• Long term effects of an integrated care intervention on hospital utilization in patients with severe COPD: A single centre controlled study 

      Titova, Elena Valerevna; Steinshamn, Sigurd Loe; Indredavik, Bent; Henriksen, Anne Hildur (Journal article; Peer reviewed, 2015)
      Chronic obstructive pulmonary disease (COPD) is one of the main causes of morbidity and mortality globally. In Trondheim in 2008 an integrated care model (COPD-Home) consisting of an education program, self-management plan, ...
    • Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomised clinical trial 

      Vaidya, Jayant S; Bulsara, Max; Baum, Michael; Wenz, Frederik; Massarut, Samuele; Pigorsch, Steffi; Alvarado, Michael; Douek, Michael; Saunders, Christobel; Flyger, Henrik; Eiermann, Wolfgang; Brew-Graves, Chris; Williams, Norman R; Potyka, Ingrid; Roberts, Nicholas; Bernstein, Marcelle; Brown, Douglas; Sperk, Elena; Laws, Siobhan; Sütterlin, Marc; Corica, Tammy; Lundgren, Steinar; Holmes, Dennis; Vinante, Lorenzo; Bozza, Fernando; Pazos, Montserrat; Le Blanc-Onfroy, Magali; Gruber, Günther; Polkowski, Wojciech; Dedes, Konstantin J; Niewald, Marcus; Blohmer, Jens; McCready, David; Hoefer, Richard; Kelemen, Pond; Petralia, Gloria; Falzon, Mary; Joseph, David J; Tobias, Jeffrey S (Peer reviewed; Journal article, 2020)
      Objective To determine whether risk adapted intraoperative radiotherapy, delivered as a single dose during lumpectomy, can effectively replace postoperative whole breast external beam radiotherapy for early breast ...
    • Long term trends of breast cancer incidence according to proliferation status 

      Klæstad, Elise; Opdahl, Signe; Raj, Sunil Xavier; Valla, Marit; Bofin, Anna M. (Peer reviewed; Journal article, 2022)
      Background Long-term breast cancer incidence trends according to proliferation status are poorly described. We studied time-trends in breast cancer incidence, using mitotic count and Ki-67 as markers of proliferation. ...
    • Long-term cardiometabolic health in people born after assisted reproductive technology: a multi-cohort analysis 

      Elhakeem, Ahmed; Taylor, Amy E.; Inskip, Hazel M.; Huang, Jonathan Yinhao; Mansell, Toby; Rodrigues, Carina; Asta, Federica; Blaauwendraad, Sophia M.; Håberg, Siri Eldevik; Halliday, Jane; Harskamp-van Ginkel, Margreet W.; He, Jian-Rong; Jaddoe, Vincent W.V.; Lewis, Sharon; Maher, Gillian M.; Manios, Yannis; McCarthy, Fergus P.; Reiss, Irwin K.M.; Rusconi, Franca; Salika, Theodosia; Tafflet, Muriel; Qiu, Xiu; Åsvold, Bjørn Olav; Burgner, David; Chan, Jerry K.Y.; Gagliardi, Luigi; Gaillard, Romy; Heude, Barbara; Magnus, Maria Christine; Moschonis, George; Murray, Deirdre; Nelson, Scott M; Porta, Daniela; Saffery, Richard; Barros, Henrique; Eriksson, Johan G.; Vrijkotte, Tanja G.M.; Lawlor, Deborah A. (Journal article; Peer reviewed, 2023)
      Aims: To examine associations of assisted reproductive technology (ART) conception (vs. natural conception: NC) with offspring cardiometabolic health outcomes and whether these differ with age. Methods and results: Differences ...
    • Long-Term Effects of an Unguided Online Cognitive Behavioral Therapy for Chronic Insomnia 

      Vedaa, Øystein; Hagatun, Susanne; Kallestad, Håvard; Pallesen, Ståle; Smith, Otto Robert Frans; Thorndike, Frances P; Ritterband, Lee M.; Sivertsen, Børge (Journal article; Peer reviewed, 2019)
      STUDY OBJECTIVES: The aim of this study was to test the efficacy of fully automated Internet-delivered cognitive behavioral therapy for insomnia (CBT-I) 18 months after the intervention period on sleep, daytime functioning, ...
    • Long-term follow-up after surgery for atrial fibrillation with concomitant open heart surgery 

      Andersen, Knut Sverre; Grong, Ketil; Hoff, Per-Ivar; Waba, Alexander (Peer reviewed; Journal article, 2021)
      BAKGRUNN Pasienter med atrieflimmer/flutter som skal gjennomgå en åpen hjerteoperasjon, kan behandles med ablasjon av arytmogene foci under samme inngrep. Sinusrytmen gjenopprettes hos de fleste på kort sikt, men ...
    • Longitudinal Brain Changes After Stroke and the Association With Cognitive Decline 

      Aamodt, Eva Birgitte; Lydersen, Stian; Alnæs, Dag; SCHELLHORN, TILL; Saltvedt, Ingvild; Beyer, Mona K.; Håberg, Asta (Peer reviewed; Journal article, 2022)
      Background: Cognitive impairment is common after stroke. So is cortical- and subcortical atrophy, with studies reporting more atrophy in the ipsilesional hemisphere than the contralesional hemisphere. The current study ...
    • Longitudinal cerebrospinal fluid measurements show glial hypo- and hyperactivation in predementia Alzheimer’s disease 

      Nordengen, Kaja; Kirsebom, Bjørn-Eivind Seljelid; Richter, Grit; Pålhaugen, Lene; Gisladottir, Berglind; Siafarikas, Nikias Ioannis; Nakling, Arne Exner; Rongve, Arvid; Bråthen, Geir; Grøntvedt, Gøril Rolfseng; Gonzalez, Fernando; Waterloo, Knut; Sharma, Kulbhushan; Karikari, Thomas; Vromen, Eleonora M.; Tijms, Betty M.; Visser, Pieter J.; Selnes, Per; Kramberger, Milicia G.; Winblad, Bengt; Blennow, Kaj; Fladby, Tormod (Peer reviewed; Journal article, 2023)
      Background Brain innate immune activation is associated with Alzheimer’s disease (AD), but degrees of activation may vary between disease stages. Thus, brain innate immune activation must be assessed in longitudinal ...
    • Longitudinal effects of adjuvant chemotherapy and lymph node staging on patient-reported outcomes in endometrial cancer survivors: a prospective cohort study 

      Forsse, David Erik; Barbero, Mark L.; Werner, Henrica Maria Johanna; Woie, Kathrine; Nordskar, Nina Jebens; Berge Nilsen, Elisabeth; Ellstrøm Engh, Marie; Vistad, Ingvild; Rege, Astri; Sævik-Lode, Margaret; Andreasen, Stine; Haldorsen, Ingfrid S.; Trovik, Jone; Krakstad, Camilla (Peer reviewed; Journal article, 2021)
      Background - Most patients with endometrial cancer with localized disease are effectively treated and survive for a long time. The primary treatment is hysterectomy, to which surgical staging procedures may be added to ...
    • Longitudinal investigation of the presence of different trajectories and associated health and socio-economic determinants, for participants who report suicidal ideation within a community-based public health survey 

      Mulholland, Helen; Whittington, Richard Charles; Lane, Steven; Haines-Delmont, Alina; Nathan, Rajan; Saini, Pooja; Kullu, Cecil; Comerford, Terence; Yameen, Farheen; Corcoran, Rhiannon (Peer reviewed; Journal article, 2023)
      Objective: Given the paucity of evidence-based research investigating different suicidal ideation profiles and trajectories, this project sought to investigate health and socio-economic factors associated with the presence ...
    • Longitudinal study of the effect of a 5-year exercise intervention on structural brain complexity in older adults. A Generation 100 substudy 

      Pani, Jasmine; Marzi, Chiara; Stensvold, Dorthe; Wisløff, Ulrik; Håberg, Asta; Diciotti, Stefano (Peer reviewed; Journal article, 2022)
      Physical inactivity has been identified as an important risk factor for dementia. High levels of cardiorespiratory fitness (CRF) have been shown to reduce the risk of dementia. However, the mechanism by which exercise ...
    • Longterm Outcomes of Temporomandibular Joints in Juvenile Idiopathic Arthritis: 17 Years of Followup of a Nordic Juvenile Idiopathic Arthritis Cohort. 

      Glerup, Mia; Stoustrup, Peter Bangsgaard; Matzen, Louise Hauge; Rypdal, Veronika Gjertsen; Nordal, Ellen Berit; Frid, Paula; Arnstad, Ellen Dalen; Rygg, Marite; Thorarensen, Olafur; Ekelund, Maria; Berntson, Lillemor; Fasth, Anders; Nilsson, H; Peltoniemi, Suvi; Aalto, Kristiina; Arte, Sirpa; Toftedal, Peter; Nielsen, Susan; Kreiborg, S.; Herlin, T; Pedersen, T. (Peer reviewed; Journal article, 2020)
      Objective. To determine the prevalence of orofacial symptoms, dysfunctions, and deformities of the temporomandibular joint (TMJ) in juvenile idiopathic arthritis (JIA) 17 years after disease onset. Methods. Drawn from ...
    • Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity 

      Hotz, Adriana L.; Jamali, Ahmed; Rieser, Nicolas N.; Niklaus, Stephanie; Aydin, Ecem; Myren-Svelstad, Sverre; Lalla, Laetitia Noelle Patricia; Jurisch-Yaksi, Nathalie; Yaksi, Emre; Neuhauss, Stephan C.F. (Peer reviewed; Journal article, 2021)
      Astroglial excitatory amino acid transporter 2 (EAAT2, GLT-1, and SLC1A2) regulates the duration and extent of neuronal excitation by removing glutamate from the synaptic cleft. Hence, an impairment in EAAT2 function could ...
    • Loss of statin treatment years during pregnancy and breastfeeding periods in women with familial hypercholesterolemia 

      Klevmoen, Marianne; Bogsrud, Martin Prøven; Retterstøl, Kjetil; Svilaas, Tone; Vesterbekkmo, Elisabeth Kleivhaug; Hovland, Anders; Berge, Christ; van Lennep, Jeanine Roeters; Holven, Kirsten Bjørklund (Peer reviewed; Journal article, 2021)
      Background and aims Women with heterozygous familial hypercholesterolemia (FH) are recommended to initiate statin treatment at the same age as men (from 8 to 10 years of age). However, statins are contraindicated when ...
    • Low dose apixaban as secondary prophylaxis of venous thromboembolism in cancer patients – 30 months follow-up 

      Larsen, Trine-Lise; Garresori, Herish; Brekke, Jorunn; Enden, Tone Rønnaug; Frøen, Hege; Jacobsen, Eva-Marie; Quist-Paulsen, Petter; Porojnicu, Alina Carmen; Ree, Anne Hansen; Torfoss, Dag; Velle, Elin Osvik; Wik, Hilde Skuterud; Ghanima, Waleed; Sandset, Per Morten; Dahm, Anders Erik A (Peer reviewed; Journal article, 2022)
      Background - There are no data on the effect of low‐dose anticoagulation as secondary prophylaxis for venous thromboembolism (VTE) in cancer patients. We assessed the efficacy and safety of low‐dose apixaban for 30 months, ...
    • Low vitamin D, but not tobacco use or high BMI, is associated with long-term disability progression in multiple sclerosis 

      Wesnes, Kristin; Myhr, Kjell-Morten; Riise, Trond; Stokke, Silje Agnethe; Torkildsen, Øivind; Wergeland, Stig; Holmøy, Trygve; Midgard, Rune; Bru, Alla Nikolajevna S; Edland, Astrid; Eikeland, Randi; Gosal, Sonia; Harbo, Hanne Flinstad; Kleveland, Grethe; Sørenes, Yvonne; Øksendal, Nina; Bjørnevik, Kjetil Lauvland (Peer reviewed; Journal article, 2021)
      Background: Low vitamin D levels, tobacco use and high body mass index (BMI) have been linked to adverse disease outcomes in multiple sclerosis (MS), but their influence on long-term disability progression remains unclear. ...
    • Lower circulating neuron-specific enolase concentrations in adults and adolescents with severe mental illness 

      Andreou, Dimitrios; Steen, Nils Eiel; Jørgensen, Kjetil Nordbø; Smelror, Runar Elle; Wedervang-Resell, Kirsten; Nerland, Stener; Westlye, Lars Tjelta; Nærland, Terje; Myhre, Anne Margrethe; Joa, Inge; Reitan, Solveig Merete Klæbo; Vaaler, Arne; Morken, Gunnar; Bøen, Erlend; Elvsåshagen, Torbjørn; Boye, Birgitte; Malt, Ulrik Fredrik; Aukrust, Pål; Skrede, Silje; Kroken, Rune Andreas; Johnsen, Erik; Djurovic, Srdjan; Andreassen, Ole; Ueland, Thor; Agartz, Ingrid (Peer reviewed; Journal article, 2021)
      Background Both neurodegenerative and neurodevelopmental abnormalities have been suggested to be part of the etiopathology of severe mental illness (SMI). Neuron-specific enolase (NSE), mainly located in the neuronal ...
    • Lower Extremity Intermittent Negative Pressure for Intermittent Claudication. Follow-Up after 24 Weeks of Treatment 

      Hoel, Henrik; Pettersen, Erik Mulder; Høiseth, Lars Øivind; Mathiesen, Iacob; Seternes, Arne; Hisdal, Jonny (Peer reviewed; Journal article, 2021)
      Background Treatment with lower extremity intermittent negative pressure (INP) of -40 mm Hg for one hour twice daily for 12 weeks, increases walking capacity in patients with intermittent claudication (IC). However, the ...
    • Lower-Grade Gliomas: An Epidemiological Voxel-Based Analysis of Location and Proximity to Eloquent Regions 

      Gómez Vecchio, Tomás; Neimantaite, Alice; Corell, Alba; Bartek, Jiri; Jensdottir, Margret; Reinertsen, Ingerid; Solheim, Ole; Jakola, Asgeir S. (Peer reviewed; Journal article, 2021)
      Background: Glioma is the most common intra-axial tumor, and its location relative to critical areas of the brain is important for treatment decision-making. Studies often report tumor location based on anatomical taxonomy ...
    • Lower-Limb Lymphedema after Sentinel Lymph Node Biopsy in Cervical Cancer Patients 

      Cibula, David; Borcinova, Martina; Marnitz, Simone; Jarkovsky, Jiri; Klat, Jaroslav; Pilka, Radovan; Torne, Aureli; Zapardiel, Ignacio; Petiz, Almerinda; Lay, Laura; Sehnal, Borek; Ponce, Jordi; Felsinger, Michal; Arencibia-Sánchez, Octavio; Kascak, Peter; Zalewski, Kamil; Presl, Jiri; Palop-Moscardo, Alicia; Tingulstad, Solveig Kristi; Vergote, Ignace; Redecha, Mikulas; Fruhauf, Filip; Kohler, Christhardt; Kocian, Roman (Peer reviewed; Journal article, 2021)
      Background: To prospectively assess LLL incidence among cervical cancer patients treated by uterine surgery complemented by SLN biopsy, without PLND. Methods: A prospective study in 150 patients with stage IA1–IB2 cervical ...