Institutt for klinisk og molekylær medisin: Nye registreringer

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    • Thinking strategies used by registered nurses during drug administration in nursing homes — An observational study 

      Solberg, Hege; Devik, Siri Andreassen; Bell, Hege Therese; Olsen, Rose Mari (Journal article; Peer reviewed, 2023)
      Aim: To explore registered nurses' thinking strategies during the drug administration process in nursing homes. Design: An exploratory qualitative design. Methods: Eight registered nurses, one male and seven female, in ...

    • Chemotherapy for colorectal cancer - Physical exercise and quality of life 

      Hatlevoll, Ingunn (Doctoral theses at NTNU;2024:34, Doctoral thesis, 2024)
      Colorectal cancer (CRC) is the third most common cancer worldwide, the second most common cancer in Norway, and the second leading cause of cancer deaths both globally and nationally. In Norway, 4745 new cases were diagnosed ...

    • Activation of multiple stress responses in Staphylococcus aureus substantially lowers the minimal inhibitory concentration when combining two novel antibiotic drug candidates 

      Singleton, Amanda Holstad; Bergum, Olaug Elisabeth Torheim; Søgaard, Caroline Krogh; Røst, Lisa M.; Olsen, Cecilie Elisabeth; Blindheim, Fredrik Heen; Ræder, Synnøve Brandt; Bjørnstad, Frithjof Andreas; Sundby, Eirik; Hoff, Bård Helge; Bruheim, Per; Otterlei, Marit (Peer reviewed; Journal article, 2023)
      The past few decades have been plagued by an increasing number of infections caused by antibiotic resistant bacteria. To mitigate the rise in untreatable infections, we need new antibiotics with novel targets and drug ...

    • Irisin reduces orthodontic tooth movement in rats by promoting the osteogenic potential in the periodontal ligament 

      Yang, Yang; Pullisaar, Helen; Stunes, Astrid Kamilla; Parreiras Nogueira, Liebert; Syversen, Unni; Reseland, Janne Elin (Peer reviewed; Journal article, 2023)
      Objectives Positive effects of irisin on osteogenic differentiation of periodontal ligament (PDL) cells have been identified previously, this study aims to examine its effect on orthodontic tooth movement (OTM) in ...

    • Multiple Myeloma: Cancer Cell Intrinsic- and Tumor Microenvironmental Factors 

      Nedal, Tonje Marie Vikene (Doctoral theses at NTNU;2024:33, Doctoral thesis, 2024)
      Myelomatose (MM) er en hematologisk kreftsykdom som skyldes ukontrollert vekst av maligne plasmaceller i beinmargen. Myelomatose utvikler seg via to asymptomatiske forstadier: monoklonal gammopati av usikker betydning ...

    • Variation in antibiotic consumption in very preterm infants-a 10 year population-based study 

      Huncikova, Zuzana; Stensvold, Hans Jørgen; Øymar, Knut Asbjørn Alexander; Vatne, Anlaug; Lang, Astri Maria; Støen, Ragnhild; Brigtsen, Anne Karin; Moster, Dag; Eriksen, Beate Horsberg; Selberg, Terje Reidar; Rønnestad, Arild Erland; Klingenberg, Claus (Peer reviewed; Journal article, 2023)
      Objectives Wide variations in antibiotic use in very preterm infants have been reported across centres despite similar rates of infection. We describe 10 year trends in use of antibiotics and regional variations among ...

    • SARS-CoV-2 activates the TLR4/MyD88 pathway in human macrophages: A possible correlation with strong pro-inflammatory responses in severe COVID-19 

      Sahanic, Sabina; Hilbe, Richard; Dünser, Christina; Tymoszuk, Piotr; Löffler-Ragg, Judith; Rieder, Dietmar; Trajanoski, Zlatko; Krogsdam, Anne; Demetz, Egon; Yurchenko, Maria; Fischer, Christine; Schirmer, Michael; Theurl, Markus; Lener, Daniela; Hirsch, Jakob; Holfeld, Johannes; Gollmann-Tepeköylü, Can; Zinner, Carl P.; Tzankov, Alexandar; Zhang, Shen-Ying; Casanova, Jean-Laurent; Posch, Wilfried; Wilflingseder, Doris; Weiss, Guenter; Tancevski, Ivan (Peer reviewed; Journal article, 2023)
      Background Toll-like receptors (TLRs) play a pivotal role in the immunologic response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Exaggerated inflammatory response of innate immune cells, ...

    • The central role of gastrin in gastric cancer 

      Waldum, Helge; Mjønes, Patricia Gjertrud (Peer reviewed; Journal article, 2023)
      The prevalence of gastric cancer has markedly declined, but due to the high mortality rates associated with gastric cancer, it is still a serious disease. The preferred classification of gastric cancer is according to ...

    • Breakthrough and Episodic Cancer Pain from a Palliative Care Perspective 

      Løhre, Erik Torbjørn; Jakobsen, Gunnhild; Solheim, Tora Skeidsvoll; Klepstad, Pål; Thronæs, Morten (Peer reviewed; Journal article, 2023)
      Cancer pain intensity (PI) fluctuates, but the relationship between pain flares and background pain with respect to pain management is not settled. We studied how flare and background PIs corresponded with treatment results ...

    • Systematic review: predictive value of organoids in colorectal cancer 

      Sakshaug, Baard Cristoffer; Folkesson, Emma Evelina; Haukaas, Tonje Husby; Visnes, Torkild; Flobak, Åsmund (Peer reviewed; Journal article, 2023)
      While chemotherapy alone or in combination with radiotherapy and surgery are important modalities in the treatment of colorectal cancer, their widespread use is not paired with an abundance of diagnostic tools to match ...

    • Nytt verktøy for tolkning av farmakogenetiske analyser 

      Tuv, Silja Skogstad; Spigset, Olav; Jensen, Elena; Vethe, Nils Tore; Nordal, Kristin (Peer reviewed; Journal article, 2023)
      Utilgjengelig kunnskap om tolkning av genvarianter som kan påvirke legemiddelrespons, er en barriere for implementering av farmakogenetikk. Vi har utviklet et nettbasert verktøy hvor man kan utføre spørringer og få ...

    • A novel serum calprotectin (MRP8/14) particle-enhanced immuno-turbidimetric assay (sCAL turbo) helps to differentiate systemic juvenile idiopathic arthritis from other diseases in routine clinical laboratory settings 

      Foell, Dirk; Saers, Melanie; Park, Carolin; Brix, Ninna; Glerup, Mia; Kessel, Christoph; Wittkowski, Helmut; Hinze, Claas; Berntson, Lillemor; Fasth, Anders; Myrup, Charlotte; Nordal, Ellen Berit; Rygg, Marite; Hasle, Henrik; Albertsen, Birgitte Klug; Herlin, Troels; Holzinger, Dirk; Niederberger, Christian; Schlüter, Bernhard (Peer reviewed; Journal article, 2023)
      Background Differential diagnosis in children with signs of unprovoked inflammation can be challenging. In particular, differentiating systemic juvenile idiopathic arthritis (SJIA) from other diagnoses is difficult. We ...

    • Association between ß-Hydroxybutyrate Plasma Concentrations after Hypocaloric Ketogenic Diets and Changes in Body Composition 

      Martins, Catia; Nymo, Siren; Aukan, Marthe Isaksen; Røkenes, Jessica Ann; Coutinho, Sílvia; Hunter, Gary R; Gower, Barbara A (Journal article; Peer reviewed, 2023)
      Background Early studies show that ketogenic diets (KDs) lead to preferential loss of fat mass (FM), whereas preserving fat-free mass (FFM). Additionally, animal data support the anticatabolic effects of DL-3-hydroxybutyrate. ...

    • Evaluation of Neoadjuvant Chemotherapy in Patients with Resectable Gastric Adenocarcinoma in Central Norway 2007 – 2016 

      Sandø, Alina Desiree (Doctoral theses at NTNU;2024:12, Doctoral thesis, 2024)
      This thesis presents three retrospective, population-based, observational studies on patients diagnosed with upfront resectable gastric adenocarcinoma and receiving neoadjuvant chemotherapy (NAC) in Central Norway during ...

    • Cluster Headache Genomewide Association Study and Meta-Analysis Identifies Eight Loci and Implicates Smoking as Causal Risk Factor 

      Winsvold, Bendik Kristoffer Slagsvold; Harder, Aster V. E.; Ran, Caroline; Chalmer, Mona A.; Dalmasso, Maria Carolina; Ferkingstad, Egil; Tripathi, Kumar Parijat; Bacchelli, Elena; Børte, Sigrid; Fourier, Carmen; Petersen, Anja S.; Vijfhuizen, Lisanne S.; Magnusson, Sigurdur H.; O'Connor, Emer; Bjornsdottir, Gyda; Häppölä, Paavo; Wang, Yen-Feng; Callesen, Ida; Kelderman, Tim; Gallardo, Victor J; de Boer, Irene; Olofsgård, Felicia Jennysdotter; Heinze, Katja; Lund, Nunu; Thomas, Laurent Francois; Hsu, Chia-Lin; Pirinen, Matti; Hautakangas, Heidi; Ribasés, Marta; Guerzoni, Simona; Sivakumar, Prasanth; Yip, Janice; Heinze, Axel; Küçükali, Fahri; Ostrowski, Sisse R.; Pedersen, Ole B.; Kristoffersen, Espen Saxhaug; Martinsen, Amy; Artigas, María S.; Lagrata, Susie; Cainazzo, Maria Michela; Adebimpe, Joycee; Quinn, Olivia; Göbel, Carl; Cirkel, Anna; Volk, Alexander E.; Heilmann-Heimbach, Stefanie; Skogholt, Anne Heidi; Gabrielsen, Maiken Elvestad; Wilbrink, Leopoldine A.; Danno, Daisuke; Mehta, Dwij; Guðbjartsson, Daníel F.; Rosendaal, Frits Richard; Willems van Dijk, Ko; Fronczek, Rolf; Wagner, Michael; Scherer, Martin; Göbel, Hartmut; Sleegers, Kristel; Sveinsson, Olafur A.; Pani, Luca; Zoli, Michele; Ramos-Quiroga, Josep A.; Dardiotis, Efthimios; Steinberg, Anna; Riedel-Heller, Steffi; Sjöstrand, Christina; Thorgeirsson, Thorgeir E.; Stefansson, Hreinn; Southgate, Laura; Trembath, Richard C.; Vandrovcova, Jana; Noordam, Raymond; Paemeleire, Koen; Stefansson, Kari; Fann, Cathy Shen-Jang; Waldenlind, Elisabet; Tronvik, Erling Andreas; Jensen, Rigmor H.; Chen, Shih-Pin; Houlden, Henry; Terwindt, Gisela M.; Kubisch, Christian; Maestrini, Elena; Vikelis, Michail; Pozo-Rosich, Patricia; Belin, Andrea C.; Matharu, Manjit; van den Maagdenberg, Arn M.J.M.; Hansen, Thomas; Ramirez, Alfredo; Zwart, John Anker Henrik (Peer reviewed; Journal article, 2023)
      Objective The objective of this study was to aggregate data for the first genomewide association study meta-analysis of cluster headache, to identify genetic risk variants, and gain biological insights. Methods A ...

    • Association between Fat-Free Mass Loss, Changes in Appetite, and Weight Regain in Individuals with Obesity 

      Alho Letra Martins, Catia Patricia; Nymo, Siren; Coutinho, Sílvia; Rehfeld, Jens F.; Hunter, Gary R.; Gower, Barbara A. (Peer reviewed; Journal article, 2023)
      Background The role of fat-free mass loss (FFML) in modulating weight regain in individuals with obesity, as well as the potential mechanisms involved, remain inconsistent. Objectives The aim of this study was to determine ...

    • Helsepersonells prevensjonsveiledning – en kvalitativ studie av unge kvinners erfaringer med prevesjonsveiledning og valg av prevensjonsmiddel 

      Dammen, Siri; Rosten, Caroline Norheim; Aune, Ingvild (Journal article; Peer reviewed, 2023)
      En stor andel unge kvinner i Norge bruker prevensjon og har oppsøkt helsepersonell for å få prevensjonsveiledning og resept på prevensjonsmidler. På tross av dette er det utført lite forskning i Norge som undersøker kvinners ...

    • A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation 

      Li, Shaobo; Spitz, Natalia; Ghantous, Akram; Abrishamcar, Sarina; Reimann, Brigitte; Marques, Irene; Silver, Matt J.; Aguilar-Lacasaña, Sofía; Kitaba, Negusse; Rezwan, Faisal I.; Röder, Stefan; Sirignano, Lea; Tuhkanen, Johanna; Mancano, Giulia; Sharp, Gemma C.; Metayer, Catherine; Morimoto, Libby; Stein, Dan J.; Zar, Heather J.; Alfano, Rossella; Nawrot, Tim; Wang, Congrong; Kajantie, Eero Olavi; Keikkala, Elina; Mustaniemi, Sanna; Ronkainen, Justiina; Sebert, Sylvain; Silva, Wnurinham; Vääräsmäki, Marja; Jaddoe, Vincent W. V.; Bernstein, Robin M.; Prentice, Andrew M.; Cosin-Tomas, Marta; Dwyer, Terence; Håberg, Siri Eldevik; Herceg, Zdenko; Magnus, Maria Christine; Munthe-Kaas, Monica Cheng; Page, Christian Magnus; Völker, Maja; Gilles, Maria; Send, Tabea; Witt, Stephanie; Zillich, Lea; Gagliardi, Luigi; Richiardi, Lorenzo; Czamara, Darina; Räikkönen, Katri; Chatzi, Lida; Vafeiadi, Marina; Arshad, S. Hasan; Ewart, Susan; Plusquin, Michelle; Felix, Janine F.; Moore, Sophie E.; Vrijheid, Martine; Holloway, John W.; Karmaus, Wilfried; Herberth, Gunda; Zenclussen, Ana; Streit, Fabian; Lahti, Jari; Hüls, Anke; Hoang, Thanh T.; London, Stephanie J.; Wiemels, Joseph L. (Peer reviewed; Journal article, 2024)
      Higher birth order is associated with altered risk of many disease states. Changes in placentation and exposures to in utero growth factors with successive pregnancies may impact later life disease risk via persistent DNA ...

    • Physical health and neurodevelopmental outcome in 7-year-old children whose mothers were at risk of gestational diabetes mellitus: a follow-up of a randomized controlled trial 

      Kolseth, Åshild Jensen; Kulseth, Signe; Stafne, Signe Nilssen; Mørkved, Siv; Salvesen, Kjell Åsmund Blix; Evensen, Kari Anne Indredavik (Peer reviewed; Journal article, 2023)
      Introduction Children born to mothers with gestational diabetes mellitus (GDM) are at risk of metabolic disturbances such as diabetes mellitus and overweight. However, few have examined the outcome of children whose ...

    • Transfer of cetirizine/levocetirizine into human breast milk and estimation of drug exposure to infants through breastfeeding: A human lactation study from the ConcePTION project 

      Nordeng, Hedvig Marie Egeland; Wegler, Christine; Lindqvist, Annika; Melander, Erik; Magnusson, Mikaela; Gandia, Peggy; Panchaud, Alice; Baranczewski, Pawel; Spigset, Olav (Peer reviewed; Journal article, 2023)
      Data on drug transfer into human breast milk are sparse. This study aimed to quantify concentrations of cetirizine and levocetirizine in breast milk and to estimate drug exposure to infants. Breastfeeding women at least ...