St. Olavs hospital
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An alternative approach to establishing unbiased colorectal cancer risk estimation in Lynch syndrome
(Peer reviewed; Journal article, 2019)Purpose Biallelic pathogenic variants in the mismatch repair (MMR) genes cause a recessive childhood cancer predisposition syndrome known as constitutional mismatch repair deficiency (CMMRD). Family members with a ... -
Hospitals' Discharge Tendency and Risk of Death - An Analysis of 60,000 Norwegian Hip Fracture Patients
(Peer reviewed; Journal article, 2020)Purpose: A reduction in the length of hospital stay may threaten patient safety. This study aimed to estimate the effect of organizational pressure to discharge on 60-day mortality among hip fracture patients. Patients ... -
Protect us from ourselves: Balancing the parental instinct of saving
(Peer reviewed; Journal article, 2019)Background: Neonatologists, legal experts and ethicists extensively discuss the ethical challenges of decision-making when a child is born at the limit of viability. The voices of parents are less heard in this discussion. ... -
Second Cancers in Patients With Locally Advanced Prostate Cancer Randomized to Lifelong Endocrine Treatment With or Without Radical Radiation Therapy: Long-Term Follow-up of the Scandinavian Prostate Cancer Group-7 Trial
(Peer reviewed; Journal article, 2019)Background Curative radiation therapy (RT) constitutes a cornerstone in prostate cancer (PC) treatment. We present long-term follow-up estimates for second cancer (SC) risk and overall survival (OS) in patients randomized ... -
Autologous BPTB ACL Reconstruction Results in Lower Failure Rates Than ACL Repair with and without Synthetic Augmentation at 30 Years of Follow-up
(Peer reviewed; Journal article, 2019)Background: The aim of this study was to compare the 30-year follow-up results after treatment of anterior cruciate ligament (ACL) ruptures with 3 different surgical procedures. Methods: A total of 150 patients with ... -
Creating and Validating a Shortened Version of the Community Balance and Mobility Scale for Application in People Who Are 61 to 70 Years of Age
(Peer reviewed; Journal article, 2020)Background The Community Balance and Mobility Scale (CBM) has been shown to be reliable and valid for detecting subtle balance and mobility deficits in people who are 61 to 70 years of age. However, item redundancy and ... -
Cognitive-behavioural group therapy for adolescents with ADHD: study protocol for a randomised controlled trial
(Peer reviewed; Journal article, 2020)Introduction Persistence of attention deficit hyperactivity disorder (ADHD) into adolescence is a significant burden to patients. Clinical guidelines recommend non-pharmacological therapies, but the evidence to support ... -
A systematic review examining nutrition support interventions in patients with incurable cancer
(Peer reviewed; Journal article, 2019)Purpose Recent guidelines by the European Society for Clinical Nutrition and Metabolism (ESPEN) have advocated increased attention to nutritional support in all patients with cancer; however, little is known about the ... -
Long term effectiveness of dialectical behavior therapy versus enhanced usual care for adolescents with self-harming and suicidal behavior
(Peer reviewed; Journal article, 2019)Background Knowledge is lacking on the long‐term outcomes of treatment for adolescents with repetitive suicidal and self‐harming behavior. Furthermore, the pathways through which treatment effects may operate are poorly ... -
Metacognitions are associated with subjective memory problems in individuals on sick leave due to chronic fatigue
(Peer reviewed; Journal article, 2016)Background: Subjective cognitive impairments are frequent, but poorly understood in patients with chronic fatigue. We hypothesized that maladaptive metacognitive beliefs at baseline were associated with baseline subjective ... -
Trajectories of Pain in Patients Undergoing Lung Cancer Surgery: A Longitudinal Prospective Study.
(Peer reviewed; Journal article, 2019)Context Lung cancer surgery is among the surgical procedures associated with the highest prevalence of pain, but prospective longitudinal studies after the pain trajectory are scarce. Objectives We aimed to describe the ... -
Radiological assessment of chest compression point and achievable compression depth in cardiac patients
(Peer reviewed; Journal article, 2016)Background Using magnetic resonance imaging (MRI) to relate cardiovascular structures to surface anatomy in a population relevant to cardiac arrest victims, relate the external thoracic anterior-posterior (AP) diameter ... -
Anxiety and depression in Nepal: Prevalence, comorbidity and associations
(Peer reviewed; Journal article, 2016)Background Anxiety and depression are two important contributors to the global burden of disease. In many developing countries, including Nepal, their prevalences are yet to be assessed. Methods A nationwide ... -
Health-related quality of life in older depressed psychogeriatric patients: one year follow-up
(Peer reviewed; Journal article, 2016)Background Knowledge about long-term change in health related quality of life (HQoL) among older adults after hospitalization for treatment of depression has clinical relevance. The aim was firstly to describe the change ... -
Variation in serum PCSK9 (proprotein convertase subtilisin/kexin type 9), cardiovascular disease risk, and an investigation of potential unanticipated effects of PCSK9 inhibition
(Peer reviewed; Journal article, 2019)PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors reduce serum LDL (low-density lipoprotein) cholesterol (LDL-C) by increasing uptake in the liver. Although some long-term trials have evaluated their safety, ... -
Interpersonal problems as a predictor of pain catastrophizing in patients with chronic pain
(Peer reviewed; Journal article, 2019)Background and aims Pain catastrophizing has consistently been related to a variety of negative outcomes within chronic pain conditions, but competing models exist explaining the role of catastrophizing. According to the ... -
Early reduced myocardial diastolic function in children and adolescents with type 1 diabetes mellitus a population-based study
(Peer reviewed; Journal article, 2016)Background Reduced diastolic myocardial function is an early sign of diabetic cardiomyopathy. The aim of this study was to test the hypothesis that children and adolescents with type 1 diabetes mellitus (T1D), but without ... -
Does preoperative health-related quality of life predict survival in high-grade glioma patients? – a prospective study
(Peer reviewed; Journal article, 2019)Purpose: To explore if preoperative patient-reported health-related quality of life (HRQoL) provides additional prognostic value as a supplement to other preoperatively known clinical factors in patients with high-grade ... -
Metabolite profiling of ortho-, meta- and para-fluorofentanyl by hepatocytes and high-resolution mass spectrometry
(Peer reviewed; Journal article, 2019)New psychoactive substances are emerging on the illegal drug market. Synthetic opioids including fentanyl analogues are of special concern due to their high potency. This indicates the possibility of low drug concentrations ... -
Cerebral cortical dimensions in headache sufferers aged 50-66 years: a population-based imaging study in the Nord-Trondelag Health Study (HUNT-MRI)
(Journal article; Peer reviewed, 2019)Based on previous clinic-based magnetic resonance imaging studies showing regional differences in the cerebral cortex between those with and without headache, we hypothesized that headache sufferers have a decrease in ...
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