Browsing Publikasjoner fra Cristin - St. Olavs hospital by Title
Now showing items 574-593 of 1465
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Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache
(Peer reviewed; Journal article, 2021)Objective Identifying common genetic variants that confer genetic risk for cluster headache. Methods We conducted a case–control study in the Dutch Leiden University Cluster headache neuro-Analysis program (LUCA) study ... -
Genetic variants associated with cardiometabolic abnormalities during treatment with selective serotonin reuptake inhibitors: a genome-wide association study
(Peer reviewed; Journal article, 2021)Selective serotonin reuptake inhibitors (SSRIs) are prescribed both to patients with schizophrenia and bipolar disorder. Previous studies have shown associations between SSRI treatment and cardiometabolic alterations. The ... -
Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer's pathophysiology and susceptibility
(Journal article; Peer reviewed, 2015)Background Alzheimer’s disease is a neurodegenerative disorder in which extracellular deposition of β-amyloid (Aβ) oligomers causes synaptic injury resulting in early memory loss, altered homeostasis, accumulation of ... -
Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease
(Peer reviewed; Journal article, 2021)Objective Haemorrhoidal disease (HEM) affects a large and silently suffering fraction of the population but its aetiology, including suspected genetic predisposition, is poorly understood. We report the first genome-wide ... -
Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease
(Peer reviewed; Journal article, 2021)Psychotic symptoms, defined as the occurrence of delusions or hallucinations, are frequent in Alzheimer disease (AD with psychosis, AD + P). AD + P affects ~50% of individuals with AD, identifies a subgroup with poor ... -
Genome-Wide Association Study Identifies New Genetic Determinants of Cardiorespiratory Fitness: The Trøndelag Health Study
(Peer reviewed; Journal article, 2022)Purpose Low cardiorespiratory fitness (CRF) is a major risk factor for cardiovascular disease (CVD) and a stronger predictor of CVD morbidity and mortality than established risk factors. The genetic component of CRF, ... -
Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors
(Peer reviewed; Journal article, 2020)Rupture of an intracranial aneurysm leads to subarachnoid hemorrhage, a severe type of stroke. To discover new risk loci and the genetic architecture of intracranial aneurysms, we performed a cross-ancestry, genome-wide ... -
Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth
(Peer reviewed; Journal article, 2023)A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), ... -
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk
(Journal article; Peer reviewed, 2019)Alzheimer’s disease (AD) is highly heritable and recent studies have identified over 20 disease-associated genomic loci. Yet these only explain a small proportion of the genetic variance, indicating that undiscovered loci ... -
Genome-wide meta-analysis of iron status biomarkers and the effect of iron on all-cause mortality in HUNT
(Peer reviewed; Journal article, 2022)Iron is essential for many biological processes, but iron levels must be tightly regulated to avoid harmful effects of both iron deficiency and overload. Here, we perform genome-wide association studies on four iron-related ... -
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders.
(Peer reviewed; Journal article, 2019)Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed ... -
Geographic and socioeconomic inequities in cesarean delivery rates at the district level in Madhya Pradesh, India: A secondary analysis of the national family health survey-5
(Peer reviewed; Journal article, 2023)Background In India, caesarean delivery (CD) accounts for 17% of the births, of which 41% occur in private facilities. However, areas to CD in rural areas are limited, particularly for the poor populations. Little information ... -
Germline pathogenic variants in patients with high-grade gastroenteropancreatic neuroendocrine neoplasms
(Peer reviewed; Journal article, 2023)High-grade gastroenteropancreatic (HG-GEP) neuroendocrine neoplasms (NENs) are highly aggressive cancers. The molecular etiology of these tumors remains unclear, and the prevalence of pathogenic germline variants in patients ... -
Gestational Age, Parent Education, and Education in Adulthood
(Journal article; Peer reviewed, 2021)BACKGROUND: Adults born preterm (<37 weeks) have lower educational attainment than those born term. Whether this relationship is modified by family factors such as socioeconomic background is, however, less well known. We ... -
Gestational weight gain outside the Institute of Medicine recommendations and adverse pregnancy outcomes: analysis using individual participant data from randomised trials
(Journal article; Peer reviewed, 2019)Background:High Body Mass Index (BMI) and gestational weight gain (GWG) affect an increasing number ofpregnancies. The Institute of Medicine (IOM) has issued recommendations on the optimal GWG for womenaccording to their ... -
Gir ACE-hemmere og angiotensinreseptorantagonister økt risiko for alvorlig covid-19?
(Peer reviewed; Journal article, 2020)Hypertensjon og diabetes mellitus er risikofaktorer for alvorlig covid-19. Det er blitt reist spørsmål om hvorvidt denne assosiasjonen er relatert til bruk av ACE-hemmere og angiotensin II-reseptorblokkere. -
Gjenvinning av mobilitet etter hoftebrudd – en prospektiv kohortestudie
(Peer reviewed; Journal article, 2020)Hensikt: Å undersøke hva som karakteriserer eldre med hoftebrudd som ikke gjenvinner mobilitet, samt å beskrive mengden fysioterapi denne gruppen mottar det første året etter hoftebrudd. Design: Prospektiv kohortestudie. ... -
Glioblastom hos voksne
(Peer reviewed; Journal article, 2023)lioblastom er den vanligste formen for primær hjernekreft hos voksne, og sykdommen har en alvorlig prognose. Selv om det er gjort store fremskritt i molekylær karakteristikk, har det ikke vært større gjennombrudd i ... -
Global longitudinal strain is a more reproducible measure of left ventricular function than ejection fraction regardless of echocardiographic training
(Peer reviewed; Journal article, 2019)Background: Left ventricular ejection fraction (LVEF) is an established method for evaluation of left ventricular (LV)systolic function. Global longitudinal strain (GLS) by speckle tracking echocardiography seems to be an ... -
The global prevalence of headache: an update, with analysis of the influences of methodological factors on prevalence estimates
(Peer reviewed; Journal article, 2022)Background According to the Global Burden of Disease (GBD) study, headache disorders are among the most prevalent and disabling conditions worldwide. GBD builds on epidemiological studies (published and unpublished) ...