Blar i Institutt for klinisk og molekylær medisin på tittel

Viser treff 1511-1530 av 3434

    • Identification of metastasis-associated microRNAs in serum from rectal cancer patients 

      Mjelle, Robin; Sellæg, Kjersti; Sætrom, Pål; Thommesen, Liv; Sjursen, Wenche; Hofsli, Eva (Peer reviewed; Journal article, 2017)
      MicroRNAs (miRNAs) are promising prognostic and diagnostic biomarkers due to their high stability in blood. Here we investigate the expression of miRNAs and other noncoding (nc) RNAs in serum of rectal cancer patients. ...

    • Identification of MicroRNA Expression in Gastrin Stimulated Adenocarcinoma Cells 

      Bergly, Laila H. (Master thesis, 2011)
      The Gastrin System Biology group studies the molecular responses to gastrin using cell line model systems. Recently microRNAs (miRNAs) have been acknowledged as essential participants in the regulation of gene expression, ...

    • Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma 

      Went, Molly; Sud, Amit; Försti, Asta; Halvarsson, Britt-Marie; Weinhold, Niels; Kimber, Scott; van Duin, Mark; Thorleifsson, Gudmar; Holroyd, Amy; Johnson, David C.; Li, Ni; Orlando, Giulia; Law, Philip J.; Ali, Mina; Chen, Bowang; Mitchell, Jonathan S.; Gudbjartsson, Daniel F.; Kuiper, Rowan; Stephens, Owen W.; Bertsch, Uta; Broderick, Peter; Campo, Chiara; Bandapalli, Obul R.; Einsele, Hermann; Gregory, Walter A.; Gullberg, Urban; Hillengass, Jens; Hoffmann, Per; Jackson, Graham H.; Jöckel, Karl-Heinz; Johnsson, Ellinor; Kristinsson, Sigurður Y.; Mellqvist, Ulf-Henrik; Nahi, Hareth; Easton, Douglas; Pharoah, Paul; Dunning, Alison; Peto, Julian; Canzian, Federico; Swerdlow, Anthony; Eeles, Rosalind A.; Kote-Jarai, ZSofia; Muir, Kenneth; Pashayan, Nora; Nickel, Jolanta; Nöthen, Markus M.; Rafnar, Thorunn; Ross, Fiona M.; da Silva Filho, Miguel Inacio; Thomsen, Hauke; Turesson, Ingemar; Vangsted, Annette; Andersen, Niels Frost; Waage, Anders; Walker, Brian A.; Wihlborg, Anna-Karin; Broyl, Annemiek; Davies, Faith E.; Thorsteinsdóttir, Unnur; Langer, Christian; Hansson, Markus; Goldschmidt, Hartmut; Kaiser, Martin; Sonneveld, Pieter; Stefansson, Kari; Morgan, Gareth J.; Hemminki, Kari; Nilsson, Björn; Houlston, Richard S. (Journal article; Peer reviewed, 2018)
      Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained. We report a new GWAS, a meta-analysis with previous ...

    • Identification of Novel Regulators of Epithelial Polarity and Cell Migration 

      Lobert, Viola Hélène (Doktoravhandlinger ved NTNU, 1503-8181; 2012:281, Doctoral thesis, 2012)
      The ability of cells to form separate apical and basolateral domains of their plasma membranes is an important aspect of epithelial integrity, and loss of epithelial polarity results in the acquisition of mesenchymal ...

    • Identification of the source of elevated hepatocyte growth factor levels in multiple myeloma patients 

      Rampa, Christoph Samuel; Tian, Erming; Våtsveen, Thea Kristin; Buene, Glenn; Slørdahl, Tobias Schmidt; Børset, Magne; Waage, Anders; Sundan, Anders (Journal article; Peer reviewed, 2014)
      Background Hepatocyte growth factor (HGF) is a pleiotropic cytokine which can lead to cancer cell proliferation, migration and metastasis. In multiple myeloma (MM) patients it is an abundant component of the bone marrow. ...

    • Identification of UCHL1 Binding Partners in Human Induced Pluripotent Stem Cell (hiPSC)-Derived Motor Neurons 

      Sæther, Anna Maria (Master thesis, 2022)
      Proper protein regulation is crucial for cell function. Ubiquitin is a 76 amino acid (aa) protein functioning as a post translational modification and thereby playing a central role in protein regulation. Ubiquitin (Ub) ...

    • Identification of unhealthy alcohol use by self-report and phosphatidylethanol (PEth) blood concentrations in an acute psychiatric department 

      Finanger, Trine; Vaaler, Arne; Spigset, Olav; Aamo, Trond Oskar; Andreassen, Trine Naalsund; Gråwe, Rolf W.; Skråstad, Ragnhild Bergene (Peer reviewed; Journal article, 2022)
      Background The use of standard screening methods could improve the detection rate of unhealthy alcohol use in patients admitted to psychiatric acute and emergency departments. The aim of the present study was to investigate ...

    • Identifying functional regulatory mutation blocks by integrating genome sequencing and transcriptome data 

      Yang, Mingyi; Ali, Omer; Bjørås, Magnar; Wang, Junbai (Peer reviewed; Journal article, 2023)
      Millions of single nucleotide variants (SNVs) exist in the human genome; however, it remains challenging to identify functional SNVs associated with diseases. We propose a non-encoding SNVs analysis tool bpb3, BayesPI-BAR ...

    • Identifying robust blood-based messenger RNA (mRNA) markers for potential detection of lung cancer: The Lung Cancer Biobank (NLCB) and the Nord-Trøndelag Health Study (HUNT) and Norwegian Women and Cancer Cohort (NOWAC) 

      Skogholt, Anne Heidi (Doctoral theses at NTNU;2021:310, Doctoral thesis, 2021)

    • Identifying small for gestational age preterm infants from the Finnish Medical Birth Register using eight growth charts 

      Hocquette, Alice; Pulakka, Anna; Metsälä, Johanna; Heikkilä, Katriina; Zeitlin, Jennifer; Kajantie, Eero Olavi (Peer reviewed; Journal article, 2022)

    • IFN-α with dasatinib broadens the immune repertoire in patients with chronic-phase chronic myeloid leukemia 

      Huuhtanen, Jani; Ilander, Mette; Yadav, Bhagwan; Dufva, Olli M.J.; Lähteenmäki, Hanna; Kasanen, Tiina; Klievink, Jay; Olsson-Strömberg, Ulla; Stentoft, Jesper; Richter, Johan; Koskenvesa, Perttu; Höglund, Martin; Söderlund, Stina; Dreimane, Arta; Porkka, Kimmo; Gedde-Dahl, Tobias; Gjertsen, Bjørn Tore; Stenke, Leif; Myhr-Eriksson, Kristina; Markevärn, Berit; Lübking, Anna; Dimitrijevic, Andreja; Udby, Lene; Bjerrum, Ole Weis; Hjorth-Hansen, Henrik; Mustjoki, Satu (Peer reviewed; Journal article, 2022)
      In chronic myeloid leukemia (CML), combination therapies with tyrosine kinase inhibitors (TKIs) aim to improve the achievement of deep molecular remission that would allow therapy discontinuation. IFN-α is one promising ...

    • IgG and IgG4 antibodies in subjects with irritable bowel syndrome: a case control study in the general population 

      Ligaarden, Solveig Catharina; Lydersen, Stian; Farup, Per Grønaas (Journal article; Peer reviewed, 2012)
      Background Patients with Irritable Bowel Syndrome (IBS) often relate their symptoms to the intake of food and modify their diet. IgE-mediated food allergy is uncommon in IBS, but the role of IgG-mediated food hypersensitivity ...

    • IL-32 and multiple myeloma bone disease 

      Aass, Kristin Roseth (Master thesis, 2016)
      Multiple myeloma is a malignancy of plasma cells characterized by multiple tumors in the bone marrow and progressive osteolytic bone disease. The bone lesions are caused by increased bone resorption by osteoclasts and ...

    • IL-32 is induced by activation of toll-like receptors in multiple myeloma cells 

      Aass, Kristin Roseth; Tryggestad, Synne Stokke; Mjelle, Robin; Kastnes, Martin Haugrud; Nedal, Tonje Marie Vikene; Misund, Kristine; Standal, Therese (Peer reviewed; Journal article, 2023)
      Multiple myeloma (MM) is a hematological cancer characterized by accumulation of malignant plasma cells in the bone marrow. The patients are immune suppressed and suffer from recurrent and chronic infections. Interleukin-32 ...

    • IL-6 receptor inhibition by tocilizumab attenuated expression of C5a receptor 1 and 2 in non-ST-elevation myocardial infarction 

      Orrem, Hilde Lang; Nilsson, Per; Pischke, Søren Erik; Kleveland, Ola; Yndestad, Arne; Ekholt, Karin; Damås, Jan Kristian; Espevik, Terje; Bendz, Bjørn; Halvorsen, Bente; Gregersen, Ida; Wiseth, Rune; Andersen, Geir Øystein; Ueland, Thor; Gullestad, Lars; Aukrust, Pål; Barratt-Due, Andreas; Mollnes, Tom Eirik (Journal article; Peer reviewed, 2018)
      Background: Elevated interleukin-6 (IL-6) and complement activation are associated with detrimental effects of inflammation in coronary artery disease (CAD). The complement anaphylatoxins C5a and C3a interact with their ...

    • The ileal fungal microbiota is altered in Crohn's disease and is associated with the disease course 

      Olaisen, Maya; Richard, Mathias L.; Beisvag, Vidar; Granlund, Atle van Beelen; Røyset, Elin Synnøve; Rué, Olivier; Martinsen, Tom Christian; Sandvik, Arne Kristian; Sokol, Harry; Fossmark, Reidar (Peer reviewed; Journal article, 2022)
      Introduction: Fungal microbiota's involvement in the pathogenesis of Crohn's disease (CD) is incompletely understood. The terminal ileum is a predilection site both for primary involvement and recurrences of CD. We, ...

    • Ileal Pouches 

      Wasmuth, Hans H. (Doktoravhandlinger ved NTNU, 1503-8181; 2012:10, Doctoral thesis, 2012)
      Background The conventional ileostomy can be avoided. Many attempts have been performed. The first successful solution was the continent ileostomy- Kock pouch. The high rate of complications and revisions some experienced ...

    • Illegalt eller medisinsk amfetamin – hva er inntatt 

      Frost, Joachim; Helland, Arne; Syrstad, Vigdis Elin Giæver; Aamo, Trond Oskar (Peer reviewed; Journal article, 2022)

    • Image-Guided Radiotherapy for Prostate Cancer and Side Effects after Treatment 

      Tøndel, Hanne (Doctoral theses at NTNU;2019:62, Doctoral thesis, 2019)
      Norsk sammendrag Prostatakreft er den vanligste kreftsykdommen blant norske menn med nesten 5000 nye tilfeller diagnostisert i 2016. Prognosen ved lokalisert sykdom er god og samlet 5-års overlevelse er nå godt over 90%. ...

    • The imaging of guard cells of thioglucosidase (tgg) mutants of Arabidopsis further links plant chemical defence systems with physical defence barriers 

      Ahuja, Ishita; Kissen, Ralph; Hoang, Linh; Sporsheim, Bjørnar; Halle, Kari Krizak; Wolff, Silje Aase; Ahmad, Samina Jam Nazeer; Ahmad, Jam Nazeer; Bones, Atle M. (Journal article; Peer reviewed, 2021)
      The glucosinolate-myrosinase system is a well-known plant chemical defence system. Two functional myrosinase-encoding genes, THIOGLUCOSIDASE 1 (TGG1) and THIOGLUCOSIDASE 2 (TGG2), express in aerial tissues of Arabidopsis. ...