• Frailty and survival in elderly intensive care patients in Norway 

  Andersen, Finn Husøy; Haaland, Øystein Ariansen; Klepstad, Pål; Flaatten, Hans (Journal article; Peer reviewed, 2021)

  Background Today, 10%-15% of Norwegian intensive care patients are ≥80 years. This proportion will increase significantly over the next 20 years, but it is unlikely that resources for intensive care increase correspondingly. ...

• CSF neurofilament light may predict progression from amnestic mild cognitive impairment to Alzheimer's disease dementia 

  Lim, Bryant; Grøntvedt, Gøril Rolfseng; Bathala, Pradeepthi; Kale, Shraddha S.; Campbell, Christopher T.; Stengelin, Martin; Sando, Sigrid Botne; Prassas, Ioannis; Diamandis, Eleftherios P.; Bråthen, Geir (Peer reviewed; Journal article, 2021)

  Neurofilament light (NfL) is a promising biomarker of neurodegeneration in Alzheimer's disease (AD). In this study, cerebrospinal fluid (CSF) NfL was measured in a 24-month longitudinal cohort consisting of control (n = ...

• The Impact of Vascular Risk Factors on Post-stroke Cognitive Impairment: The Nor-COAST Study 

  Aam, Stina; Gynnild, Mari Nordbø; Munthe-Kaas, Ragnhild; Saltvedt, Ingvild; Lydersen, Stian; Knapskog, Anne Brita; Ihle-Hansen, Hege; Ellekjær, Hanne; Eldholm, Rannveig Sakshaug; Fure, Brynjar (Peer reviewed; Journal article, 2021)

  Introduction: Post-stroke cognitive impairment (PSCI) is common, but evidence on the impact of vascular risk factors is lacking. We explored the association between pre-stroke vascular risk factors and PSCI and studied the ...

• Short-term outcome after open-heart surgery for severe chronic rheumatic heart disease in a low-income country, with comparison with an historical control group: An observational study 

  Hauge, Ståle Wågen; Dalen, Havard; Estensen, Mette-Elise; Persson, Robert Matongo; Abebe, Sintayehu; Mekonnen, Desalew; Nega, Berhanu; Solholm, Atle; Farstad, Marit; Bogale, Nigussie; Graven, Torbjorn; Nielssen, Niels-Erik; Brekke, Hege Kristin; Vikenes, Kjell; Haaverstad, Rune (Peer reviewed; Journal article, 2021)

  Objectives Rheumatic heart disease (RHD) is a major burden in low-income and middle-income countries (LMICs). Cardiac surgery is the only curative treatment. Little is known about patients with severe chronic RHD operated ...

• The fat mass and obesity-associated (FTO) gene allele rs9939609 and glucose tolerance, hepatic and total insulin sensitivity, in adults with obesity 

  De Soysa, Ann Kristin Hjelle; Langaas, Mette; Jakic, Anida; Shojaee-Moradie, Fariba; Umpleby, A. Margot; Grill, Valdemar Erik Robert; Mostad, Ingrid Løvold (Peer reviewed; Journal article, 2021)

  The objective of the study was to assess associations of the rs9939609 FTO allele to glucose tolerance, hepatic and total insulin sensitivity (IS) in individuals with obesity. From a low-dose hyperinsulinemic euglycemic ...

• Dyspnea, lung function and CT findings three months after hospital admission for COVID-19 

  Lerum, Tøri Vigeland; Aaløkken, Trond M; Brønstad, Eivind; Aarli, Bernt Bøgvald; Ikdahl, Eirik; Lund, Kristine Marie Aarberg; Durheim, Michael; Rivero, Jezabel Rodriguez; Meltzer, Carin; Tonby, Kristian; Stavem, Knut; Skjønsberg, Ole Henning; Ashraf, Haseem; Einvik, Gunnar (Peer reviewed; Journal article, 2020)

  The long-term pulmonary outcomes of coronavirus disease 2019 (COVID-19) are unknown. We aimed to describe self-reported dyspnoea, quality of life, pulmonary function, and chest CT findings three months following hospital ...

• Cognitive behavioural group therapy for adolescents with ADHD: a study of satisfaction and feasibility 

  Andersen, Ann Christin; Sund, Anne Mari; Thomsen, Per Hove; Lydersen, Stian; Young, Susan; Nøvik, Torunn Stene (Peer reviewed; Journal article, 2021)

  Adolescents with ADHD are at increased risk of adverse outcomes and a negative life trajectory into adulthood. Evidence regarding treatment specifically tailored for the needs of this age group are still limited. High ...

• 3D Myocardial Mechanical Wave Measurements: Toward In Vivo 3D Myocardial Elasticity Mapping 

  Salles, Sebastien; Espeland, Torvald; Rodriguez-Molares, Alfonso; Aase, Svein Arne; Hammer, Tommy; Støylen, Asbjørn; Aakhus, Svend; Løvstakken, Lasse; Torp, Hans (Peer reviewed; Journal article, 2020)

  Objectives This study aimed to investigate the potential of a novel 3-dimensional (3D) mechanical wave velocity mapping technique, based on the natural mechanical waves produced by the heart itself, to approach a noninvasive ...

• Power comparisons and clinical meaning of outcome measures in assessing treatment effect in cancer cachexia: secondary analysis from a randomised pilot multimodal intervention trial 

  Balstad, Trude Rakel; Brunelli, Cinzia; Pettersen, Caroline Hild; Schønberg, Svanhild Margrethe Arentz; Skorpen, Frank; Fallon, Marie T.; Kaasa, Stein; Bye, Asta; Laird, Barry J. A.; Stene, Guro Birgitte; Solheim, Tora Skeidsvoll (Peer reviewed; Journal article, 2020)

  Background: New clinical trials in cancer cachexia are essential and outcome measures with high responsiveness to detect meaningful changes are crucial. This secondary analysis from a multimodal intervention trial estimates ...

• Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomised clinical trial 

  Vaidya, Jayant S; Bulsara, Max; Baum, Michael; Wenz, Frederik; Massarut, Samuele; Pigorsch, Steffi; Alvarado, Michael; Douek, Michael; Saunders, Christobel; Flyger, Henrik; Eiermann, Wolfgang; Brew-Graves, Chris; Williams, Norman R; Potyka, Ingrid; Roberts, Nicholas; Bernstein, Marcelle; Brown, Douglas; Sperk, Elena; Laws, Siobhan; Sütterlin, Marc; Corica, Tammy; Lundgren, Steinar; Holmes, Dennis; Vinante, Lorenzo; Bozza, Fernando; Pazos, Montserrat; Le Blanc-Onfroy, Magali; Gruber, Günther; Polkowski, Wojciech; Dedes, Konstantin J; Niewald, Marcus; Blohmer, Jens; McCready, David; Hoefer, Richard; Kelemen, Pond; Petralia, Gloria; Falzon, Mary; Joseph, David J; Tobias, Jeffrey S (Peer reviewed; Journal article, 2020)

  Objective To determine whether risk adapted intraoperative radiotherapy, delivered as a single dose during lumpectomy, can effectively replace postoperative whole breast external beam radiotherapy for early breast ...

• Thromboembolic Events During Treatment with Cisplatin-based Chemotherapy in Metastatic Testicular Germ-cell Cancer 2000–2014: A Population-based Cohort Study 

  Haugnes, Hege S.; Negaard, Helene F.; Negaard, Helene Francisca Stigter; Jensvoll, Hilde; Wilsgaard, Tom; Tandstad, Torgrim; Solberg, Arne (Peer reviewed; Journal article, 2021)

  Background Cisplatin-based chemotherapy (CBCT) in testicular cancer (TC) is associated with elevated venous thromboembolism (VTE) risk, but trials evaluating the safety and efficacy of thromboprophylaxis are lacking. ...

• Epidurals during normal labour and birth — Midwives’ attitudes and experiences 

  Aune, Ingvild; Brøtmet, Siri; Grytskog, Katrine Heggem; Sperstad, Eldri Bakken (Peer reviewed; Journal article, 2020)

  Background Midwives have their own beliefs and values regarding pain during childbirth. Their preferences concerning labour pain management may influence women’s choices. Aim To gain a deeper understanding of midwives’ ...

• The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2 

  Skjesol, Astrid; Yurchenko, Mariya; Bösl, Korbinian; Gravastrand, Caroline S.; Nilsen, Kaja Elisabeth; Grøvdal, Lene Melsæther; Agliano, Federica; Patane, Francesco; Lentini, Germana; Kim, Hera; Teti, Giuseppe; Sharma, Aditya Kumar; Kandasamy, Richard Kumaran; Sporsheim, Bjørnar; Starheim, Kristian K.; Golenbock, Douglas T.; Stenmark, Harald; McCaffrey, Mary; Espevik, Terje; Husebye, Harald (Peer reviewed; Journal article, 2019)

  Phagocytosis is a complex process that eliminates microbes and is performed by specialised cells such as macrophages. Toll-like receptor 4 (TLR4) is expressed on the surface of macrophages and recognizes Gram-negative ...

• Aptamer-Based Proteomic Platform Identifies Novel Protein Predictors of Incident Heart Failure and Echocardiographic Traits 

  Nayor, Matthew; Short, Meghan I.; Rasheed, Humaira; Lin, Honghuang; Jonasson, Christian; Yang, Qiong; Hveem, Kristian; Felix, Janine F.; Morrison, Alanna C.; Wild, Philipp S.; Morley, Michael P.; Cappola, Thomas P.; Benson, Mark D.; Ngo, Debby; Sinha, Sumita; Keyes, Michelle J.; Shen, Dongxiao; Wang, Thomas J.; Larson, Martin G.; Brumpton, Ben Michael; Gerszten, Robert E.; Omland, Torbjørn; Vasan, Ramachandran S. (Peer reviewed; Journal article, 2020)

  Abstract Background: We used a large-scale, high-throughput DNA aptamer-based discovery proteomic platform to identify circulating biomarkers of cardiac remodeling and incident heart failure (HF) in community-dwelling ...

• Self-reported sleep quality with mandibular advancement device or continuous positive airway pressure: A randomized clinical trial on patients with mild and moderate obstructive sleep apnea 

  Berg, Lars Martin; Ankjell, Torun Karina Solheim; Trovik, Tordis A; Sjögren, Anders; Rikardsen, Oddveig G; Moen, Ketil; Sun, Yi-Qian; Bugten, Vegard (Peer reviewed; Journal article, 2020)

  Study objectives To compare self-reported sleep quality, treatment compliance and respiratory event index (REI) after 4 months of treatment with mandibular advancement device (MAD) or continuous positive airway pressure ...

• Limited effect of red blood cell transfusion on long-term mortality among anaemic cardiac surgery patients 

  Tran, Long; Greiff, Guri; Wahba, Alexander; Pleym, Hilde; Videm, Vibeke (Peer reviewed; Journal article, 2020)

  OBJECTIVES Our goal was to investigate long-term mortality associated with red blood cell (RBC) transfusion among patients with anaemia undergoing cardiac surgery when adjusting for known risk factors. METHODS Adults with ...

• Transfusion of red blood cells in coronary surgery: is there an effect on long-term mortality when adjusting for risk factors and postoperative complications? 

  Tran, Long; Greiff, Guri; Pleym, Hilde; Wahba, Alexander; Stenseth, Roar; Videm, Vibeke (Peer reviewed; Journal article, 2017)

  OBJECTIVES The aim of this study was to compare long-term mortality in patients undergoing primary isolated coronary artery bypass grafting who received ≥1 units of red blood cells (RBCs) or no RBCs. We hypothesized that ...

• Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases. 

  de Jesus, Adriana Almeida; Hou, Yangfeng; Brooks, Stephen; Malle, Louise; Biancotto, Angelique; Huang, Yan; Calvo, Katherine R.; Marrero, Bernadette; Moir, Susan; Oler, Andrew J.; Deng, Zuoming; Sanchez, Gina A. Montealegre; Ahmed, Amina; Allenspach, Eric; Srabshahi, Bita; Behrens, Edward M.; Benseler, Susanne; Berzrodnik, Liliana; Bout-Tabaku, Sharon; Brescia, AnneMarie; Brown, Diane; Burnham, Jon M.; Caldirola, Maria Soledad; Carrasco, Ruy; Chan, Alice; Cimaz, Rolando; Dancey, Paul; Dare, Jason; DeGuzman, Marietta; Dimitriades, Victoria; Ferguson, Ian; Ferguson, Polly J.; Finn, Laura; Gattorno, Marco; Grom, Alexei; Hanson, Eric P.; Hashkes, Philip; Hedrich, Christian M.; Herzog, Ronit; Horneff, Gerd; Jerath, Rita; Kessler, Elizabeth; Kim, Hanna; Kingsbury, Daniel J.; Laxer, Ronald M; Lee, Pui Y.; Lee-Kirsch, Min Ae; Lewandowski, Laura; Li, Suzanne; Lilleby, Vibke; Mammadova, Vafa; Moorthy, Lakshmi N.; Nasrullayeva, Gulnara M.; O'Neill, Kathleen; Onel, Karen; Ozen, Seza; Pan, Nancy; Pillet, Pascal; Piotto, Daniela G. P.; Punaro, Marilynn G.; Reiff, Andreas; Reinhardt, Adam L.; Rider, Lisa G.; Rivas-Chacon, Rafael; Ronis, Tova; Rosen-Wolff, Angela; Roth, Johannes; Ruth, Natasha Mckerran; Rygg, Marite; Schmeling, Heinrike; Schulert, Grant; Scott, Christiaan; Seminario, Gisella; Schulman, Andrew; Sivaraman, Vidya; Son, Mary Beth; Stepanovskiy, Yuriy; Stringer, Elizabeth; Taber, Sara; Terreri, Maria Teresa; Tifft, Cynthia J; Torgerson, Troy R.; Tosi, Laura; Royen-Kerkhof, Annet Van; Muskardin, Theresa Wampler; Canna, Scott W.; Goldbach-Mansky, Raphaela (Peer reviewed; Journal article, 2020)

  BACKGROUND. Undifferentiated systemic autoinflammatory diseases (USAIDs) present diagnostic and therapeutic challenges. Chronic interferon (IFN) signaling and cytokine dysregulation may identify diseases with available ...

• Experimental study on the effect of exhaust airflows on the surgical environment in an operating room with mixing ventilation 

  Xue, Kai; Cao, Guangyu; Liu, Meng; Zhang, Yixian; Pedersen, Christoffer; Mathisen, Hans Martin; Stenstad, Liv Inger; Skogås, Jan Gunnar (Peer reviewed; Journal article, 2020)

  Due to the requirements of indoor environment parameters, including temperature, humidity, air speed and indoor quality, the design of the surgical environment is a very complex task. However, with limited studies on the ...

• Human Metapneumovirus Induces IRF1 via TANK-Binding Kinase 1 and Type I IFN 

  Loevenich, Simon; Spahn, Alix Saskia; Rian, Kristin; Boyartchuk, Victor; Anthonsen, Marit Walbye (Peer reviewed; Journal article, 2021)

  The innate immune and host-protective responses to viruses, such as the airway pathogen human metapneumovirus (HMPV), depend on interferons (IFNs) that is induced through TANK-binding kinase 1 (TBK1) and IFN regulatory ...

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