• An alternative approach to establishing unbiased colorectal cancer risk estimation in Lynch syndrome 

  Suerink, Manon; Rodriguez-Girondo, Mar; van der Klift, Heleen M.; Colas, Chrystelle; Brugieres, Laurence; Lavoine, Noémie; Jongmans, Marjolijn; Munar, Gabriel Capellá; Evans, D. Gareth; Farrell, Michael P.; Genuardi, Maurizio; Goldberg, Yael; Gomez-Garcia, Encarna; Heinimann, Karl; Hoell, Jessica I.; Aretz, Stefan; Jasperson, Kory W.; Kedar, Inbal; Modi, Mitul B.; Nikolaev, Sergey; van Os, Theo A.M.; Ripperger, Tim; Rueda, Daniel; Senter, Leigha; Sjursen, Wenche; Sunde, Lone; Therkildsen, Christina; Tibiletti, Maria G.; Trainer, Alison H.; Vos, Yvonne J.; Wagner, Anja; Winship, Ingrid; Wimmer, Katharina; Zimmermann, Stefanie Y.; Vasen, Hans F.; van Asperen, Christi J.; Houwing-Duistermaat, Jeanine J.; ten Broeke, Sanne W.; Nielsen, Maartje (Peer reviewed; Journal article, 2019)

  Purpose Biallelic pathogenic variants in the mismatch repair (MMR) genes cause a recessive childhood cancer predisposition syndrome known as constitutional mismatch repair deficiency (CMMRD). Family members with a ...

• Protect us from ourselves: Balancing the parental instinct of saving 

  Ursin, Lars Øystein; Syltern, Janicke Marita (Peer reviewed; Journal article, 2019)

  Background: Neonatologists, legal experts and ethicists extensively discuss the ethical challenges of decision-making when a child is born at the limit of viability. The voices of parents are less heard in this discussion. ...

• Autologous BPTB ACL Reconstruction Results in Lower Failure Rates Than ACL Repair with and without Synthetic Augmentation at 30 Years of Follow-up 

  Sporsheim, Anne; Gifstad, Tone; Lundemo, Trond Olav; Engebretsen, Lars; Strand, Torbjørn; Mølster, Anders; Drogset, Jon Olav (Peer reviewed; Journal article, 2019)

  Background: The aim of this study was to compare the 30-year follow-up results after treatment of anterior cruciate ligament (ACL) ruptures with 3 different surgical procedures. Methods: A total of 150 patients with ...

• Cognitive-behavioural group therapy for adolescents with ADHD: study protocol for a randomised controlled trial 

  Nøvik, Torunn Stene; Haugan, Anne-Lise; Lydersen, Stian; Thomsen, Per Hove; Young, Susan; Sund, Anne Mari (Peer reviewed; Journal article, 2020)

  Introduction Persistence of attention deficit hyperactivity disorder (ADHD) into adolescence is a significant burden to patients. Clinical guidelines recommend non-pharmacological therapies, but the evidence to support ...

• An epidemiological study on the prevalence of hallucinations in a general-population sample: Effects of age and sensory modality 

  Larøi, Frank; Bless, Josef J; Laloyaux, Julien Freddy; Kråkvik, Bodil; Vedul-Kjelsås, Einar; Kalhovde, Anne Martha; Hirnstein, Marco; Hugdahl, Kenneth (Journal article; Peer reviewed, 2019)

  Epidemiological studies have repeatedly shown that a significant minority of the general population have experienced hallucinations, however, a potential effect of age on the prevalence of hallucinations in the general ...

• A systematic review examining nutrition support interventions in patients with incurable cancer 

  Blackwood, Honor A.; Hall, Charlie C.; Balstad, Trude Rakel; Solheim, Tora Skeidsvoll; Fallon, Marie; Haraldsdottir, Erna; Laird, Barry J (Peer reviewed; Journal article, 2019)

  Purpose Recent guidelines by the European Society for Clinical Nutrition and Metabolism (ESPEN) have advocated increased attention to nutritional support in all patients with cancer; however, little is known about the ...

• Metacognitions are associated with subjective memory problems in individuals on sick leave due to chronic fatigue 

  Jacobsen, Henrik Børsting; Aasvik, Julie Kristine; Borchgrevink, Petter Chr.; Landrø, Nils Inge; Stiles, Tore Charles (Peer reviewed; Journal article, 2016)

  Background: Subjective cognitive impairments are frequent, but poorly understood in patients with chronic fatigue. We hypothesized that maladaptive metacognitive beliefs at baseline were associated with baseline subjective ...

• Trajectories of Pain in Patients Undergoing Lung Cancer Surgery: A Longitudinal Prospective Study. 

  Gjeilo, Kari Hanne; Oksholm, Trine; Follestad, Turid; Wahba, Alexander; Rustøen, Tone (Peer reviewed; Journal article, 2019)

  Context Lung cancer surgery is among the surgical procedures associated with the highest prevalence of pain, but prospective longitudinal studies after the pain trajectory are scarce. Objectives We aimed to describe the ...

• Variation in serum PCSK9 (proprotein convertase subtilisin/kexin type 9), cardiovascular disease risk, and an investigation of potential unanticipated effects of PCSK9 inhibition 

  Brumpton, Ben Michael; Fritsche, Lars; Zheng, Jie; Nielsen, Jonas Bille; Mannila, Maria Nastase; Surakka, Ida; Rasheed, Humaira; Vie, Gunnhild Åberge; Graham, Sarah E.; Gabrielsen, Maiken Elvestad; Laugsand, Lars Erik; Aukrust, Pål; Vatten, Lars Johan; Damås, Jan Kristian; Ueland, Thor; Janszky, Imre; Zwart, John-Anker; van't Hooft, Ferdinand M.; Seidah, Nabil Georges; Hveem, Kristian; Willer, Cristen; Smith, George Davey; Åsvold, Bjørn Olav (Peer reviewed; Journal article, 2019)

  PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors reduce serum LDL (low-density lipoprotein) cholesterol (LDL-C) by increasing uptake in the liver. Although some long-term trials have evaluated their safety, ...

• Interpersonal problems as a predictor of pain catastrophizing in patients with chronic pain 

  Ryum, Truls; Jacobsen, Henrik Børsting; Borchgrevink, Petter Chr.; Landrø, Nils Inge; Stiles, Tore C (Peer reviewed; Journal article, 2019)

  Background and aims Pain catastrophizing has consistently been related to a variety of negative outcomes within chronic pain conditions, but competing models exist explaining the role of catastrophizing. According to the ...

• Early reduced myocardial diastolic function in children and adolescents with type 1 diabetes mellitus a population-based study 

  Brunvand, Leif; Fugelseth, Drude; STENSÆTH, KNUT-HAAKON; Dahl-Jørgensen, Knut; MARGEIRSDOTTIR, HANNA DIS (Peer reviewed; Journal article, 2016)

  Background Reduced diastolic myocardial function is an early sign of diabetic cardiomyopathy. The aim of this study was to test the hypothesis that children and adolescents with type 1 diabetes mellitus (T1D), but without ...

• Metabolite profiling of ortho-, meta- and para-fluorofentanyl by hepatocytes and high-resolution mass spectrometry 

  Gundersen, Per Ole Mobråten; Åstrand, Anna; Gréen, Henrik; Josefsson, Martin; Spigset, Olav; Vikingsson, Svante (Peer reviewed; Journal article, 2019)

  New psychoactive substances are emerging on the illegal drug market. Synthetic opioids including fentanyl analogues are of special concern due to their high potency. This indicates the possibility of low drug concentrations ...

• Cerebral cortical dimensions in headache sufferers aged 50-66 years: a population-based imaging study in the Nord-Trondelag Health Study (HUNT-MRI) 

  Husøy, Andreas Kattem; Håberg, Asta Kristine; Rimol, Lars Morten; Hagen, Knut; Vangberg, Torgil Riise; Stovner, Lars Jacob (Journal article; Peer reviewed, 2019)

  Based on previous clinic-based magnetic resonance imaging studies showing regional differences in the cerebral cortex between those with and without headache, we hypothesized that headache sufferers have a decrease in ...

• Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk 

  Jansen, Iris E.; Savage, Jeanne E.; Watanabe, Kyoko; Bryois, Julien; Williams, Dylan M.; Steinberg, Stacy; Sealock, Julia; Karlsson, Ida K.; Hägg, Sara; Athanasiu, Lavinia; Voyle, Nicola; Proitsi, Petroula; Witoelar, Aree; Stringer, Sven; Aarsland, Dag; Almdahl, Ina Selseth; Andersen, Fred; Bergh, Sverre; Bettella, Francesco; Björnsson, Sigurbjörn; Brækhus, Anne; Bråthen, Geir; de Leeuw, Christiaan A.; Desikan, Rahul S.; Djurovic, Srdjan; Dumitrescu, Logan; Fladby, Tormod; Hohman, Timothy J.; Jónsson, Pálmi V.; Kiddle, Steven J; Rongve, Arvid; Saltvedt, Ingvild; Sando, Sigrid Botne; Selbæk, Geir; Shoai, Maryam; Skene, Nathan G.; Snædal, Jón G.; Stordal, Eystein; Ulstein, Ingun; Wang, Yunpeng; White, Linda Rosemary; Hardy, John; Hjerling-Leffler, Jens; Sullivan, Patrick; van der Flier, Wiesje M.; Dobson, Richard; Davis, Lea K; Stefánsson, Hreinn; Stefánsson, Kári; Pedersen, Nancy L; Ripke, Stephan; Andreassen, Ole Andreas; Posthuma, Danielle (Journal article; Peer reviewed, 2019)

  Alzheimer’s disease (AD) is highly heritable and recent studies have identified over 20 disease-associated genomic loci. Yet these only explain a small proportion of the genetic variance, indicating that undiscovered loci ...

• Adverse events of exercise therapy in randomised controlled trials: A systematic review and meta-analysis 

  Niemeijer, Andre; Lund, Hans; Stafne, Signe Nilssen; Ipsen, Thomas; Goldschmidt, Cathrine Luhaäär; Jørgensen, Claus Thomas; Juhl, Carsten B. (Journal article; Peer reviewed, 2019)

  Objective To evaluate the relative risk (RR) of serious and non-serious adverse events in patients treated with exercise therapy compared with those in a non-exercising control group. Design Systematic review and ...

• Association of Conventional Cardiovascular Risk Factors With Cardiovascular Disease After Hypertensive Disorders of Pregnancy: Analysis of the Nord-Trøndelag Health Study 

  Haug, Eirin Beate; Horn, Julie; Markovitz, Amanda R; Fraser, Abigail; Klykken, Bjørnar E.; Dalen, Håvard; Vatten, Lars Johan; Romundstad, Pål Richard; Rich-Edwards, Janet W.; Åsvold, Bjørn Olav (Journal article; Peer reviewed, 2019)

  Importance Women with a history of hypertensive disorders of pregnancy (HDP) have higher risk of cardiovascular disease (CVD). It is not known how much of the excess CVD risk in women with a history of HDP is associated ...

• How intensive care patients’ family members can play a more active role 

  Kirkjebø, Gislaug; Gjeilo, Kari Hanne; Skolbekken, John-Arne (Journal article; Peer reviewed, 2019)

  Background: Family members can provide crucial support for the patient, including during stays in an intensive care unit, but the family members’ situation and efforts have not been sufficiently elucidated in earlier ...

• 18F-FACBC PET/MRI in diagnostic assessment and neurosurgery of gliomas 

  Karlberg, Anna Maria; Berntsen, Erik Magnus; Johansen, Håkon; Skjulsvik, Anne Jarstein; Reinertsen, Ingerid; Hong, Yan Dai; Xiao, Yiming; Rivaz, Hassan; Borghammer, Per; Solheim, Ole; Eikenes, Live (Journal article; Peer reviewed, 2019)

  Purpose This pilot study aimed to evaluate the amino acid tracer 18F-FACBC with simultaneous PET/MRI in diagnostic assessment and neurosurgery of gliomas. Materials and Methods Eleven patients with suspected primary or ...

• Stromal collagen content in breast tumors correlates with in vivo diffusion-weighted imaging: A comparison of multi b-value DWI with histologic specimen from benign and malignant breast lesions 

  Egnell, Liv Elisabet; Vidic, Igor; Jerome, Neil Peter; Bofin, Anna M.; Bathen, Tone Frost; Goa, Pål Erik (Journal article; Peer reviewed, 2019)

  Background:Increased deposition and reorientation of stromal collagenfibers are associated with breast cancer progres-sion and invasiveness. Diffusion-weighted imaging (DWI) may be sensitive to the collagenfiber organization ...

• The Association of Bone Mineral Density with Mortality in a COPD Cohort. The HUNT Study, Norway 

  Vikjord, Sigrid Anna; Brumpton, Ben Michael; Mai, Xiao-Mei; Bhatta, Laxmi; Vanfleteren, Lowie E.G.W.; Langhammer, Arnulf (Journal article; Peer reviewed, 2019)

  In individuals with chronic obstructive pulmonary disease (COPD), the presence of comorbidities is associated with increased mortality risk. We wanted to study the association between bone mineral density (BMD) and mortality ...

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