Now showing items 293-312 of 495

    • Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium 

      Hansen, Jan; Kaiser, Fabian; Klausen, Christina; Stüven, Birthe; Chong, Raymond; Bönigk, Wolfgang; Mick, David; Möglich, Andreas; Jurisch-Yaksi, Nathalie; Schmidt, Florian; Wachten, Dagmar (Peer reviewed; Journal article, 2020)
      Compartmentalization of cellular signaling forms the molecular basis of cellular behavior. The primary cilium constitutes a subcellular compartment that orchestrates signal transduction independent from the cell body. ...
    • NeoDoppler: New ultrasound technology for continous cerebral circulation monitoring in neonates. 

      Vik, Sigrid Dannheim; Torp, Hans; Follestad, Turid; Støen, Ragnhild; Nyrnes, Siri Ann (Journal article; Peer reviewed, 2019)
      BACKGROUND: There is a strong need for continuous cerebral circulation monitoring in neonatal care, since suboptimal cerebral blood flow may lead to brain injuries in preterm infants and other critically ill neonates. ...
    • Neurocognitive Outcome and Compensating Possibilities in Children and Adolescents Treated for Acute Lymphoblastic Leukemia With Chemotherapy Only 

      Lofstad, Grete Elisabeth; Reinfjell, Trude; Weider, Siri; Diseth, Trond H; Hestad, Knut (Journal article; Peer reviewed, 2019)
      Aim: To examine the neurocognitive outcomes in children and adolescents with acute lymphoblastic leukemia (ALL) in remission who were treated with systemic chemotherapy only (CTO). Methods: Neurocognitive performances ...
    • Neuromodulatory effect of NLRP3 and ASC in neonatal hypoxic ischemic encephalopathy 

      Ystgaard, Martin Bogale; Scheffler, Katja; Suganthan, Rajikala; Bjørås, Magnar; Ranheim, Trine; Sagen, Ellen Lund; Halvorsen, Bente; Saugstad, Ola Didrik; Yndestad, Arne (Journal article; Peer reviewed, 2019)
      Background: Following birth asphyxia there is a robust inflammatory response. NLRP3 is a receptor of the innate immune system. Upon activation, NLRP3 forms an inflammasome together with ASC and procaspase-1 to mediate ...
    • Neurosurgical treatment and outcome patterns of meningioma in Sweden: a nationwide registry-based study 

      Corell, Alba; Thurin, Erik; Skoglund, Thomas; Farahmand, Dan; Henriksson, Roger; Rydenhag, Bertil; Gulati, Sasha; Bártek, Jiří; Jakola, Asgeir Store (Peer reviewed; Journal article, 2019)
      Background Surgery is the main treatment modality for intracranial meningiomas, but data on short-term surgical outcome are limited. The aim of this Swedish nationwide registry-based study was to benchmark the 30-day ...
    • "Never in my mind to give up!" A qualitative study of long-term intensive care patients' inner strength and willpower-Promoting and challenging aspects 

      Alexandersen, Ingeborg; Stjern, Berit; Eide, Regina; Haugdahl, Hege Selnes; Paulsby, Tove Engan; Lund, Stine Borgen; Haugan, Gørill (Journal article; Peer reviewed, 2019)
      Aims and objectives To explore aspects that promote and challenge long‐term ICU patients’ inner strength and willpower. Background Considerable research has been devoted to ICU patients’ experiences; however, research ...
    • New reference intervals for cortisol, cortisol binding globulin and free cortisol index in women using ethinyl estradiol 

      Panton, Kristine Kollerøs; Mikkelsen, Gustav; Irgens, Wenche Elna Øiestad; Hovde, Ann Kristin; Killingmo, Marte Wien; Øien, Monja Airin; Thorsby, Per Medbøe; Åsberg, Arne (Peer reviewed; Journal article, 2019)
      Healthy women using contraceptives containing a low dose of an estrogen may have a higher serum concentration of cortisol (s-cortisol) and cortisol binding globulin (s-CBG) than the commonly used upper reference limits. ...
    • NICU dialects: Understanding Norwegian practice variation 

      Syltern, Janicke Marita; Markestad, Trond Jacob; Saugstad, Ola Didrik; Støen, Ragnhild (Journal article; Peer reviewed, 2018)
      In Norway, a national consensus-based guideline used to address thresholds for offering life support at extreme preterm birth was issued in 1998. Since then, therapeutic advances may have changed attitudes and expectations ...
    • NMR spectroscopy of human eye tissues: A new insight into ocular biochemistry 

      Kryczka, Tomasz Aleksander; Wylegala, E; Dobrowolski, D; Midelfart, Anna (Journal article; Peer reviewed, 2014)
      Background. The human eye is a complex organ whose anatomy and functions has been described very well to date. Unfortunately, the knowledge of the biochemistry and metabolic properties of eye tissues varies. Our objective ...
    • Non-communicable diseases at a regional hospital in Nepal: Findings of a high burden of alcohol-related disease 

      Amundsen, Marie S.; Kirkeby, Tine Marita Gjervan; Giri, Samita; Koju, R; Krishna, SS; Ystgaard, Brynjulf; Solligård, Erik; Risnes, Kari (Peer reviewed; Journal article, 2016)
      Recent global burden of disease reports find that a major proportion of global deaths and disability worldwide can be attributed to alcohol use. Thus, it may be surprising that very few studies have reported on the burden ...
    • Non-disclosure of suicidal ideation in psychiatric inpatients: Rates and correlates 

      Høyen, Karina Sagmo; Solem, Stian; Cohen, Lisa Janet; Prestmo, Astrid; Hjemdal, Odin; Vaaler, Arne; Galynker, Igor; Torgersen, Terje (Peer reviewed; Journal article, 2021)
      The study explored how common non-disclosure of suicidal ideation is in a sample of adult psychiatric inpatients (N = 171) plus associated patient characteristics. A large percentage (51.5%) withheld some information on ...
    • Nonfatal occupational injuries in norwegian Farmers 

      Svendsen, Kristin V Hirsch; Aas, Oddfrid; Hilt, Bjørn (Journal article; Peer reviewed, 2014)
      Background Agriculture ranks among the most dangerous trades worldwide. There is, however, still a lack of knowledge on nonfatal injuries in agriculture. The aim of this study was to describe the nature and occurrence of ...
    • Nonsupine positioning after macular hole surgery: A prospective multicenter study 

      Lindtjørn, Birger; Krohn, Jørgen Gitlesen; Austeng, Dordi; Fossen, Kristian; Varhaug, Pål; Basit, Samy; Helgesen, Ole Harald; Eide, Geir Egil; Forsaa, Vegard Asgeir (Journal article; Peer reviewed, 2019)
      Purpose To evaluate the postoperative closure rate of full-thickness macular holes (MHs) after nonsupine positioning, which means that the patients avoid upward gaze and a supine sleeping position, and to investigate the ...
    • The novel arthroscopic subscapular quadriceps tendon–bone sling procedure provides increased stability in shoulder cadavers with severe glenoid bone loss 

      Klungsøyr, Jan Arild; Vagstad, Terje; Ferle, Manuel; Drogset, Jon Olav; Hoff, Solveig Roth; Dalen, Andreas F.; Hurschler, Christof; von, Falck; Klungsøyr, Peter J. (Peer reviewed; Journal article, 2020)
      Purpose Treatment of anterior glenoid bone loss in patients with recurrent anterior shoulder instability is a challenge. The subscapular sling method with quadriceps tendon bone (QTB) graft is a modification of the ...
    • Nutcracker syndrome mimicking new daily persistent headache: A case report 

      Stubberud, Anker; Cheema, Sanjay; Tronvik, Erling Andreas; Matharu, Manjit (Peer reviewed; Journal article, 2020)
      Introduction Compression of the duodenum and left renal vein between the aorta and superior mesenteric artery usually leads to symptoms of proximal bowel obstruction or hematuria and, more rarely, nonspecific mild ...
    • Obsessive-compulsive disorder (OCD) in patients with first- episode psychosis (FEP): A prospective study 

      Hagen, Kristen; Solem, Stian; Larsen, Tor Ketil; Joa, Inge; Kvale, Gerd; Hansen, Bjarne (Journal article; Peer reviewed, 2014)
    • Olaparib monotherapy as primary treatment in unselected triple negative breast cancer 

      Eikesdal, Hans Petter; Yndestad, Synnøve; Elzawahry, Asmaa; Llop-Guevara, Alba; Gilje, Bjørnar; Blix, Egil Støre; Espelid, Helge; Lundgren, Steinar; Geisler, Jürgen; Vagstad, Geirfinn; Venizelos, Andreas; Minsaas, Laura; Leirvaag, Beryl; Gudlaugsson, Einar; Vintermyr, Olav Karsten; Aase, Hildegunn Siv; Aas, Turid; Balmaña, Judith; Serra, Violeta; Janssen, Emiel; Knappskog, Stian; Lønning, Per Eystein (Peer reviewed; Journal article, 2020)
      Background The antitumor efficacy of PARP inhibitors (PARPi) for breast cancer patients harboring germline BRCA1/2 (gBRCA1/2) mutations is well established. While PARPi monotherapy was ineffective in patients with metastatic ...
    • Optimal timing of assessment tasks depending on experience level of surgical trainees 

      Våpenstad, Cecilie; Hofstad, Erlend Fagertun; Bernstein, Tor Eivind; Aadahl, Petter; Johnsen, Gjermund; Mårvik, Ronald (Peer reviewed; Journal article, 2019)
      Introduction: Box trainers with motion analysis are important add-ons to surgical training and skills assessment outside the operating room, given that they exhibit construct validity. Material and methods: Four different ...
    • Oral health in children and adolescents with juvenile idiopathic arthritis - a systematic review and meta-analysis 

      Skeie, Marit Slåttelid; Gil, Elisabeth; Cetrelli, Lena; Rosén, Annika; Fischer, Johannes Maria; Åstrøm, Anne Nordrehaug; Luukko, Keijo; Feuerherm, Astrid Jullumstrø; Sen, Abhijit; Frid, Paula; Rygg, Marite; Bletsa, Athanasia (Journal article; Peer reviewed, 2019)
      Background Observational studies examining the association between oral health and juvenile idiopathic arthritis (JIA) among children and adolescents have reported inconsistent findings. The aims of this systematic review ...
    • Osimertinib in T790M-positive and -negative patients with EGFR-mutated advanced non-small cell lung cancer (the TREM-study) 

      Eide, Inger Johanne; Helland, Åslaug; Ekman, Simon; Mellemgaard, Anders; Hansen, Karin Holmskov; Cicenas, Saulius; Koivunen, Jussi; Grønberg, Bjørn Henning; Brustugun, Odd Terje (Peer reviewed; Journal article, 2020)
      Objectives In non-small cell lung cancer patients with acquired resistance to first- or second-generation EGFR-TKIs, osimertinib is approved in the presence of the T790 M resistance mutation. We assessed the efficacy of ...