Institutt for sirkulasjon og bildediagnostikk
Recent Submissions
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Identification of novel genetic variants associated with cardiorespiratory fitness
(Peer reviewed; Journal article, 2020)Introduction Low maximal oxygen uptake (VO2max) is a strong and independent risk factor for all-cause and cardiovascular disease (CVD) mortality. For other CVD risk factors, numerous genetic association studies have been ... -
Investigation of cellular and structural basis of cardiac arrhythmias using two-photon microscopy
(Doctoral theses at NTNU;2020:165, Doctoral thesis, 2020)Cardiovascular diseases are often associated with arrhythmias, an electrical dysfunction in which the normal heart rhythm is disturbed. Arrhythmias are multifactorial phenomena, and understanding the mechanisms underlying ... -
Physical activity and cardiorespiratory fitness as determinants of atrial fibrillation incidence and prognosis. Observational findings from the HUNT study
(Doctoral theses at NTNU;2020:110, Doctoral thesis, 2020)Atrieflimmer er en hjerterytmeforstyrrelse som karakteriseres ved rask og uregelmessig elektrisk aktivitet i hjertets forkamre. Tilstanden er meget utbredt med en forekomst på 2-3% i den voksne befolkningen, og middelaldrende ... -
Pediatric Patients in a Local Nepali Emergency Department: Presenting Complaints, Triage and Post-Discharge Mortality
(Peer reviewed; Journal article, 2020)Background. In low-income countries, pediatric emergency care is largely underdeveloped although child mortality in emergency care is more than twice that of adults, and mortality after discharge is high. Aim. We aimed at ... -
Emergency health care in a Nepali hospital: patient characteristics and mortality after emergency care. Findings from a local emergency registry and implications for strengthening emergency health care system in low-resource settings
(Doctoral theses at NTNU;2020:76, Doctoral thesis, 2020) -
Rapid declines in systolic blood pressure are associated with an increase in pulse transit time
(Peer reviewed; Journal article, 2020)Background The correlation between pulse transit time and blood pressure has been proposed as a route to measure continuous non-invasive blood pressure. We investigated whether pulse transit time trends could model blood ... -
Cardiac arrest as a reportable condition: A cohort study of the first 6 years of the Norwegian out-of-hospital cardiac arrest registry
(Peer reviewed; Journal article, 2020)Objectives The Norwegian Cardiac Arrest Registry (NorCAR) was established in 2013 when cardiac arrest became a mandatory reportable condition. The aim of this cohort study is to describe how the world’s first mandatory, ... -
YKL-40 (Chitinase-3-Like Protein 1) Serum Levels in Aortic Stenosis
(Peer reviewed; Journal article, 2020)BACKGROUND: Identification of novel biomarkers could provide prognostic information and improve risk stratification in patients with aortic stenosis (AS). YKL-40 (chitinase-3-like protein 1), a protein involved in ... -
Circulating and Adipose Tissue miRNAs in Women With Polycystic Ovary Syndrome and Responses to High-Intensity Interval Training
(Peer reviewed; Journal article, 2020)MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post-transcriptionally. In women with polycystic ovary syndrome (PCOS), several miRNAs are differentially expressed compared to women without PCOS, ... -
Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection
(Peer reviewed; Journal article, 2020)Mycobacterium tuberculosis is a global health problem in part as a result of extensive cytotoxicity caused by the infection. Here, we show how M. tuberculosis causes caspase-1/NLRP3/gasdermin D-mediated pyroptosis of human ... -
The short-term impact of methylprednisolone on patient-reported sleep in patients with advanced cancer in a randomized, placebo-controlled, double-blind trial
(Peer reviewed; Journal article, 2020)Purpose: Although corticosteroids are frequently used in patients with advanced cancer, few studies have examined the impact of these drugs on patient-reported sleep. We aimed to examine the short-term impact of ... -
NMR-Based Prostate Cancer Metabolomics
(Journal article; Peer reviewed, 2018)Prostate cancer is the second most common malignancy, and the fifth leading cause of cancer-related death among men, worldwide. A major unsolved clinical challenge in prostate cancer is the ability to accurately distinguish ... -
Left ventricular longitudinal shortening: relation to stroke volume and ejection fraction in ageing, blood pressure, body size and gender in the HUNT3 study
(Peer reviewed; Journal article, 2020)Background: Aims of this cross-sectional study were to assess: the relative contribution of left ventricular (LV) systolic long-axis shortening (mean mitral annular plane systolic excursion, MAPSE) to stroke volume (SV), ... -
Radiological review of prior screening mammograms of screen-detected breast cancer
(Peer reviewed; Journal article, 2020)Objective: To perform a radiological review of mammograms from prior screening and diagnosis of screen-detected breast cancer in BreastScreen Norway, a population-based screening program. Methods: We performed a consensus-based ... -
Effects of external inspections on sepsis detection and treatment: a stepped-wedge study With cluster-level randomisation
(Peer reviewed; Journal article, 2020)Objective To evaluate the effects of external inspections on (1) hospital emergency departments’ clinical processes for detecting and treating sepsis and (2) length of hospital stay and 30-day mortality. Design Incomplete ... -
Left ventricular longitudinal shortening: relation to stroke volume and ejection fraction in ageing, blood pressure, body size and gender in the HUNT3 study
(Peer reviewed; Journal article, 2020)Background: Aims of this cross-sectional study were to assess: the relative contribution of left ventricular (LV) systolic long-axis shortening (mean mitral annular plane systolic excursion, MAPSE) to stroke volume (SV), ... -
Oscillations in biological signal
(Doctoral theses at NTNU;2020:302, Doctoral thesis, 2020)This thesis is a study of electrocardiography, blood pressure and glucose signals in the search for oscillatory physiological processes that are of importance for resilience and the development of disease. An oscillation ... -
A needs assessment of resuscitative endovascular balloon occlusion of the aorta (REBOA) in non-traumatic out-of-hospital cardiac arrest in Norway
(Peer reviewed; Journal article, 2020)Introduction: Out of hospital cardiac arrest (OHCA) carries an 86% mortality rate in Norway. Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a potential adjunct in management of non-traumatic cardiac ... -
Physicians’ Recognition and Management of Kidney Disease: A Randomized Vignette Study Evaluating the Impact of the KDIGO 2012 CKD Classification System
(Peer reviewed; Journal article, 2020)Rationale & Objective The Kidney Disease Outcome Quality Initiative (KDOQI) and Kidney Disease: Improving Global Outcomes (KDIGO) chronic kidney disease (CKD) classification systems published in 2002 and 2012, respectively, ... -
Endothelial dysfunction in small arteries and early signs of atherosclerosis in ApoE knockout rats
(Peer reviewed; Journal article, 2020)Endothelial dysfunction is recognized as a major contributor to atherosclerosis and has been suggested to be evident far before plaque formation. Endothelial dysfunction in small resistance arteries has been suggested to ...
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