• Disease-Course Adapting Machine Learning Prognostication Models in Elderly Patients Critically Ill With COVID-19: Multicenter Cohort Study With External Validation 

  Jung, Christian; Mamandipoor, Behrooz; Fjølner, Jesper; Bruno, Raphael Romano; Wernly, Bernhard; Artigas, Antonio; Pinto, Bernardo Bollen; Schefold, Joerg C.; Wolff, Georg; Kelm, Malte; Beil, Michael; Sviri, Sigal; van Heerden, Peter V.; Szczeklik, Wojciech; Czuczwar, Miroslaw; Elhadi, Muhammed; Joannidis, Michael; Oeyen, Sandra; Zafeiridis, Tilemachos; Marsh, Brian; Andersen, Finn Husøy; Moreno, Rui; Cecconi, Maurizio; Leaver, Susannah; De Lange, Dylan W.; Guidet, Bertrand; Flaatten, Hans Kristian; Osmani, Venet (Peer reviewed; Journal article, 2022)

  Background:The COVID-19 pandemic caused by SARS-CoV-2 is challenging health care systems globally. The disease disproportionately affects the elderly population, both in terms of disease severity and mortality risk. ...

• Sex-specific treatment characteristics and 30-day mortality outcomes of critically ill COVID-19 patients over 70 years of age—results from the prospective COVIP study 

  Wolff, Georg; Wernly, Bernhard; Flaatten, Hans Kristian; Fjølner, Jesper; Bruno, Raphael Romano; Artigas, Antonio; Pinto, Bernardo Bollen; Schefold, Joerg C.; Kelm, Malte; Binneboessel, Stephan; Baldia, Philipp; Beil, Michael; Sivri, Sigal; van Heerden, Peter Vernon; Szczeklik, Wojciech; Elhadi, Muhammed; Joannidis, Michael; Oeyen, Sandra; Flamm, Maria; Zafeiridis, Tilemachos; Marsh, Brian; Andersen, Finn Husøy; Moreno, Rui; Boumendil, Ariane; De Lange, Dylan W.; Guidet, Bertrand; Leaver, Susannah; Jung, Christian (Peer reviewed; Journal article, 2022)

  Purpose Older critically ill patients with COVID-19 have been the most vulnerable during the ongoing pandemic, with men being more prone to hospitalization and severe disease than women. We aimed to explore sex-specific ...

• Comparing the impact of vaccination strategies on the spread of COVID-19, including a novel household-targeted vaccination strategy 

  Voigt, Andre; Omholt, Stig William; Almaas, Eivind (Peer reviewed; Journal article, 2022)

  With limited availability of vaccines, an efficient use of the limited supply of vaccines in order to achieve herd immunity will be an important tool to combat the wide-spread prevalence of COVID-19. Here, we compare a ...

• Heat tolerance during uncompensable heat stress in men and women wearing firefighter personal protective equipment 

  Renberg, Julie; Lignier, Maxime Jeanovitch; Wiggen, Øystein; Færevik, Hilde; Helgerud, Jan; Sandsund, Mariann (Peer reviewed; Journal article, 2022)

  Firefighters run a risk of heat strain during occupational tasks. The number of female firefighters has been increasing, but research relevant to this group is still scarce. We aimed to investigate whether there are any ...

• Vedvarende bruk av opioider og samtidig bruk av andre vanedannende legemidler 

  Odsbu, Ingvild; Handal, Marte; Hjellvik, Vidar; Borchgrevink, Petter Chr.; Clausen, Thomas; Nesvåg, Ragnar; Skurtveit, Svetlana Ondrasova (Journal article; Peer reviewed, 2022)

• A retrospective cohort study comparing differences in 30-day mortality among critically ill patients aged ≥ 70 years treated in European tax-based healthcare systems (THS) versus social health insurance systems 

  Wernly, Bernhard; Flaatten, Hans Kristian; Beil, Michael; Fjølner, Jesper; Bruno, Raphael Romano; Artigas, Antonio; Pinto, Bernardo Bollen; Schefold, Joerg C.; Kelm, Malte; Sigal, Sviri; van Heerden, Peter Vernon; Szczeklik, Wojciech; Elhadi, Muhammed; Joannidis, Michael; Rezar, Richard; Oeyen, Sandra; Wolff, Georg; Marsh, Brian; Andersen, Finn Husøy; Moreno, Rui; Wernly, Sarah; Leaver, Susannah; Boumendil, Ariane; De Lange, Dylan W.; Guidet, Bertrand; Perings, Stefan; Jung, Christian (Peer reviewed; Journal article, 2022)

  In Europe, tax-based healthcare systems (THS) and social health insurance systems (SHI) coexist. We examined differences in 30-day mortality among critically ill patients aged ≥ 70 years treated in intensive care units in ...

• Association of chronic heart failure with mortality in old intensive care patients suffering from Covid-19 

  Bruno, Raphael Romano; Wernly, Bernhard; Wolff, Georg; Fjølner, Jesper; Artigas, Antonio; Bollen Pinto, Bernardo; Schefold, Joerg C.; Kindgen-Milles, Detlef; Baldia, Philipp Heinrich; Kelm, Malte; Beil, Michael; Sviri, Sigal; van Heerden, Peter Vernon; Szczeklik, Wojciech; Topeli, Arzu; Elhadi, Muhammed; Joannidis, Michael; Oeyen, Sandra; Kondili, Eumorfia; Marsh, Brian; Andersen, Finn Husøy; Moreno, Rui; Leaver, Susannah; Boumendil, Ariane; De Lange, Dylan W.; Guidet, Bertrand; Flaatten, Hans Kristian; Jung, Christian (Peer reviewed; Journal article, 2022)

  Aims Chronic heart failure (CHF) is a major risk factor for mortality in coronavirus disease 2019 (COVID-19). This prospective international multicentre study investigates the role of pre-existing CHF on clinical outcomes ...

• Vinorelbine and gemcitabine vs vinorelbine and carboplatin as first-line treatment of advanced NSCLC. A phase III randomised controlled trial by the Norwegian Lung Cancer Study Group 

  Fløtten, Øystein; Grønberg, Bjørn Henning; Bremnes, Roy M.; Amundsen, Tore; Sundstrøm, Stein Harald; Rolke, Heidi; HORNSLIEN, KJERSTI; Wentzel-Larsen, Tore; Aasebø, Ulf; von Plessen, Christian (Journal article; Peer reviewed, 2012)

  Background: Platinum-based doublet chemotherapy is the standard first-line treatment for advanced non-small cell lung cancer (NSCLC), but earlier studies have suggested that non-platinum combinations are equally effective ...

• Do Breast Cancer Patients Manage to Participate in an Outdoor, Tailored, Physical Activity Program during Adjuvant Breast Cancer Treatment, Independent of Health and Socio-Demographic Characteristics? 

  Stalsberg, Ragna; Bertheussen, Gro Falkener; Børset, Harriet; Thomsen, Simon Nørskov; Husøy, Anders; Flote, Vidar Gordon; Thune, Inger; Lundgren, Steinar (Peer reviewed; Journal article, 2022)

  Exercise could reduce the side-effects of adjuvant breast cancer treatment; however, socio-demographic, health, and intervention conditions may affect patients’ adherence to interventions. This study aimed to examine ...

• Inhomogeneous P- and S-wavefields radiated into isotropic elastic solids 

  Viggen, Erlend Magnus; Arnestad, Håvard (Chapter, 2022)

  A vibrating surface in contact with a solid material will generate P- and S-waves in the solid. When the surface vibration is spatially attenuated, we must take into account that the generated waves are always inhomogeneous. ...

• Spatial heterogeneity of nanomedicine investigated by multiscale imaging of the drug, the nanoparticle and the tumour environment 

  de Maar, Josanne Sophia; Sofias, Alexandros Marios; Porta Siegel, Tiffany; Vreeken, Rob J.; Moonen, Chrit; Bos, Clemens; Deckers, Roel (Journal article; Peer reviewed, 2020)

• Iron and sex matter in severe infections Epidemiological studies of bloodstream infections, sepsis and COVID-19 

  Mohus, Randi Marie (Doctoral theses at NTNU;2022:360, Doctoral thesis, 2022)

• Do Physical Activity and Cardiorespiratory Fitness Hold the Key to Prevent Dementia? From Society to Bench to Bedside - Targeting the Systemic Environment with Exercised Blood 

  Tari, Atefe R. (Doctoral theses at NTNU;2022:362, Doctoral thesis, 2022)

• Cytokine Patterns in Maternal Serum From First Trimester to Term and Beyond 

  Jarmund, Anders Hagen; Giskeødegård, Guro F.; Ryssdal, Mariell; Steinkjer, Bjørg; Stokkeland, Live Marie; Madssen, Torfinn Støve; Stafne, Signe Nilssen; Stridsklev, Solhild; Moholdt, Trine; Heimstad, Runa Kristine; Vanky, Eszter; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2021)

  Pregnancy implies delicate immunological balance between two individuals, with constant changes and adaptions in response to maternal capacity and fetal demands. We performed cytokine profiling of 1149 longitudinal serum ...

• Anxiety and depression symptoms, albuminuria and risk of acute myocardial infarction in the Norwegian HUNT cohort study 

  Gustad, Lise Tuset; Myklebust, Tor Åge; Bjerkeset, Ottar; Williams, Lana J; Laugsand, Lars Erik; Dalen, Håvard; Berk, Michael; Romundstad, Solfrid (Peer reviewed; Journal article, 2022)

  Background Studies suggest increased risk for an outcome in people with joint exposures that share common causal pathways. The objective of this study was to determine the risk of incident acute myocardial infarction ...

• Digital interventions to promote physical activity among inactive adults: A study protocol for a hybrid type I effectiveness-implementation randomized controlled trial 

  Zanaboni, Paolo; Manskow, Unn Sollid; Sagelv, Edvard Hamnvik; Morseth, Bente; Edvardsen, Alf Egil; Aksetøy, Inger-Lise Aamot; Nes, Bjarne; Hastings, Bryce; Gagnon, Marie-Pierre; Antypas, Konstantinos (Peer reviewed; Journal article, 2022)

  Introduction: Physical inactivity is the fourth leading risk factor for global mortality, and inactive adults have a higher risk to develop lifestyle diseases. To date, there is preliminary evidence of the efficacy of ...

• Code-Free Development and Deployment of Deep Segmentation Models for Digital Pathology 

  Pettersen, Henrik P Sahlin; Belevich, Ilya; Røyset, Elin Synnøve; Smistad, Erik; Simpson, Melanie Rae; Jokitalo, Eija; Reinertsen, Ingerid; Bakke, Ingunn; Pedersen, André (Peer reviewed; Journal article, 2022)

  Application of deep learning on histopathological whole slide images (WSIs) holds promise of improving diagnostic efficiency and reproducibility but is largely dependent on the ability to write computer code or purchase ...

• DNA methylation changes in response to neoadjuvant chemotherapy are associated with breast cancer survival 

  Pedersen, Christine Aaserød; Cao, Maria Dung; Fleischer, Thomas; Rye, Morten Beck; Knappskog, Stian; Eikesdal, Hans Petter; Lønning, Per Eystein; Tost, Jörg; Kristensen, Vessela N.; Tessem, May-Britt; Giskeødegård, Guro F.; Bathen, Tone Frost (Peer reviewed; Journal article, 2022)

  Background Locally advanced breast cancer is a heterogeneous disease with respect to response to neoadjuvant chemotherapy (NACT) and survival. It is currently not possible to accurately predict who will benefit from the ...

• A novel MRI index for paraspinal muscle fatty infiltration: reliability and relation to pain and disability in lumbar spinal stenosis: results from a multicentre study 

  BANITALEBI, HASAN; Aaen, Jørn Ståle; Storheim, Kjersti; Negård, Anne; Myklebust, Tor Åge; Grotle, Margreth; Hellum, Christian; Espeland, Ansgar; Anvar, Masoud D; Indrekvam, Kari; Weber, Clemens; Brox, Jens Ivar; Brisby, Helena; Hermansen, Erland (Peer reviewed; Journal article, 2022)

  Background Fatty infiltration of the paraspinal muscles may play a role in pain and disability in lumbar spinal stenosis. We assessed the reliability and association with clinical symptoms of a method for assessing fatty ...

• Inflammatory Markers and Radiotherapy Response in Patients With Painful Bone Metastases 

  Habberstad, Ragnhild H; Aass, Nina Kathrine; Mollnes, Tom Eirik; Damås, Jan Kristian; Brunelli, Cinzia; Rossi, Romina; Garcia-Alonso, Elena; Kaasa, Stein; Klepstad, Pål (Peer reviewed; Journal article, 2022)

  Context Inflammation is proposed to influence tumor response in radiotherapy (RT). Clinical studies to investigate the relationship between inflammatory markers and RT response is warranted to understand the variable RT ...

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