Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 1760-1779 of 3464
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Invasive properties of cancer - a treatment target?: In vitro studies in human prostate cancer cell lines
(Doktoravhandlinger ved NTNU, 1503-8181; 2006:215, Doctoral thesis, 2007) -
Investigating a novel function of Ogg1 and Mutyh DNA glycosylases in memory formation
(Master thesis, 2021)Abstract The capacity to form and store new memories is one of the most important cognitive ability that characterizes the human brain. At the same time, is one of the brain faculties most affected by neurodegenerative ... -
Investigating iPSC derived macrophages as a model to study Mtb infection compared to alveolar macrophages, monocyte derived macrophages and THP-1 macrophages
(Master thesis, 2022)Mycobacterium tuberculosis (Mtb) er fortsatt et omfattende folkehelseproblem for en stor del av verdens utviklingsland, og forårsaker mer enn 1,5 millioner dødsfall årlig. Imidlertid forblir mange aspekter av interaksjonene ... -
Investigating novel biomarkers of immune activation and modulation in the context of sedentary behaviour: a multicentre prospective ischemic stroke cohort study
(Peer reviewed; Journal article, 2021)Background Sedentary behaviour is associated with disease, but the molecular mechanisms are not understood. Valid biomarkers with predictive and explanatory properties are required. Therefore, we have investigated traditional ... -
Investigating optimal β-cell-preserving treatment in latent autoimmune diabetes in adults: Results from a 21-month randomized trial
(Peer reviewed; Journal article, 2019)Aims To compare outcomes of glucagon‐stimulated C‐peptide tests (GSCTs) in people with latent autoimmune diabetes in adults (LADA) after a 21‐month intervention with either insulin or the dipeptidyl peptidase‐4 inhibitor ... -
Investigating survival, quality of life and cognition in PROton versus photon therapy for IDH- mutated diffuse grade 2 and 3 GLIOmas (PRO-GLIO): a randomised controlled trial in Norway and Sweden
(Peer reviewed; Journal article, 2023)Abstract Introduction The use of proton therapy increases globally despite a lack of randomised controlled trials demonstrating its efficacy and safety. Proton therapy enables sparing of non-neoplastic tissue from ... -
Investigating the anti-tumoural effect of novel therapeutics in cell lines generated from patient-derived glioblastoma organoids
(Master thesis, 2024)Glioblastom (GBM) er klassifisert som en grad 4 hjernesvulst og er beryktet for sin aggressive og diffuse vekst. Etter diagnose har kreften en median overlevelse på under 15 måneder. Betydelige utfordringer oppstår på grunn ... -
Investigating the causal effect of smoking on hay fever and asthma: A Mendelian randomization meta-analysis in the CARTA consortium
(Journal article; Peer reviewed, 2017)Observational studies on smoking and risk of hay fever and asthma have shown inconsistent results. However, observational studies may be biased by confounding and reverse causation. Mendelian randomization uses genetic ... -
Investigating the effect of sex and ketosis on weight-loss-induced changes in appetite
(Peer reviewed; Journal article, 2019)Background Diet-induced weight loss (WL) is usually accompanied by increased appetite, a response that seems to be absent when ketogenic diets are used. It remains unknown if sex modulates the appetite suppressant effect ... -
Investigating the immunomodulatory effects of SARS-CoV-2 proteins ORF3a, ORF6 and ORF9b on the inflammatory response of human lung epithelial cells
(Master thesis, 2022)The COVID-19 pandemic has taken an unprecedented number of lives and brought incredibly high social costs across the globe. The disease severity is associated with a strong innate immune dysregulation characterised by low ... -
Investigating the missing data mechanism in quality of life outcomes: a comparison of approaches
(Journal article; Peer reviewed, 2009)Background: Missing data is classified as missing completely at random (MCAR), missing at random (MAR) or missing not at random (MNAR). Knowing the mechanism is useful in identifying the most appropriate analysis. The ... -
Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium
(Journal article; Peer reviewed, 2014)Objectives: To investigate whether associations of smoking with depression and anxiety are likely to be causal, using a Mendelian randomisation approach. Design: Mendelian randomisation meta-analyses using a genetic ... -
Investigating the Role of PRL-3 and Targeting PHGDH in Multiple Myeloma
(Doctoral theses at NTNU;2020:378, Doctoral thesis, 2020)Myelomatose er en hematologisk kreftsykdom som skyldes klonal ekspansjon av plasmaceller som infiltrerer beinmargen. Til tross for fremskritt innen behandlingen av myelomatose, er sykdommen fortsatt uhelbredelig. Artiklene ... -
Investigation into the cardiovascular effects of the 2nd generation reverse transcriptase inhibitors Rilpivirine and Dapivirine
(Master thesis, 2021)Humant immunsviktvirus (HIV) er et virus som angriper immunsystemet og uten behandling fører til immunsviktsykdommen, ervervet immunsviktsyndrom (AIDS). Tidligere var behandlingen for denne gruppe pasienter dårlig, men ... -
Investigation of an outbreak caused by antibiotic susceptible Klebsiella oxytoca in a neonatal intensive care unit in Norway
(Journal article; Peer reviewed, 2018)Abstract Aim Klebsiella spp. have been stated to be the most frequent cause of neonatal intensive care unit (NICU) outbreaks. We report an outbreak of Klebsiella oxytoca in a NICU at a tertiary care hospital in Norway ... -
Investigation of Pattern Recognition Receptor Expression and Cytokine Responses in CAL-1 and PMDC05 cell lines and human Plasmacytoid Dendritic Cells (pDCs)
(Master thesis, 2022)Abstract will be available on 2027-06-30 -
Investigation of properties and classification of human transcription factors
(Doctoral theses at NTNU;2016:243, Doctoral thesis, 2016)Studier av egenskaper og klassifisering av humane transkripsjonsfaktorer Egenskaper og funksjonen av ulike celler bestemmes gjennom regulering av genuttrykket, og en rekke ulike mekanismer er aktive i den enkelte ... -
Investigation of single cells in tumor tissue and microRNAs in serum of colorectal cancer patients
(Master thesis, 2022)Kolorektal kreft er en sykdom som påvirker nesten 2 millioner mennesker hvert år, og omtrent 20% av pasientene blir diagnostisert ved avanserte kreftstadier hvor behandling har dårlig effekt, som følge av mangel på symptomer ... -
Investigation of the long-term sustainability of changes in appetite after weight loss
(Journal article; Peer reviewed, 2018)Background/Objective Diet-induced weight loss (WL) leads to a compensatory increase in appetite and changes in the plasma concentration of appetite-regulating hormones are likely to play a role. Whether these changes are ...