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dc.contributor.authorHosainey, Sayied Abdol Mohieb
dc.contributor.authorBouget, David
dc.contributor.authorReinertsen, Ingerid
dc.contributor.authorSagberg, Lisa Millgård
dc.contributor.authorTorp, Sverre Helge
dc.contributor.authorJakola, Asgeir Store
dc.contributor.authorSolheim, Ole
dc.identifier.citationNeurosurgical review. 2021, 1-10.en_US
dc.description.abstractMeningioma is the most common benign intracranial tumor and is believed to arise from arachnoid cap cells of arachnoid granulations. We sought to develop a population-based atlas from pre-treatment MRIs to explore the distribution of intracranial meningiomas and to explore risk factors for development of intracranial meningiomas in different locations. All adults (≥ 18 years old) diagnosed with intracranial meningiomas and referred to the department of neurosurgery from a defined catchment region between 2006 and 2015 were eligible for inclusion. Pre-treatment T1 contrast-enhanced MRI-weighted brain scans were used for semi-automated tumor segmentation to develop the meningioma atlas. Patient variables used in the statistical analyses included age, gender, tumor locations, WHO grade and tumor volume. A total of 602 patients with intracranial meningiomas were identified for the development of the brain tumor atlas from a wide and defined catchment region. The spatial distribution of meningioma within the brain is not uniform, and there were more tumors in the frontal region, especially parasagittally, along the anterior part of the falx, and on the skull base of the frontal and middle cranial fossa. More than 2/3 meningioma patients were females (p < 0.001) who also were more likely to have multiple meningiomas (p < 0.01), while men more often have supratentorial meningiomas (p < 0.01). Tumor location was not associated with age or WHO grade. The distribution of meningioma exhibits an anterior to posterior gradient in the brain. Distribution of meningiomas in the general population is not dependent on histopathological WHO grade, but may be gender-related.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleAre there predilection sites for intracranial meningioma? A population-based atlasen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalNeurosurgical reviewen_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal