St. Olavs hospital
Recent Submissions
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Separating the genetics of childhood and adult obesity: a validation study of genetic scores for body mass index in adolescence and adulthood in the HUNT Study
(Peer reviewed; Journal article, 2020)From a life-course perspective, genetic and environmental factors driving childhood obesity may have a lasting inf luence on health later in life. However, how obesity trajectories vary throughout the life-course remains ... -
Mild to Moderate Cognitive Impairment Does Not Affect the Ability to Self-Report Important Symptoms in Patients With Cancer: A Prospective Longitudinal Multinational Study (EPCCS)
(Peer reviewed; Journal article, 2020)Context Patients with advanced cancer commonly suffer from both distressing symptoms and cognitive impairment, but the effect of cognitive impairment on the reliability and validity of symptom self-report is unknown. ... -
Hypoxia imaging and theranostic potential of [64Cu][Cu(ATSM)] and ionic Cu(II) salts: a review of current evidence and discussion of the retention mechanisms
(Peer reviewed; Journal article, 2020)Background Tumor hypoxia (low tissue oxygenation) is an adverse condition of the solid tumor environment, associated with malignant progression, radiotherapy resistance, and poor prognosis. One method to detect tumor ... -
Prescription of analgesics to long-term survivors of cancer in early adulthood, adolescence and childhood in Norway: a national cohort study
(Peer reviewed; Journal article, 2020)Increasing numbers survive cancers in childhood and adolescence. Long-term survivors of cancers in adulthood have increased prevalence of pain and consumption of analgesics. It is not established whether long-term survivors ... -
Change in Self-Reported Cognitive Symptoms After Mild Traumatic Brain Injury Is Associated With Changes in Emotional and Somatic Symptoms and Not Changes in Cognitive Performance
(Peer reviewed; Journal article, 2020)Objective: To investigate (a) whether self-reported cognitive symptoms after mild traumatic brain injury (MTBI) are associated with cognitive test performances, and (b) whether improvement in self-reported symptoms from 2 ... -
Epidemiological differences in levels of depressive signs among nocturnal symptoms of insomnia; results from the HUNT study
(Peer reviewed; Journal article, 2020)Background Insomnia is a sleep disorder characterized by multiple nocturnal symptoms (sleep onset, maintenance and terminal insomnia). However, these symptoms are assumed to have the same weight in the diagnosis and ... -
The co-occurrence between symptoms of internet gaming disorder and psychiatric disorders in childhood and adolescence: prospective relations or common causes?
(Peer reviewed; Journal article, 2020)Internet gaming disorder (IGD) is highlighted as a condition for further study in the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM‐5). Some studies indicate that IGD appears comorbid with other ... -
Physical rehabilitation in patients with head and neck cancer: Impact on health-related quality of life and suitability of a post-treatment program
(Peer reviewed; Journal article, 2020)Objective: Physical rehabilitation programs hold the potential to mitigate deterioration in health-related quality of life (HRQoL) in patients with head and neck cancer. The objective was to assess development in relevant ... -
Healthy Healthcare: Empirical Occupational Health Research and Evidence-Based Practice
(Peer reviewed; Journal article, 2020) -
Real-Time Automatic Ejection Fraction and Foreshortening Detection Using Deep Learning
(Peer reviewed; Journal article, 2020)Volume and ejection fraction (EF) measurements of the left ventricle (LV) in 2-D echocardiography are associated with a high uncertainty not only due to interobserver variability of the manual measurement, but also due to ... -
The EACVI survey on cardiac imaging in cardio-oncology
(Journal article, 2020)Early and late cardiovascular (CV) toxicities related to many cancer treatments may complicate the clinical course of patients, offsetting therapeutic benefits, and altering prognosis. The early detection, monitoring, and ... -
Employment status three years after percutaneous coronary intervention and predictors for being employed: A nationwide prospective cohort study
(Journal article; Peer reviewed, 2020)Background - Vocational support is recommended for patients in cardiac rehabilitation (CR), as returning to work is important in patients social readjusting after an acute coronary event. Information is lacking on whether ... -
Translating big data to better treatment in bipolar disorder - a manifesto for coordinated action
(Peer reviewed; Journal article, 2020)Bipolar disorder (BD) is a major healthcare and socio-economic challenge. Despite its substantial burden on society, the research activity in BD is much smaller than its economic impact appears to demand. There is a consensus ... -
Influence of patient-specific rehearsal on operative metrics and technical success for endovascular aneurysm repair
(Peer reviewed; Journal article, 2020)Introduction: Patient-specific rehearsal (PsR) is a recent technology within virtual reality (VR) simulation that lets the operators train on patient-specific data in a simulated environment prior to the procedure. ... -
Validation and development of models using clinical, biochemical and ultrasound markers for predicting pre-eclampsia: an individual participant data meta-analysis
(Peer reviewed; Journal article, 2020)Background: Pre-eclampsia is a leading cause of maternal and perinatal mortality and morbidity. Early identification of women at risk is needed to plan management. Objectives: To assess the performance of existing pre-eclampsia ... -
End-of-life practices in traumatic brain injury patients: Report of a questionnaire from the CENTER-TBI study
(Peer reviewed; Journal article, 2020)Purpose We aimed to study variation regarding specific end-of-life (EoL) practices in the intensive care unit (ICU) in traumatic brain injury (TBI) patients. Materials and methods Respondents from 67 hospitals ... -
Test Accuracy of the Montreal Cognitive Assessment in Screening for Early Poststroke Neurocognitive Disorder
(Peer reviewed; Journal article, 2020)Background. Human immunodeficiency virus (HIV)–infected immunological nonresponders (INRs) fail to reconstitute their CD4+ T-cell pool after initiation of antiretroviral therapy, and their prognosis is inferior to that of ... -
Impact of genotype-predicted CYP2D6 metabolism on clinical effects and tolerability of metoprolol in patients after myocardial infarction – a prospective observational study
(Peer reviewed; Journal article, 2020)Purpose The β-1 adrenergic receptor blocker metoprolol is primarily metabolized by the polymorphic enzyme cytochrome P 450 2D6 (CYP2D6), an enzyme with substantial genetic heterogeneity. Our purpose was to investigate the ... -
Osimertinib in T790M-positive and -negative patients with EGFR-mutated advanced non-small cell lung cancer (the TREM-study)
(Peer reviewed; Journal article, 2020)Objectives In non-small cell lung cancer patients with acquired resistance to first- or second-generation EGFR-TKIs, osimertinib is approved in the presence of the T790 M resistance mutation. We assessed the efficacy of ... -
Effect of exercise training for five years on all cause mortality in older adults-The Generation 100 study: Randomised controlled trial
(Peer reviewed; Journal article, 2020)Objective To evaluate the effect of five years of supervised exercise training compared with recommendations for physical activity on mortality in older adults (70-77 years). Design Randomised controlled trial. Setting ...
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