Now showing items 2260-2279 of 2387

    • Ubiquitin-proteasome-system and enzymes of energy metabolism in skeletal muscle of patients with HFpEF and HFrEF 

      Adams, Volker; Wunderlich, Sebastian; Mangner, Norman; Hommel, Jennifer; Esefeld, Katrin; Gielen, Stephan; Halle, Martin; Ellingsen, Øyvind; Van Craenenbroeck, Emeline M.; Wisløff, Ulrik; Pieske, Burkert; Linke, Axel; Winzer, Ephraim (Peer reviewed; Journal article, 2021)
      Background Skeletal muscle (SM) alterations contribute to exercise intolerance in heart failure patients with preserved (HFpEF) or reduced (HFrEF) left ventricular ejection fraction (LVEF). Protein degradation via the ...
    • Ulcer-associated cell lineage expresses genes involved in regeneration and is hallmarked by high neutrophil gelatinase-associated lipocalin (NGAL) levels 

      Thorsvik, Silje; Granlund, Atle van Beelen; Svendsen, Tarjei Dahl; Bakke, Ingunn; Røyset, Elin Synnøve; Flo, Trude Helen; Damås, Jan Kristian; Østvik, Ann Elisabet; Bruland, Torunn; Sandvik, Arne Kristian (Peer reviewed; Journal article, 2019)
      Neutrophil gelatinase‐associated lipocalin (NGAL), also known as Lipocalin 2, is an antimicrobial protein, encoded by the gene LCN2, strongly upregulated in inflammatory bowel disease (IBD) and a promising biomarker for ...
    • Ultrapure Wood Nanocellulose - Assessments of Coagulation and Initial Inflammation Potential 

      Nordli, Henriette R.; Pukstad, Brita; Chinga-Carrasco, Gary; Rokstad, Anne Mari (Journal article; Peer reviewed, 2019)
      Using a lepirudin-based human whole blood model, we evaluated the initial inflammatory and coagulation responses of dense and porous ultrapure (<50 endotoxin units/grams) cellulose nanofibrils (CNF), of carboxylated grade. ...
    • Ultrasound and Microbubbles Increase the Uptake of Platinum in Murine Orthotopic Pancreatic Tumors 

      Haram, Karin Margrete; Snipstad, Sofie; Berg, Sigrid; Mjønes, Patricia; Rønne, Elin; Lage Fernandez, Jessica; Mühlenpfordt, Melina; Davies, Catharina de Lange (Peer reviewed; Journal article, 2023)
      Objective Currently available cytotoxic treatments have limited effect on pancreatic ductal adenocarcinoma (PDAC) because desmoplastic stroma limits drug delivery. Efforts have been made to overcome these barriers by drug ...
    • Ultrasound and microbubbles to beat barriers in tumors: Improving delivery of nanomedicine 

      Snipstad, Sofie; Vikedal, Krister; Maardalen, Matilde; Kurbatskaya, Anna; Sulheim, Einar; Davies, Catharina de Lange (Peer reviewed; Journal article, 2021)
      Successful delivery of drugs and nanomedicine to tumors requires a functional vascular network, extravasation across the capillary wall, penetration through the extracellular matrix, and cellular uptake. Nanomedicine has ...
    • Ultrasound and microbubbles to beat barriers in tumors: Improving delivery of nanomedicine 

      Snipstad, Sofie; Vikedal, Krister; Maardalen, Matilde; Kurbatskaya, Anna; Sulheim, Einar; Davies, Catharina de Lange (Peer reviewed; Journal article, 2021)
      Successful delivery of drugs and nanomedicine to tumors requires a functional vascular network, extravasation across the capillary wall, penetration through the extracellular matrix, and cellular uptake. Nanomedicine has ...
    • Ultrasound-mediated delivery enhances therapeutic efficacy of MMP sensitive liposomes 

      Olsman, Marieke; Sereti, Viktoria; Andreassen, Kristine; Snipstad, Linn Sofie; van Wamel, Johanna Elisabeth Theodora; Eliasen, Rasmus; Berg, Sigrid; Urquhart, Andrew J.; Andresen, Thomas L.; Davies, Ruth Catharina de Lange (Peer reviewed; Journal article, 2020)
      To improve therapeutic efficacy of nanocarrier drug delivery systems, it is essential to improve their uptake and penetration in tumour tissue, enhance cellular uptake and ensure efficient drug release at the tumour site. ...
    • Ultrasound-Mediated Delivery of Chemotherapy into the Transgenic Adenocarcinoma of the Mouse Prostate Model 

      Fagerland, Stein-Martin Tilrum; Berg, Sigrid; Hill, Deborah Katherine; Snipstad, Sofie; Sulheim, Einar; Hyldbakk, Astrid; Kim, Jana; Davies, Catharina de Lange (Peer reviewed; Journal article, 2020)
      Ultrasound (US) in combination with microbubbles (MB) has had promising results in improving delivery of chemotherapeutic agents. However, most studies are done in immunodeficient mice with xenografted tumors. We used two ...
    • An Unbalanced Chromosome Translocation Between 7p22 and 12q13 Leads to ACTB-GLI1 Fusion in Pericytoma 

      Panagopoulos, Ioannis; Gorunova, Ludmila; Rise, Tor Vikan; Andersen, Kristin; Micci, Francesca; Heim, Sverre (Peer reviewed; Journal article, 2020)
      Background/Aim: Since the first description of five pericytomas with the t(7;12)/ACTB-GLI1 fusion gene, only three new tumors were studied by both cytogenetics and molecular techniques. We report here genetic data on another ...
    • Uncertainty quantification and sensitivity analysis for computational FFR estimation in stable coronary artery disease 

      Fossan, Fredrik Eikeland; Sturdy, Jacob; Muller, Lucas Omar; Strand, Andreas; Bråten, Anders Tjellaug; Jørgensen, Arve; Wiseth, Rune; Hellevik, Leif Rune (Journal article; Peer reviewed, 2018)
      Purpose The main objectives of this study are to validate a reduced-order model for the estimation of the fractional flow reserve (FFR) index based on blood flow simulations that incorporate clinical imaging and ...
    • Understanding peer support: a qualitative interview study of doctors one year after seeking support 

      Horne, Ingrid Marie Taxt; Veggeland, Frode; Bååthe, Fredrik; Drewes, Christina; Rø, Karin (Peer reviewed; Journal article, 2023)
      Background Doctors’ health is of importance for the quality and development of health care and to doctors themselves. As doctors are hesitant to seek medical treatment, peer support services, with an alleged lower threshold ...
    • Understanding the possibilities and limitations of assistive technology in health and welfare services for people with intellectual disabilities, staff perspectives 

      Rasouli, Omid; Kvam, Lisbeth; Husby, Vigdis Schnell; Røstad, Monica; Witsø, Aud Elisabeth (Journal article; Peer reviewed, 2021)
      Purpose: Little is known regarding what assistive technology (AT) exists and how it is used in welfare services for people with intellectual disabilities (ID). This study aimed to explore healthcare staff’s perspectives ...
    • Understanding the relationship between cognitive performance and function in daily life after traumatic brain injury 

      Wilson, Lindsay; Horton, Lindsay; Kunzmann, Kevin; Sahakian, Barbara J.; Newcombe, Virginia; Stamatakis, E; Steinbuechel, Nicole; Cunitz, Kathrin; Covic, Amra; Maas, Andrew; van Praag, Dominigue; Menon, David; Andelic, Nada; Andreassen, Lasse; Anke, Audny; Frisvold, Shirin; Helseth, Eirik; Røe, Cecilie; Røise, Olav; Skandsen, Toril; Vik, Anne; Åkerlund, Cecilia; Amrein, Krisztina; Antoni, Anna; Audibert, Gerard; Azouvi, Philippe; Azzolini, Maria Luisa; Bartels, Ronald; Barzo, Pal; Beauvais, Romuald; Beer, Ronny; Bellander, Bo-Michael; Belli, Antonio; Benali, Habib; Berardino, Maurizio; Beretta, Luigi; Blaabjerg, Morten; Bragge, Peter; Brazinova, Alexandra; Brinck, Vibeke; Brooker, Joanne; Brorsson, Camilla; Buki, Andras; Bullinger, Monika; Cabeleira, Manuel; Caccioppola, Alessio; Calappi, Emiliana; Calvi, Maria Rosa; Cameron, Peter; Lozano, Guillermo Carbayo (Peer reviewed; Journal article, 2020)
      Objective: Cognitive impairment is a key cause of disability after traumatic brain injury (TBI) but relationships with overall functioning in daily life are often modest. The aim is to examine cognition at different levels ...
    • Undertriage in Trauma: An Ignored Quality Indicator? 

      Jeppesen, Elisabeth; Cuevas-Østrem, Mathias; Gram-Knutsen, Cathrine; Uleberg, Oddvar (Peer reviewed; Journal article, 2020)
      Background Early identification of life-threatening injuries is essential to reduce morbidity and mortality in trauma patients. Failure to detect severe injury may cause delayed diagnosis and therapeutic interventions ...
    • Undiagnosed diabetes: Prevalence and cardiovascular risk profile in a population-based study of 52,856 individuals. The HUNT Study, Norway 

      Bjarkø, Vera Vik; Haug, Eirin Beate; Sørgjerd, Elin Pettersen; Stene, Lars Christian Mørch; Lopez-Doriga Ruiz, Paz; Birkeland, Kåre Inge; Berg, Tore Julsrud; Gulseth, Hanne Løvdal; Iversen, Marjolein M.; Langhammer, Arnulf; Åsvold, Bjørn Olav (Peer reviewed; Journal article, 2022)
      Aims We investigated the current extent of undiagnosed diabetes and prediabetes and their associated cardiovascular risk profile in a population-based study. Methods All residents aged ≥20 years in the Nord-Trøndelag ...
    • Unidimensionality of the Strengths and Vulnerabilities Scales in the Short-Term Assessment of Risk and Treatability (START) 

      Whittington, Richard; Pollak, Charlotte; Keski-Valkama, Alice; Brown, Andrew; Haines, Alina; Bak, Jesper; Hvidhjelm, Jacob; Almvik, Roger; Palmstierna, Tom (Peer reviewed; Journal article, 2021)
      The Short-Term Assessment of Risk and Treatability (START) is a 20-item structured professional judgment instrument for assessing dynamic risk in mental health services. Much of the START research literature examines the ...
    • A universal outcome measure for headache treatments, care-delivery systems and economic analysis 

      Steiner, Timothy J; Linde, Mattias; Schnell-Inderst, Petra (Peer reviewed; Journal article, 2021)
      Background The first manuscript in this series delineated a model of structured headache services, potentially cost-effective but requiring formal cost-effectiveness analysis (CEA). We envisaged a need for a new outcome ...
    • Unsatisfactory risk factor control and high rate of new cardiovascular events in patients with myocardial infarction and prior coronary artery disease 

      Jortveit, Jarle; Halvorsen, Sigrun; Kaldal, Anete; Pripp, Are Hugo; Govatsmark, Ragna Elise Støre; Langørgen, Jørund (Peer reviewed; Journal article, 2019)
      Background: Patients with established coronary artery disease (CAD) have an increased risk of new cardiovascular events. An underuse of secondary preventive drugs has been observed, and many patients may not attain the ...
    • Update on genetic predisposition to colorectal cancer and polyposis 

      Valle, Laura; de Voer, Richarda M.; Goldberg, Yael; Sjursen, Wenche; Försti, Asta; Ruiz-Ponte, Clara; Caldés, Trinidad; Garré, Pilar; Olsen, Maren Fridtjofsen; Nordling, Margareta; Castellví-Bel, Sergi; Hemminki, Kari (Journal article; Peer reviewed, 2019)
      The present article summarizes recent developments in the characterization of genetic predisposition to colorectal cancer (CRC). The main themes covered include new hereditary CRC and polyposis syndromes, non-CRC hereditary ...
    • An Update on Prevalence, Assessment, and Risk Factors for Sleep Disturbances in Patients with Advanced Cancer—Implications for Health Care Providers and Clinical Research 

      Jakobsen, Gunnhild; Gjeilo, Kari Hanne; Hjermstad, Marianne Jensen; Klepstad, Pål (Peer reviewed; Journal article, 2022)
      Simple Summary This review focuses on sleep in patients with advanced cancer. Cancer patients experience multiple symptoms and they receive concomitant medications. These are all factors that may affect sleep. In this ...