Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 2235-2254 of 3436
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NRF2 drives an oxidative stress response predictive of breast cancer
(Peer reviewed; Journal article, 2022)Many breast cancer patients are diagnosed with small, well-differentiated, hormone receptor-positive tumors. Risk of relapse is not easily identified in these patients, resulting in overtreatment. To identify metastasis-related ... -
Nucleoside Analogues Are Potent Inducers of Pol V-mediated Mutagenesis
(Peer reviewed; Journal article, 2021)Drugs targeting DNA and RNA in mammalian cells or viruses can also affect bacteria present in the host and thereby induce the bacterial SOS system. This has the potential to increase mutagenesis and the development of ... -
Nucleoside Analogues Are Potent Inducers of Pol V-mediated Mutagenesis
(Journal article; Peer reviewed, 2021)Drugs targeting DNA and RNA in mammalian cells or viruses can also affect bacteria present in the host and thereby induce the bacterial SOS system. This has the potential to increase mutagenesis and the development of ... -
Nucleotide excision repair is associated with the replisome and its efficiency depends on a direct interaction between XPA and PCNA
(Journal article; Peer reviewed, 2012)Proliferating cell nuclear antigen (PCNA) is an essential protein for DNA replication, DNA repair, cell cycle regulation, chromatin remodeling, and epigenetics. Many proteins interact with PCNA through the PCNA interacting ... -
Nurse-administered intravitreal injections of anti-VEGF: study protocol for noninferiority randomized controlled trial of safety, cost and patient satisfaction
(Journal article; Peer reviewed, 2016)Background: Intravitreal injections (IVI) of anti-vascular endothelial growth factor (anti-VEGF) now improve or stabilize visual acuity in a number of previously untreatable eye diseases, of which the main are age-related ... -
Nurses' experiences of compassionate care in the palliative pathway
(Peer reviewed; Journal article, 2020)Aims and objectives The aim was to explore how nurses experience compassionate care for patients with cancer and family caregivers in different phases of the palliative pathway. Background Compassion is fundamental ... -
Nutrition Care in Cancer Patients: Nutrition assessment: diagnostic criteria and theassociation to survival and health-related quality oflife in patients with advanced colorectal carcinoma.
(Doktoravhandlinger ved NTNU, 1503-8181; 2012:82, Doctoral thesis, 2012)God ernæringspraksis for kreftpasienter. Ernæringsutredning; diagnostiske kriterier og sammenheng med overlevelse og helserelatert livskvalitet hos pasienter med avansert tykk- og endetarmskreft. Avhandlingen bygger på ... -
Nutrition impact symptoms in advanced cancer patients: frequency and specific interventions, a case-control study
(Journal article; Peer reviewed, 2013)Background Involuntary weight loss (IWL) is frequent in advanced cancer patients causing compromised anticancer treatment outcomes and function. Cancer cachexia is influenced by nutrition impact symptoms (NIS). The aim ... -
Nutritional experiences in head and neck cancer patients
(Journal article; Peer reviewed, 2019)Objective Extensive research has documented the negative nutritional impact of head neck cancer (HNC) treatment, but few studies have addressed the patients' experiences. The purpose of this study was to describe how ... -
Ny og nyttig screening for preeklampsirisiko
(Journal article; Peer reviewed, 2023) -
Nye biomarkører for vurdering av risiko for preeklampsi
(Peer reviewed; Journal article, 2022)Preeklampsi, eller svangerskapsforgiftning, forekommer hos 3 % av norske gravide (1) og kan være livstruende for både mor og barn. Tilstanden kjennetegnes av endoteldysfunksjon, hypertensjon og proteinuri, men diagnostikken ... -
Nytt verktøy for tolkning av farmakogenetiske analyser
(Peer reviewed; Journal article, 2023)Utilgjengelig kunnskap om tolkning av genvarianter som kan påvirke legemiddelrespons, er en barriere for implementering av farmakogenetikk. Vi har utviklet et nettbasert verktøy hvor man kan utføre spørringer og få ... -
O-GlcNAc Transferase Inhibition Differentially Affects Breast Cancer Subtypes
(Journal article; Peer reviewed, 2019)Post-translational modification of intracellular proteins with a single N-acetylglucosamine sugar (O-GlcNAcylation) regulates signaling, proliferation, metabolism and protein stability. In breast cancer, expression of the ... -
Obesity does not protect from subarachnoid haemorrhage: Pooled analysis of 3 large prospective Nordic cohorts
(Journal article; Peer reviewed, 2021)Background and Purpose: Several population-based cohort studies have related higher body mass index (BMI) to a decreased risk of subarachnoid hemorrhage (SAH). The main objective of our study was to investigate whether ... -
Obesity Knowledge amongst final year medical students in Norway
(Journal article; Peer reviewed, 2017)Objectives: To assess the level of obesity knowledge in final-year medical students in Norway and to compare it to an expert group and first-year medical students. Methods: A 20-item questionnaire was specifically designed ... -
Obesity, adipose tissue dysfunction and metabolic disease: possible roles of GPD1L
(Master thesis, 2014) -
Obesity, diabetes and hypovitaminosis D among women in a rural district of Nepal: Prevalence and risk factors. A population-based study
(Doctoral theses at NTNU;2024:143, Doctoral thesis, 2024)The prevalence of obesity, diabetes, and hypovitaminosis D has increased worldwide over the last decades, and these conditions have reached epidemic proportions. Low- and middleincome countries have experienced the most ... -
Octogenarian patients with colon cancer – postoperative morbidity and mortality are the major challenges
(Peer reviewed; Journal article, 2022)Background Few studies have addressed colon cancer surgery outcomes in an unselected cohort of octogenarian patients. The present study aimed to evaluate the relative survival of octogenarian patients after a major resection ... -
‘Ok, stranger fetus-baby: I love you’ The ethics of life and death decisions at the border of viability
(Doctoral theses at NTNU;2023:343, Doctoral thesis, 2023)Advances in neonatal medicine have allowed us to rescue extremely preterm infants. However, both long-term vulnerability and the burden of treatment in the neonatal period increase with decreasing gestational age. Some of ... -
Olaparib monotherapy as primary treatment in unselected triple negative breast cancer
(Peer reviewed; Journal article, 2020)Background The antitumor efficacy of PARP inhibitors (PARPi) for breast cancer patients harboring germline BRCA1/2 (gBRCA1/2) mutations is well established. While PARPi monotherapy was ineffective in patients with metastatic ...