Institutt for klinisk og molekylær medisin: Recent submissions

Now showing items 61-80 of 3512

    • Body composition in adults born preterm with very low birth weight 

      Jussinniemi, Laura; Kulmala, Maarit K.; Aakvik, Kristina Anna Djupvik; Benum, Silje Dahl; Jørgensen, Anna Perregaard Munch; Balasuriya, Chandima Nirupa Dilruks; Stunes, Astrid Kamilla; Syversen, Unni; Indredavik, Marit Sæbø; Andersson, Sture; Hovi, Petteri; Evensen, Kari Anne Indredavik; Kajantie, Eero Olavi (Journal article; Peer reviewed, 2024)
      Background: Studies on body composition in preterm very low birth weight (VLBW < 1500 g) survivors are inconsistent and trajectories later in life unknown. We assessed body composition and its change from young to mid-adulthood ...

    • Mixed reality training application to perform obstetric pulsed-wave Doppler ultrasound 

      Nylund, Maria Emine; Jain, Shubham; Tegnander, Eva; Jensen, Eva Johanne Leknes; Prasolova-Førland, Ekaterina; Lindseth, Frank; Kiss, Gabriel Hanssen (Peer reviewed; Journal article, 2023)
      Pulsed-wave Doppler ultrasound is a widely used technique for monitoring pregnancies. As ultrasound equipment becomes more advanced, it becomes harder to train practitioners to be proficient in the procedure as it requires ...

    • The Cardioprotective Role of Extracellular Vesicles (EVs) in Remote Ischemic Conditioning (RIC) 

      Busher Mazen Tinaoui (Master thesis, 2024)
      Bakgrunn: Akutt hjerteinfarkt (AMI) er blant de ledende dødsårsakene globalt, og dødeligheten forventes å fortsatt stige det neste tiåret ifølge Verdens Helseorganisasjon (WHO). Det er derfor viktig å ytterligere forbedre ...

    • Cancer-induced muscle atrophy is determined by intrinsic muscle oxidative capacity 

      Alves, Christiano R. R.; Eichelberger, Eric J.; das Neves, Willian; Ribeiro, Márcio A. C.; Bechara, Luiz R.G.; Voltarelli, Vanessa A.; de Almeida, Ney R.; Hagen, Lars; Sharma, Animesh; Ferreira, Julio C. B.; Swoboda, Kathryn J.; Slupphaug, Geir; Brum, Patricia C. (Peer reviewed; Journal article, 2021)
      We tested the hypothesis that cancer cachexia progression would induce oxidative post-translational modifications (Ox-PTMs) associated with skeletal muscle wasting, with different responses in muscles with the prevalence ...

    • Genome-wide meta-analysis implicates variation affecting mast cell biology in urticaria 

      McSweeney, Sheila Mary; Saklatvala, Jake; Rispoli, Rossella; Ganier, Clarisse; Woszczek, Grzegorz; Thomas, Laurent Francois; Hveem, Kristian; Løset, Mari; Dand, Nick; Tziotzios, Christos; Simpson, Michael; McGrath, John Alexander (Peer reviewed; Journal article, 2023)
      Background Urticaria is characterized by inappropriate mast cell degranulation leading to the development of wheals and/or angioedema. Twin and family studies indicate that there is a substantial heritable component to ...

    • Early Intervention for Children Aged 0 to 2 Years with or at High Risk of Cerebral Palsy: International Clinical Practice Guideline Based on Systematic Reviews 

      Morgan, Catherine; Fetters, Linda; Adde, Lars; Badawi, Nadia; Bancale, Ada; Boyd, Roslyn N.; Chorna, Olena; Cioni, Giovanni; Damiano, Diane L.; Darrah, Johanna; De Vries, Linda S.; Dusing, Stacey; Einspieler, Christa; Eliasson, Ann-Christin; Ferriero, Donna; Fehlings, Darcy; Forssberg, Hans; Gordon, Andrew M.; Greaves, Susan; Guzzetta, Andrea; Hadders-Algra, Mijna; Harbourne, Regina; Karlsson, Petra; Krumlinde-Sundholm, Lena; Latal, Beatrice; Loughran-Fowlds, Alison; Mak, Catherine; Maitre, Nathalie; McIntyre, Sarah; Mei, Cristina; Morgan, Angela; Kakooza-Mwesige, Angelina; Romeo, Domenico M.; Sanchez, Katherine; Spittle, Alicia; Shepherd, Roberta; Thornton, Marelle; Valentine, Jane; Ward, Roslyn; Whittingham, Koa; Zamany, Alieh; Novak, Iona (Journal article; Peer reviewed, 2021)
      Importance: Cerebral palsy (CP) is the most common childhood physical disability. Early intervention for children younger than 2 years with or at risk of CP is critical. Now that an evidence-based guideline for early ...

    • Ivermectin effectively inhibits hepatitis E virus replication, requiring the host nuclear transport protein importin α1 

      Li, Yunlong; Miao, Zhijiang; Li, Pengfei; Zhang, Ruyi; Kainov, Denis; Ma, Zhongren; de Man, Robert A.; Peppelenbosch, Maikel Petrus; Pan, Qiuwei (Journal article; Peer reviewed, 2021)
      We show that ivermectin, an FDA-approved anti-parasitic drug, effectively inhibits infection with hepatitis E virus (HEV) genotypes 1 and 3 in a range of cell culture models, including hepatic and extrahepatic cells. ...

    • High-dose versus standard-dose twice-daily thoracic radiotherapy for patients with limited stage small-cell lung cancer: an open-label, randomised, phase 2 trial 

      Grønberg, Bjørn Henning; Killingberg, Kristin Toftaker; Fløtten, Øystein; Brustugun, Odd; HORNSLIEN, KJERSTI; Madebo, Tesfaye; Langer, Seppo Wang; Schytte, Tine; Nyman, Jan; Risum, Signe; Tsakonas, Georgios; Engleson, Jens; Halvorsen, Tarje Onsøien (Journal article; Peer reviewed, 2021)
      High-dose versus standard-dose twice-daily thoracic radiotherapy for patients with limited stage small-cell lung cancer: an open-label, randomised, phase 2 trial

    • Generation and Characterization of Induced Pluripotent Stem Cells from Individuals Affected by Metachromatic Leukodystrophy 

      Berg, Martine Engebakken (Master thesis, 2024)
      Metakromatisk leukodystrofi (MLD) er en ødeleggende lysosomal avleiringssykdom (LSD) forårsaket av mangel på enzymet arylsulfatase A (ARSA). Dette enzymet spiller en avgjørende rolle i nedbrytningen av sulfatider, som er ...

    • Mental health, pain and tiredness in adults born very preterm or with very low birthweight 

      Hollund, Ingrid Marie Husby; Aakvik, Kristina Anna Djupvik; Benum, Silje Dahl; Ingvaldsen, Sigrid Hegna; Lydersen, Stian; Tikanmäki, Marjaana; Hovi, Petteri; Räikkönen, Katri; Kajantie, Eero Olavi; Johnson, Samantha; Marlow, Neil; Baumann, Nicole; Wolke, Dieter; Indredavik, Marit Sæbø; Evensen, Kari Anne Indredavik (Journal article; Peer reviewed, 2023)
      Aim: Adults born preterm have increased risk of mental health problems and other neurodevelopmental conditions. We aimed to investigate associations of mental health with pain and tiredness in adults born very preterm (VP; ...

    • Organoids as a potential model for studying pancreatic ductal adenocarcinoma 

      Aarvik, Anne Maren Schistad (Master thesis, 2024)
      Bakgrunn/ Formål: Adenokarsinom i bukspyttkjertelen (PDAC) er en dødelig sykdom som tilsynelatende ikke har noen kur. Flere forskningsmodeller inkludert cellelinjer, sfæroider, organoider, og mus har blitt brukt for å ...

    • Radiotherapy of Lung Cancer 

      Graabak, Gustav (Doctoral theses at NTNU;2024:254, Doctoral thesis, 2024)
      Strålebehandling av lungekreft Lungekreft er nest hyppigst og forårsaker flest dødsfall av alle kreftformer. Det er to hovedtyper lungekreft: ikke-småcellet lungekreft og småcellet lungekreft (SCLC). SCLC er den mest ...

    • Aspects of selection and treatment of basal cell carcinoma for photodynamic therapy 

      Mørk, Erik (Doctoral theses at NTNU;2024:238, Doctoral thesis, 2024)

    • Avvik i legemiddelhåndteringen i en av Norges største kommuner 

      Lorentsen, Silje Kleven (Master thesis, 2024)
      Bakgrunn: Legemiddelfeil er et globalt problem som kan føre til økt risiko for pasientskader og sykehusinnleggelser. I den norske kommunehelsetjenesten vet man lite om omfanget av avvik i legemiddelhåndteringen, og hvor ...

    • En deskriptiv studie av innmeldte legemiddelhåndteringsavvik i hjemmetjenesten 

      Nielsen, Nora Miland (Master thesis, 2024)
      Bakgrunn og hensikt: Legemiddelbruk kan utgjøre en stor risiko for pasientsikkerheten. Uforsvarlig legemiddelhåndtering er årsaken bak en betydelig andel pasientskader, til tross for at slike avvik i mange tilfeller er ...

    • Geriatric assessment with management for older patients with cancer receiving radiotherapy: a cluster-randomised controlled pilot study 

      Jordhøy, Marit Slaaen; Røyset, Inga Marie; Saltvedt, Ingvild Tina; Grønberg, Bjørn Henning; Halsteinli, Vidar; Døhl, Øystein; Vossius, Corinna Elisabeth; Kirkevold, Øyvind; Bergh, Sverre; Rostoft, Siri; Oldervoll, Line Merethe; Bye, Asta; Melby, Line Kari; Røsstad, Tove Garåsen; Eriksen, Guro Falk; Sollid, May Ingvild Volungholen; Rolfson, Darryl; Saltyte Benth, Jurate (Journal article; Peer reviewed, 2024)
      Background: Geriatric assessment and management (GAM) improve outcomes in older patients with cancer treated with surgery or chemotherapy. It is unclear whether GAM may provide better function and quality of life (QoL), ...

    • Mapping population access to essential surgical care in Liberia using equipment, personnel, and bellwether capability standards 

      Adde, Håvard Askim; van Duinen, Aalke Johan; Andrews, Benetta; Bakker, Juul Marlies; Goyah, Kezelebah; Salvesen, Øyvind Olav; Sheriff, Swaliho; Utam, Terseer; Yaskey, Clarence; Weiser, Thomas G.; Bolkan, Håkon Angell (Journal article; Peer reviewed, 2022)
      Background: Accurate surveillance of population access to essential surgery is key for strategic healthcare planning. This study aimed to estimate population access to surgical facilities meeting standards for safe surgery ...

    • Immune Profiling of Tumor and Microenvironment Cells in Multiple Myeloma 

      Behsen, Alenka Djarmila (Doctoral thesis, 2024)
      Myelomatose, også kalt benmargskreft, er en kreftsykdom som oppstår ved ukontrollert vekst av antistoff-produserende plasmaceller i benmargen. Når plasmaceller deler seg ukontrollert utvikler de seg til kreftceller, eller ...

    • A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans 

      Moksnes, Marta Riise; Hansen, Ailin Falkmo; Wolford, Brooke; Thomas, Laurent Francois; Rasheed, Humaira; Simic, Anica; Bhatta, Laxmi; Brantsæter, Anne Lise; Surakka, Ida; Zhou, Wei; Magnus, Per Minor; Njølstad, Pål Rasmus; Andreassen, Ole; Syversen, Tore; Zheng, Jie; Fritsche, Lars; Evans, David M.; Warrington, Nicole Maree; Nøst, Therese Haugdahl; Åsvold, Bjørn Olav; Flaten, Trond Peder; Willer, Cristen J.; Hveem, Kristian; Brumpton, Ben Michael (Journal article; Peer reviewed, 2024)
      Trace elements are important for human health but may exert toxic or adverse effects. Mechanisms of uptake, distribution, metabolism, and excretion are partly under genetic control but have not yet been extensively mapped. ...

    • Treatment of Liver Metastases With Focused Ultrasound and Microbubbles in Patients With Colorectal Cancer Receiving Chemotherapy 

      Haram, Karin Margrete; Hansen, Rune; Bouget, David Nicolas Jean-Marie; Myhre, Ola Finneng; Davies, Catharina de Lange; Hofsli, Eva (Journal article; Peer reviewed, 2023)
      Objective: Pre-clinical trials have obtained promising results that focused ultrasound (FUS) combined with microbubbles (MBs) increases tumor uptake and the therapeutic effect of drugs. The aims of the study described here ...