Journal article; Peer reviewed, 2017)Background Subjects with morbid obesity commonly use Non-Nutritive Sweeteners (NNS), but the health-related effects of NNS have been questioned. The objectives of this study were to explore the associations between ... -
Integrated approaches for motif discovery in genomic regions
(Doktoravhandlinger ved NTNU, 1503-8181; 2013:143, Doctoral thesis, 2013)Recipes for all the proteins that are needed by an organism are described in its genes which are encoded in DNA. In order to create a new protein, a copy of the DNA recipe must first be transcribed into RNA and this ...