Blar i Publikasjoner fra Cristin - St. Olavs hospital på tittel

Viser treff 937-956 av 1610

    • Metabolic adaptation is associated with less weight and fat mass loss in response to low-energy diets 

      Martins, Catia; Røkenes, Jessica Ann; Gower, Barbara A.; Hunter, Gary R. (Peer reviewed; Journal article, 2021)
      Background: The practical relevance of metabolic adaptation remains a controversial issue. To the best of our knowledge, no study has properly evaluated the role of metabolic adaptation in modulating weight loss outcomes. ...

    • Metabolic characterization of triple negative breast cancer 

      Cao, Maria Dung; Lamichhane, Santosh; Lundgren, Steinar; Bofin, Anna M.; Fjøsne, Hans Erikssønn; Giskeødegård, Guro F.; Bathen, Tone Frost (Journal article; Peer reviewed, 2014)
      Background The aims of this study were to characterize the metabolite profiles of triple negative breast cancer (TNBC) and to investigate the metabolite profiles associated with human epidermal growth factor receptor-2/neu ...

    • Metabolite profiling of ortho-, meta- and para-fluorofentanyl by hepatocytes and high-resolution mass spectrometry 

      Gundersen, Per Ole Mobråten; Åstrand, Anna; Gréen, Henrik; Josefsson, Martin; Spigset, Olav; Vikingsson, Svante (Peer reviewed; Journal article, 2019)
      New psychoactive substances are emerging on the illegal drug market. Synthetic opioids including fentanyl analogues are of special concern due to their high potency. This indicates the possibility of low drug concentrations ...

    • Metabolomics identifies placental dysfunction and confirms Flt-1 (FMS-like tyrosine kinase receptor 1) biomarker specificity 

      Austdal, Marie; Silva, Gabriela; Bowe, Sophie; Thomsen, Liv Cecilie Vestrheim; Tangerås, Line Haugstad; Bjørge, Line; Bathen, Tone Frost; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2019)
      Clinical end-stage parameters define the pregnancy disorders preeclampsia and fetal growth restriction while classification of the underlying placental dysfunction is missing and urgently needed. Flt-1 (FMS-like tyrosine ...

    • Metachronous Contralateral Testicular Cancer in the Cisplatin Era: A Population-Based Cohort Study 

      Hellesnes, Ragnhild; Myklebust, Tor Åge; Bremnes, Roy M.; Karlsdottir, Åsa; Kvammen, Øivind; Negaard, Helene Francisca Stigter; Tandstad, Torgrim; Wilsgaard, Tom; Fosså, Sophie Dorothea; Haugnes, Hege Sagstuen (Peer reviewed; Journal article, 2020)
      PURPOSE It is hypothesized that cisplatin-based chemotherapy (CBCT) reduces the occurrence of metachronous contralateral (second) germ cell testicular cancer (TC). However, studies including treatment details are lacking. ...

    • Metacognitions are associated with subjective memory problems in individuals on sick leave due to chronic fatigue 

      Jacobsen, Henrik Børsting; Aasvik, Julie Kristine; Borchgrevink, Petter Chr.; Landrø, Nils Inge; Stiles, Tore Charles (Peer reviewed; Journal article, 2016)
      Background: Subjective cognitive impairments are frequent, but poorly understood in patients with chronic fatigue. We hypothesized that maladaptive metacognitive beliefs at baseline were associated with baseline subjective ...

    • Metacognitive beliefs prospectively predict level of personality functioning beyond maladaptive personality traits within-individuals: Results from a four-wave longitudinal study 

      Strand, Eivind Rauø; Anyan, Frederick; Hjemdal, Odin; Nordahl, Hans Morten; Nordahl, Henrik (Peer reviewed; Journal article, 2024)
      Identifying within-person dynamic factors influencing personality functioning (operationalized as self- and interpersonal functioning) above maladaptive personality traits could increase the applicability of the alternative ...

    • Metacognitive strategies mediate the association between metacognitive beliefs and perceived quality of life 

      Havnen, Audun; Anyan, Frederick; Nordahl, Henrik (Journal article; Peer reviewed, 2024)
      Quality of life may be understood as a multidimensional evaluation of life circumstances in relation to values, expectations, and perceived well-being. Quality of life is thus dependent on the subjective perception of the ...

    • Metacognitive Therapy for Emotional Distress in Adult Cancer Survivors: A Case Series 

      Fisher, Peter Leonard; Byrne, Angela; Salmon, Peter (Peer reviewed; Journal article, 2017)
      Many adult cancer survivors experience persistent emotional distress after completing cancer treatment. The aim of this study was to test the potential of a brief transdiagnostic psychological intervention—metacognitive ...

    • Metformin in Pregnancy Study (MiPS): protocol for a systematic review with individual patient data meta-analysis 

      Mousa, Aya; Løvvik, Tone Shetelig; Ijas, Hilkka; Carlsen, Sven Magnus; Morin-Papunen, Laure; Tertti, Kristiina; Rönnema, Tapani; Syngelaki, Argyro; Nicolaides, Kypros; Shehata, Hassan; Burden, Chirsty; Rowan, Janet; Norman, Jane E.; Dodd, Jodie M.; Hague, William; Vanky, Eszter; Teede, Helena J. (Peer reviewed; Journal article, 2020)
      Introduction: Gestational diabetes mellitus (GDM) is a common disorder of pregnancy and contributes to adverse pregnancy outcomes. Metformin is often used for the prevention and management of GDM; however, its use in ...

    • MGMT Promoter Methylation Status Is Not Related to Histological or Radiological Features in IDH Wild-type Glioblastomas 

      Mikkelsen, Vilde Elisabeth; Hong, Yan Dai; Stensjøen, Anne Line; Berntsen, Erik Magnus; Salvesen, Øyvind; Solheim, Ole; Torp, Sverre Helge (Peer reviewed; Journal article, 2020)
      O6-methylguanine DNA methyltransferase (MGMT) promoter methylation is an important favorable predictive marker in patients with glioblastoma (GBM). We hypothesized that MGMT status could be a surrogate marker of pretreatment ...

    • Microglia and macrophages in human glioblastomas: A morphological and immunohistochemical study 

      Kvisten, Magnus; Mikkelsen, Vilde Elisabeth; Stensjøen, Anne Line; Solheim, Ole; van der Want, Johannes Jacobus Leendert; Torp, Sverre Helge (Journal article; Peer reviewed, 2019)
      Glioblastomas (GBMs), a type of highly malignant brain tumour, contain various macrophages/microglia that are known as tumour‑associated macrophages (TAMs). These TAMs have various roles in tumour biology. Histopathological ...

    • MicroRNA profiling of psoriatic skin identifies 11 miRNAs associated with disease severity 

      Solvin, Åshild Øksnevad; Chawla, Konika; Olsen, Lene Christin; Hegre, Siv Anita; Danielsen, Kjersti; Jenssen, Marita; Furberg, Anne-Sofie; Saunes, Marit; Hveem, Kristian; Sætrom, Pål; Løset, Mari (Peer reviewed; Journal article, 2021)
      MicroRNAs (miRNAs) are small non-coding RNAs that have emerged as central regulators of gene expression and powerful biomarkers of disease. Much is yet unknown about their role in psoriasis pathology. To globally characterize ...

    • microRNA-451a prevents activation of matrix metalloproteinases 2 and 9 in human cardiomyocytes during pathological stress stimulation. 

      Scrimgeour, Nathan Robert; Wrobel, Aleksandra Zofia; Pinho, Maria; Høydal, Morten (Peer reviewed; Journal article, 2019)
      Matrix metalloproteinases (MMP) are important for cardiac remodeling. Recently, microRNA (miR)-451a has been found to inhibit the expression of both MMP-2 and MMP-9 in human malignancies, but its role in cardiomyocytes has ...

    • A middle-out modeling strategy to extend a colon cancer logical model improves drug synergy predictions in epithelial-derived cancer cell lines 

      Tsirvouli, Eirini; Touré, Vasundra; Niederdorfer, Barbara; Vazquez Garcia, Miguel; Flobak, Åsmund; Kuiper, Martin (Peer reviewed; Journal article, 2020)
      Cancer is a heterogeneous and complex disease and one of the leading causes of death worldwide. The high tumor heterogeneity between individuals affected by the same cancer type is accompanied by distinct molecular and ...

    • Migraine and risk of stroke 

      Øie, Lise Rystad; Kurth, Tobias; Gulati, Sasha; Dodick, David W. (Peer reviewed; Journal article, 2020)
      Migraine and stroke are two common and heterogeneous neurovascular disorders responsible for a significant burden for those affected and a great economic cost for the society. There is growing evidence that migraine increases ...

    • Mild to Moderate Cognitive Impairment Does Not Affect the Ability to Self-Report Important Symptoms in Patients With Cancer: A Prospective Longitudinal Multinational Study (EPCCS) 

      Ekström, Magnus P.; Palmqvist, Sebastian; Currow, David C.; Sjøgren, Per; Kurita, Geana Paula; Jakobsen, Gunnhild; Kaasa, Stein; Hjermstad, Marianne Jensen (Peer reviewed; Journal article, 2020)
      Context Patients with advanced cancer commonly suffer from both distressing symptoms and cognitive impairment, but the effect of cognitive impairment on the reliability and validity of symptom self-report is unknown. ...

    • miR-210 Regulates Apoptotic Cell Death during Cellular Hypoxia and Reoxygenation in a Diametrically Opposite Manner 

      Marwarha, Gurdeep; Røsand, Øystein; Scrimgeour, Nathan Robert; Slagsvold, Katrine Hordnes; Høydal, Morten (Peer reviewed; Journal article, 2021)
      Apoptotic cell death of cardiomyocytes is a characteristic hallmark of ischemia–reperfusion (I/R) injury. The master hypoxamiR, microRNA-210 (miR-210), is considered the primary driver of the cellular response to hypoxic ...

    • Missing Data in Prediction Research: A Five-Step Approach for Multiple Imputation, Illustrated in the CENTER-TBI Study 

      Gravesteijn, Benjamin; Sewalt, Charlie; Venema, Esmee; Nieboer, Daan; Steyerberg, Ewout W.; Andelic, Nada; Andreassen, Lasse; Anke, Audny Gabriele Wagner; Frisvold, Shirin; Helseth, Eirik; Røe, Cecilie; Røise, Olav; Skandsen, Toril; Vik, Anne; Åkerlund, Cecilia; Amrein, Krisztina; Antoni, Anna; Audibert, Gerard; Azouvi, Philippe; Azzolini, Maria luisa; Bartels, Ronald; Barzo, Pal; Beauvais, Romuald; Beer, Ronny; Bellander, Bo-michael; Belli, Antonio; Benali, Habib; Berardino, Maurizio; Beretta, Luigi; Blaabjerg, Morten; Bragge, Peter; Brazinova, Alexandra; Brinck, Vibeke; Brooker, Joanne; Brorsson, Camilla; Buki, Andras; Bullinger, Monika; Cabeleira, Manuel; Caccioppola, Alessio; Calappi, Emiliana; Calvi, Maria rosa; Cameron, Peter; Lozano, Guillermo carbayo; Carbonara, Marco; Chevallard, Giorgio; Chieregato, Arturo; Citerio, Giuseppe; Cnossen, Maryse; Coburn, Mark (Peer reviewed; Journal article, 2021)
      In medical research, missing data is common. In acute diseases, such as traumatic brain injury (TBI), even well-conducted prospective studies may suffer from missing data in baseline characteristics and outcomes. Statistical ...

    • Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation 

      Niyonzima, Nathalie; Rahman, Jubayer; Kunz, Natalie; West, Erin; Freiwald, Tilo; Desai, Jigar V.; Merle, Nicolas; Gidon, Alexandre; Sporsheim, Bjørnar; Lionakis, Michail S.; Evensen, Kristin; Lindberg, Beate; Skagen, Karolina; Skjelland, Mona; Singh, Parul; Haug, Markus; Ruseva, Marieta M.; Kolev, Martin; Bibby, Jack; Marshall, Olivia; O’Brien, Brett; Deeks, Nigel; Afzali, Behdad; Clark, Richard J.; Woodruff, Trent M.; Pryor, Mylton; Yang, Zhi-Hong; Remaley, Alan T.; Mollnes, Tom Eirik; Hewitt, Stephen M.; Yan, Bingyu; Kazemian, Majid; Kiss, Mate G.; Binder, Christoph J.; Halvorsen, Bente; Espevik, Terje; Kemper, Claudia (Peer reviewed; Journal article, 2021)
      While serum-circulating complement destroys invading pathogens, intracellularly active complement, termed the “complosome,” functions as a vital orchestrator of cell-metabolic events underlying T cell effector responses. ...