Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 1518-1537 of 3585
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Host Genome Variation and Toxicity in Childhood Acute Lymphoblastic Leukaemia
(Doktoravhandlinger ved NTNU, 1503-8181; 2014:41, Doctoral thesis, 2014)Kreft er den vanligste medisinske dødsårsaken hos barn mellom 1 og 15 år. Akutt lymfatisk leukemi (ALL) er den vanligste kreftformen hos barn og i Norge får ca. 30-40 barn ALL hvert år. Behandlingen strekker seg over 2,5 ... -
Host-Viral Interactions in the Pathogenesis of Ulcerative Colitis
(Peer reviewed; Journal article, 2021)Ulcerative colitis is characterized by relapsing and remitting colonic mucosal inflammation. During the early stages of viral infection, innate immune defenses are activated, leading to the rapid release of cytokines and ... -
Hours lying down per day, as a proxy for sedentary behaviour and risk of diabetes in young and middle-aged adults in Norway: an 11-year follow-up of the HUNT study
(Peer reviewed; Journal article, 2020)Objective We aimed to examine relationship between hours lying down per day, as a proxy for sedentary behaviour and risk of diabetes in young and middle-aged adults, and to assess if leisure-time physical activity and body ... -
How Did People with Prediabetes Who Attended the Diabetes Prevention Education Program (DiPEP) Experience Making Lifestyle Changes? A Qualitative Study in Nepal
(Journal article; Peer reviewed, 2023)Diabetes can be prevented through lifestyle modification in the prediabetic phase. A group-based lifestyle intervention called ‘Diabetes Prevention Education Program’ (DiPEP) was tested recently in Nepal. The present study ... -
How do women want their gynaecologist to address sexual function? A cross-sectional survey among outpatients
(Peer reviewed; Journal article, 2022)Aim Our aim was to examine women's attitudes towards addressing and documenting sexual function in a Nordic gynaecological and obstetric outpatient setting. Materials and Methods We performed a cross-sectional, anonymous ... -
HR MAS NMR based metabolic profiling of colorectal tumor progression organoids
(Master thesis, 2020)Kolorektal kreft er den nest dødeligste krefttypen i Norge. Dette er delvis på grunn av et asymptomatisk sykdomsforløp som ofte forårsaker at pasienter søker medisinsk hjelp sent i sykdommen. Rask diagnose, staging og ... -
Human ALKBH4 Interacts with Proteins Associated with Transcription
(Journal article; Peer reviewed, 2012)The Fe(II)- and 2-oxoglutarate (2OG)-dependent dioxygenase AlkB from E. coli is a demethylase which repairs alkyl lesions in DNA, as well as RNA, through a direct reversal mechanism. Humans possess nine AlkB homologs ... -
Human Base Excision Repair for Preservation of Genomic Stability
(Doktoravhandlinger ved NTNU, 1503-8181; 2006:56, Doctoral thesis, 2006) -
Human Breast Milk miRNA, Maternal Probiotic Supplementation and Atopic Dermatitis in Offspring
(Peer reviewed; Journal article, 2015)Background: Perinatal probiotic ingestion has been shown to prevent atopic dermatitis (AD) in infancy in a number of randomised trials. The Probiotics in the Prevention of Allergy among Children in Trondheim (ProPACT) trial ... -
Human endothelial cell activation by Escherichia coli and staphylococcus aureus is mediated by TNF and IL-1β secondarily to activation of C5 and CD14 in whole blood
(Journal article; Peer reviewed, 2016)Endothelial cells (EC) play a central role in inflammation. E-selectin and ICAM-1 expression are essential for leukocyte recruitmentand are good markers of EC activation. Most studies of EC activation are done in vitro ... -
Human Glioblastomas: Histopathology, Tumor Growth, and MGMT Status
(Doctoral theses at NTNU;2021:22, Doctoral thesis, 2021)Glioblastomer er den vanligste og mest aggressive typen hjernesvulst som oppstår i hjernen hos voksne. Glioblastomene har en meget aggressiv og kompleks biologi, som medfører en dårlig prognose på omtrent 10 måneder etter ... -
Human meningiomas: Histopathology, brain invasion, and prognosis
(Doktoravhandlinger ved NTNU, 1503-8181; 2014:195, Doctoral thesis, 2014)Meningeomer er kreftsvulster som vokser i hjernehinnene. De er vanligvis godartede og saktevoksende. Primærbehandlingen av symptomgivende meningeomer er kirurgisk fjerning med helbredende hensikt. Likevel vil omtrent én ... -
Human meningiomas: Histopathology, brain invasion, and prognosis
(Doktoravhandlinger ved NTNU, 1503-8181; 2014:195, Doctoral thesis, 2014)Meningeomer er kreftsvulster som vokser i hjernehinnene. De er vanligvis godartede og saktevoksende. Primærbehandlingen av symptomgivende meningeomer er kirurgisk fjerning med helbredende hensikt. Likevel vil omtrent én ... -
Human metapneumovirus driven IFN-β production antagonizes macrophage transcriptional induction of IL1-β in response to bacterial pathogens
(Journal article; Peer reviewed, 2023) -
Human Metapneumovirus Induces IRF1 via TANK-Binding Kinase 1 and Type I IFN
(Peer reviewed; Journal article, 2021)The innate immune and host-protective responses to viruses, such as the airway pathogen human metapneumovirus (HMPV), depend on interferons (IFNs) that is induced through TANK-binding kinase 1 (TBK1) and IFN regulatory ... -
Human Metapneumovirus Infection Inhibits Cathelicidin Antimicrobial Peptide Expression in Human Macrophages
(Journal article; Peer reviewed, 2018)Human cathelicidin antimicriobial peptide (CAMP) is a critical component of host innate immunity with both antimicrobial and immunomodulatory functions. Several pathogens have been shown to downregulate CAMP expression, ... -
Human metapneumovirus: Clinical and virological aspects in Norwegian children
(Doctoral theses at NTNU;2017:192, Doctoral thesis, 2017)Background Human metapneumovirus (HMPV) was discovered in 2001. Later studies have shown that HMPV is quite similar to respiratory syncytial virus (RSV), and a common cause of respiratory tract infections (RTI) in ... -
The human RAD5 homologs, HLTF and SHPRH, have separate functions in DNA damage tolerance dependent on the DNA lesion type
(Peer reviewed; Journal article, 2020)Helicase-like transcription factor (HLTF) and SNF2, histone-linker, PHD and RING finger domain-containing helicase (SHPRH), the two human homologs of yeast Rad5, are believed to have a vital role in DNA damage tolerance ... -
Human Toll-like Receptor 8 (TLR8) Is an Important Sensor of Pyogenic Bacteria, and Is Attenuated by Cell Surface TLR Signaling
(Journal article; Peer reviewed, 2019)TLR8 is an endosomal sensor of RNA degradation products in human phagocytes, and is involved in the recognition of viral and bacterial pathogens. We previously showed that in human primary monocytes and monocyte derived ... -
Humoral and cellular immune responses in mice after airway administration of Bacillus thuringiensis Cry1Ab and MON810 cry1Ab-transgenic maize
(Journal article; Peer reviewed, 2014)Genetically modified (GM) crops may bring new proteins with immunogenic and allergenic properties into the food and feed chains. The most commonly grown GM maize, MON810 expresses a modified version of the insecticidal ...