Institutt for klinisk og molekylær medisin: Nye registreringer
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Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response
(Peer reviewed; Journal article, 2023)Severe infections with coronaviruses are often accompanied with hyperinflammation, requiring therapeutic strategies to simultaneously tackle the virus and inflammation. By screening a safe-in-human broad-spectrum antiviral ... -
Impact of KRAS and BRAF mutations on treatment efficacy and survival in high-grade gastroenteropancreatic neuroendocrine neoplasms
(Peer reviewed; Journal article, 2023)High-grade gastroenteropancreatic neuroendocrine neoplasms (HG GEP-NEN) typically disseminate early. Treatment of metastatic disease has limited benefit and prognosis is generally discouraging. Data on the clinical impact ... -
Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in nonhuman primates
(Peer reviewed; Journal article, 2023)The COVID-19 pandemic represents a global challenge that has impacted and is expected to continue to impact the lives and health of people across the world for the foreseeable future. The rollout of vaccines has provided ... -
Multippel erythema migrans, borrelialymfocytom og nevroborreliose hos eit barn
(Peer reviewed; Journal article, 2023) -
Methadone pharmacokinetics in opioid agonist treatment: Influencing factors and clinical implications
(Peer reviewed; Journal article, 2024)Background A considerable inter-individual variability has been reported in the relationship between methadone doses applied and serum concentrations achieved in methadone maintenance treatment. However, the underlying ... -
Cumulative incidence of first recurrence after curative treatment of stage I–III colorectal cancer. Competing risk analyses of temporal and anatomic patterns
(Peer reviewed; Journal article, 2023)Background Updated knowledge about the rates of recurrence and time to recurrence following curative treatment of colorectal cancer is essential to secure better patient information on prognosis, to serve as a premise ... -
Rheumatoid arthritis, disease-modifying antirheumatic drugs and risk of major osteoporotic fracture: prospective data from the HUNT Study, Norway
(Peer reviewed; Journal article, 2023)Objectives Rheumatoid arthritis has been associated with increased fracture risk. New treatments have improved the course of the disease substantially, but it is not clear if this influences fracture risk. We examined if ... -
Escherichia coli-induced inflammatory responses are temperature-dependent in human whole blood ex vivo
(Peer reviewed; Journal article, 2023) -
X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements
(Peer reviewed; Journal article, 2024)X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis ... -
Local Postoperative Graft Inflammation in Pancreas Transplant Patients With Early Graft Thrombosis
(Peer reviewed; Journal article, 2023)Background. Graft thrombosis is the main cause of early graft loss following pancreas transplantation, and is more frequent in pancreas transplant alone (PTA) compared with simultaneous pancreas-kidney (SPK) recipients. ... -
Validity of the Behavioural Assessment of the Dysexecutive Syndrome for Children (BADS-C) in children and adolescents with pediatric acquired brain injury
(Peer reviewed; Journal article, 2023)The Behavioural Assessment of the Dysexecutive Syndrome for Children (BADS-C) was developed to address the need for a standardized ecologically valid test of executive function (EF) in the pediatric population. Our study ... -
Exercised blood plasma promotes hippocampal neurogenesis in the Alzheimer's disease rat brain
(Peer reviewed; Journal article, 2023)Background Exercise training promotes brain plasticity and is associated with protection against cognitive impairment and Alzheimer's disease (AD). These beneficial effects may be partly mediated by blood-borne factors. ... -
Optimizing non-invasive respiratory support for preterm infants
(Doctoral theses at NTNU;2024:55, Doctoral thesis, 2024)Optimizing non-invasive respiratory support for preterm infants Optimizing non-invasive breathing support for preterm infants with respiratory distress syndrome (RDS) includes different treatment strategies and perspectives: ... -
Norwegian paediatric habilitation centres judge their own competence on cerebral visual impairment as limited
(Peer reviewed; Journal article, 2023)Aim: Cerebral visual impairment (CVI), a frequently occurring functional impairment in children with neurodevelopmental disorders, leads to communicative, social and academic challenges. In Norway, children with ... -
Pharmacologic and Genetic Downregulation of Proprotein Convertase Subtilisin/Kexin Type 9 and Survival from Sepsis
(Peer reviewed; Journal article, 2023)OBJECTIVES: Treatments that prevent sepsis complications are needed. Circulating lipid and protein assemblies—lipoproteins play critical roles in clearing pathogens from the bloodstream. We investigated whether early ... -
Prevention of obstetric anal sphincter injuries with perineal support and lateral episiotomy: A historical cohort study
(Journal article; Peer reviewed, 2023)Introduction - There are many risk factors for obstetric anal sphincter injury (OASIS) and the interaction between these risk factors is complex and understudied. The many observational studies that have shown a reduction ... -
Initial management and survival of patients with primary metastatic bladder cancer before the immunotherapy era: a population-based study from Norway
(Peer reviewed; Journal article, 2023)Before immunotherapy became part of the management of metastatic bladder cancer (mBC), systemic anti-cancer treatment comprised primarily of platinum-based chemotherapy. The objective of this study was to describe the ... -
Randomised, placebo-controlled, double-blinded trial of fecal microbiota transplantation in severe obesity: a study protocol
(Peer reviewed; Journal article, 2023)Introduction - Obesity is one of the main threats to public health in western countries and increases the risk of several diseases, overall morbidity and mortality. Sustained weight loss will reduce risk factors and improve ... -
Mortality and subsequent healthcare use among older patients discharged to a municipality with excess demand for elderly care
(Peer reviewed; Journal article, 2023)There is limited knowledge on how excess demand for elderly care influences patient outcomes. We used a natural experiment to estimate the causal effect of discharging elderly patients from hospital to municipalities with ... -
Homologous Recombination Deficiency Across Subtypes of Primary Breast Cancer
(Peer reviewed; Journal article, 2023)Purpose Homologous recombination deficiency (HRD) is highly prevalent in triple-negative breast cancer (TNBC) and associated with response to PARP inhibition (PARPi). Here, we studied the prevalence of HRD in non-TNBC to ...