Institutt for klinisk og molekylær medisin: Nye registreringer
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Absorption and pharmacokinetics of bupivacaine after bilateral topical administration in tonsillar fossae for posttonsillectomy pain relief
(Journal article; Peer reviewed, 2024)No previous studies have investigated the systemic absorption of bupivacaine when used topically for posttonsillectomy pain. The present study was undertaken to investigate the pharmacokinetics of bupivacaine after ... -
Single-cell tracking as a tool for studying EMT-phenotypes
(Journal article; Peer reviewed, 2024)This article demonstrates that label-free single-cell video tracking is a useful approach for in vitro studies of Epithelial-Mesenchymal Transition (EMT). EMT is a highly heterogeneous process, involved in wound healing, ... -
Obesity, diabetes and hypovitaminosis D among women in a rural district of Nepal: Prevalence and risk factors. A population-based study
(Doctoral theses at NTNU;2024:143, Doctoral thesis, 2024)The prevalence of obesity, diabetes, and hypovitaminosis D has increased worldwide over the last decades, and these conditions have reached epidemic proportions. Low- and middleincome countries have experienced the most ... -
Chronic kidney disease and risk of bloodstream infections and sepsis: a 17-year follow-up of the population-based Trøndelag Health Study in Norway
(Journal article; Peer reviewed, 2024)Purpose: Bloodstream infections (BSI) and sepsis are important causes of hospitalization, loss of health, and death globally. Targetable risk factors need to be identified to improve prevention and treatment. In this study, ... -
Circulating calprotectin: from measurement to clinical application - studies of preanalytical, analytical, and cardiovascular biomarker performance
(Doctoral theses at NTNU;2024:161, Doctoral thesis, 2024)Norsk sammendrag Hjerte-karsykdom er en svært vanlig årsak til sykdom og tidlig død på verdensbasis og skyldes i hovedsak åreforkalkning (aterosklerose) som oppstår pga. fettavleiringer og inflammasjon i åreveggene. ... -
Exercise training and high-sensitivity cardiac troponin-I in patients with heart failure with reduced ejection fraction
(Journal article; Peer reviewed, 2024)Aims: The aims of this sub-study of the SMARTEX trial were (1) to evaluate the effects of a 12-week exercise training programme on serum levels of high sensitivity cardiac troponin I (hs-cTnI) in patients with moderate ... -
The Role of DNA Repair Enzyme NEIL3 in Hippocampal Development and Function
(Master thesis, 2024)Nylige funn understreker nye innsikter i de mange rollene NEIL3 har i hjernen, spesielt i hippocampus-regionen. Studier med gnagere har avdekket et tydelig uttrykksmønster for NEIL3 i den subgranulære sonen av dentate gyrus ... -
VRD versus VCD as induction therapy before autologous stem cell transplantation in multiple myeloma: a nationwide population-based study
(Journal article; Peer reviewed, 2024)Induction therapy followed by autologous stem cell transplantation (ASCT) is standard of care for young and fit patients with newly diagnosed multiple myeloma (MM) [1]. Induction therapy has evolved from doublet to triplet ... -
Predicting In-Hospital Death from Derived EHR Trajectory Features
(Chapter, 2024)Medical histories of patients can provide insight into the immediate future of a patient. While most studies propose to predict survival from vital signs and hospital tests within one episode of care, we carry out selective ... -
Kodepraksis ved sepsis 2008–21
(Journal article; Peer reviewed, 2024)Bakgrunn:Sepsis har høy insidens og mortalitet. For planlegging av helsetjenester og i forskning trengs presise data, og det er behov for å kartlegge kodepraksis i Norge. Materiale og metode: Alle personer over 17 år som ... -
Congenital duodenal obstruction - National trends in management and outcomes during the last quarter of a century in Norway
(Journal article; Peer reviewed, 2023)Introduction During the last quarter of a century, new surgical techniques in neonates have been introduced, and neonatal intensive care has developed. Few studies have explored the implementation of new techniques and if ... -
Oxycodone, Morphine, and Fentanyl in Patients with Chronic Pain: Proposal of Dose-Specific Concentration Ranges
(Peer reviewed; Journal article, 2023)Background: Interpreting opioid concentrations is challenging because of the lack of reference ranges. Therefore, the authors aimed to propose dose-specific concentration ranges in serum for oxycodone, morphine, and ... -
Baseline Serum Prostate-specific Antigen Value Predicts the Risk of Subsequent Prostate Cancer Death—Results from the Norwegian Prostate Cancer Consortium
(Peer reviewed; Journal article, 2023)Background Prostate-specific antigen (PSA) levels in midlife are strongly associated with the long-term risk of lethal prostate cancer in cohorts not subject to screening. This is the first study evaluating the association ... -
Lokal bruk av traneksamsyre som blødningsprofylakse
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How Did People with Prediabetes Who Attended the Diabetes Prevention Education Program (DiPEP) Experience Making Lifestyle Changes? A Qualitative Study in Nepal
(Journal article; Peer reviewed, 2023)Diabetes can be prevented through lifestyle modification in the prediabetic phase. A group-based lifestyle intervention called ‘Diabetes Prevention Education Program’ (DiPEP) was tested recently in Nepal. The present study ... -
TAK1- and IAP-inhibitors as novel approaches to multiple myeloma therapy
(Doctoral theses at NTNU;2024:74, Doctoral thesis, 2024)TAK1- and IAP-inhibitors as novel approaches to multiple myeloma therapy Multiple myeloma is a hematological malignancy characterized by accumulation of malignant plasma cells in the bone marrow. This can lead to uncontrolled ... -
Expanding the coverage of regulons from high-confidence prior knowledge for accurate estimation of transcription factor activities
(Peer reviewed; Journal article, 2023)Gene regulation plays a critical role in the cellular processes that underlie human health and disease. The regulatory relationship between transcription factors (TFs), key regulators of gene expression, and their target ... -
Structured Moderate Exercise and Biomarkers of Kidney Health in Sedentary Older Adults: The Lifestyle Interventions and Independence for Elders Randomized Clinical Trial
(Peer reviewed; Journal article, 2023)Rationale & Objective In the Lifestyle Interventions and Independence for Elders (LIFE) trial, a structured exercise intervention slowed kidney function decline in sedentary older adults. Biomarkers of kidney health could ... -
No association between disease severity and respiratory syncytial virus subtypes RSV-A and RSV-B in hospitalized young children in Norway
(Peer reviewed; Journal article, 2024)Objective There is conflicting evidence whether subtypes of Respiratory syncytial virus have different seasonality or are differentially associated with clinical severity. We aimed to explore the associations between ... -
Ultrasound and microbubble-enhanced therapy of Gastrointestinal tumors using conventional cytotoxic drugs in preclinical and clinical settings
(Doctoral theses at NTNU;2024:94, Doctoral thesis, 2024)Pancreatic ducal adenocarcinoma (PDAC) remains one of the deadliest cancers, with a very short life expectancy. Together with late diagnosis and aggressive biology, chemoresistance is one important cause of poor survival. ...