Blar i Publikasjoner fra Cristin - St. Olavs hospital på tittel

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    • Mental health disorders, functioning and health-related quality of life among extensively hospitalized patients due to severe self-harm – results from the Extreme Challenges project 

      Langjord, Tuva; Pedersen, Geir Arild Feigum; Bovim, Tone; Christensen, Tore Buer; Eikenæs, Ingeborg Helene Ulltveit-Moe; Hove, Oddbjørn; Kildahl, Arvid Nikolai; Mork, Erlend; Norheim, Astrid Berge; Ramleth, Ruth-Kari; Ringen, Petter Andreas; Romm, Kristin Lie; Siqveland, Johan; Schønning, Thea; Stänicke, Line Indrevoll; Torgersen, Terje; Pettersen, Mona; Tveit, Tone; Urnes, Øyvind; Walby, Fredrik A; Kvarstein, Elfrida Hartveit (Peer reviewed; Journal article, 2023)
      Background: Severe self-harm leading to extensive hospitalization generates extreme challenges for patients, families, and health services. Controversies regarding diagnoses and health care often follow. Most evidence-based ...

    • MEPE loss-of-function variant associates with decreased bone mineral density and increased fracture risk 

      Surakka, Ida; Fritsche, Lars; Zhou, Wei; Backman, Joshua; Kosmicki, Jack A.; Lu, Haocheng; Brumpton, Ben Michael; Nielsen, Jonas B.; Gabrielsen, Maiken Elvestad; Skogholt, Anne Heidi; Wolford, Brooke N.; Graham, Sarah E.; Chen, Y. Eugene; Lee, Seunggeun; Kang, Hyun Min; Langhammer, Arnulf; Forsmo, Siri; Åsvold, Bjørn Olav; Styrkarsdottir, Unnur; Holm, Hilma; Gudbjartsson, Daniel F.; Stefansson, Kari; Baras, Aris; Bai, Xiaodong; Balasubramanian, Suganthi; Barnard, Leland; Blumenfeld, Andrew; Cantor, Michael; Coppola, Giovanni; Economides, Aris; Eom, Gisu; Habegger, Lukas; Hahn, Young; Hawes, Alicia; Jones, Marcus B.; Khalid, Shareef; Lotta, Luca A.; Maxwell, Evan K.; Mitnaul, Lyndon J.; Overton, John D.; Reid, Jeffrey G.; Ferreira, Manuel Allen Revez; Salerno, William; Sharma, Deepika; Shuldiner, Alan R.; Staples, Jeffrey C.; Yadav, Ashish; Abecasis, Goncalo R.; Hveem, Kristian; Willer, Cristen J. (Peer reviewed; Journal article, 2020)
      A major challenge in genetic association studies is that most associated variants fall in the non-coding part of the human genome. We searched for variants associated with bone mineral density (BMD) after enriching the ...

    • Mer fysikalsk behandling og mindre kirurgi for pasienter med skuldersmerte. Virkningen av behandlingen, kunnskapshullene og veien videre. 

      Røe, Yngve; Granviken, Fredrik; Bentsen, Lennart; Kenneth, Chance-Larsen; Fersum, Kjartan; Major, Daniel Høgli (Peer reviewed; Journal article, 2020)
      Innledning: Skuldersmerte er en vanlig og ofte langvarig muskelskjelettplage. Subakromial smerte utgjør den klart største diagnostiske gruppen. I nye faglige retningslinjer frarådes den mest vanlige formen for skulderkirurgi; ...

    • Metabolic adaptation is an illusion, only present when participants are in negative energy balance 

      Martins, Catia; Røkenes, Jessica Ann; Salamati, Saideh; Gower, Barbara A.; Hunter, Gary R. (Peer reviewed; Journal article, 2020)
      Background The existence of metabolic adaptation, following weight loss, remains a controversial issue. To our knowledge, no study has evaluated the role of energy balance (EB) in modulating metabolic adaptation. Obj ...

    • Metabolic adaptation is associated with less weight and fat mass loss in response to low-energy diets 

      Martins, Catia; Røkenes, Jessica Ann; Gower, Barbara A.; Hunter, Gary R. (Peer reviewed; Journal article, 2021)
      Background: The practical relevance of metabolic adaptation remains a controversial issue. To the best of our knowledge, no study has properly evaluated the role of metabolic adaptation in modulating weight loss outcomes. ...

    • Metabolic characterization of triple negative breast cancer 

      Cao, Maria Dung; Lamichhane, Santosh; Lundgren, Steinar; Bofin, Anna M.; Fjøsne, Hans Erikssønn; Giskeødegård, Guro F.; Bathen, Tone Frost (Journal article; Peer reviewed, 2014)
      Background The aims of this study were to characterize the metabolite profiles of triple negative breast cancer (TNBC) and to investigate the metabolite profiles associated with human epidermal growth factor receptor-2/neu ...

    • Metabolite profiling of ortho-, meta- and para-fluorofentanyl by hepatocytes and high-resolution mass spectrometry 

      Gundersen, Per Ole Mobråten; Åstrand, Anna; Gréen, Henrik; Josefsson, Martin; Spigset, Olav; Vikingsson, Svante (Peer reviewed; Journal article, 2019)
      New psychoactive substances are emerging on the illegal drug market. Synthetic opioids including fentanyl analogues are of special concern due to their high potency. This indicates the possibility of low drug concentrations ...

    • Metabolomics identifies placental dysfunction and confirms Flt-1 (FMS-like tyrosine kinase receptor 1) biomarker specificity 

      Austdal, Marie; Silva, Gabriela; Bowe, Sophie; Thomsen, Liv Cecilie Vestrheim; Tangerås, Line Haugstad; Bjørge, Line; Bathen, Tone Frost; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2019)
      Clinical end-stage parameters define the pregnancy disorders preeclampsia and fetal growth restriction while classification of the underlying placental dysfunction is missing and urgently needed. Flt-1 (FMS-like tyrosine ...

    • Metachronous Contralateral Testicular Cancer in the Cisplatin Era: A Population-Based Cohort Study 

      Hellesnes, Ragnhild; Myklebust, Tor Åge; Bremnes, Roy M.; Karlsdottir, Åsa; Kvammen, Øivind; Negaard, Helene Francisca Stigter; Tandstad, Torgrim; Wilsgaard, Tom; Fosså, Sophie Dorothea; Haugnes, Hege Sagstuen (Peer reviewed; Journal article, 2020)
      PURPOSE It is hypothesized that cisplatin-based chemotherapy (CBCT) reduces the occurrence of metachronous contralateral (second) germ cell testicular cancer (TC). However, studies including treatment details are lacking. ...

    • Metacognitions are associated with subjective memory problems in individuals on sick leave due to chronic fatigue 

      Jacobsen, Henrik Børsting; Aasvik, Julie Kristine; Borchgrevink, Petter Chr.; Landrø, Nils Inge; Stiles, Tore Charles (Peer reviewed; Journal article, 2016)
      Background: Subjective cognitive impairments are frequent, but poorly understood in patients with chronic fatigue. We hypothesized that maladaptive metacognitive beliefs at baseline were associated with baseline subjective ...

    • Metacognitive Therapy for Emotional Distress in Adult Cancer Survivors: A Case Series 

      Fisher, Peter Leonard; Byrne, Angela; Salmon, Peter (Peer reviewed; Journal article, 2017)
      Many adult cancer survivors experience persistent emotional distress after completing cancer treatment. The aim of this study was to test the potential of a brief transdiagnostic psychological intervention—metacognitive ...

    • Metformin in Pregnancy Study (MiPS): protocol for a systematic review with individual patient data meta-analysis 

      Mousa, Aya; Løvvik, Tone Shetelig; Ijas, Hilkka; Carlsen, Sven Magnus; Morin-Papunen, Laure; Tertti, Kristiina; Rönnema, Tapani; Syngelaki, Argyro; Nicolaides, Kypros; Shehata, Hassan; Burden, Chirsty; Rowan, Janet; Norman, Jane E.; Dodd, Jodie M.; Hague, William; Vanky, Eszter; Teede, Helena J. (Peer reviewed; Journal article, 2020)
      Introduction: Gestational diabetes mellitus (GDM) is a common disorder of pregnancy and contributes to adverse pregnancy outcomes. Metformin is often used for the prevention and management of GDM; however, its use in ...

    • MGMT Promoter Methylation Status Is Not Related to Histological or Radiological Features in IDH Wild-type Glioblastomas 

      Mikkelsen, Vilde Elisabeth; Hong, Yan Dai; Stensjøen, Anne Line; Berntsen, Erik Magnus; Salvesen, Øyvind; Solheim, Ole; Torp, Sverre Helge (Peer reviewed; Journal article, 2020)
      O6-methylguanine DNA methyltransferase (MGMT) promoter methylation is an important favorable predictive marker in patients with glioblastoma (GBM). We hypothesized that MGMT status could be a surrogate marker of pretreatment ...

    • Microglia and macrophages in human glioblastomas: A morphological and immunohistochemical study 

      Kvisten, Magnus; Mikkelsen, Vilde Elisabeth; Stensjøen, Anne Line; Solheim, Ole; van der Want, Johannes Jacobus Leendert; Torp, Sverre Helge (Journal article; Peer reviewed, 2019)
      Glioblastomas (GBMs), a type of highly malignant brain tumour, contain various macrophages/microglia that are known as tumour‑associated macrophages (TAMs). These TAMs have various roles in tumour biology. Histopathological ...

    • MicroRNA profiling of psoriatic skin identifies 11 miRNAs associated with disease severity 

      Solvin, Åshild Øksnevad; Chawla, Konika; Olsen, Lene Christin; Hegre, Siv Anita; Danielsen, Kjersti; Jenssen, Marita; Furberg, Anne-Sofie; Saunes, Marit; Hveem, Kristian; Sætrom, Pål; Løset, Mari (Peer reviewed; Journal article, 2021)
      MicroRNAs (miRNAs) are small non-coding RNAs that have emerged as central regulators of gene expression and powerful biomarkers of disease. Much is yet unknown about their role in psoriasis pathology. To globally characterize ...

    • microRNA-451a prevents activation of matrix metalloproteinases 2 and 9 in human cardiomyocytes during pathological stress stimulation. 

      Scrimgeour, Nathan Robert; Wrobel, Aleksandra Zofia; Pinho, Maria; Høydal, Morten (Peer reviewed; Journal article, 2019)
      Matrix metalloproteinases (MMP) are important for cardiac remodeling. Recently, microRNA (miR)-451a has been found to inhibit the expression of both MMP-2 and MMP-9 in human malignancies, but its role in cardiomyocytes has ...

    • A middle-out modeling strategy to extend a colon cancer logical model improves drug synergy predictions in epithelial-derived cancer cell lines 

      Tsirvouli, Eirini; Touré, Vasundra; Niederdorfer, Barbara; Vazquez Garcia, Miguel; Flobak, Åsmund; Kuiper, Martin (Peer reviewed; Journal article, 2020)
      Cancer is a heterogeneous and complex disease and one of the leading causes of death worldwide. The high tumor heterogeneity between individuals affected by the same cancer type is accompanied by distinct molecular and ...

    • Migraine and risk of stroke 

      Øie, Lise Rystad; Kurth, Tobias; Gulati, Sasha; Dodick, David W. (Peer reviewed; Journal article, 2020)
      Migraine and stroke are two common and heterogeneous neurovascular disorders responsible for a significant burden for those affected and a great economic cost for the society. There is growing evidence that migraine increases ...

    • Mild to Moderate Cognitive Impairment Does Not Affect the Ability to Self-Report Important Symptoms in Patients With Cancer: A Prospective Longitudinal Multinational Study (EPCCS) 

      Ekström, Magnus P.; Palmqvist, Sebastian; Currow, David C.; Sjøgren, Per; Kurita, Geana Paula; Jakobsen, Gunnhild; Kaasa, Stein; Hjermstad, Marianne Jensen (Peer reviewed; Journal article, 2020)
      Context Patients with advanced cancer commonly suffer from both distressing symptoms and cognitive impairment, but the effect of cognitive impairment on the reliability and validity of symptom self-report is unknown. ...

    • miR-210 Regulates Apoptotic Cell Death during Cellular Hypoxia and Reoxygenation in a Diametrically Opposite Manner 

      Marwarha, Gurdeep; Røsand, Øystein; Scrimgeour, Nathan Robert; Slagsvold, Katrine Hordnes; Høydal, Morten (Peer reviewed; Journal article, 2021)
      Apoptotic cell death of cardiomyocytes is a characteristic hallmark of ischemia–reperfusion (I/R) injury. The master hypoxamiR, microRNA-210 (miR-210), is considered the primary driver of the cellular response to hypoxic ...