Institutt for klinisk og molekylær medisin: Nye registreringer
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VRD versus VCD as induction therapy before autologous stem cell transplantation in multiple myeloma: a nationwide population-based study
(Journal article; Peer reviewed, 2024)Induction therapy followed by autologous stem cell transplantation (ASCT) is standard of care for young and fit patients with newly diagnosed multiple myeloma (MM) [1]. Induction therapy has evolved from doublet to triplet ... -
Predicting In-Hospital Death from Derived EHR Trajectory Features
(Chapter, 2024)Medical histories of patients can provide insight into the immediate future of a patient. While most studies propose to predict survival from vital signs and hospital tests within one episode of care, we carry out selective ... -
Kodepraksis ved sepsis 2008–21
(Journal article; Peer reviewed, 2024)Bakgrunn:Sepsis har høy insidens og mortalitet. For planlegging av helsetjenester og i forskning trengs presise data, og det er behov for å kartlegge kodepraksis i Norge. Materiale og metode: Alle personer over 17 år som ... -
Congenital duodenal obstruction - National trends in management and outcomes during the last quarter of a century in Norway
(Journal article; Peer reviewed, 2023)Introduction During the last quarter of a century, new surgical techniques in neonates have been introduced, and neonatal intensive care has developed. Few studies have explored the implementation of new techniques and if ... -
Oxycodone, Morphine, and Fentanyl in Patients with Chronic Pain: Proposal of Dose-Specific Concentration Ranges
(Peer reviewed; Journal article, 2023)Background: Interpreting opioid concentrations is challenging because of the lack of reference ranges. Therefore, the authors aimed to propose dose-specific concentration ranges in serum for oxycodone, morphine, and ... -
Baseline Serum Prostate-specific Antigen Value Predicts the Risk of Subsequent Prostate Cancer Death—Results from the Norwegian Prostate Cancer Consortium
(Peer reviewed; Journal article, 2023)Background Prostate-specific antigen (PSA) levels in midlife are strongly associated with the long-term risk of lethal prostate cancer in cohorts not subject to screening. This is the first study evaluating the association ... -
Lokal bruk av traneksamsyre som blødningsprofylakse
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How Did People with Prediabetes Who Attended the Diabetes Prevention Education Program (DiPEP) Experience Making Lifestyle Changes? A Qualitative Study in Nepal
(Journal article; Peer reviewed, 2023)Diabetes can be prevented through lifestyle modification in the prediabetic phase. A group-based lifestyle intervention called ‘Diabetes Prevention Education Program’ (DiPEP) was tested recently in Nepal. The present study ... -
TAK1- and IAP-inhibitors as novel approaches to multiple myeloma therapy
(Doctoral theses at NTNU;2024:74, Doctoral thesis, 2024)TAK1- and IAP-inhibitors as novel approaches to multiple myeloma therapy Multiple myeloma is a hematological malignancy characterized by accumulation of malignant plasma cells in the bone marrow. This can lead to uncontrolled ... -
Expanding the coverage of regulons from high-confidence prior knowledge for accurate estimation of transcription factor activities
(Peer reviewed; Journal article, 2023)Gene regulation plays a critical role in the cellular processes that underlie human health and disease. The regulatory relationship between transcription factors (TFs), key regulators of gene expression, and their target ... -
Structured Moderate Exercise and Biomarkers of Kidney Health in Sedentary Older Adults: The Lifestyle Interventions and Independence for Elders Randomized Clinical Trial
(Peer reviewed; Journal article, 2023)Rationale & Objective In the Lifestyle Interventions and Independence for Elders (LIFE) trial, a structured exercise intervention slowed kidney function decline in sedentary older adults. Biomarkers of kidney health could ... -
No association between disease severity and respiratory syncytial virus subtypes RSV-A and RSV-B in hospitalized young children in Norway
(Peer reviewed; Journal article, 2024)Objective There is conflicting evidence whether subtypes of Respiratory syncytial virus have different seasonality or are differentially associated with clinical severity. We aimed to explore the associations between ... -
Ultrasound and microbubble-enhanced therapy of Gastrointestinal tumors using conventional cytotoxic drugs in preclinical and clinical settings
(Doctoral theses at NTNU;2024:94, Doctoral thesis, 2024)Pancreatic ducal adenocarcinoma (PDAC) remains one of the deadliest cancers, with a very short life expectancy. Together with late diagnosis and aggressive biology, chemoresistance is one important cause of poor survival. ... -
Healthy ageing from birth to age 84 years in the Helsinki Birth Cohort Study, Finland: a longitudinal study
(Peer reviewed; Journal article, 2023)Background The true prevalence of healthy ageing on a population level is unknown. In this study we aimed to examine the upper limit for the prevalence of healthy ageing, by quantifying the probability of surviving and ... -
Protocol of a randomised, controlled trial comparing immediate curative therapy with conservative treatment in men aged ≥75 years with non-metastatic high-risk prostate cancer (SPCG 19/GRand-P)
(Peer reviewed; Journal article, 2024)Background Older men (aged ≥75 years) with high risk, non-metastatic prostate cancer (PCa) are increasingly treated with curative therapy (surgery or radiotherapy). However, it is unclear if curative therapy prolongs ... -
Complement factors B, D, C3bBbP and risk of future venous thromboembolism
(Peer reviewed; Journal article, 2023)The complement system appears to be involved in the pathogenesis of venous thromboembolism (VTE). We investigated the association of complement factors (CF) B, D, and the alternative pathway convertase, C3bBbP, measured ... -
Inflammation and Digestive Cancer
(Journal article; Peer reviewed, 2023)Chronic inflammation is linked to carcinogenesis, particularly in the digestive organs, i.e., the stomach, colon, and liver. The mechanism of this effect has, however, only partly been focused on. In this review, we focus ... -
APOE Polymorphism Is Associated with Changes in the Kynurenine Pathway
(Peer reviewed; Journal article, 2023)Abstract: Background: APOE polymorphism and the Kynurenine pathway (KP) are associated with many disorders, but little is known about associations between APOE polymorphism and the KP. This study explored the associations ... -
Methplotlib: Analysis of modified nucleotides from nanopore sequencing
(Journal article; Peer reviewed, 2020)Summary Modified nucleotides play a crucial role in gene expression regulation. Here, we describe methplotlib, a tool developed for the visualization of modified nucleotides detected from Oxford Nanopore Technologies ...