Browsing Institutt for klinisk og molekylær medisin by Title
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Towards understanding of gastric cancer based upon physiological role of gastrin and ECL cells
(Peer reviewed; Journal article, 2020)The stomach is an ideal organ to study because the gastric juice kills most of the swallowed microbes and, thus, creates rather similar milieu among individuals. Combined with a rather easy access to gastric juice, gastric ... -
Toxicity of cytostatic drug-loaded nanoparticles: The role of endocytosis
(Master thesis, 2016)Poly alkyl cyanoacrylate nanoparticles have caught interest because of its desireable properties, such as biocompatibility and biodegradability. They are relatively easy to make and can entrap molecules which make them ... -
Trace Elements in the Large Population-Based HUNT3 Survey
(Peer reviewed; Journal article, 2020)The Nord-Trøndelag Health Study (The HUNT Study) is a large health survey population study in the county of Trøndelag, Norway. The survey has been repeated four times in about 10-year intervals. In the HUNT3 survey ... -
Trajectories of brain development in school-age children born preterm with very low birth weight
(Journal article; Peer reviewed, 2018)Preterm birth (gestational age < 37 weeks) with very low birth weight (VLBW, birth weight ≤ 1500 g) is associated with lifelong cognitive deficits, including in executive function, and persistent alterations in cortical ... -
Trajectory of health-related quality of life during the last year of life in patients with advanced non-small–cell lung cancer
(Peer reviewed; Journal article, 2022)Background The aims of this study were to assess the trajectory of health-related quality of life (HRQOL) during the last year of life in patients with advanced non-small–cell lung cancer (NSCLC) and to explore when and ... -
Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease
(Peer reviewed; Journal article, 2021)Background: This study was to systematically test whether previously reported risk factors for chronic kidney disease (CKD) are causally related to CKD in European and East Asian ancestries using Mendelian randomization. ... -
Trans-fatty acids and survival in renal transplantation
(Journal article; Peer reviewed, 2018)Objective High consumption of trans-fatty acids (TFAs) is associated with increased mortality. Design and methods Observational cohort study of 1.988 Norwegian renal transplant recipients with a median follow-up time ... -
Transcription Factor Properties - Machine Learning, Classification and Computational Annotation
(Doctoral theses at NTNU;2016:269, Doctoral thesis, 2016) -
Transcription profiling during the cell cycle shows that a subset of Polycomb-targeted genes is upregulated during DNA replication
(Journal article; Peer reviewed, 2013) -
Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever
(Peer reviewed; Journal article, 2022)Pyrin is a cytosolic immune sensor that nucleates an inflammasome in response to inhibition of RhoA by bacterial virulence factors, triggering the release of inflammatory cytokines, including IL-1β. Gain-of-function mutations ... -
Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas
(Journal article; Peer reviewed, 2018)Chronic inflammation increases the risk of developing one of several types of cancer. Inflammatory responses are currently thought to be controlled by mechanisms that rely on transcriptional networks that are distinct from ... -
Transcriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathway
(Journal article; Peer reviewed, 2015)The oxidation resistance gene 1 (OXR1) is crucial for protecting against oxidative stress; however, its molecular function is unknown. We employed RNA sequencing to examine the role of human OXR1 for genome wide transcription ... -
Transcriptome sequencing (RNAseq) enables utilization of formalin-fixed, paraffin-embedded biopsies with clear cell renal cell carcinoma for exploration of disease biology and biomarker development
(Journal article; Peer reviewed, 2016)Formalin-fixed, paraffin-embedded (FFPE) tissues are an underused resource for molecular analyses. This proof of concept study aimed to compare RNAseq results from FFPE biopsies with the corresponding RNAlater® (Qiagen, ... -
Transcriptomic Profiling of Collagenous Colitis Identifies Hallmarks of Nondestructive Inflammatory Bowel Disease
(Peer reviewed; Journal article, 2021)Background and aims: The pathophysiology of the inflammatory bowel disease collagenous colitis (CC) is poorly described. Our aim was to use RNA sequencing of mucosal samples from patients with active CC, CC in remission, ... -
Transdiagnostic Associations between Anger Hostility and Chemokine Interferon-gamma Inducible Protein 10
(Journal article; Peer reviewed, 2024)Objective: Many psychiatric disorders are linked to low grade systemic inflammation as measured by systemic cytokine levels. Exploration of cytokines and immune activity and their role in psychiatric symptoms may inform ... -
Transfer of cetirizine/levocetirizine into human breast milk and estimation of drug exposure to infants through breastfeeding: A human lactation study from the ConcePTION project
(Peer reviewed; Journal article, 2023)Data on drug transfer into human breast milk are sparse. This study aimed to quantify concentrations of cetirizine and levocetirizine in breast milk and to estimate drug exposure to infants. Breastfeeding women at least ... -
Transfer of triptans into human breast milk and estimation of infant drug exposure through breastfeeding
(Peer reviewed; Journal article, 2021)Clinical data on the transfer of triptans into human breast milk remain scarce. In a lactation study including 19 breastfeeding women with migraine, we examined the excretion of six different triptans into milk. Following ... -
Transforming growth factor beta (TGF‑β)in adolescent chronic fatigue syndrome
(Journal article; Peer reviewed, 2017)Background Chronic fatigue syndrome (CFS) is a prevalent and disabling condition among adolescent. The disease mechanisms are unknown. Previous studies have suggested elevated plasma levels of several cytokines, but a ... -
Transfusion of red blood cells in coronary surgery: is there an effect on long-term mortality when adjusting for risk factors and postoperative complications?
(Peer reviewed; Journal article, 2017)OBJECTIVES The aim of this study was to compare long-term mortality in patients undergoing primary isolated coronary artery bypass grafting who received ≥1 units of red blood cells (RBCs) or no RBCs. We hypothesized that ...