Institutt for klinisk og molekylær medisin: Recent submissions

Now showing items 21-40 of 3426

    • Gestational diabetes is associated with the risk of offspring's congenital anomalies: a register-based cohort study 

      Kinnunen, Jenni; Nikkinen, Hilkka; Keikkala, Elina; Mustaniemi, Sanna; Gissler, Mika; Laivuori, Hannele; Eriksson, Johan G.; Kaaja, Risto; Pouta, Anneli; Kajantie, Eero Olavi; Vääräsmäki, Marja (Peer reviewed; Journal article, 2023)
      Background Gestational diabetes mellitus (GDM) is a common pregnancy-related disorder and a well-known risk factor for adverse pregnancy outcomes. There are conflicting findings on the association of GDM with the risk of ...

    • Støtte til fallforebygging hos eldre 

      Ruths, Sabine; Bakken, Marit Stordal; Ranhoff, Anette Hylen; Granås, Anne Gerd; Spigset, Olav (Journal article; Peer reviewed, 2023)

    • Liquid Biopsy in Organ Damage: small extracellular vesicle chip-based assessment of polytrauma 

      Wang, Bingduo; Wöhler, Aliona; Greven, Johannes; Salzmann, Rebekka J. S.; Keller, Cindy M.; Tertel, Tobias; Zhao, Qun; Mert, Ümit; Horst, Klemens; Lupu, Ludmila; Huber-Lang, Markus; van Griensven, Martijn; Mollnes, Tom Erik; Schaaf, Sebastian; Schwab, Robert; Strassburg, Christian P.; Schmidt-Wolf, Ingo G. H.; Giebel, Bernd; Hildebrand, Frank; Lukacs-Kornek, Veronika; Willms, Arnulf G.; Kornek, Miroslaw T. (Journal article; Peer reviewed, 2023)
      Background Despite major advances in medicine, blood-borne biomarkers are urgently needed to support decision-making, including polytrauma. Here, we assessed serum-derived extracellular vesicles (EVs) as potential markers ...

    • Effectiveness of a group-based Diabetes Prevention Education Program (DiPEP) in a population with pre-diabetes: a cluster randomised controlled trial in Nepal 

      Shakya, Pushpanjali; Shrestha, Archana; Bajracharya, Monish; Shrestha, Abha; Kulseng, Bård Eirik; Karmacharya, Biraj Man; Shrestha, Smriti; Das, Seema; Shrestha, Ishwori Byanju; Barun, Krishnaa; Shrestha, Nistha; Skovlund, Eva; Sen, Abhijit (Journal article; Peer reviewed, 2023)
      Background Although several lifestyle intervention studies have been conducted in low/middle-income countries, there were no such studies in Nepal. Therefore, a group-based culturally tailored Diabetes Prevention Education ...

    • Decreased adiponectin/leptin ratio relates to insulin resistance in adults with obesity 

      Castela, Inês; Morais, Juliana; Barreiros-Mota, Inês; Silvestre, Marta P.; Marques, Cláudia; Rodrigues, Catarina; Ismael, Shámila; Araújo, João R; Ângelo-Dias, Miguel; Martins, Catarina; Borrego, Luís Miguel; Monteiro, Rosário; dos Santos Ribeiro F. Coutinho, Silvia; Calhau, Conceição; Alho Letra Martins, Catia Patricia; Faria, Ana; Pestana, Diogo; Teixeira, Diana (Journal article; Peer reviewed, 2023)
      Adiponectin/leptin ratio, triacylglycerols, and waist-to-hip ratio explained almost half of HOMA-IR variance in the context of obesity. This study provides evidence to support adipose tissue dysfunction as a central feature ...

    • Mutation Spectrum in Liquid Versus Solid Biopsies From Patients With Advanced astroenteropancreatic Neuroendocrine Carcinoma 

      Knappskog, Stian; Grob, Tobias; Venizelos, Andreas; Amstutz, Ursula; Hjortland, Geir Olav; Lothe, Inger Marie Bowitz; Kersten, Christian; Hofsli, Eva; Sundlöv, Anna; Elvebakken, Hege; Garresori, Herish; Couvelard, Anne; Svensson, Johanna; Sorbye, Halfdan; Perren, Aurel (Peer reviewed; Journal article, 2023)
      Purpose Gastroenteropancreatic neuroendocrine carcinomas (GEP-NEC) are rare and have a poor prognosis. Most GEP-NEC are diagnosed with metastatic disease, with only minor biopsies available for molecular diagnostics. We ...

    • Antenatal corticosteroid treatment and infectious diseases in children: a nationwide observational study 

      Räikkönen, Katri; Gissler, Mika; Kajantie, Eero Olavi; Tapiainen, Terhi (Peer reviewed; Journal article, 2023)
      Background Antenatal Corticosteroid Treatment (ACT) improves the outcome of preterm infants, but may influence immune system development and risk of immune-related diseases. We investigated whether ACT is associated ...

    • Quality learning in undergraduate medical education - Improving teaching and assessment practices 

      Martinsen, Susanne Skjervold Smeby (Doctoral theses at NTNU;2024:88, Doctoral thesis, 2024)
      Although there have been significant advancements in our understanding of human learning over the last century, many educational practices within the medical field have not integrated educational research findings. ...

    • A 39 kb structural variant causing Lynch Syndrome detected by optical genome mapping and nanopore sequencing 

      Bjørnstad, Pål Marius; Aaløkken, Ragnhild Margrethe; Åsheim, June; Sundaram, Arvind; Nangota Felde, Caroline; Østby, Gina Henriette; Dalland, Marianne; Sjursen, Wenche; Carrizosa, Christian; Vigeland, Magnus Dehli; Sorte, Hanne Sørmo; Sheng, Ying; Ariansen, Sarah Louise; Grindedal, Eli Marie; Gilfillan, Gregor (Peer reviewed; Journal article, 2023)
      Lynch Syndrome (LS) is a hereditary cancer syndrome caused by pathogenic germline variants in one of the four mismatch repair (MMR) genes MLH1, MSH2, MSH6 and PMS2. It is characterized by a significantly increased risk of ...

    • TFCheckpoint database update, a cross-referencing system for transcription factors from human, mouse and rat 

      Acencio, Marcio Luis; Vázquez, Miguel; Chawla, Konika; Lægreid, Astrid Renner; Kuiper, Martin (Journal article; Peer reviewed, 2023)
      Prior knowledge about DNA-binding transcription factors (dbTFs), transcription co-regulators (coTFs) and general transcriptional factors (GTFs) is crucial for the study and understanding of the regulation of transcription. ...

    • Established and novel methods and biomarkers in breast cancer 

      Skjervold, Anette Hansen (Doctoral theses at NTNU;2024:80, Doctoral thesis, 2024)
      The present thesis is based on three published papers. The work arises from three cohorts of women from Trøndelag county in Norway. These were women born between 1886 and 1977, that were diagnosed with breast cancer (BC). ...

    • The Patient-Practitioner interaction in post bariatric surgery consultations: an interpersonal process recall study 

      Natvik, Eli; Lavik, Kristina Osland; Ogden, Jane; Strømmen, Magnus Nordvik; Moltu, Christian (Peer reviewed; Journal article, 2022)
      Materials and Methods We interviewed patients (11), video recorded consultations (10), conducted video-assisted individual interviews with patients (10) and practitioners (11) and a dyadic data analysis. Results We ...

    • Association of oxytocin augmentation and duration of labour with postpartum haemorrhage: A cohort study of nulliparous women 

      Bernitz, Stine; Betran, Ana Pilar; Gunnes, Nina; Zhang, Jun; Blix, Ellen; Øian, Pål; Eggebø, Torbjørn Moe; Dalbye, Rebecka (Peer reviewed; Journal article, 2023)
      Objective Both duration of labour and use of oxytocin for augmentation are known risk factors for postpartum haemorrhage but distinguishing between the significance of these factors is complex. In this study, we aimed to ...

    • Coeliac disease in the Trøndelag Health Study (HUNT), Norway, a population-based cohort of coeliac disease patients 

      Lukina, Polina; Andersen, Ina Lervåg; Eggen, Petter Tinbod; Mjønes, Patricia Gjertrud; Rønne, Elin; Bolstad, Nils; Klaasen, Rolf; Warren, David; Iversen, Rasmus; Hveem, Kristian; Bernklev, Tomm; Jelsness-Jørgensen, Lars-Petter; Pedersen, Lise; Jonkers, Iris; Lagergren, Pernilla; Sollid, Ludvig Magne; Lundin, Knut; Ness-Jensen, Eivind (Peer reviewed; Journal article, 2024)
      Purpose - Coeliac disease (CD) is a common disorder and affects about 1% of the population worldwide. CD in the Trøndelag Health Study (HUNT) is a population-based cohort study which was established to provide new knowledge ...

    • A pan-SARS-CoV-2-specific soluble angiotensin-converting enzyme 2-albumin fusion engineered for enhanced plasma half-life and needle-free mucosal delivery 

      Benjakul, Sopisa; Anthi, Aina Karen; Kolderup, Heidi Anette; Vaysburd, Marina; Lode, Heidrun Elisabeth; Mallery, D; Fossum, Even; Vikse, Elisabeth Lea; Albecka, Anna; Ianevski, Aleksandr; Kaynov, Denis; Karlsen, Karine Flem; Sakya, Siri Aastedatter; Nyquist-Andersen, Mari; gjølberg, torleif; Moe, Morten Carsten; Bjørås, Magnar; Sandlie, Inger; James, Leo C.; Andersen, Jan Terje (Peer reviewed; Journal article, 2023)
      Immunocompromised patients often fail to raise protective vaccine-induced immunity against the global emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. Although monoclonal antibodies have ...

    • Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response 

      Wang, Yining; Li, Pengfei; Xu, Lei; de Vries, Annemarie C.; Rottier, Robbert J.; Wang, Wenshi; Crombag, Marie-Rose B.S.; Peppelenbosch, Maikel P.; Kaynov, Denis; Pan, Qiuwei (Peer reviewed; Journal article, 2023)
      Severe infections with coronaviruses are often accompanied with hyperinflammation, requiring therapeutic strategies to simultaneously tackle the virus and inflammation. By screening a safe-in-human broad-spectrum antiviral ...

    • Impact of KRAS and BRAF mutations on treatment efficacy and survival in high-grade gastroenteropancreatic neuroendocrine neoplasms 

      Elvebakken, Hege; Hjortland, Geir Olav; Garresori, Herish; Andresen, Per Arne; Janssen, Emiel; Vintermyr, Olav Karsten; Lothe, Inger Marie Bowitz; Sorbye, Halfdan (Peer reviewed; Journal article, 2023)
      High-grade gastroenteropancreatic neuroendocrine neoplasms (HG GEP-NEN) typically disseminate early. Treatment of metastatic disease has limited benefit and prognosis is generally discouraging. Data on the clinical impact ...

    • Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in nonhuman primates 

      Hermet, Paule; Delache, Benoît; Herate, Cecile; Wolf, Esther; Kivi, Gaily; Juronen, Erkki; Mumm, Karl; Žusinaite, Eva; Kaynov, Denis; Sankovski, Eve; Virumäe, Kai; Planken, Anu; Merits, Andres; Besaw, Jessica E.; Yee, Ai Woon; Morizumi, Takefumi; Kim, Kyumhyuk; Kuo, Anling; Berriche, Asma; Dereuddre-Bosquet, Nathalie; Sconosciuti, Quentin; Naninck, Thibaut; Relouzat, Francis; Cavarelli, Mariangela; Wilson, Derek; Ernst, Oliver P.; Männik, Andres; LeGrand, Roger; Ustav, Mart (Peer reviewed; Journal article, 2023)
      The COVID-19 pandemic represents a global challenge that has impacted and is expected to continue to impact the lives and health of people across the world for the foreseeable future. The rollout of vaccines has provided ...

    • Multippel erythema migrans, borrelialymfocytom og nevroborreliose hos eit barn 

      Schei, Kasper; Modalsli, Ellen Heilmann; Nag, Torbjørn (Peer reviewed; Journal article, 2023)

    • Methadone pharmacokinetics in opioid agonist treatment: Influencing factors and clinical implications 

      Chalabianloo, Fatemeh; Fadnes, Lars T.; Johansson, Kjell Arne; Høiseth, Gudrun; Vold, Jørn Henrik; Kringen, Marianne K.; Spigset, Olav; Bramness, Jørgen Gustav (Peer reviewed; Journal article, 2024)
      Background A considerable inter-individual variability has been reported in the relationship between methadone doses applied and serum concentrations achieved in methadone maintenance treatment. However, the underlying ...