• Spatial heterogeneity of nanomedicine investigated by multiscale imaging of the drug, the nanoparticle and the tumour environment 

  de Maar, Josanne Sophia; Sofias, Alexandros Marios; Porta Siegel, Tiffany; Vreeken, Rob J.; Moonen, Chrit; Bos, Clemens; Deckers, Roel (Journal article; Peer reviewed, 2020)

• Iron and sex matter in severe infections Epidemiological studies of bloodstream infections, sepsis and COVID-19 

  Mohus, Randi Marie (Doctoral theses at NTNU;2022:360, Doctoral thesis, 2022)

• Do Physical Activity and Cardiorespiratory Fitness Hold the Key to Prevent Dementia? From Society to Bench to Bedside - Targeting the Systemic Environment with Exercised Blood 

  Tari, Atefe R. (Doctoral theses at NTNU;2022:362, Doctoral thesis, 2022)

• Cytokine Patterns in Maternal Serum From First Trimester to Term and Beyond 

  Jarmund, Anders Hagen; Giskeødegård, Guro F.; Ryssdal, Mariell; Steinkjer, Bjørg; Stokkeland, Live Marie; Madssen, Torfinn Støve; Stafne, Signe Nilssen; Stridsklev, Solhild; Moholdt, Trine; Heimstad, Runa Kristine; Vanky, Eszter; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2021)

  Pregnancy implies delicate immunological balance between two individuals, with constant changes and adaptions in response to maternal capacity and fetal demands. We performed cytokine profiling of 1149 longitudinal serum ...

• Anxiety and depression symptoms, albuminuria and risk of acute myocardial infarction in the Norwegian HUNT cohort study 

  Gustad, Lise Tuset; Myklebust, Tor Åge; Bjerkeset, Ottar; Williams, Lana J; Laugsand, Lars Erik; Dalen, Håvard; Berk, Michael; Romundstad, Solfrid (Peer reviewed; Journal article, 2022)

  Background Studies suggest increased risk for an outcome in people with joint exposures that share common causal pathways. The objective of this study was to determine the risk of incident acute myocardial infarction ...

• DNA methylation changes in response to neoadjuvant chemotherapy are associated with breast cancer survival 

  Pedersen, Christine Aaserød; Cao, Maria Dung; Fleischer, Thomas; Rye, Morten Beck; Knappskog, Stian; Eikesdal, Hans Petter; Lønning, Per Eystein; Tost, Jörg; Kristensen, Vessela N.; Tessem, May-Britt; Giskeødegård, Guro F.; Bathen, Tone Frost (Peer reviewed; Journal article, 2022)

  Background Locally advanced breast cancer is a heterogeneous disease with respect to response to neoadjuvant chemotherapy (NACT) and survival. It is currently not possible to accurately predict who will benefit from the ...

• A novel MRI index for paraspinal muscle fatty infiltration: reliability and relation to pain and disability in lumbar spinal stenosis: results from a multicentre study 

  BANITALEBI, HASAN; Aaen, Jørn Ståle; Storheim, Kjersti; Negård, Anne; Myklebust, Tor Åge; Grotle, Margreth; Hellum, Christian; Espeland, Ansgar; Anvar, Masoud D; Indrekvam, Kari; Weber, Clemens; Brox, Jens Ivar; Brisby, Helena; Hermansen, Erland (Peer reviewed; Journal article, 2022)

  Background Fatty infiltration of the paraspinal muscles may play a role in pain and disability in lumbar spinal stenosis. We assessed the reliability and association with clinical symptoms of a method for assessing fatty ...

• Digital interventions to promote physical activity among inactive adults: A study protocol for a hybrid type I effectiveness-implementation randomized controlled trial 

  Zanaboni, Paolo; Manskow, Unn Sollid; Sagelv, Edvard Hamnvik; Morseth, Bente; Edvardsen, Alf Egil; Aksetøy, Inger-Lise Aamot; Nes, Bjarne; Hastings, Bryce; Gagnon, Marie-Pierre; Antypas, Konstantinos (Peer reviewed; Journal article, 2022)

  Introduction: Physical inactivity is the fourth leading risk factor for global mortality, and inactive adults have a higher risk to develop lifestyle diseases. To date, there is preliminary evidence of the efficacy of ...

• Code-Free Development and Deployment of Deep Segmentation Models for Digital Pathology 

  Pettersen, Henrik P Sahlin; Belevich, Ilya; Røyset, Elin Synnøve; Smistad, Erik; Simpson, Melanie Rae; Jokitalo, Eija; Reinertsen, Ingerid; Bakke, Ingunn; Pedersen, André (Peer reviewed; Journal article, 2022)

  Application of deep learning on histopathological whole slide images (WSIs) holds promise of improving diagnostic efficiency and reproducibility but is largely dependent on the ability to write computer code or purchase ...

• Inflammatory Markers and Radiotherapy Response in Patients With Painful Bone Metastases 

  Habberstad, Ragnhild H; Aass, Nina Kathrine; Mollnes, Tom Eirik; Damås, Jan Kristian; Brunelli, Cinzia; Rossi, Romina; Garcia-Alonso, Elena; Kaasa, Stein; Klepstad, Pål (Peer reviewed; Journal article, 2022)

  Context Inflammation is proposed to influence tumor response in radiotherapy (RT). Clinical studies to investigate the relationship between inflammatory markers and RT response is warranted to understand the variable RT ...

• Hvordan kan motivasjon bidra til endring av levevaner hos voksne for å forebygge diabetes type 2 

  Skånøy, Line Kristin (Master thesis, 2022)

  SAMMENDRAG Bakgrunn: Overvekt, fedme og diabetes type 2 er blant de største folkehelseutfordringene vi står ovenfor i dagens samfunn. Mange mennesker opplever helseplager som en konsekvens av fedmen. Det er i dag behov for ...

• Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN 

  Alves, Christiano R. R.; des Neves, Willian; de Almeida, Ney R; Eichelberger, Eric J; Jannig, Paulo R.; Voltarelli, Vanessa A; Tobias, Gabriel C; Bechara, Luiz R G; de Paula Faria, Daniele; Alves, Maria J N; Hagen, Lars; Sharma, Animesh; Slupphaug, Geir; Moreira, Jose Bianco Nascimento; Wisløff, Ulrik; Hirshman, Michael F.; Negrao, Carlos E.; de Castro Jr, Gilberto; Chammas, Roger; Swoboda, Kathryn J.; Ruas, Jorge L.; Goodyear, Laurie J.; Brum, Patricia Chakur (Peer reviewed; Journal article, 2020)

  Objective We tested the hypothesis that exercise training would attenuate metabolic impairment in a model of severe cancer cachexia. Methods We used multiple in vivo and in vitro methods to explore the mechanisms ...

• Detailed stratified GWAS analysis for severe COVID-19 in four European populations 

  Degenhardt, Frauke; Ellinghaus, David; Juzenas, Simonas; Lerga-Jaso, Jon; Wendorff, Mareike; Maya-Miles, Douglas; Uellendahl-Werth, Florian; ElAbd, Hesham; Lenning, Ole Bernt; Myhre, Ronny; Vadla, May Sissel; Holten, Aleksander Rygh; Kildal, Anders Benjamin; Lind, Andreas; Dyrhol-Riise, Anne Ma; Hoff, Dag Arne Lihaug; Müller, Fredrik; Solligård, Erik; Holter, Jan Cato; Afset, Jan Egil; Damås, Jan Kristian; Bergan, Jonas; Risnes, Kari; Muller, Karl Erik; Tonby, Kristian; Heggelund, Lars; Gustad, Lise Tuset; Grimsrud, Marit Mæhle; Dudman, Susanne Gjeruldsen; Folseraas, Trine; Skogen, Vegard; Hov, Johannes Espolin Roksund; Karlsen, Tom Hemming; Rühlemann, Malte C.; Arora, Jatin; Özer, Onur; Wacker, Eike Matthias; Wienbrandt, Lars; Ortiz, Aron Blandino; de Salazar, Adolfo; Chercoles, Adolfo Garrido; Palom, Adriana; Ruiz, Agustin; Garzia-Fernandez, Alba-Estela; Blanco-Grau, Albert; Mantovani, Alberto; Zanella, Alberto; Mayer, Alena; Bandera, Alessandra; Franke, Andre (Peer reviewed; Journal article, 2022)

  Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease ...

• Explaining sex differences in risk of bloodstream infections using mediation analysis in the population-based HUNT study in Norway 

  Mohus, Randi Marie; Gustad, Lise Tuset; Furberg, Anne-Sofie; Moen, Martine Kjølberg; Liyanarachi, Kristin Vardheim; Askim, Åsa Susanne; Åsberg, Signe Elisabeth; DeWan, Andrew T.; Rogne, Tormod; Simonsen, Gunnar Skov; Nilsen, Tom Ivar Lund; Åsvold, Bjørn Olav; Damås, Jan Kristian; Solligård, Erik (Peer reviewed; Journal article, 2022)

  Previous studies indicate sex differences in incidence and severity of bloodstream infections (BSI). We examined the effect of sex on risk of BSI, BSI mortality, and BSI caused by the most common infecting bacteria. Using ...

• Exercise and obstructive sleep apnoea: a 24-week follow-up study 

  Karlsen, Trine; Engstrøm, Morten; Steinshamn, Sigurd Loe (Peer reviewed; Journal article, 2022)

  Objective Report on long-term follow-up results in the apnoea hypopnea index (AHI) and self-reported daytime sleepiness in participants with moderate to severe obstructive sleep apnoea at 12 weeks after completion of a ...

• Quality and safety for inpatients on the ward after surgery: Development, evaluation and implementation of a new tool, the Efficacy Safety Score (ESS). 

  Skraastad, Erlend Johan (Doctoral theses at NTNU;2022:328, Doctoral thesis, 2022)

  SAMMENDRAG Adekvat smertebehandling hos opererte pasienter er viktig for en god rekonvalesens. Hovedproblemet i smertebehandling er å balansere nytte mot risiko og bivirkninger. På sengepost blir vurdering og dokumentasjon ...

• Prediction of Ventricular Arrhythmias by QRS/QTc - Ratio in Citalopram or Escitalopram Intoxication 

  Dietrichs, Erik Sveberg; Smith, Godfrey L (Peer reviewed; Journal article, 2022)

  Background: The U.S. Food and Drug Administration (FDA) has stated that citalopram and escitalopram should not be used at daily doses above 40 mg/20 mg due to risk for development of fatal ventricular arrhythmias like ...

• MRI in the Assessment of TMJ-Arthritis in Children with JIA; Repeatability of a Newly Devised Scoring System 

  Angenete, Oskar W; Augdal, Thomas Angell; Rygg, Marite; Rosendahl, Karen (Peer reviewed; Journal article, 2021)

  Rationale and Objectives: The temporomandibular joint (TMJ) is commonly involved in children with juvenile idiopathic arthritis. The diagnosis and evaluation of the disease progression is dependent on medical imaging. The ...

• Drug-Eluting versus Bare-Metal Stents in Saphenous Vein Grafts Compared to Native Coronary Vessels: The Norwegian Coronary Stent Trial Study 

  Mølstad, Per; Nordrehaug, Jan Erik; Steigen, Terje; Wilsgaard, Tom; Wiseth, Rune; Rotevatn, Svein; Mannsverk, Jan Torbjørn; Larsen, Tommy; Larsby, Kristina; Skarstad, Sigrun; Fosse, Eivind Øygard; Dahl-Eriksen, Øystein; Bønaa, Kaare Harald (Peer reviewed; Journal article, 2021)

  Background: Drug-eluting stents (DES) reduce target lesion revascularization (TLR) with no effect on mortality or myocardial infarction (MI) compared to bare-metal stents (BMS) in native vessels. Randomized stent studies ...

• Analyses of Increased Mortality in New and Known Diabetes in Patients with Coronary Disease Enrolled in the NORSTENT Randomized Study 

  Mølstad, Per; Nordrehaug, Jan Erik; Steigen, Terje; Wilsgaard, Tom; Wiseth, Rune; Bønaa, Kaare Harald (Peer reviewed; Journal article, 2021)

  Background: NORSTENT trial randomized 9,013 patients to percutaneous coronary intervention with drug-eluting stents (DES) or bare-metal stents (BMS) with a 5-year follow-up. Among the patients, 5,512 had measured either ...

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