Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 3243-3262 of 3438
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Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas
(Journal article; Peer reviewed, 2018)Chronic inflammation increases the risk of developing one of several types of cancer. Inflammatory responses are currently thought to be controlled by mechanisms that rely on transcriptional networks that are distinct from ... -
Transcriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathway
(Journal article; Peer reviewed, 2015)The oxidation resistance gene 1 (OXR1) is crucial for protecting against oxidative stress; however, its molecular function is unknown. We employed RNA sequencing to examine the role of human OXR1 for genome wide transcription ... -
Transcriptome sequencing (RNAseq) enables utilization of formalin-fixed, paraffin-embedded biopsies with clear cell renal cell carcinoma for exploration of disease biology and biomarker development
(Journal article; Peer reviewed, 2016)Formalin-fixed, paraffin-embedded (FFPE) tissues are an underused resource for molecular analyses. This proof of concept study aimed to compare RNAseq results from FFPE biopsies with the corresponding RNAlater® (Qiagen, ... -
Transcriptomic Profiling of Collagenous Colitis Identifies Hallmarks of Nondestructive Inflammatory Bowel Disease
(Peer reviewed; Journal article, 2021)Background and aims: The pathophysiology of the inflammatory bowel disease collagenous colitis (CC) is poorly described. Our aim was to use RNA sequencing of mucosal samples from patients with active CC, CC in remission, ... -
Transfer of cetirizine/levocetirizine into human breast milk and estimation of drug exposure to infants through breastfeeding: A human lactation study from the ConcePTION project
(Peer reviewed; Journal article, 2023)Data on drug transfer into human breast milk are sparse. This study aimed to quantify concentrations of cetirizine and levocetirizine in breast milk and to estimate drug exposure to infants. Breastfeeding women at least ... -
Transfer of triptans into human breast milk and estimation of infant drug exposure through breastfeeding
(Peer reviewed; Journal article, 2021)Clinical data on the transfer of triptans into human breast milk remain scarce. In a lactation study including 19 breastfeeding women with migraine, we examined the excretion of six different triptans into milk. Following ... -
Transforming growth factor beta (TGF‑β)in adolescent chronic fatigue syndrome
(Journal article; Peer reviewed, 2017)Background Chronic fatigue syndrome (CFS) is a prevalent and disabling condition among adolescent. The disease mechanisms are unknown. Previous studies have suggested elevated plasma levels of several cytokines, but a ... -
Transfusion of red blood cells in coronary surgery: is there an effect on long-term mortality when adjusting for risk factors and postoperative complications?
(Peer reviewed; Journal article, 2017)OBJECTIVES The aim of this study was to compare long-term mortality in patients undergoing primary isolated coronary artery bypass grafting who received ≥1 units of red blood cells (RBCs) or no RBCs. We hypothesized that ... -
Transient effect of melatonin treatment after neonatal hypoxic-ischemic brain injury in rats
(Journal article; Peer reviewed, 2019)Melatonin has potential neuroprotective capabilities after neonatal hypoxia-ischemia (HI), but long-term effects have not been investigated. We hypothesized that melatonin treatment directly after HI could protect against ... -
Transitioning patients with juvenile idiopathic arthritis to adult care: the Nordic experience
(Peer reviewed; Journal article, 2022)Background With juvenile idiopathic arthritis (JIA), there are several protocols and practices used worldwide for the transition from paediatric to adult care. In this study, we examined the transferral rates and disease ... -
Transitions Between Circulatory States After Out-of-Hospital Cardiac Arrest: Protocol for an Observational, Prospective Cohort Study
(Journal article; Peer reviewed, 2018)Background: The post cardiac arrest syndrome (PCAS) is responsible for the majority of in-hospital deaths following cardiac arrest (CA). The major elements of PCAS are anoxic brain injury and circulatory failure. Objective: ... -
Translational Research in Obesity: Animal Models of Bariatric Surgery and the Underlying Mechanisms
(Doktoravhandlinger ved NTNU, 1503-8181; 2014:232, Doctoral thesis, 2014)Background/Aims: The number of obese individuals is increasing rapidly, leading to a global obesity epidemic. Only bariatric surgery has demonstrated long-term therapeutic effects, and the use of these procedures is ... -
Translational Research in Personalized Medicine with Special References to Gastric Cancer and Obesity
(Doctoral theses at NTNU;2020:285, Doctoral thesis, 2020)Translational research in personalized medicine with special references to gastric cancer and obesity Background: Translational research in medical science is essential because the rapid progression of science and technology ... -
Translational Research on Gastric Cancer – Pharmacological Validations of Metabolism-Based Treatments
(Doctoral theses at NTNU;2022:66, Doctoral thesis, 2022)Bakgrunn/mål: Metabolsk reprogrammering er et kjennetegn for kreft og et lovende område for nyutvikling av kreftbehandling. Magekreft er den femte mest vanlige kreftformen på verdensbasis, og er den tredje dødeligste blant ... -
Translational Studies of Eating Behavior and Obesity Treatment
(Doctoral theses at NTNU;2017:280, Doctoral thesis, 2017) -
Travel time and perinatal mortality after emergency caesarean sections: an evaluation of the 2-hour proximity indicator in Sierra Leone
(Peer reviewed; Journal article, 2020)Introduction Longer travel times are associated with increased adverse maternal and perinatal outcomes. Geospatial modelling has been increasingly used to estimate geographic proximity in emergency obstetric care. In this ... -
Treatment and survival of patients with colon cancer aged 80 years and older: a EURECCA international comparison
(Peer reviewed; Journal article, 2018)Background Colon cancer in older patients represents a major public health issue. As older patients are hardly included in clinical trials, the optimal treatment of these patients remains unclear. The present international ... -
Treatment of Liver Metastases With Focused Ultrasound and Microbubbles in Patients With Colorectal Cancer Receiving Chemotherapy
(Journal article; Peer reviewed, 2023)Objective: Pre-clinical trials have obtained promising results that focused ultrasound (FUS) combined with microbubbles (MBs) increases tumor uptake and the therapeutic effect of drugs. The aims of the study described here ...