• Machine learning algorithms performed no better than regression models for prognostication in traumatic brain injury 

      Gravesteijn, BY; Nieboer, Daan; Ercole, Ari; Lingsma, Hester F; Nelson, David; Van Calster, Ben; Steyerberg, Ewout W; Andelic, Nada; Anke, Audny; Frisvold, Shirin; Helseth, Eirik; Røe, Cecilie; Røise, Olav; Skandsen, Toril; Vik, Anne (Peer reviewed; Journal article, 2020)
      Objective We aimed to explore the added value of common machine learning (ML) algorithms for prediction of outcome for moderate and severe traumatic brain injury. Study Design and Setting We performed logistic regression ...
    • Measuring the Cognitive Attentional Syndrome Associated with Emotional Distress: Psychometric Properties of the CAS-1 

      Nordahl, Henrik; Wells, Adrian (Journal article; Peer reviewed, 2019)
      The self-regulatory executive function model is the basis of metacognitive therapy and proposes that psychological disorders are caused by maladaptive beliefs about thinking (metacognitive beliefs) and a perseverative ...
    • MEPE loss-of-function variant associates with decreased bone mineral density and increased fracture risk 

      Surakka, Ida; Fritsche, Lars; Zhou, Wei; Backman, Joshua; Kosmicki, Jack A.; Lu, Haocheng; Brumpton, Ben Michael; Nielsen, Jonas B.; Gabrielsen, Maiken Elvestad; Skogholt, Anne Heidi; Wolford, Brooke N.; Graham, Sarah E.; Chen, Y. Eugene; Lee, Seunggeun; Kang, Hyun Min; Langhammer, Arnulf; Forsmo, Siri; Åsvold, Bjørn Olav; Styrkarsdottir, Unnur; Holm, Hilma; Gudbjartsson, Daniel F.; Stefansson, Kari; Baras, Aris; Bai, Xiaodong; Balasubramanian, Suganthi; Barnard, Leland; Blumenfeld, Andrew; Cantor, Michael; Coppola, Giovanni; Economides, Aris; Eom, Gisu; Habegger, Lukas; Hahn, Young; Hawes, Alicia; Jones, Marcus B.; Khalid, Shareef; Lotta, Luca A.; Maxwell, Evan K.; Mitnaul, Lyndon J.; Overton, John D.; Reid, Jeffrey G.; Ferreira, Manuel Allen Revez; Salerno, William; Sharma, Deepika; Shuldiner, Alan R.; Staples, Jeffrey C.; Yadav, Ashish; Abecasis, Goncalo R.; Hveem, Kristian; Willer, Cristen J. (Peer reviewed; Journal article, 2020)
      A major challenge in genetic association studies is that most associated variants fall in the non-coding part of the human genome. We searched for variants associated with bone mineral density (BMD) after enriching the ...
    • Mer fysikalsk behandling og mindre kirurgi for pasienter med skuldersmerte. Virkningen av behandlingen, kunnskapshullene og veien videre. 

      Røe, Yngve; Granviken, Fredrik; Bentsen, Lennart; Kenneth, Chance-Larsen; Fersum, Kjartan; Major, Daniel Høgli (Peer reviewed; Journal article, 2020)
      Innledning: Skuldersmerte er en vanlig og ofte langvarig muskelskjelettplage. Subakromial smerte utgjør den klart største diagnostiske gruppen. I nye faglige retningslinjer frarådes den mest vanlige formen for skulderkirurgi; ...
    • Metabolic adaptation is an illusion, only present when participants are in negative energy balance 

      Martins, Catia; Røkenes, Jessica Ann; Salamati, Saideh; Gower, Barbara A.; Hunter, Gary R. (Peer reviewed; Journal article, 2020)
      Background The existence of metabolic adaptation, following weight loss, remains a controversial issue. To our knowledge, no study has evaluated the role of energy balance (EB) in modulating metabolic adaptation. Obj ...
    • Metabolic characterization of triple negative breast cancer 

      Cao, Maria Dung; Lamichhane, Santosh; Lundgren, Steinar; Bofin, Anna M.; Fjøsne, Hans Erikssønn; Giskeødegård, Guro F.; Bathen, Tone Frost (Journal article; Peer reviewed, 2014)
      Background The aims of this study were to characterize the metabolite profiles of triple negative breast cancer (TNBC) and to investigate the metabolite profiles associated with human epidermal growth factor receptor-2/neu ...
    • Metabolite profiling of ortho-, meta- and para-fluorofentanyl by hepatocytes and high-resolution mass spectrometry 

      Gundersen, Per Ole Mobråten; Åstrand, Anna; Gréen, Henrik; Josefsson, Martin; Spigset, Olav; Vikingsson, Svante (Peer reviewed; Journal article, 2019)
      New psychoactive substances are emerging on the illegal drug market. Synthetic opioids including fentanyl analogues are of special concern due to their high potency. This indicates the possibility of low drug concentrations ...
    • Metabolomics identifies placental dysfunction and confirms Flt-1 (FMS-like tyrosine kinase receptor 1) biomarker specificity 

      Austdal, Marie; Silva, Gabriela; Bowe, Sophie; Thomsen, Liv Cecilie Vestrheim; Tangerås, Line Haugstad; Bjørge, Line; Bathen, Tone Frost; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2019)
      Clinical end-stage parameters define the pregnancy disorders preeclampsia and fetal growth restriction while classification of the underlying placental dysfunction is missing and urgently needed. Flt-1 (FMS-like tyrosine ...
    • Metachronous Contralateral Testicular Cancer in the Cisplatin Era: A Population-Based Cohort Study 

      Hellesnes, Ragnhild; Myklebust, Tor Åge; Bremnes, Roy M.; Karlsdottir, Åsa; Kvammen, Øivind; Negaard, Helene Francisca Stigter; Tandstad, Torgrim; Wilsgaard, Tom; Fosså, Sophie Dorothea; Haugnes, Hege Sagstuen (Peer reviewed; Journal article, 2020)
      PURPOSE It is hypothesized that cisplatin-based chemotherapy (CBCT) reduces the occurrence of metachronous contralateral (second) germ cell testicular cancer (TC). However, studies including treatment details are lacking. ...
    • Metacognitions are associated with subjective memory problems in individuals on sick leave due to chronic fatigue 

      Jacobsen, Henrik Børsting; Aasvik, Julie Kristine; Borchgrevink, Petter Chr.; Landrø, Nils Inge; Stiles, Tore Charles (Peer reviewed; Journal article, 2016)
      Background: Subjective cognitive impairments are frequent, but poorly understood in patients with chronic fatigue. We hypothesized that maladaptive metacognitive beliefs at baseline were associated with baseline subjective ...
    • Metformin in Pregnancy Study (MiPS): protocol for a systematic review with individual patient data meta-analysis 

      Mousa, Aya; Løvvik, Tone Shetelig; Ijas, Hilkka; Carlsen, Sven Magnus; Morin-Papunen, Laure; Tertti, Kristiina; Rönnema, Tapani; Syngelaki, Argyro; Nicolaides, Kypros; Shehata, Hassan; Burden, Chirsty; Rowan, Janet; Norman, Jane E.; Dodd, Jodie M.; Hague, William; Vanky, Eszter; Teede, Helena J. (Peer reviewed; Journal article, 2020)
      Introduction: Gestational diabetes mellitus (GDM) is a common disorder of pregnancy and contributes to adverse pregnancy outcomes. Metformin is often used for the prevention and management of GDM; however, its use in ...
    • MGMT Promoter Methylation Status Is Not Related to Histological or Radiological Features in IDH Wild-type Glioblastomas 

      Mikkelsen, Vilde Elisabeth; Hong, Yan Dai; Stensjøen, Anne Line; Berntsen, Erik Magnus; Salvesen, Øyvind; Solheim, Ole; Torp, Sverre Helge (Peer reviewed; Journal article, 2020)
      O6-methylguanine DNA methyltransferase (MGMT) promoter methylation is an important favorable predictive marker in patients with glioblastoma (GBM). We hypothesized that MGMT status could be a surrogate marker of pretreatment ...
    • Microglia and macrophages in human glioblastomas: A morphological and immunohistochemical study 

      Kvisten, Magnus; Mikkelsen, Vilde Elisabeth; Stensjøen, Anne Line; Solheim, Ole; van der Want, Johannes Jacobus Leendert; Torp, Sverre Helge (Journal article; Peer reviewed, 2019)
      Glioblastomas (GBMs), a type of highly malignant brain tumour, contain various macrophages/microglia that are known as tumour‑associated macrophages (TAMs). These TAMs have various roles in tumour biology. Histopathological ...
    • A middle-out modeling strategy to extend a colon cancer logical model improves drug synergy predictions in epithelial-derived cancer cell lines 

      Tsirvouli, Eirini; Touré, Vasundra; Niederdorfer, Barbara; Vazquez Garcia, Miguel; Flobak, Åsmund; Kuiper, Martin (Peer reviewed; Journal article, 2020)
      Cancer is a heterogeneous and complex disease and one of the leading causes of death worldwide. The high tumor heterogeneity between individuals affected by the same cancer type is accompanied by distinct molecular and ...
    • Migraine and risk of stroke 

      Øie, Lise Rystad; Kurth, Tobias; Gulati, Sasha; Dodick, David W. (Peer reviewed; Journal article, 2020)
      Migraine and stroke are two common and heterogeneous neurovascular disorders responsible for a significant burden for those affected and a great economic cost for the society. There is growing evidence that migraine increases ...
    • Mild to Moderate Cognitive Impairment Does Not Affect the Ability to Self-Report Important Symptoms in Patients With Cancer: A Prospective Longitudinal Multinational Study (EPCCS) 

      Ekström, Magnus P.; Palmqvist, Sebastian; Currow, David C.; Sjøgren, Per; Kurita, Geana Paula; Jakobsen, Gunnhild; Kaasa, Stein; Hjermstad, Marianne Jensen (Peer reviewed; Journal article, 2020)
      Context Patients with advanced cancer commonly suffer from both distressing symptoms and cognitive impairment, but the effect of cognitive impairment on the reliability and validity of symptom self-report is unknown. ...
    • Mobile Sensing in Substance Use Research: A Scoping Review 

      Lauvsnes, Anders Dahlen Forsmo; Langaas, Mette; Toussaint, Pieter Jelle; Gråwe, Rolf W. (Peer reviewed; Journal article, 2020)
      Background:Addictive disorders and substance use are significant health challenges worldwide, and relapse is a core component of addictive disorders. The dynamics surrounding relapse and especially the immediate period ...
    • Modes of e-Health delivery in secondary prevention programmes for patients with coronary artery disease: A systematic review 

      Brørs, Gunhild; Pettersen, Trond Røed; Hansen, Tina B.; Fridlund, Bengt Gotthard Anton; Hølvold, Linn Benjaminsen; Lund, Hans; Norekvål, Tone M. (Peer reviewed; Journal article, 2019)
      Background: Electronic health (e-Health) interventions are emerging as an effective alternative model for improving secondary prevention of coronary artery disease (CAD). The aim of this study was to describe the effectiveness ...
    • More than just a bed: Mental health service users' experiences of self-referral admission 

      Olsø, Turid Møller; Gudde, Camilla Buch; Moljord, Inger Elise Opheim; Evensen, Gretha Helen; Antonsen, Dag Øivind; Eriksen, Lasse (Peer reviewed; Journal article, 2016)
      Background Several community mental health centres and mental hospitals in Norway now allow users with a diagnosis of severe mental illness to self-refer for admission. This give a group of service users who are well-known ...
    • Mortality among patients discharged from an acute psychiatric department: A 5-year prospective study 

      Prestmo, Astrid; Høyen, Karina Sagmo; Vaaler, Arne; Torgersen, Terje; Drange, Ole Kristian (Peer reviewed; Journal article, 2020)
      The primary aim of the study was to explore the post discharge standardized mortality ratio of patients from an acute psychiatric department in Norway. The secondary aims were to explore if the standardized mortality ratio ...