Browsing Institutt for klinisk og molekylær medisin by Title
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Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer
(Journal article; Peer reviewed, 2019)Introduction Glutaminase inhibitors target cancer cells by blocking the conversion of glutamine to glutamate, thereby potentially interfering with anaplerosis and synthesis of amino acids and glutathione. The drug CB-839 ... -
Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death
(Peer reviewed; Journal article, 2022)First recognized more than 30 years ago, glycine protects cells against rupture from diverse types of injury. This robust and widely observed effect has been speculated to target a late downstream process common to multiple ... -
gp130 in late osteoblasts and osteocytes is required for PTH-induced osteoblast differentiation
(Journal article; Peer reviewed, 2014)Parathyroid hormone (PTH) treatment stimulates osteoblast differentiation and bone formation, and is the only currently approved anabolic therapy for osteoporosis. In cells of the osteoblast lineage, PTH also stimulates ... -
Granulocyte and monocyte CD11b expression during plasma separation is dependent on complement factor 5 (C5) – an ex vivo study with blood from a C5‐deficient individual
(Journal article, 2018)The aim of the study was to investigate the role of complement factor 5 (C5) in reactions elicited by plasma separation using blood from a C5‐deficient (C5D) individual, comparing it to C5‐deficient blood reconstituted ... -
GREM1 is associated with metastasis and predicts poor prognosis in ER-negative breast cancer patients
(Journal article; Peer reviewed, 2019)Background In breast cancer, activation of bone morphogenetic protein (BMP) signaling and elevated levels of BMP-antagonists have been linked to tumor progression and metastasis. However, the simultaneous upregulation of ... -
Growth and survival of follicular and diffuse large B cell lymphoma cells: the role of toll-like receptors and their ligands, IL-21, BMP-4 and BMP-6
(Master thesis, 2010)The main purpose of this thesis was to characterize the expression of toll-like receptors (TLRs) and to investigate the role of TLR-induced responses in growth and survival of follicular lymphoma (FL) and diffuse large ... -
Growth during infancy and early childhood in children with cerebral palsy: a population-based study
(Peer reviewed; Journal article, 2016)Aim To describe growth in infancy and early childhood in children with cerebral palsy (CP). Method One hundred and four children with CP born at minimum 36 weeks' gestation in 2002 to 2010 were included. Prospectively ... -
Growth, Nutritional Status, and Feeding Difficulties in Children with Cerebral Palsy
(Doctoral thesis at NTNU;2015:12, Doctoral thesis, 2015)Cerebral palsy (CP) is the most common cause of chronic motor disability in childhood, and is caused by an early injury affecting the parts of the brain responsible for body movement and control. In addition to motor ... -
Guanylate cyclase-C signaling in Inflammatory Bowel Disease: Cellular expression of guanylin and uroguanylin encoding genes in human and rat duodenum and colon
(Doctoral theses at NTNU;2016:131, Doctoral thesis, 2016) -
Gut microbiota-dependent trimethylamine N-oxide associates with inflammation in common variable immunodeficiency
(Peer reviewed; Journal article, 2020)A substantial proportion of patients with common variable immunodeficiency (CVID) have inflammatory and autoimmune complications of unknown etiology. We have previously shown that systemic inflammation in CVID correlates ... -
Gynecological cancer patients' attitudes toward follow-up care after cancer treatment: Do preferences reflect patients' experience? A cross-sectional questionnaire study
(Journal article; Peer reviewed, 2018)Introduction Due to an increasing number of cancer patients, new follow‐up models are being debated, among them follow‐up by general practitioners. Before changing surveillance, it is important to explore patients’ views. ... -
Gynecological complaints and management of women subjected to female genital mutilation - A descriptive study among women attending a university hospital in Norway
(Master thesis, 2017)Abstract Background Female genital mutilation (FGM) is a harmful traditional practice comprising procedures involving partial or total removal of external female genitalia and/or narrowing of the vaginal orifice for ... -
H2G-Net: A multi-resolution refinement approach for segmentation of breast cancer region in gigapixel histopathological images
(Journal article; Peer reviewed, 2022)Over the past decades, histopathological cancer diagnostics has become more complex, and the increasing number of biopsies is a challenge for most pathology laboratories. Thus, development of automatic methods for evaluation ... -
H2S-Enriched Flush out Does Not Increase Donor Organ Quality in a Porcine Kidney Perfusion Model
(Peer reviewed; Journal article, 2023)Kidney extraction time has a detrimental effect on post-transplantation outcome. This study aims to improve the flush-out and potentially decrease ischemic injury by the addition of hydrogen sulphide (H2S) to the flush ... -
Halogenated Pyrrolopyrimidines with Low MIC on Staphylococcus aureus and Synergistic Effects with an Antimicrobial Peptide
(Peer reviewed; Journal article, 2022)Currently, there is a world-wide rise in antibiotic resistance causing burdens to individuals and public healthcare systems. At the same time drug development is lagging behind. Therefore, finding new ways of treating ... -
Haplotype Analysis of Suspected Lynch Syndrome Families
(Master thesis, 2019)Lynch syndrome is the most common type of hereditary colorectal cancer and is characterized by a germline mutation in one of the DNA mismatch repair (MMR) genes (PMS2, MSH2, MSH6 or MLH1). Identification of Lynch syndrome ... -
Håndtering av legemiddelmangel i apotek - En kvalitativ studie med fokus på apotekkunders perspektiv
(Master thesis, 2021)Bakgrunn Det eksisterer per i dag ikke en uniform definisjon for legemiddelmangel, noe som gjør analyse av årsaker, omfang og kommunikasjon om problemet vanskelig. Omfanget synes å øke for hvert år, og 1 av 3 apotekkunder ... -
Håndtering av legemiddelmangel i apotek: En kvalitativ studie fra farmasøyters perspektiv
(Master thesis, 2021)Sammendrag Bakgrunn Antall tilfeller av legemiddelmangel er økende både i Norge og globalt. Apotekforeningens spørreundersøkelse fra 2019 viser at 1 av 3 legemiddelbrukere er bekymret for legemiddelmangel. Farmasøytens ... -
HbA1c as screening for gestational diabetes mellitus in women with polycystic ovary syndrome
(Journal article; Peer reviewed, 2015)Background Gestational diabetes mellitus (GDM) is associated with adverse pregnancy outcomes such as preeclampsia and macrosomia. Women with polycystic ovary syndrome (PCOS) are at increased risk of developing GDM. ... -
HDACi Mediate UNG2 Depletion, Dysregulated Genomic Uracil and Altered Expression of Oncoproteins and Tumor Suppressors in B- And T-cell Lines
(Peer reviewed; Journal article, 2020)Background HDAC inhibitors (HDACi) belong to a new group of chemotherapeutics that are increasingly used in the treatment of lymphocyte-derived malignancies, but their mechanisms of action remain poorly understood. Here ...