Browsing Publikasjoner fra Cristin - St. Olavs hospital by Title
Now showing items 614-633 of 1611
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General movement optimality score and general movements trajectories following early parent-administrated physiotherapy in the neonatal intensive care unit
(Peer reviewed; Journal article, 2021)Background The Prechtl General Movement Assessment (GMA) is a reliable tool for the functional assessment of the young nervous system. It is based on a global assessment of the quality of infants' movements. In addition, ... -
General practitioners retiring or relocating and its association with healthcare use and mortality: a cohort study using Norwegian national data
(Journal article; Peer reviewed, 2024) -
Generation of a Mouse Model Lacking the Non-Homologous End-Joining Factor Mri/Cyren
(Journal article; Peer reviewed, 2019)Classical non-homologous end joining (NHEJ) is a molecular pathway that detects, processes, and ligates DNA double-strand breaks (DSBs) throughout the cell cycle. Mutations in several NHEJ genes result in neurological ... -
The genes controlling normal function of citrate and spermine secretion are lost in aggressive prostate cancer and prostate model systems
(Peer reviewed; Journal article, 2022)High secretion of the metabolites citrate and spermine is a unique hallmark for normal prostate epithelial cells, and is reduced in aggressive prostate cancer. However, the identity of the genes controlling this biological ... -
Genetic architecture of subcortical brain structures in 38,851 individuals
(Journal article, 2019)Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus ... -
The genetic architecture of the human cerebral cortex
(Peer reviewed; Journal article, 2020)The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, ... -
Genetic associations with temporal shifts in obesity and severe obesity during the obesity epidemic in Norway: A longitudinal population-based cohort (the HUNT Study)
(Peer reviewed; Journal article, 2020)Background Obesity has tripled worldwide since 1975 as environments are becoming more obesogenic. Our study investigates how changes in population weight and obesity over time are associated with genetic predisposition ... -
Genetic control of variability in subcortical and intracranial volumes
(Peer reviewed; Journal article, 2020)Sensitivity to external demands is essential for adaptation to dynamic environments, but comes at the cost of increased risk of adverse outcomes when facing poor environmental conditions. Here, we apply a novel methodology ... -
Genetic diversity of rotavirus strains circulating in Norway before and after the introduction of rotavirus vaccination in children
(Peer reviewed; Journal article, 2021)Globally, rotavirus (RV) is the leading cause of acute gastroenteritis (AGE) in young children under 5 years of age. Implementation of RV vaccination is expected to result in fewer cases of RV in the target population, but ... -
Genetic epidemiology of amyotrophic lateral sclerosis in Norway - a 2-year population based study
(Peer reviewed; Journal article, 2022)Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor neurons. In Europe, disease-causing genetic variants have been identified in 40-70% of familial ALS patients and approximately ... -
Genetic insight into sick sinus syndrome
(Peer reviewed; Journal article, 2021) -
Genetic polymorphisms associated with sleep-related phenotypes; relationships with individual nocturnal symptoms of insomnia in the HUNT study
(Journal article; Peer reviewed, 2019)Background In recent years, several GWAS (genome wide association studies) of sleep-related traits have identified a number of SNPs (single nucleotides polymorphism) but their relationships with symptoms of insomnia are ... -
Genetic predisposition to PEG-asparaginase hypersensitivity in children treated according to NOPHO ALL2008
(Peer reviewed; Journal article, 2018)Asparaginase is essential in childhood acute lymphoblastic leukaemia (ALL) treatment, however hypersensitivity reactions to pegylated asparaginase (PEG-asparaginase) hampers anti-neoplastic efficacy. Patients with ... -
Genetic risk score associations for myocardial infarction are comparable in persons with and without rheumatoid arthritis: the population-based HUNT study
(Peer reviewed; Journal article, 2020)Persons with rheumatoid arthritis (RA) have increased risk of myocardial infarction (MI). Overlapping associations with MI of weighted genetic risk scores (wGRS) for coronary artery disease (CAD) and RA is unknown in a ... -
Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache
(Peer reviewed; Journal article, 2021)Objective Identifying common genetic variants that confer genetic risk for cluster headache. Methods We conducted a case–control study in the Dutch Leiden University Cluster headache neuro-Analysis program (LUCA) study ... -
Genetic variants associated with cardiometabolic abnormalities during treatment with selective serotonin reuptake inhibitors: a genome-wide association study
(Peer reviewed; Journal article, 2021)Selective serotonin reuptake inhibitors (SSRIs) are prescribed both to patients with schizophrenia and bipolar disorder. Previous studies have shown associations between SSRI treatment and cardiometabolic alterations. The ... -
Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer's pathophysiology and susceptibility
(Journal article; Peer reviewed, 2015)Background Alzheimer’s disease is a neurodegenerative disorder in which extracellular deposition of β-amyloid (Aβ) oligomers causes synaptic injury resulting in early memory loss, altered homeostasis, accumulation of ... -
Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease
(Peer reviewed; Journal article, 2021)Objective Haemorrhoidal disease (HEM) affects a large and silently suffering fraction of the population but its aetiology, including suspected genetic predisposition, is poorly understood. We report the first genome-wide ... -
Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease
(Peer reviewed; Journal article, 2021)Psychotic symptoms, defined as the occurrence of delusions or hallucinations, are frequent in Alzheimer disease (AD with psychosis, AD + P). AD + P affects ~50% of individuals with AD, identifies a subgroup with poor ... -
Genome-Wide Association Study Identifies New Genetic Determinants of Cardiorespiratory Fitness: The Trøndelag Health Study
(Peer reviewed; Journal article, 2022)Purpose Low cardiorespiratory fitness (CRF) is a major risk factor for cardiovascular disease (CVD) and a stronger predictor of CVD morbidity and mortality than established risk factors. The genetic component of CRF, ...