Institutt for klinisk og molekylær medisin: Nye registreringer
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Quality learning in undergraduate medical education - Improving teaching and assessment practices
(Doctoral theses at NTNU;2024:88, Doctoral thesis, 2024)Although there have been significant advancements in our understanding of human learning over the last century, many educational practices within the medical field have not integrated educational research findings. ... -
A 39 kb structural variant causing Lynch Syndrome detected by optical genome mapping and nanopore sequencing
(Peer reviewed; Journal article, 2023)Lynch Syndrome (LS) is a hereditary cancer syndrome caused by pathogenic germline variants in one of the four mismatch repair (MMR) genes MLH1, MSH2, MSH6 and PMS2. It is characterized by a significantly increased risk of ... -
TFCheckpoint database update, a cross-referencing system for transcription factors from human, mouse and rat
(Journal article; Peer reviewed, 2023)Prior knowledge about DNA-binding transcription factors (dbTFs), transcription co-regulators (coTFs) and general transcriptional factors (GTFs) is crucial for the study and understanding of the regulation of transcription. ... -
Established and novel methods and biomarkers in breast cancer
(Doctoral theses at NTNU;2024:80, Doctoral thesis, 2024)The present thesis is based on three published papers. The work arises from three cohorts of women from Trøndelag county in Norway. These were women born between 1886 and 1977, that were diagnosed with breast cancer (BC). ... -
The Patient-Practitioner interaction in post bariatric surgery consultations: an interpersonal process recall study
(Peer reviewed; Journal article, 2022)Materials and Methods We interviewed patients (11), video recorded consultations (10), conducted video-assisted individual interviews with patients (10) and practitioners (11) and a dyadic data analysis. Results We ... -
Association of oxytocin augmentation and duration of labour with postpartum haemorrhage: A cohort study of nulliparous women
(Peer reviewed; Journal article, 2023)Objective Both duration of labour and use of oxytocin for augmentation are known risk factors for postpartum haemorrhage but distinguishing between the significance of these factors is complex. In this study, we aimed to ... -
Coeliac disease in the Trøndelag Health Study (HUNT), Norway, a population-based cohort of coeliac disease patients
(Peer reviewed; Journal article, 2024)Purpose - Coeliac disease (CD) is a common disorder and affects about 1% of the population worldwide. CD in the Trøndelag Health Study (HUNT) is a population-based cohort study which was established to provide new knowledge ... -
A pan-SARS-CoV-2-specific soluble angiotensin-converting enzyme 2-albumin fusion engineered for enhanced plasma half-life and needle-free mucosal delivery
(Peer reviewed; Journal article, 2023)Immunocompromised patients often fail to raise protective vaccine-induced immunity against the global emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. Although monoclonal antibodies have ... -
Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response
(Peer reviewed; Journal article, 2023)Severe infections with coronaviruses are often accompanied with hyperinflammation, requiring therapeutic strategies to simultaneously tackle the virus and inflammation. By screening a safe-in-human broad-spectrum antiviral ... -
Impact of KRAS and BRAF mutations on treatment efficacy and survival in high-grade gastroenteropancreatic neuroendocrine neoplasms
(Peer reviewed; Journal article, 2023)High-grade gastroenteropancreatic neuroendocrine neoplasms (HG GEP-NEN) typically disseminate early. Treatment of metastatic disease has limited benefit and prognosis is generally discouraging. Data on the clinical impact ... -
Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in nonhuman primates
(Peer reviewed; Journal article, 2023)The COVID-19 pandemic represents a global challenge that has impacted and is expected to continue to impact the lives and health of people across the world for the foreseeable future. The rollout of vaccines has provided ... -
Multippel erythema migrans, borrelialymfocytom og nevroborreliose hos eit barn
(Peer reviewed; Journal article, 2023) -
Methadone pharmacokinetics in opioid agonist treatment: Influencing factors and clinical implications
(Peer reviewed; Journal article, 2024)Background A considerable inter-individual variability has been reported in the relationship between methadone doses applied and serum concentrations achieved in methadone maintenance treatment. However, the underlying ... -
Cumulative incidence of first recurrence after curative treatment of stage I–III colorectal cancer. Competing risk analyses of temporal and anatomic patterns
(Peer reviewed; Journal article, 2023)Background Updated knowledge about the rates of recurrence and time to recurrence following curative treatment of colorectal cancer is essential to secure better patient information on prognosis, to serve as a premise ... -
Rheumatoid arthritis, disease-modifying antirheumatic drugs and risk of major osteoporotic fracture: prospective data from the HUNT Study, Norway
(Peer reviewed; Journal article, 2023)Objectives Rheumatoid arthritis has been associated with increased fracture risk. New treatments have improved the course of the disease substantially, but it is not clear if this influences fracture risk. We examined if ... -
Escherichia coli-induced inflammatory responses are temperature-dependent in human whole blood ex vivo
(Peer reviewed; Journal article, 2023) -
X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements
(Peer reviewed; Journal article, 2024)X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis ... -
Local Postoperative Graft Inflammation in Pancreas Transplant Patients With Early Graft Thrombosis
(Peer reviewed; Journal article, 2023)Background. Graft thrombosis is the main cause of early graft loss following pancreas transplantation, and is more frequent in pancreas transplant alone (PTA) compared with simultaneous pancreas-kidney (SPK) recipients. ... -
Validity of the Behavioural Assessment of the Dysexecutive Syndrome for Children (BADS-C) in children and adolescents with pediatric acquired brain injury
(Peer reviewed; Journal article, 2023)The Behavioural Assessment of the Dysexecutive Syndrome for Children (BADS-C) was developed to address the need for a standardized ecologically valid test of executive function (EF) in the pediatric population. Our study ... -
Exercised blood plasma promotes hippocampal neurogenesis in the Alzheimer's disease rat brain
(Peer reviewed; Journal article, 2023)Background Exercise training promotes brain plasticity and is associated with protection against cognitive impairment and Alzheimer's disease (AD). These beneficial effects may be partly mediated by blood-borne factors. ...