Blar i Institutt for klinisk og molekylær medisin på tittel

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    • Gastrin and gastric cancer 

      Waldum, Helge; Sagatun, Liv; Mjønes, Patricia (Journal article; Peer reviewed, 2017)
      Gastric cancer although occurring in reduced frequency is still an important disease, partly because of the bad prognosis when occurring in western countries. This decline in occurrence may mainly be due to the reduced ...

    • Gastrin induced autophagy in gastric adenocarcinoma cells 

      Solum, Guri (Master thesis, 2014)
      The Gastroenterology and Cell biology research group at NTNU studies the role of gastrin in gastric cancer. Gastrin is shown to be involved in proliferation, anti-apoptosis, migration, invasion and angiogenesis. The role ...

    • Gastrin regulated activation of proteins in the elF2α-p-ATF4 network   

      Afroz, Wahida (Master thesis, 2013)
      This master's thesis is a part of a research project of The Gastroenterology Cell Biology Group investigating molecular responses to gastrin induced gene expression, with focus on how duration and intensity of gastrin ...

    • Gastrin-mediated regulation of gene expression; a systems biology approach 

      Fjeldbo, Christina Sæten (Doktoravhandlinger ved NTNU, 1503-8181; 2012:336, Doctoral thesis, 2012)
      Gastrin-regulert genuttrykk; en systembiologisk tilnærming I tillegg til å være det viktigste hormonet som kontrollerer utskillelsen av magesyre (saltsyre, HCl), er gastrin også involvert i vekstregulering av mageslimhinnen. ...

    • Gastritis, Gastric Polyps and Gastric Cancer 

      Waldum, Helge; Fossmark, Reidar (Peer reviewed; Journal article, 2021)
      Gastric cancer is still an important disease causing many deaths worldwide, although there has been a marked reduction in prevalence during the last few decades. The decline in gastric cancer prevalence is due to a reduction ...

    • Gastrointestinal hormones and appetite ratings after weight loss induced by diet or bariatric surgery 

      Aukan, Marthe Isaksen; Skårvold, Silje; Brandsæter, Ingrid Øfsti; Rehfeld, Jens Frederik; Holst, Jens Juul; Nymo, Siren; Coutinho, Silvia; Martins, Catia (Peer reviewed; Journal article, 2023)
      Objective The aim of this study was to compare changes in gastrointestinal hormones and appetite ratings after a similar weight loss induced by a very low-energy diet alone or in combination with sleeve gastrectomy (SG) ...

    • Gefitinib or Erlotinib as Maintenance Therapy in Patients with Advanced Stage Non-Small Cell Lung Cancer: A Systematic Review 

      Chen, Xiaofeng; Liu, YQ; Røe, Oluf Dimitri; Qian, YY; Guo, RH; Zhu, LJ; Yin, YM; Shu, YQ (Journal article; Peer reviewed, 2013)
      Background: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI), gefitinib and erlotinib have been tested as maintenance therapy in patients with advanced non-small-cell lung cancer (NSCLC). The ...

    • Gene expression differences between PAXgene and Tempus blood RNA tubes are highly reproducible between independent samples and biobanks 

      Skogholt, Anne Heidi; Ryeng, Einar; Erlandsen, Sten Even; Skorpen, Frank; Arentz Schønberg, Svanhild Margrethe; Sætrom, Pål (Journal article; Peer reviewed, 2017)
      Background Gene expression profiling from blood is sensitive to technology choices. For example, the main blood RNA collection systems—the PAXgene and Tempus tubes—differently influence RNA expression signatures. The aim ...

    • Gene expression in blood reflects smoking exposure among cancer-free women in the Norwegian Women and Cancer (NOWAC) postgenome cohort 

      Baiju, Nikita; Sandanger, Torkjel M; Sætrom, Pål; Nøst, Therese Haugdahl (Journal article; Peer reviewed, 2021)
      Active smoking has been linked to modulated gene expression in blood. However, there is a need for a more thorough understanding of how quantitative measures of smoking exposure relate to differentially expressed genes ...

    • Gene expression profile changes after short-activating RNA-mediated induction of endogenous pluripotency factors in human mesenchymal stem cells 

      Voutila, J; Sætrom, Pål; Mintz, Paul J; Sun, Guihua; Alluin, Jessica; Rossi, JJ; Habib, Nagy A.; Kasahara, N. (Journal article; Peer reviewed, 2012)
      It is now recognized that small noncoding RNA sequences have the ability to mediate transcriptional activation of specific target genes in human cells. Using bioinformatics analysis and functional screening, we screened ...

    • Gene expression profiling of Gram-negative bacteria-induced inflammation in human whole blood: The role of complement and CD14-mediated innate immune response 

      Lau, Corinna; Olstad, Ole Kristoffer; Holden, Marit; Nygård, Ståle; Fure, Hilde; Lappegård, Knut Tore; Brekke, Ole Lars; Espevik, Terje; Hovig, Johannes Eivind; Mollnes, Tom Eirik (Journal article; Peer reviewed, 2015)
      Non-sterile pathogen-induced sepsis and sterile inflammation like in trauma or ischemia–reperfusion injury may both coincide with the life threatening systemic inflammatory response syndrome and multi-organ failure. ...

    • Gene expression studies and targeted metabolomics reveal disturbed serine, methionine, and tyrosine metabolism in early hypertensive nephrosclerosis 

      Øvrehus, Marius Altern; Bruheim, Per; Ju, Wenjun; Zelnick, Leila R.; Langlo, Knut Asbjørn Rise; Sharma, Kumar; de Boer, Ian H.; Hallan, Stein (Journal article; Peer reviewed, 2019)
      Introduction Hypertensive nephrosclerosis is among the leading causes of end-stage renal disease, but its pathophysiology is poorly understood. We wanted to explore early metabolic changes using gene expression and targeted ...

    • Gene expression studies in gastrointestinal pathophysiology and neoplasia 

      Nørsett, Kristin Gabestad (Doktoravhandlinger ved NTNU, 1503-8181; 2006:89, Doctoral thesis, 2006)

    • Gene Network Inference and Biochemical Assessment Delineates GPCR Pathways and CREB Targets in Small Intestinal Neuroendocrine Neoplasia 

      Drozdov, Ignat; Svejda, Bernhard; Gustafsson, Björn; Mane, S; Pfragner, Roswitha; Kidd, Mark; Modlin, Irvin M (Journal article; Peer reviewed, 2011)
      Small intestinal (SI) neuroendocrine tumors (NET) are increasing in incidence, however little is known about their biology. High throughput techniques such as inference of gene regulatory networks from microarray experiments ...

    • Gene Ontology annotation of sequence-specific DNA binding transcription factors: setting the stage for a large-scale curation effort 

      Tripathi, Sushil; Christie, KR; Balakrishnan, Ravin; Huntley, R; Hill, DP; Thommesen, Liv; Blake, JA; Kuiper, Martin; Lægreid, Astrid (Journal article; Peer reviewed, 2013)
      Transcription factors control which information in a genome becomes transcribed to produce RNAs that function in the biological systems of cells and organisms. Reliable and comprehensive information about transcription ...

    • The Gene Ontology resource: enriching a GOld mine 

      Carbon, Seth J.; Douglass, Eric; Good, Benjamin M; Unni, Deepak R; Harris, Nomi L.; Mungall, Christopher J.; Basu, Siddartha; Chisholm, Rex L.; Dodson, Robert J.; Hartline, Eric; Fey, Petra; Thomas, Paul D.; Albou, Laurent-Philippe; Ebert, Dustin; Kesling, Michael J; Mi, Huaiyu; Muruganujan, Anushya; Huang, Xiaosong; Mushayahama, Tremayne; LaBonte, Sandra A.; Siegele, Deborah A.; Antonazzo, Giulia; Attrill, Helen; Brown, Nick H.; Garapati, Phani; Marygold, Steven J.; Trovisco, Vitor; dos Santos, Gil; Falls, Kathleen; Tabone, Christopher; Zhou, Pinglei; Goodman, Joshua L.; Strelets, Victor B.; Thurmond, Jim; Garmiri, Penelope; Ishtiaq, Rizwan; Rodríguez-López, Milagros; Acencio, Marcio Luis; Kuiper, Martin; Lægreid, Astrid; Logie, Colin; Lovering, Ruth C.; Kramarz, Barbara; Saverimuttu, Shirin C.C.; Pinheiro, Sandra M.; Gunn, Heather; Su, Renzhi; Thurlow, Katherine E.; Chibucos, Marcus; Giglio, Michelle; Nadendla, Suvarna; Munro, James; Jackson, Rebecca; Duesbury, Margaret J.; del-Toro, Noemi; Meldal, Birgit H.M.; Paneerselvam, Kalpana; Perfetto, Livia; Porras, Pablo; Orchard, Sandra; Shrivastava, Anjali (Peer reviewed; Journal article, 2021)
      The Gene Ontology Consortium (GOC) provides the most comprehensive resource currently available for computable knowledge regarding the functions of genes and gene products. Here, we report the advances of the consortium ...

    • Gene regulation knowledge commons: community action takes care of DNA binding transcription factors 

      Tripathi, Sushil; Vercruysse, Steven; Chawla, Konika; Christie, Karen R.; Blake, Judith A; Huntley, Rachael P.; Orchard, Sandra; Hermjakob, Henning; Thommesen, Liv; Lægreid, Astrid; Kuiper, Martin (Journal article; Peer reviewed, 2016)
      A large gap remains between the amount of knowledge in scientific literature and the fraction that gets curated into standardized databases, despite many curation initiatives. Yet the availability of comprehensive knowledge ...

    • The gene regulation knowledge commons: the action area of GREEKC 

      Kuiper, Martin; Bonello, Joseph; Fernández-Breis, Jesualdo Tomás; Bucher, Philipp; Futschik, Matthias E; Gaudet, Pascale; Kulakovskiy, Ivan V.; Licata, Luana; Logie, Colin; Lovering, Ruth C.; Makeev, Vsevolod J; Orchard, Sandra; Panni, Simona; Perfetto, Livia; Sant, David; Schulz, Stefan M.; Vercruysse, Steven; Zerbino, Daniel; Lægreid, Astrid (Peer reviewed; Journal article, 2022)
      As computational modeling becomes more essential to analyze and understand biological regulatory mechanisms, governance of the many databases and knowledge bases that support this domain is crucial to guarantee reliability ...

    • Gene signatures ESC, MYC and ERG-fusion are early markers of a potentially dangerous subtype of prostate cancer 

      Rye, Morten Beck; Bertilsson, Helena; Drabløs, Finn; Angelsen, Anders; Bathen, Tone Frost; Tessem, May-Britt (Journal article; Peer reviewed, 2014)
      Background Good prognostic tools for predicting disease progression in early stage prostate cancer (PCa) are still missing. Detection of molecular subtypes, for instance by using microarray gene technology, can give new ...

    • General movement optimality score and general movements trajectories following early parent-administrated physiotherapy in the neonatal intensive care unit 

      Ustad, Tordis; Fjørtoft, Toril Larsson; Øberg, Gunn Kristin (Peer reviewed; Journal article, 2021)
      Background The Prechtl General Movement Assessment (GMA) is a reliable tool for the functional assessment of the young nervous system. It is based on a global assessment of the quality of infants' movements. In addition, ...