Now showing items 21-40 of 1877

    • A high-throughput drug combination screen of targeted small molecule inhibitors in cancer cell lines 

      Flobak, Åsmund; Niederdorfer, Barbara; To, Vu; Thommesen, Liv; Klinkenberg, Geir; Lægreid, Astrid (Journal article; Peer reviewed, 2019)
      While there is a high interest in drug combinations in cancer therapy, openly accessible datasets for drug combination responses are sparse. Here we present a dataset comprising 171 pairwise combinations of 19 individual ...
    • A longitudinal study of associations between psychiatric symptoms and disorders and cerebral gray matter volumes in adolescents born very preterm 

      Lozano-Botellero, Violeta Nazaret; Skranes, Jon Sverre; Bjuland, Knut Jørgen; Håberg, Asta; Lydersen, Stian; Brubakk, Ann-Mari; Indredavik, Marit Sæbø; Martinussen, Marit (Journal article; Peer reviewed, 2017)
      Background:Being born preterm with very low birthweight (VLBW≤1500 g) poses a risk for cortical andsubcortical gray matter (GM) abnormalities, as well as for having more psychiatric problems during childhood andadolescence ...
    • A manually curated ChIP-seq benchmark demonstrates room for improvement in current peak-finder programs 

      Rye, Morten Beck; Sætrom, Pål; Drabløs, Finn (Journal article; Peer reviewed, 2011)
      Chromatin immunoprecipitation (ChIP) followed by high throughput sequencing (ChIP-seq) is rapidly becoming the method of choice for discovering cell-specific transcription factor binding locations genome wide. By aligning ...
    • A massive parallel sequencing workflow for diagnostic genetic testing of mismatch repair genes 

      Hansen, Maren Fridtjofsen; Neckmann, Ulrike; Lavik, Liss Anne; Vold, Trine; Gilde, Bodil; Toft, Ragnhild Karlgård; Sjursen, Wenche (Journal article; Peer reviewed, 2014)
      The purpose of this study was to develop a massive parallel sequencing (MPS) workflow for diagnostic analysis of mismatch repair (MMR) genes using the GS Junior system (Roche). A pathogenic variant in one of four MMR genes, ...
    • A method to assess obstetric outcomes using the 10-Group Classification System: A quantitative descriptive study 

      Rossen, Janne; Lucovnik, Miha; Eggebø, Torbjørn Moe; Tul, Natasa; Murphy, Martina; Vistad, Ingvild; Robson, Michael (Journal article; Peer reviewed, 2017)
      Objectives Internationally, the 10-Group Classification System (TGCS) has been used to report caesarean section rates, but analysis of other outcomes is also recommended. We now aim to present the TGCS as a method to assess ...
    • A novel antimycobacterial compound acts as an intracellular iron chelator 

      Dragset, Marte Singsås; Poce, Giovanna; Alfonso, Salvatore; Padilla-Benavides, Teresita; Ioerger, Thomas R.; Kaneko, Takushi; Sacchettini, James C.; Biava, Mariangela; Parish, Tanya; Argüello, José M.; Steigedal, Magnus; Rubin, Eric J. (Journal article; Peer reviewed, 2015)
      Efficient iron acquisition is crucial for the pathogenesis of Mycobacterium tuberculosis. Mycobacterial iron uptake and metabolism are therefore attractive targets for antitubercular drug development. Resistance mutations ...
    • A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA 

      Robertson, Adam Brian; Dahl, John Arne; Vågbø, Cathrine Broberg; Tripathi, P; Krokan, Hans Einar; Klungland, Arne (Journal article; Peer reviewed, 2011)
      Recently, 5-hydroxymethylcytosine (5hmC) was identified in mammalian genomic DNA. The biological role of this modification remains unclear; however, identifying the genomic location of this modified base will assist in ...
    • A novel non-canonical Wnt signature for prostate cancer aggressiveness 

      Sandsmark, Elise; Hansen, Ailin Falkmo; Selnæs, Kirsten Margrete; Bertilsson, Helena; Bofin, Anna M.; Wright, Alan J.; Viset, Trond; Richardsen, Elin; Drabløs, Finn Sverre; Bathen, Tone Frost; Tessem, May-Britt; Rye, Morten Beck (Journal article; Peer reviewed, 2016)
      Activation of the Canonical Wnt pathway (CWP) has been linked to advanced and metastatic prostate cancer, whereas the Wnt5a-induced non-canonical Wnt pathway (NCWP) has been associated with both good and poor prognosis. A ...
    • A Novel Truncated Form of Nephronectin Is Present in Small Extracellular Vesicles Isolated from 66cl4 Cells 

      Toraskar, Jimita Prashant; Norvoll Magnussen, Synnøve; Hagen, Lars; Sharma, Animesh; Hoang, Linh; Bjørkøy, Geir; Svineng, Gunbjørg; Steigedal, Tonje S. (Journal article; Peer reviewed, 2019)
      Extracellular vesicles are emerging as biomarkers in breast cancer. Our recent report suggested that an intracellular granular staining pattern of the extracellular matrix protein nephronectin (NPNT) in breast tumor sections ...
    • A PET/MRI study towards finding the optimal [18F]Fluciclovine PET protocol for detection and characterisation of primary prostate cancer. 

      Elschot, Mattijs; Selnæs, Kirsten Margrete; Sandsmark, Elise; Krüger-Stokke, Brage; Størkersen, Øystein; Tessem, May-Britt; Moestue, Siver Andreas; Bertilsson, Helena; Bathen, Tone Frost (Journal article; Peer reviewed, 2016)
      Purpose: [18F]Fluciclovine PET imaging shows promise for the assessment of prostate cancer. The purpose of this PET/MRI study is to optimise the PET imaging protocol for detection and characterisation of primary prostate ...
    • A Preoperative Multimarker Approach to Evaluate Acute Kidney Injury After Cardiac Surgery. 

      Enger, Tone Bull; Pleym, Hilde; Stenseth, Roar; Greiff, Guri; Wahba, Alexander; Videm, Vibeke (Journal article; Peer reviewed, 2016)
      Objective To investigate whether a multimarker strategy combining preoperative biomarkers representing distinct pathophysiologic pathways enhances preoperative risk assessment of acute kidney injury after cardiac surgery ...
    • A property-based analysis of human transcription factors 

      Bahrami, Shahram; Ehsani, Rezvan; Drabløs, Finn (Journal article; Peer reviewed, 2015)
      Background Transcription factors are essential proteins for regulating gene expression. This regulation depends upon specific features of the transcription factors, including how they interact with DNA, how they interact ...
    • A prospective study examining cachexia predictors in patients with incurable cancer 

      Vagnildhaug, Ola Magne; Brunelli, Cinzia; Hjermstad, Marianne Jensen; Strasser, Florian; Baracos, Vickie; Wilcock, Andrew; Nabal, María; Kaasa, Stein; Laird, Barry J; Solheim, Tora Skeidsvoll (Journal article; Peer reviewed, 2019)
      Background Early intervention against cachexia necessitates a predictive model. The aims of this study were to identify predictors of cachexia development and to create and evaluate accuracy of a predictive model based ...
    • A randomized phase II feasibility trial of a multimodal intervention for the management of cachexia in lung and pancreatic cancer 

      Solheim, Tora Skeidsvoll; Laird, Barry J; Balstad, Trude Rakel; Stene, Guro Birgitte; Bye, Asta; Johns, Neil; Pettersen, Caroline Hild Hakvåg; Fallon, Marie; Fayers, Peter; Fearon, Kenneth; Kaasa, Stein (Journal article; Peer reviewed, 2017)
      Background: Cancer cachexia is a syndrome of weight loss (including muscle and fat), anorexia, and decreased physical function. It has been suggested that the optimal treatment for cachexia should be a multimodal intervention. ...
    • A reliability study of the rapid emergency triage and treatment system for children 

      Henning, Brita; Lydersen, Stian; Døllner, Henrik (Journal article; Peer reviewed, 2016-02-24)
      Background To evaluate inter- and intrarater reliability of a new Scandinavian triage system for children, the Rapid Emergency Triage and Treatment System-pediatric (RETTS-p). Methods Two observational studies ...
    • A Review of the Current Challenges Associated with the Development of an Artificial Pancreas by a Double Subcutaneous Approach 

      Christiansen, Sverre; Fougner, Anders Lyngvi; Stavdahl, Øyvind; Kölle, Konstanze; Ellingsen, Reinold; Carlsen, Sven Magnus (Journal article; Peer reviewed, 2017)
      Introduction Patients with diabetes type 1 (DM1) struggle daily to achieve good glucose control. The last decade has seen a rush of research groups working towards an artificial pancreas (AP) through the application of a ...
    • A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling 

      Nilsen, Nadra; Gregory I., Vladimer; Stenvik, Jørgen; Ørning, Mathias Pontus; Zeid-Kilani, Maria Vanessa; Bugge, Marit; Bergstrøm, Bjarte; Conlon, Joseph; Husebye, Harald; Amy, Hise; Fitzgerald, Katherine A.; Espevik, Terje; Lien, Egil (Journal article; Peer reviewed, 2015)
      Toll-like receptors (TLRs) are involved in sensing invading microbes by host innate immunity. TLR2 recognizes bacterial lipoproteins/lipopeptides, and lipopolysaccharide activates TLR4. TLR2 and TLR4 signal via the ...
    • A short-activating RNA oligonucleotide targeting the islet β-cell transcriptional factor MafA in CD34(+) cells 

      Reebye, Vikash; Sætrom, Pål; Mintz, Paul J; Rossi, JJ; Kasahara, Noriyuki; Nteliopoulos, G; Nicholls, Joanna P; Haoudi, Abdelali; Gordon, Myrtle YA; Habib, Nagy A (Journal article; Peer reviewed, 2013)
      Upon functional loss of insulin producing islet β-cells, some patients with diabetes become dependent on life-long insulin supplementation therapy. Bioengineering surrogate insulin producing cells is an alternative replacement ...
    • A study of the transcriptional repressor ICER: Regulatory networks in gastrin-induced gene expression 

      Misund, Kristine (Doktoravhandlinger ved NTNU, 1503-8181; 2009:117, Doctoral thesis, 2009)
      En studie av transkripsjonsrepressoren ICER. Regulatoriske nettverk i gastrin-indusert genuttrykk. Nar et hormon eller en vekstfaktor binder til spesifikke mottagere pa celleoverflaten, vil dette fore til en intracellular ...
    • A Study of Toll-like Receptors in Trophoblasts, and the Influence of Cytomegalovirus Infection 

      Stødle, Guro Kristine Sannerud (Master thesis, 2012)
      Toll-like receptors (TLRs) act as sensors against invading pathogens and endogenous danger signals, and are critical mediators of inflammatory immune responses. During pregnancy, intrauterine activation of TLRs might evoke ...