• Gir ACE-hemmere og angiotensinreseptorantagonister økt risiko for alvorlig covid-19? 

  Aamodt, Anne Hege; Bjørk, Marte-Helene; Tronvik, Erling Andreas; Buanes, Eirik Alnes; Stovner, Lars Jacob; Atar, Dan (Peer reviewed; Journal article, 2020)

  Hypertensjon og diabetes mellitus er risikofaktorer for alvorlig covid-19. Det er blitt reist spørsmål om hvorvidt denne assosiasjonen er relatert til bruk av ACE-hemmere og angiotensin II-reseptorblokkere.

• Relative difference in muscle strength between patients with knee osteoarthritis and healthy controls when tested bilaterally and joint-inclusive: an exploratory cross-sectional study. 

  Vårbakken, Kjartan; Lorås, Håvard; Nilsson, Kjell Gunnar; Engdal, Monika; Stensdotter, Ann-Katrin (Peer reviewed; Journal article, 2019)

  Background: To improve the goal-directedness of strength exercises for patients with knee osteoarthritis (KOA), physical rehabilitation specialists need to know which muscle-groups are most substantially weakened across ...

• MGMT Promoter Methylation Status Is Not Related to Histological or Radiological Features in IDH Wild-type Glioblastomas 

  Mikkelsen, Vilde Elisabeth; Hong, Yan Dai; Stensjøen, Anne Line; Berntsen, Erik Magnus; Salvesen, Øyvind; Solheim, Ole; Torp, Sverre Helge (Peer reviewed; Journal article, 2020)

  O6-methylguanine DNA methyltransferase (MGMT) promoter methylation is an important favorable predictive marker in patients with glioblastoma (GBM). We hypothesized that MGMT status could be a surrogate marker of pretreatment ...

• Vitamin K2 modulates vitamin D induced mechanical properties of human 3D bone spheroids in vitro 

  Schröder, Maria; Riksen, Elisabeth Aurstad; He, Jianying; Skallerud, Bjørn Helge; Møller, Mona Elisabeth; Lian, Aina-Mari; Syversen, Unni; Reseland, Janne Elin (Peer reviewed; Journal article, 2020)

  Rotational culture promotes primary human osteoblasts (hOBs) to form three-dimensional (3D) multicellular spheroids with bone tissue-like structure without any scaffolding material. Cell-based bone models enable us to ...

• Factors affecting quality of end-of-life hospital care - a qualitative analysis of free text comments from the i-CODE survey in Norway 

  Hansen, Marit Irene Tuen; Haugen, Dagny Faksvåg; Sigurdardottir, Katrin Rut; Kvikstad, Anne; Mayland, Catriona Rachel; Schaufel, Margrethe Aase (Peer reviewed; Journal article, 2020)

  Background The ERANet-LAC CODE (Care Of the Dying Evaluation) international survey assessed quality of care for dying cancer patients in seven countries, by use of the i-CODE questionnaire completed by bereaved relatives. ...

• Clinical effect modifiers of antibiotic treatment in patients with chronic low back pain and Modic changes - Secondary analyses of a randomised, placebo-controlled trial (the AIM study) 

  Bråten, Lars Christian Haugli; Grøvle, Lars; Espeland, Ansgar; Pripp, Are Hugo; Grotle, Margreth; Hellum, Christian; Haugen, Anne Julsrud; Froholdt, Anne; Rolfsen, Mads Peder; Nygaard, Øystein Petter; Lutro, Olav; Kristoffersen, Per M; Anke, Audny; Schistad, Ellina Iordanova; Skouen, Jan Sture; Brox, Jens Ivar; Zwart, John-Anker; Storheim, Kjersti (Peer reviewed; Journal article, 2020)

  Background Randomised trials on antibiotic treatment for patients with chronic low back pain and vertebral endplate changes visible on MRI (Modic changes) have shown mixed results. A possible explanation might be a real ...

• Vascular risk factor control and adherence to secondary preventive medication after ischemic stroke 

  Gynnild, Mari Nordbø; Aakerøy, Rachel; Spigset, Olav; Askim, Torunn; Beyer, Mona Kristiansen; Ihle-Hansen, Hege; Munthe-Kaas, Ragnhild; Knapskog, Anne Brita; Lydersen, Stian; Næss, Halvor; Røsstad, Tove Garåsen; Seljeseth, Yngve Müller; Thingstad, Pernille; Saltvedt, Ingvild; Ellekjær, Hanne (Peer reviewed; Journal article, 2020)

  Background Studies regarding adequacy of secondary stroke prevention are limited. We report medication adherence, risk factor control and factors influencing vascular risk profile following ischaemic stroke. Methods A ...

• Gender, class, employment status and social mobility following spinal cord injury in Denmark, the Netherlands, Norway and Switzerland 

  Leiulfsrud, Annelie; Solheim, Erling; Reinhardt, Jan D; Post, Marcel W. M.; Horsewell, Jane; Biering-Sørensen, Fin; Leiulfsrud, Håkon (Peer reviewed; Journal article, 2019)

  Study design: Cross sectional survey of 1055 persons with spinal cord injury (SCI) in Denmark, the Netherlands, Norway and Switzerland. Objectives: (1) To analyse the employment levels of people of working age with SCI, ...

• ‘Violence exists to show manhood’: Nepali men’s views on domestic violence – a qualitative study 

  Pun, Kunta Devi; Tjomsland R, Tine; Infanti, Jennifer; Darj, Elisabeth (Peer reviewed; Journal article, 2020)

  Background: There is significant evidence of the prevalence and factors associated with domestic violence in high and low-income country settings. However, men’s views on domestic violence are still understudied and have ...

• Intraoperative 3D ultrasound-guided resection of diffuse low-grade gliomas: radiological and clinical results. 

  Bø, Hans Kristian; Solheim, Ole; Kvistad, Kjell Arne; Berntsen, Erik Magnus; Torp, Sverre Helge; Skjulsvik, Anne Jarstein; Reinertsen, Ingerid; Iversen, Daniel Høyer; Unsgård, Geirmund; Jakola, Asgeir S (Peer reviewed; Journal article, 2019)

  OBJECTIVE Extent of resection (EOR) and residual tumor volume are linked to prognosis in low-grade glioma (LGG) and there are various methods for facilitating safe maximal resection in such patients. In this prospective ...

• Effects of different increments in workload and duration on peak physiological responses during seated upper-body poling 

  Brurok, Berit; Mellema, Mirjam; Sandbakk, Øyvind; Baumgart, Julia Kathrin (Peer reviewed; Journal article, 2019)

  Purpose To compare the effects of test protocols with different increments in workload and duration on peak oxygen uptake (V˙O2peak), and related physiological parameters during seated upper-body poling (UBP). Methods Thirteen ...

• OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation 

  Yang, Mingyi; Lin, Xiaolin; Segers, Filip; Suganthan, Rajikala; Hildrestrand, Gunn Annette; Rinholm, Johanne Egge; Aas, Per Arne; Sousa, Mirta; Holm, Sverre; Bolstad, Nils; Warren, David; Berge, Rolf Kristian; Johansen, Rune Forstrøm; Yndestad, Arne; Kristiansen, Elise; Klungland, Arne; Gomez, Luisa Fernanda Luna; Eide, Lars; Halvorsen, Bente; Aukrust, Pål; Bjørås, Magnar (Peer reviewed; Journal article, 2020)

  Oxidation resistance gene 1 (OXR1) protects cells against oxidative stress. We find that male mice with brain-specific isoform A knockout (Oxr1A−/−) develop fatty liver. RNA sequencing of male Oxr1A−/− liver indicates ...

• Why do myeloma patients have bone disease? A historical perspective. 

  Børset, Magne; Sundan, Anders; Waage, Anders; Standal, Therese (Peer reviewed; Journal article, 2019)

  The question of how myeloma cells cause destruction of skeletal tissue has interested scientists for many years, and knowledge in this field has developed in parallel with the understanding of physiological bone remodeling. ...

• Undertriage in Trauma: An Ignored Quality Indicator? 

  Jeppesen, Elisabeth; Cuevas-Østrem, Mathias; Gram-Knutsen, Cathrine; Uleberg, Oddvar (Peer reviewed; Journal article, 2020)

  Background Early identification of life-threatening injuries is essential to reduce morbidity and mortality in trauma patients. Failure to detect severe injury may cause delayed diagnosis and therapeutic interventions ...

• Ultrasound-mediated delivery enhances therapeutic efficacy of MMP sensitive liposomes 

  Olsman, Marieke; Sereti, Viktoria; Andreassen, Kristine; Snipstad, Linn Sofie; van Wamel, Johanna Elisabeth Theodora; Eliasen, Rasmus; Berg, Sigrid; Urquhart, Andrew J.; Andresen, Thomas L.; Davies, Ruth Catharina de Lange (Peer reviewed; Journal article, 2020)

  To improve therapeutic efficacy of nanocarrier drug delivery systems, it is essential to improve their uptake and penetration in tumour tissue, enhance cellular uptake and ensure efficient drug release at the tumour site. ...

• Low thyroid function is not associated with an accelerated deterioration in renal function 

  Meuwese, Christiaan L.; van Diepen, Merel; Cappola, Anne R.; Sarnak, Mark J.; Shlipak, Michael G.; Bauer, Douglas C.; Fried, Linda P.; Iacoviello, Massimo; Vaes, Bert; Degryse, Jean; Khaw, Kay-Tee; Luben, Robert N.; Åsvold, Bjørn Olav; Bjøro, Trine; Vatten, Lars Johan; de Craen, Anton J.M.; Trompet, Stella; Iervasi, Giorgio; Molinaro, Sabrina; Ceresini, Graziano; Ferrucci, Luigi; Dullaart, Robin P.F.; Bakker, Stephan J.L.; Jukema, J. Wouter; Kearney, Patricia M.; Stott, David J.; Peeters, Robin P.; Franco, Oscar H.; Völzke, Henry; Walsh, John P.; Bremner, Alexandra; Sgarbi, José A.; Maciel, Rui M.B.; Imaizumi, Misa; Ohishi, Waka; Dekker, Friedo W.; Rodondi, Nicolas; Gussekloo, Jacobijn; den Elzen, Wendy P.J. (Peer reviewed; Journal article, 2019)

  Background Chronic kidney disease (CKD) is frequently accompanied by thyroid hormone dysfunction. It is currently unclear whether these alterations are the cause or consequence of CKD. This study aimed at studying the ...

• Post-stroke Cognitive Impairment—Impact of Follow-Up Time and Stroke Subtype on Severity and Cognitive Profile: The Nor-COAST Study 

  Aam, Stina; Einstad, Marte Stine; Munthe-Kaas, Ragnhild; Lydersen, Stian; Ihle-Hansen, Hege; Knapskog, Anne Brita; Ellekjær, Hanne; Seljeseth, Yngve Müller; Saltvedt, Ingvild (Peer reviewed; Journal article, 2020)

  Background: Post-stroke cognitive impairment (PSCI) is common, but evidence of cognitive symptom profiles, course over time, and pathogenesis is scarce. We investigated the significance of time and etiologic stroke subtype ...

• Targeted sequencing of genes associated with the mismatch repair pathway in patients with endometrial cancer 

  Singh, Ashish Kumar; McPhillips, Mary; Talseth-Palmer, Bente; Lavik, Liss Ane; Xavier, Alexandre; Drabløs, Finn; Sjursen, Wenche (Peer reviewed; Journal article, 2020)

  Germline variants inactivating the mismatch repair (MMR) genes MLH1, MSH2, MSH6 and PMS2 cause Lynch syndrome that implies an increased cancer risk, where colon and endometrial cancer are the most frequent. Identification ...

• An Open Time Perspective and Social Support to Sustain in Healthcare Work: Results of a Two-Wave Complete Panel Study 

  de Lange, Annet H.; Pak, Karen; Osagie, Eghe; van Dam, Karen; Christensen, Marit; Furunes, Trude; Løvseth, Lise T; Detaille, Sarah (Peer reviewed; Journal article, 2020)

  Based on lifespan developmental psychology and psychosocial work characteristics theory, we examined longitudinal relations between calendar age, occupational time perspective, different types of job demands and job resources ...

• Variation in the practice of tracheal intubation in Europe after traumatic brain injury: a prospective cohort study 

  Gravesteijn, BY; Sewalt, C.; Ercole, Ari; Lecky, Fiona; Menon, David; Steyerberg, Ewout W; Maas, AIR; Lingsma, Hester F; Klimek, Magdalena; Vik, Anne; Andelic, Nada; Andreassen, Lasse; Anke, Audny; Frisvold, Shirin; Helseth, Eirik; Røise, Olav; Røe, Cecilie; Schirmer-Mikalsen, Kari; Sandrød, Oddrun; Borgen Lund, Stine (Peer reviewed; Journal article, 2020)

  Traumatic brain injury patients frequently undergo tracheal intubation. We aimed to assess current intubation practice in Europe and identify variation in practice. We analysed data from patients with traumatic brain injury ...

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