Blar i Publikasjoner fra Cristin - St. Olavs hospital på tittel
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Inhibition of Cytosolic Phospholipase A2α Induces Apoptosis in Multiple Myeloma Cells
(Peer reviewed; Journal article, 2021)Cytosolic phospholipase A2α (cPLA2α) is the rate-limiting enzyme in releasing arachidonic acid and biosynthesis of its derivative eicosanoids. Thus, the catalytic activity of cPLA2α plays an important role in cellular ... -
Inhibitory Control Moderates the Effect of Anxiety on Vagally Mediated Heart Rate Variability: Findings from a Community Sample of Young School-Aged Children
(Peer reviewed; Journal article, 2021)Background Individuals with anxiety disorders show both excessive and blunted vagally mediated heart rate variability (vmHRV) reactivity to stress. Scholars have suggested that differences in cognitive control could ... -
Initial management and survival of patients with primary metastatic bladder cancer before the immunotherapy era: a population-based study from Norway
(Peer reviewed; Journal article, 2023)Before immunotherapy became part of the management of metastatic bladder cancer (mBC), systemic anti-cancer treatment comprised primarily of platinum-based chemotherapy. The objective of this study was to describe the ... -
Initiation of anti-osteoporotic drugs in high-risk female patients starting glucocorticoid treatment: a population study in Norway
(Peer reviewed; Journal article, 2020)Summary Glucocorticoid use is a risk factor for osteoporosis and fractures. We studied whether women initiating glucocorticoid treatment also started anti-osteoporotic treatment, according to clinical guidelines. Women ... -
Inpatients in substance use treatment with co-occurring psychiatric disorders: a prospective cohort study of characteristics and relapse predictors
(Peer reviewed; Journal article, 2023)Background The characteristics of substance use disorder (SUD) inpatients with co-occurring psychiatric disorders (COD) have been scantly described in the extant literature. This study investigated psychological, demographic ... -
Insight into ALKBH8-related intellectual developmental disability based on the first pathogenic missense variant
(Peer reviewed; Journal article, 2021)ALKBH8 is a methyltransferase that modifies tRNAs by methylating the anticodon wobble uridine residue. The syndrome of ALKBH8-related intellectual developmental disability (MRT71) has thus far been reported solely in the ... -
Insight into the relationship between resting heart rate and atrial fibrillation: a Mendelian randomization study
(Peer reviewed; Journal article, 2023)Aims A low resting heart rate (RHR) implies a more efficient heart function and a lower risk of cardiovascular disease. However, observational studies have reported a U-shaped association between RHR and atrial fibrillation ... -
Instant Detection of Cerebral Blood Flow Changes in Infants with Congenital Heart Disease during Transcatheter Interventions
(Journal article; Peer reviewed, 2024)Background: Transcatheter interventions are increasingly used in children with congenital heart disease. However, these interventions can affect cardiac output and cerebral circulation. In this pilot study, we aimed to ... -
Integrated master surgery and outpatient clinic scheduling
(Peer reviewed; Journal article, 2022)In this paper, we study an integrated master surgery and outpatient clinic scheduling problem, motivated by the situation at the Orthopaedic Department at St. Olav’s Hospital, Trondheim. During a treatment process, the ... -
Integrated treatment vs. treatment-as-usual for recent onset schizophrenia; 12 year follow-up on a randomized controlled trial
(Journal article; Peer reviewed, 2013)Background The aim of this study is to compare the 12-year follow-up effects on in- and outpatient services of 2 years of integrated treatment for recent-onset schizophrenia versus treatment as usual in a randomized ... -
Intellectual disabilities and offending behaviour: the awareness and concerns of the police, district attorneys and judges
(Peer reviewed; Journal article, 2019)Purpose: The purpose of this paper is to examine the awareness of intellectual disabilities (ID) amongst professionals in the criminal justice system (CJS) and their knowledge of those persons, either as victims, witnesses, ... -
Intensive outpatient treatment for PTSD: an open trial combining prolonged exposure therapy, EMDR, and physical activity
(Peer reviewed; Journal article, 2022)Background: Intensive outpatient treatment could be a promising option for patients with post-traumatic stress disorder (PTSD). Objective: The aim of the study was to test the effectiveness of an eight-day (two-week) ... -
Inter-and Intraobserver Agreement of Morphological Grading for Central Lumbar Spinal Stenosis on Magnetic Resonance Imaging
(Journal article; Peer reviewed, 2015)Study Design Validation study of a morphological grading system for central lumbar spinal stenosis. Objective To evaluate and validate the inter- and intraobserver agreement of a morphological grading system for central ... -
Inter-observer reliability using the General Movement Assessment is influenced by rater experience
(Peer reviewed; Journal article, 2021)Objective To describe the inter-observer reliability of the General Movement Assessment (GMA) among a sample of infants at high-risk of cerebral palsy (CP) among raters with various levels of experience. Methods Video ... -
Inter-rater reliability of the Silverman and Andersen index-a measure of respiratory distress in preterm infants
(Peer reviewed; Journal article, 2023)Background There are various methods of respiratory support available to optimize respiratory function in preterm infants. Respiratory scoring tools might provide information on which method to choose and the level and ... -
Interaction between overweight and genotypes of HLA, TCF7L2, and FTO in relation to the risk of latent autoimmune diabetes in adults and type 2 diabetes
(Peer reviewed; Journal article, 2019)Objective We investigated potential interactions between body mass index (BMI) and genotypes of human leukocyte antigen (HLA), TCF7L2-rs7903146, and FTO-rs9939609 in relation to the risk of latent autoimmune diabetes in ... -
Interdisciplinary care of hip fractures: Orthogeriatric models, alternative models, interdisciplinary teamwork
(Journal article; Peer reviewed, 2019)Hip fractures are common among older people, and the prognosis is serious in terms of mobility, independence in daily life activities, and cognition, with 42% of patients never achieving the same function as before the ... -
Interest in using patient portals among adolescents in mental health care - a cross-sectional study
(Peer reviewed; Journal article, 2023)Introduction Adolescents in mental health care may benefit from using patient portals to access personalised information about their health and treatment. While no studies have considered the interest in using patient ... -
Interleukin-6 inhibition in ST-elevation myocardial infarction: Immune cell profile in the randomised ASSAIL-MI trial
(Peer reviewed; Journal article, 2022)We recently showed that interleukin (IL)-6 inhibition by tocilizumab improves myocardial salvage in ST-elevation myocardial infarction (STEMI). However, the mechanisms for this effect are not clear. Methods In this ... -
Interleukin-6 receptor inhibition with tocilizumab induces a selective and substantial increase in plasma IP-10 and MIP-1β in non-ST-elevation myocardial infarction
(Journal article; Peer reviewed, 2018)Aim To evaluate the effect of interleukin-6 inhibition with tocilizumab on the cytokine network in patients with acute non-ST-elevation myocardial infarction (NSTEMI). Methods 117 patients with acute NSTEMI were randomised ...