Blar i Publikasjoner fra Cristin - St. Olavs hospital på tittel

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    • Genetic associations with temporal shifts in obesity and severe obesity during the obesity epidemic in Norway: A longitudinal population-based cohort (the HUNT Study) 

      Brandkvist, Maria Charlotta; Bjørngaard, Johan Håkon; Ødegård, Rønnaug; Brumpton, Ben Michael; Smith, George Davey; Åsvold, Bjørn Olav; Sund, Erik; Kvaløy, Kirsti; Willer, Cristen J.; Vie, Gunnhild Åberge (Peer reviewed; Journal article, 2020)
      Background Obesity has tripled worldwide since 1975 as environments are becoming more obesogenic. Our study investigates how changes in population weight and obesity over time are associated with genetic predisposition ...

    • Genetic control of variability in subcortical and intracranial volumes 

      Còrdova Palomera, Aldo; van der Meer, Dennis; Kaufmann, Tobias; Bettella, Francesco; Wang, Yunpeng; Alnæs, Dag; Doan, Nhat Trung; Agartz, Ingrid; Bertolino, Alessandro; Buitelaar, Jan; Coynel, David; Djurovic, Srdjan; Dørum, Erlend Solberg; Espeseth, Thomas; Fazio, Leonardo; Franke, Barbara; Frei, Oleksandr; Håberg, Asta; Le Hellard, Stephanie; Jönsson, Erik Gunnar; Kolskår, Knut-Kristian; Lund, Martina Jonette; Moberget, Torgeir; Nordvik, Jan; Nyberg, Lars; Papassotiropoulos, Andreas; Pergola, Giulio; de Quervain, Dominique; Rampino, Antonio; Richard, Geneviève; Rokicki, Jaroslav; Sanders, Anne-Marthe; Schwarz, Emanuel; Smeland, Olav Bjerkehagen; Steen, Vidar Martin; Starrfelt, Jostein; Sønderby, Ida Elken; Ulrichsen, Kristine Moe; Andreassen, Ole Andreas; Westlye, Lars Tjelta (Peer reviewed; Journal article, 2020)
      Sensitivity to external demands is essential for adaptation to dynamic environments, but comes at the cost of increased risk of adverse outcomes when facing poor environmental conditions. Here, we apply a novel methodology ...

    • Genetic diversity of rotavirus strains circulating in Norway before and after the introduction of rotavirus vaccination in children 

      Gibory, Moustafa; Bruun, Tone; Flem, Elmira; Dembinski, Jennifer Lynn; Haltbakk, Ildri; Størdal, Ketil; Nordbø, Svein Arne; Jakobsen, Kirsti; Haarr, Elisebet; Leegaard, Truls Michael; Dudman, Susanne Gjeruldsen (Peer reviewed; Journal article, 2021)
      Globally, rotavirus (RV) is the leading cause of acute gastroenteritis (AGE) in young children under 5 years of age. Implementation of RV vaccination is expected to result in fewer cases of RV in the target population, but ...

    • Genetic epidemiology of amyotrophic lateral sclerosis in Norway - a 2-year population based study 

      Olsen, Cathrine Goberg; Busk, Øyvind Løvold; Aanjesen, Tori Navestad; Alstadhaug, Karl Bjørnar; Bjørnå, Ingrid Kristine; Braathen, Geir Julius; Breivik, Kristin Lif; Demic, Natasha; Flemmen, Heidi Øyen; Hallerstig, Erika; HogenEsch, Ineke; Holla, Øystein Lunde; Jøntvedt, Anne Berit; Kampman, Margitta T.; Kleveland, Grethe; Kvernmo, Helene Ballo; Ljøstad, Unn; Maniaol, Angelina; Morsund, Åse Hagen; Nakken, Ola; Novy, Camilla; Rekand, Tiina; Schlüter, Katrin Ruth; Schuler, Stephan; Tveten, Kristian; Tysnes, Ole-Bjørn; Holmøy, Trygve; Høyer, Helle (Peer reviewed; Journal article, 2022)
      Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor neurons. In Europe, disease-causing genetic variants have been identified in 40-70% of familial ALS patients and approximately ...

    • Genetic insight into sick sinus syndrome 

      Thorolfsdottir, Rosa B.; Sveinbjornsson, Gardar; Aegisdottir, Hildur M.; Benonisdottir, Stefania; Stefánsdóttir, Lilja; Ivarsdottir, Erna V.; Halldorsson, Gisli H.; Sigurdsson, Jon K.; Torp-Pedersen, Christian; Weeke, Peter E.; Brunak, Søren; Westergaard, David; Pedersen, Ole B.; Sorensen, Erik; Nielsen, Kaspar R.; Burgdorf, Kristoffer S.; Banasik, Karina; Brumpton, Ben Michael; Zhou, Wei; Oddsson, Asmundur; Tragante, Vinicius; Hjorleifsson, Kristjan E.; Davidsson, Olafur B.; Rajamani, Sridharan; Jonsson, Stefan; Torfason, Bjarni; Valgardsson, Atli S.; Thorgeirsson, Gudmundur; Frigge, Michael L.; Thorleifsson, Gudmar; Norddahl, Gudmundur L.; Helgadottir, Anna; Gretarsdotti, Solveig; Sulem, Patrick; Jonsdottir, Ingileif; Willer, Cristen J.; Hveem, Kristian; Bundgaard, Henning; Ullum, Henrik; Arnar, David O.; Thorsteinsdottir, Unnur; Gudbjartsson, Daniel F.; Holm, Hilma; Stefansson, Kari (Peer reviewed; Journal article, 2021)

    • Genetic polymorphisms associated with sleep-related phenotypes; relationships with individual nocturnal symptoms of insomnia in the HUNT study 

      Bragantini, Daniela; Sivertsen, Børge; Gehrman, Philip; Lydersen, Stian; Guzey, Ismail Cuneyt (Journal article; Peer reviewed, 2019)
      Background In recent years, several GWAS (genome wide association studies) of sleep-related traits have identified a number of SNPs (single nucleotides polymorphism) but their relationships with symptoms of insomnia are ...

    • Genetic predisposition to PEG-asparaginase hypersensitivity in children treated according to NOPHO ALL2008 

      Højfeldt, Sofie G; Wolthers, Benjamin Ole; Tulstrup, Morten; Abrahamsson, Jonas; Gupta, Ramneek; Harila-Saari, Arja; Heyman, Mats; Henriksen, Louise T; Jonsson, Olafur G.; Lähteenmäki, Päivi M.; Lund, Bendik; Pruunsild, Kaie; Vaitkeviciene, Goda; Schmiegelow, Kjeld; Albertsen, Birgitte K. (Peer reviewed; Journal article, 2018)
      Asparaginase is essential in childhood acute lymphoblastic leukaemia (ALL) treatment, however hypersensitivity reactions to pegylated asparaginase (PEG-asparaginase) hampers anti-neoplastic efficacy. Patients with ...

    • Genetic risk score associations for myocardial infarction are comparable in persons with and without rheumatoid arthritis: the population-based HUNT study 

      Rostami, Sina; Hoff, Mari; Dalen, Håvard; Hveem, Kristian; Videm, Vibeke (Peer reviewed; Journal article, 2020)
      Persons with rheumatoid arthritis (RA) have increased risk of myocardial infarction (MI). Overlapping associations with MI of weighted genetic risk scores (wGRS) for coronary artery disease (CAD) and RA is unknown in a ...

    • Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache 

      Harder, Aster V.E.; Winsvold, Bendik K S; Noordam, Raymond; Vijfhuizen, Lisanne S.; Børte, Sigrid; Kogelman, Lisette J.A.; de Boer, Irene; Tronvik, Erling Andreas; Rosendaal, Frits; Willems van Dijk, Ko; O'Connor, Emer; Fourier, Carmen; Thomas, Laurent; Kristoffersen, Espen Saxhaug; Fronczek, Rolf; Pozo-Rosich, Patricia; Jensen, Rigmor; Ferrari, Michel D.; Hansen, Thomas; Zwart, John-Anker; Terwindt, Gisela M.; van den Maagdenberg, Arn M.J.M (Peer reviewed; Journal article, 2021)
      Objective Identifying common genetic variants that confer genetic risk for cluster headache. Methods We conducted a case–control study in the Dutch Leiden University Cluster headache neuro-Analysis program (LUCA) study ...

    • Genetic variants associated with cardiometabolic abnormalities during treatment with selective serotonin reuptake inhibitors: a genome-wide association study 

      Fjukstad, Katrine Kveli; Athanasiu, Lavinia; Bahrami, Shahram; O`Connell, Kevin; van der Meer, Dennis; Bettella, Francesco; Dieset, Ingrid; Steen, Nils Eiel; Djurovic, Srdjan; Spigset, Olav; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2021)
      Selective serotonin reuptake inhibitors (SSRIs) are prescribed both to patients with schizophrenia and bipolar disorder. Previous studies have shown associations between SSRI treatment and cardiometabolic alterations. The ...

    • Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer's pathophysiology and susceptibility 

      Sevlever, Daniel; Zou, Fang Geng; Ma, Li; Carrasquillo, Sebastian; Crump, Michael G; Culley, Oliver J; Hunter, Talisha A; Bisceglio, Gina; Younkin, Linda; Allen, Mariet; Carrasquillo, Minerva; Sando, Sigrid Botne; Aasly, Jan; Dickson, Dennis W; Graff-Radford, Neill; Petersen, Ronald C.; Morgan, Kevin; Belbin, Olivia (Journal article; Peer reviewed, 2015)
      Background Alzheimer’s disease is a neurodegenerative disorder in which extracellular deposition of β-amyloid (Aβ) oligomers causes synaptic injury resulting in early memory loss, altered homeostasis, accumulation of ...

    • Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease 

      Zheng, Thenghao; Skogholt, Anne Heidi; Gabrielsen, Maiken Elvestad; Hveem, Kristian; Thomas, Laurent; Ness-Jensen, Eivind (Peer reviewed; Journal article, 2021)
      Objective Haemorrhoidal disease (HEM) affects a large and silently suffering fraction of the population but its aetiology, including suspected genetic predisposition, is poorly understood. We report the first genome-wide ...

    • Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease 

      DeMichele-Sweet, Mary Ann A.; Klei, Lambertus; Creese, Byron; Harwood, Janet C.; Weamer, Elise A.; McClain, Lora; Sims, Rebekka; Hernández, Isabel; Moreno-Grau, Sonia; Tárraga, Lluís; Boada, Mercè; Alarcón-Martín, Emilio; Valero, Sergi; Liu, Yushi; Hooli, Basavaraj; Aarsland, Dag; Selbæk, Geir; Bergh, Sverre; Rongve, Arvid; Saltvedt, Ingvild; Skjellegrind, Håvard; Engdahl, Bo Lars; Stordal, Eystein; Andreassen, Ole Andreas; Djurovic, Srdjan; Athanasiu, Lavinia; Seripa, Davide; Borroni, Barbara; Albani, Diego; Forloni, Gianluigi; Mecocci, Patrizia; Seretti, Alessandro; De Ronchi, Diana; Politis, Antonis; Williams, Julie; Mayeux, Richard; Foroud, Tatiana; Ruiz, Agustin; Ballard, Clive; Holmans, Peter; Lopez, Oscar L.; Kamboh, M. Ilyas; Devlin, Bernie; Sweet, Robert A. (Peer reviewed; Journal article, 2021)
      Psychotic symptoms, defined as the occurrence of delusions or hallucinations, are frequent in Alzheimer disease (AD with psychosis, AD + P). AD + P affects ~50% of individuals with AD, identifies a subgroup with poor ...

    • Genome-Wide Association Study Identifies New Genetic Determinants of Cardiorespiratory Fitness: The Trøndelag Health Study 

      Klevjer, Marie; Nordeidet, Ada Nilsen; Hansen, Ailin Falkmo; Madssen, Erik; Wisløff, Ulrik; Brumpton, Ben Michael; Bye, Anja (Peer reviewed; Journal article, 2022)
      Purpose Low cardiorespiratory fitness (CRF) is a major risk factor for cardiovascular disease (CVD) and a stronger predictor of CVD morbidity and mortality than established risk factors. The genetic component of CRF, ...

    • Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors 

      Bakker, Mark K.; Spek, Rick A.A. var der; Rheenen, Wouter van; Morel, Sandrine; Bourcier, Romain; Hostettler, Isabel C.; Varinder, S. Alg; Eijk, Kristel R. van; Koido, Masaru; Akiyama, Masato; Terao, Chikashi; Matsuda, Koichi; Walters, Robin G.; Lin, Kuang; Li, Liming; Millwood, Iona Y.; Chen, Zhengming; Rouleau, Guy A.; Zhou, Sirui; Rannikmae, Kristiina; Sudlow, Cathie L.M.; Houlden, Henry; Berg, Leonard H. van den; Dina, Christian; Naggara, Olivier; Gentric, Jean-Christophe; Shotar, Eimad; Eugène, François; Desal, Hubert; Winsvold, Bendik K S; Børte, Sigrid; Johnsen, Marianne Bakke; Brumpton, Ben Michael; Sandvei, Marie Søfteland; Willer, Cristen J.; Hveem, Kristian; Zwart, John-Anker; Verschuren, W.M. Monique; Friedrich, Christoph M.; Hirsch, Sven; Schilling, Sabine; Dauvillier, Jérôme; Martin, Olivier; Jones, Gregory T.; Bown, Matthew J.; Ko, Nerissa U.; Kim, Helen; Coleman, Jonathan R. I.; Breen, Gerome; Zaroff, Jonathan G. (Peer reviewed; Journal article, 2020)
      Rupture of an intracranial aneurysm leads to subarachnoid hemorrhage, a severe type of stroke. To discover new risk loci and the genetic architecture of intracranial aneurysms, we performed a cross-ancestry, genome-wide ...

    • Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth 

      Beaumont, Robin N.; Flatley, Christopher; Vaudel, Marc; Wu, Xiaoping; Chen, Jing; Moen, Gunn-Helen Øiseth; Skotte, Line; Helgeland, Øyvind; Solé-Navais, Pol; Banasik, Karina; Albiñana, Clara; Ronkainen, Justiina; Fadista, João; Stinson, Sara Elizabeth; Trajanoska, Katerina; Wang, Carol A.; Westergaard, David; Srinivasan, Sundararajan; Sánchez-Soriano, Carlos; Bilbao, Jose Ramon; Allard, Catherine; Groleau, Marika; Kuulasmaa, Teemu; Leirer, Daniel J.; White, Frédérique; Jacques, Pierre-Étienne; Cheng, Haoxiang; Hao, Ke; Andreassen, Ole; Åsvold, Bjørn Olav; Atalay, Mustafa; Bhatta, Laxmi; Bouchard, Luigi; Brumpton, Ben Michael; Brunak, Søren; Bybjerg-Grauholm, Jonas; Ebbing, Cathrine; Elliott, Paul; Engelbrechtsen, Line; Erikstrup, Christian; Estarlich, Marisa; Franks, Stephen; Gaillard, Romy; Geller, Frank; Grove, Jakob; Hougaard, David M.; Kajantie, Eero Olavi; Morgen, Camilla S.; Nøhr, Ellen Aagaard; Nyegaard, Mette; Palmer, Colin N. A.; Pedersen, Ole Birger; Rivadeneira, Fernando; Sebert, Sylvain; Shields, Beverley M.; Stoltenberg, Camilla; Surakka, Ida; Thørner, Lise Wegner; Ullum, Henrik; Vaarasmaki, Marja; Vilhjalmsson, Bjarni J.; Willer, Cristen J.; Lakka, Timo A.; Gybel-Brask, Dorte; Bustamante, Mariona; Hansen, Torben; Pearson, Ewan R.; Reynolds, Rebecca M.; Ostrowski, Sisse R.; Pennell, Craig E.; Jaddoe, Vincent W. V.; Felix, Janine F.; Hattersley, Andrew T.; Melbye, Mads; Lawlor, Deborah A.; Hveem, Kristian; Werge, Thomas; Nielsen, Henriette Svarre; Magnus, Per Minor; Evans, David M.; Jacobsson, Bo; Järvelin, Marjo-Riitta; Zhang, Ge; Hivert, Marie-France; Johansson, Stefan; Freathy, Rachel M.; Feenstra, Bjarke; Njølstad, Pål Rasmus (Peer reviewed; Journal article, 2023)
      A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), ...

    • Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk 

      Jansen, Iris E.; Savage, Jeanne E.; Watanabe, Kyoko; Bryois, Julien; Williams, Dylan M.; Steinberg, Stacy; Sealock, Julia; Karlsson, Ida K.; Hägg, Sara; Athanasiu, Lavinia; Voyle, Nicola; Proitsi, Petroula; Witoelar, Aree; Stringer, Sven; Aarsland, Dag; Almdahl, Ina Selseth; Andersen, Fred; Bergh, Sverre; Bettella, Francesco; Björnsson, Sigurbjörn; Brækhus, Anne; Bråthen, Geir; de Leeuw, Christiaan A.; Desikan, Rahul S.; Djurovic, Srdjan; Dumitrescu, Logan; Fladby, Tormod; Hohman, Timothy J.; Jónsson, Pálmi V.; Kiddle, Steven J; Rongve, Arvid; Saltvedt, Ingvild; Sando, Sigrid Botne; Selbæk, Geir; Shoai, Maryam; Skene, Nathan G.; Snædal, Jón G.; Stordal, Eystein; Ulstein, Ingun; Wang, Yunpeng; White, Linda Rosemary; Hardy, John; Hjerling-Leffler, Jens; Sullivan, Patrick; van der Flier, Wiesje M.; Dobson, Richard; Davis, Lea K; Stefánsson, Hreinn; Stefánsson, Kári; Pedersen, Nancy L; Ripke, Stephan; Andreassen, Ole Andreas; Posthuma, Danielle (Journal article; Peer reviewed, 2019)
      Alzheimer’s disease (AD) is highly heritable and recent studies have identified over 20 disease-associated genomic loci. Yet these only explain a small proportion of the genetic variance, indicating that undiscovered loci ...

    • Genome-wide meta-analysis of iron status biomarkers and the effect of iron on all-cause mortality in HUNT 

      Moksnes, Marta Riise; Graham, Sarah E.; Wu, Kuan-Han; Hansen, Ailin Falkmo; Gagliano Taliun, Sarah A.; Zhou, Wei; Thorstensen, Ketil; Fritsche, Lars; Gill, Dipender; Mason, Amy; Cucca, Francesco; Schlessinger, David; Abecasis, Gonçalo R.; Burgess, Stephen; Åsvold, Bjørn Olav; Nielsen, Jonas Bille; Hveem, Kristian; Willer, Cristen J.; Brumpton, Ben Michael (Peer reviewed; Journal article, 2022)
      Iron is essential for many biological processes, but iron levels must be tightly regulated to avoid harmful effects of both iron deficiency and overload. Here, we perform genome-wide association studies on four iron-related ...

    • Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. 

      Lee, Phil H.; Antilla, Verneri; Won, Hyejung; Bettella, Francesco; Agartz, Ingrid; Dale, Anders; Nærland, Terje; Elvsåshagen, Torbjørn; Ødegaard, Ketil Joachim; Melle, Ingrid; Knudsen, Gun Peggy Strømstad; Le Hellard, Stephanie; Reichborn-Kjennerud, Ted; Smeland, Olav Bjerkehagen; Andreassen, Ole Andreas; Neale, Benjamin M; Kendler, Kenneth S.; Smoller, Jordan W. (Peer reviewed; Journal article, 2019)
      Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed ...

    • Geographic and socioeconomic inequities in cesarean delivery rates at the district level in Madhya Pradesh, India: A secondary analysis of the national family health survey-5 

      Dutta, Rohini; Tuli, Shagun; Shukla, Minal; Patil, Priti; van Duinen, Aalke Johan; Thivalapill, Neil; Ghoshal, Rakhi; Jayaram, Anusha; Roy, Nobhojit; Gadgil, Anita (Peer reviewed; Journal article, 2023)
      Background In India, caesarean delivery (CD) accounts for 17% of the births, of which 41% occur in private facilities. However, areas to CD in rural areas are limited, particularly for the poor populations. Little information ...