• Low C-peptide together with a high glutamic acid decarboxylase autoantibody level predicts progression to insulin dependence in latent autoimmune diabetes in adults: The HUNT study 

  Sørgjerd, Elin P.; Åsvold, Bjørn O.; Grill, Valdemar (Journal article; Peer reviewed, 2021)

  Aim: To search for risk factors that could predict progression in latent autoimmune diabetes in adults (LADA) and compare them with those for type 2 diabetes. Materials and Methods: This study included 175 participants ...

• Development of national curriculum guidelines using a modified RAND/UCLA appropriateness method 

  Hill, Sophie; Rusaw, David F.; Goihl, Tobias; Hjerman, Anne Katrine; Bolstad Schwanborg, Linn; Bauge, Krister (Peer reviewed; Journal article, 2020)

  In 2017, the Norwegian Ministry of Education and Research implemented a project to develop curriculum guidelines for all health and social care programmes. The modified RAND/UCLA appropriateness method used by the group ...

• Novel Peptides Targeting the β-Clamp Rapidly Kill Planktonic and Biofilm Staphylococcus epidermidis Both in vitro and in vivo 

  Ræder, Synnøve Brandt; Sandbakken, Erik Thorvaldsen; Nepal, Anala; Løseth, Kirsti; Bergh, Kåre; Witsø, Eivind; Otterlei, Marit (Peer reviewed; Journal article, 2021)

  Antimicrobial resistance is an increasing threat to global health and challenges the way we treat infections. Peptides containing the PCNA interacting motif APIM (APIM-peptides) were recently shown to bind to the bacterial ...

• Clinically accessible neuroimaging predictors of post-stroke neurocognitive disorder: a prospective observational study 

  SCHELLHORN, TILL; Aamodt, Eva Birgitte; Lydersen, Stian; Aam, Stina; Wyller, Torgeir Bruun; Saltvedt, Ingvild; Beyer, Mona Kristiansen (Peer reviewed; Journal article, 2021)

  Background Neurocognitive disorder (NCD) is common in stroke survivors. We aimed to identify clinically accessible imaging markers of stroke and chronic pathology that are associated with early post-stroke NCD. Methods We ...

• Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations 

  Boer, Cindy G.; Hatzikotoulas, Konstantinos; Southam, Lorraine; Stefánsdóttir, Lilja; Almeida, Rodrigo Coutinho de; Zhang, Yanfei; Wu, Tian T.; Zheng, Jie; Hartley, April; Teder-Laving, Maris; Skogholt, Anne Heidi; Terao, Chikashi; Zengini, Eleni; Alexiadis, George; Barysenka, Andrei; Bjornsdottir, Gyda; Gabrielsen, Maiken Elvestad; Gilly, Arthur; Ingvarsson, Thorvaldur; Johnsen, Marianne Bakke; Jonsson, Helgi; Kloppenburg, Margreet; Luetge, Almut; Lund, Sigrun H; Magi, Reedik; Mangino, Massimo; Nelissen, Rob G.H.H.; Shivakumar, Manu; Steinberg, Julia; Takuwa, Hiroshi; Thomas, Laurent; Tuerlings, Margo; Babis, George C.; Cheung, Jason Pui Yin; Kang, Jae Hee; Kraft, Peter; Lietman, Steven A.; Samartzis, Dino; Slagboom, P. Eline; Stefansson, Kari; Thorsteinsdottir, Unnur; Tobias, Jonathan H.; Uitterlinden, André G.; Winsvold, Bendik K S; Zwart, John Anker Henrik; Smith, George Davey; Sham, Pak Chung; Thorleifsson, Gudmar; Hveem, Kristian; Zeggini, Eleftheria (Peer reviewed; Journal article, 2021)

  Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated ...

• Visuopathy of prematurity: is retinopathy just the tip of the iceberg? 

  Ingvaldsen, Sigrid Hegna; Morken, Tora Sund; Austeng, Dordi; Dammann, Olaf (Peer reviewed; Journal article, 2021)

  Background: Chronic brain pathology and pre-stroke cognitive impairment (PCI) is predictive of post-stroke dementia. The aim of the current study was to measure pre-stroke neurodegenerative and vascular disease burden found ...

• Informed consent procedures in patients with an acute inability to provide informed consent: Policy and practice in the CENTER-TBI study 

  van Wijk, Roel P J; van Dijck, Jeroen T. J. M.; Timmers, Marjolein; van Veen, Ernest; Citerio, Giuseppe; Lingsma, Hester F; Maas, Andrew I. R.; Menon, David K; Peul, Wilco C.; Stocchetti, Nino; Kompanje, Erwin J.O.; Andelic, Nada; Andreassen, Lasse; Anke, Audny; Frisvold, Shirin; Helseth, Eirik; Røe, Cecilie; Røise, Olav; Skandsen, Toril; Vik, Anne; Åkerlund, Cecilia; Amrein, Krisztina; Antoni, Anna; Audibert, Gerard; Azouvi, Philippe; Azzolini, Maria Luisa; Bartels, Ronald; Barzo, Pal; Beauvais, Romuald; Beer, Ronny; Bellander, Bo-Michael; Belli, Antonio; Benali, Habib; Berardino, Maurizio; Beretta, Luigi; Blaabjerg, Morten; Bragge, Peter; Brazinova, Alexandra; Brinck, Vibeke; Brooker, Joanne; Brorsson, Camilla; Buki, Andras; Bullinger, Monika; Cabeleira, Manuel; Caccioppola, Alessio; Calappi, Emiliana; Calvi, Maria Rosa; Cameron, Peter; Lozano, Guillermo Carbayo; Carbonara, Marco (Peer reviewed; Journal article, 2020)

  Purpose: Enrolling traumatic brain injury (TBI) patients with an inability to provide informed consent in research is challenging. Alternatives to patient consent are not sufficiently embedded in European and national ...

• Surgical Complications in Postchemotherapy Retroperitoneal Lymph Node Dissection for Nonseminoma Germ Cell Tumour: A Population-based Study from the Swedish Norwegian Testicular Cancer Group 

  Gerdtsson, Axel; Håkansson, Ulf; Törnblom, Magnus; Jancke, George; Negaard, Helene Francisca Stigter; Glimelius, Ingrid; Halvorsen, Dag; Karlsdottir, Åsa; Haugnes, Hege Sagstuen; Andreassen, Kristine Engen; Larsen, Signe Melsen; Holmberg, Göran; Wahlqvist, Rolf; Tandstad, Torgrim; Cohn-Cedermark, Gabriella; Ståhl, Olof; Kjellmann, Anders (Journal article, 2020)

  Background Reports on perioperative complications after postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) for nonseminoma germ cell tumour (NSGCT) are from experienced single centres, with a lack of ...

• Randomized phase III trial comparing switch-maintenance pemetrexed with observation followed by pemetrexed at progression in advanced NSCLC 

  Halvorsen, Tarje Onsøien; Stokke, Kristin; Killingberg, Kristin Toftaker; Raj, Sunil Xavier; Sørhaug, Sveinung; Brustugun, Odd Terje; Fløtten, Øystein; Helbekkmo, Nina; Hornslien, Kjersti; Madebo, Tesfaye; Fluge, Sverre; Grønberg, Bjørn Henning (Peer reviewed; Journal article, 2020)

  Objectives: Two phase III trials show that maintenance pemetrexed therapy after platinum-doublet chemotherapy prolongs overall survival (OS) and progression free survival (PFS) in advanced non-squamous non-small-cell lung ...

• Functional profiling reveals altered metabolic activity in divers’ oral microbiota during commercial heliox saturation diving 

  Monnoyer, Roxane; Eftedal, Ingrid; Hjelde, Astrid; Deb, Sanjoy Kumar; Haugum, Kjersti; Lautridou, Jacky (Peer reviewed; Journal article, 2021)

  Background: The extreme environment in saturation diving affects all life forms, including the bacteria that reside on human skin and mucosa. The oral cavity alone is home to hundreds of different bacteria. In this study, ...

• Past, present and future of zebrafish in epilepsy research 

  Yaksi, Emre; Jamali, Ahmed; Diaz Verdugo, Carmen; Jurisch-Yaksi, Nathalie (Journal article; Peer reviewed, 2021)

  Animal models contribute greatly to our understanding of brain development and function as well as its dysfunction in neurological diseases. Epilepsy research is a very good example of how animal models can provide us with ...

• Survival and disease recurrence in patients with duodenal neuroendocrine tumours—a single centre cohort 

  Folkestad, Oddry; Wasmuth, Hans; Mjønes, Patricia; Fougner, Reidun; Hauso, Øyvind; Fossmark, Reidar (Journal article; Peer reviewed, 2021)

  Background: Duodenal neuroendocrine tumours (D-NETs) are rare but increasingly diagnosed. This study aimed to assess the overall survival and recurrence rate among patients treated for D-NETs. Methods: Patients with D-NETs ...

• Loss of statin treatment years during pregnancy and breastfeeding periods in women with familial hypercholesterolemia 

  Klevmoen, Marianne; Bogsrud, Martin Prøven; Retterstøl, Kjetil; Svilaas, Tone; Vesterbekkmo, Elisabeth Kleivhaug; Hovland, Anders; Berge, Christ; van Lennep, Jeanine Roeters; Holven, Kirsten Bjørklund (Peer reviewed; Journal article, 2021)

  Background and aims Women with heterozygous familial hypercholesterolemia (FH) are recommended to initiate statin treatment at the same age as men (from 8 to 10 years of age). However, statins are contraindicated when ...

• Olfactory hallucinations in a population-based sample 

  Wehling, Eike Ines; Bless, Josef J; Hirnstein, Marco; Kråkvik, Bodil; Vedul-Kjelsås, Einar; Hugdahl, Kenneth; Kalhovde, Anne Martha; Larøi, Frank (Peer reviewed; Journal article, 2021)

  Olfactory hallucinations referring to olfactory perceptions in the absence of chemical stimuli, occur in non-clinical and clinical populations. Few studies have investigated their prevalence in the general population and ...

• Examining the educational impact of the mini-CEX: a randomised controlled study 

  Smeby, Susanne Skjervold; Espeland, Torvald; Berg, Erik Andreas Rye; Samstad, Eivind; Lillebo, Børge; Slørdahl, Tobias Schmidt (Journal article; Peer reviewed, 2021)

  Background: The purpose of this study is to evaluate the mini-Clinical Evaluation Exercise (mini-CEX) as a formative assessment tool among undergraduate medical students, in terms of student perceptions, effects on direct ...

• Lung function and peak oxygen uptake in chronic obstructive pulmonary disease phenotypes with and without emphysema 

  Rasch-Halvorsen, Øystein; Steinshamn, Sigurd Loe; Langhammer, Arnulf; Hassel, Erlend; Brumpton, Ben Michael; Jenssen, Haldor; Spruit, Martijn A. (Journal article; Peer reviewed, 2021)

  Previous studies of associations of forced expiratory lung volume in one second (FEV1) with peak oxygen uptake (VO2peak) in chronic obstructive pulmonary disease (COPD) have not taken sex, age and height related variance ...

• Cardiovascular outcomes at recommended blood pressure targets in middle-aged and elderly patients with type 2 diabetes mellitus compared to all middle-aged and elderly hypertensive study patients with high cardiovascular risk 

  Olsen, Erik; Holzhauer, Björn; Julius, Stevo; Kjeldsen, Sverre; Larstorp, Anne Cecilie Kjeldsen; Mancia, Giuseppe; Mehlum, Maria Hollund; Mo, Rune; Rostrup, Morten; Søraas, Camilla Lund; Zappe, Dion H.; Weber, Michael A. (Peer reviewed; Journal article, 2021)

  Purpose Event-based clinical outcome trials have shown limited evidence to support guidelines recommendations to lower blood pressure (BP) to <130/80 mmHg in middle-aged and elderly hypertensive patients with diabetes ...

• Non-coding RNAs in human breast milk: A systematic review 

  Tingö, Lina; Ahlberg, Emelie; Johansson, Lovisa; Pedersen, Sindre Andre; Chawla, Konika; Sætrom, Pål; Cione, Erika; Simpson, Melanie Rae (Peer reviewed; Journal article, 2021)

  Breast milk is the primary source of nutrition and hydration for the newborn infant but also plays an important role in the child’s first immune defense. Additionally, several breast milk factors have been implicated in ...

• Semiquantitative Real-Time PCR to Distinguish Pneumocystis Pneumonia from Colonization in a Heterogeneous Population of HIV-Negative Immunocompromised Patients 

  Grønseth, Stine; Rogne, Tormod; Hannula, Raisa; Åsvold, Bjørn Olav; Afset, Jan Egil; Damås, Jan Kristian (Peer reviewed; Journal article, 2021)

  Pneumocystis jirovecii is a threat to iatrogenically immunosuppressed individuals, a heterogeneous population at rapid growth. We assessed the ability of an in-house semiquantitative real-time PCR assay to discriminate ...

• Management of cluster headache and other trigeminal autonomic cephalalgias in pregnancy and breastfeeding 

  Bjørk, Marte-Helene; Kristoffersen, Espen Saxhaug; Tronvik, Erling Andreas; Nordeng, Hedvig Marie Egeland (Peer reviewed; Journal article, 2021)

  Many clinicians lack experience in managing trigeminal autonomic cephalalgias (TACs) in pregnancy and lactation. In addition to cluster headache, TACs include hemicrania continua, paroxysmal hemicrania, and short-lasting ...

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