Browsing St. Olavs hospital by Title
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Sonopermeation Enhances Uptake and Therapeutic Effect of Free and Encapsulated Cabazitaxel
(Peer reviewed; Journal article, 2021)Delivery of drugs and nanomedicines to tumors is often heterogeneous and insufficient and, thus, of limited efficacy. Microbubbles in combination with ultrasound have been found to improve delivery to tumors, enhancing ... -
Sonopermeation with nanoparticle-stabilized microbubbles reduces solid stress and improves nanomedicine delivery to tumors
(Peer reviewed; Journal article, 2021)Drug delivery to tumors is challenging due to biological barriers obstructing effective delivery. Sonopermeation with ultrasound and microbubbles has been shown to improve therapeutic effect of many classes of drugs, but ... -
Spatial distribution of malignant transformation in patients with low-grade glioma
(Journal article; Peer reviewed, 2020)Background Malignant transformation represents the natural evolution of diffuse low-grade gliomas (LGG). This is a catastrophic event, causing neurocognitive symptoms, intensified treatment and premature death. However, ... -
The spectrum of pyridoxine dependent epilepsy across the age span: A nationwide retrospective observational study
(Peer reviewed; Journal article, 2023)Background Pyridoxine-dependent epilepsy (PDE) is a rare seizure disorder usually presenting with neonatal seizures. Most cases are caused by biallelic pathogenic ALDH7A1variants. While anti-seizure medications are ... -
Sperm counts and endocrinological markers of spermatogenesis in long-term survivors of testicular cancer
(Peer reviewed; Journal article, 2012)Background: The objective of this study was to assess markers of spermatogenesis in long-term survivors of testicular cancer (TC) according to treatment, and to explore correlations between the markers and associations ... -
Spinal cord compression in relation to clinical symptoms in patients with spinal meningiomas
(Peer reviewed; Journal article, 2021)Objective: Spinal meningiomas are common primary tumors of the spinal canal and the resulting spinal cord compression (SCC) is intrinsically related to symptoms and outcome, but literature concerning this association is ... -
SPIOMET4HEALTH—efficacy, tolerability and safety of lifestyle intervention plus a fixed dose combination of spironolactone, pioglitazone and metformin (SPIOMET) for adolescent girls and young women with polycystic ovary syndrome: study protocol for a multicentre, randomised, double-blind, placebo-controlled, four-arm, parallel-group, phase II clinical trial
(Peer reviewed; Journal article, 2023)Background: Polycystic ovary syndrome (PCOS) is the most prevalent, chronic endocrine‑metabolic disorder of adolescents and young women (AYAs), affecting 5–10% of AYAs worldwide. There is no approved pharmacological therapy ... -
Spiritual quality of life in family carers of patients with advanced cancer—a cross-sectional study
(Peer reviewed; Journal article, 2021)Purpose Caring affects carers’ psychological and physical health, mortality, and quality of life (QoL) negatively. Lower spiritual QoL is associated with anxiety and depression, but the spiritual dimension is rarely ... -
Stability and Change of the Personality Traits Languidity and Flexibility in a Sample of Nurses: A 7–8 Years Follow-Up Study
(Peer reviewed; Journal article, 2021)The traits languidity (tendency to become tired/sleepy upon losing sleep) and flexibility (ability to sleep and work at odd times) have been implicated in shift work tolerance. However, there is a dearth of knowledge about ... -
Stability of Phosphatidylethanol 16:0/18:1 in Freshly Drawn, Authentic Samples from Healthy Volunteers
(Peer reviewed; Journal article, 2020)Due to its specificity, phosphatidylethanol (PEth) 16:0/18:1 has gained increased popularity as a marker for high alcohol consumption in recent years. As conflicting results regarding the stability of PEth 16:0/18:1 in ... -
Stable cerebrospinal fluid neurogranin and β-site amyloid precursor protein cleaving enzyme 1 levels differentiate predementia Alzheimer's disease patients
(Peer reviewed; Journal article, 2022)Cerebrospinal fluid (CSF) β-site amyloid precursor protein cleaving enzyme 1 (BACE1), neurogranin and the neurogranin/BACE1 ratio are proposed markers for Alzheimer’s disease. BACE1 is also a drug target. However, CSF ... -
Stable incidence but regional differences in retinopathy of prematurity in Norway from 2009 to 2017
(Peer reviewed; Journal article, 2020)Purpose To explore the changes over time and regional differences in the incidence of retinopathy of prematurity (ROP) in a national cohort of infants born <28 weeks' gestational age (GA). Methods A population‐based ... -
Standardised Competency-Based Training of Medical Doctors and Associate Clinicians in Inguinal Repair with Mesh in Sierra Leone
(Peer reviewed; Journal article, 2023)Introduction In low-income settings, there is a high unmet need for hernia surgery, and most procedures are performed with tissue repair techniques. In preparation for a randomized clinical trial, medical doctors and ... -
Statistical analysis plan for the randomized controlled trial Tenecteplase in Wake-up Ischaemic Stroke Trial (TWIST)
(Peer reviewed; Journal article, 2022)Background Patients with wake-up ischemic stroke are frequently excluded from thrombolytic treatment due to unknown symptom onset time and limited availability of advanced imaging modalities. The Tenecteplase in Wake-up ... -
A Steerable and Electromagnetically Tracked Catheter: Navigation Performance Compared With Image Fusion in a Swine Model
(Peer reviewed; Journal article, 2022)Purpose: Cannulation of visceral vessels is necessary during fenestrated and branched endovascular aortic repair. In an attempt to reduce the associated radiation and contrast dose, an electromagnetically (EM) trackable ... -
Stent edge vascular response and in-stent geometry after aerobic exercise
(Journal article; Peer reviewed, 2020) -
Strålebehandling med Volumetric Modulated Arc Therapy (VMAT) mot venstresidig brystkreft med spredning til regionale lymfeknuter
(Journal article, 2020)Bakgrunn: Studier har vist høyere dødelighet av hjertesykdom blant pasienter som fikk strålebehandling mot venstre bryst sammenlignet med de som fikk behandling mot høyre bryst. Pustestyrt behandlingsteknikk reduserer ... -
The Streptococcus agalactiae R3 surface protein is encoded by sar5
(Peer reviewed; Journal article, 2022)Streptococcus agalactiae (group B streptococcus; GBS) is an important human pathogen causing pneumonia, sepsis and meningitis in neonates, as well as infections in pregnant women, immunocompromised individuals, and the ... -
Stroke and bleeding risk in atrial fibrillation with CHA2DS2-VASC risk score of one: the Norwegian AFNOR study
(Peer reviewed; Journal article, 2023)Background and Aims The benefit of oral anticoagulant (OAC) therapy in atrial fibrillation (AF) and intermediate stroke risk is debated. In a nationwide Norwegian cohort with a non-sex CHA2DS2-VASc risk score of one, ... -
Stroke follow-up in primary care: a prospective cohort study on guideline adherence
(Journal article; Peer reviewed, 2018)Background After a stroke, a person has an increased risk of recurrent strokes. Effective secondary prevention can provide significant gains in the form of reduced disability and mortality. While considerable efforts ...