Institutt for klinisk og molekylær medisin: Recent submissions
Now showing items 61-80 of 3443
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X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements
(Peer reviewed; Journal article, 2024)X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis ... -
Local Postoperative Graft Inflammation in Pancreas Transplant Patients With Early Graft Thrombosis
(Peer reviewed; Journal article, 2023)Background. Graft thrombosis is the main cause of early graft loss following pancreas transplantation, and is more frequent in pancreas transplant alone (PTA) compared with simultaneous pancreas-kidney (SPK) recipients. ... -
Validity of the Behavioural Assessment of the Dysexecutive Syndrome for Children (BADS-C) in children and adolescents with pediatric acquired brain injury
(Peer reviewed; Journal article, 2023)The Behavioural Assessment of the Dysexecutive Syndrome for Children (BADS-C) was developed to address the need for a standardized ecologically valid test of executive function (EF) in the pediatric population. Our study ... -
Exercised blood plasma promotes hippocampal neurogenesis in the Alzheimer's disease rat brain
(Peer reviewed; Journal article, 2023)Background Exercise training promotes brain plasticity and is associated with protection against cognitive impairment and Alzheimer's disease (AD). These beneficial effects may be partly mediated by blood-borne factors. ... -
Optimizing non-invasive respiratory support for preterm infants
(Doctoral theses at NTNU;2024:55, Doctoral thesis, 2024)Optimizing non-invasive respiratory support for preterm infants Optimizing non-invasive breathing support for preterm infants with respiratory distress syndrome (RDS) includes different treatment strategies and perspectives: ... -
Norwegian paediatric habilitation centres judge their own competence on cerebral visual impairment as limited
(Peer reviewed; Journal article, 2023)Aim: Cerebral visual impairment (CVI), a frequently occurring functional impairment in children with neurodevelopmental disorders, leads to communicative, social and academic challenges. In Norway, children with ... -
Pharmacologic and Genetic Downregulation of Proprotein Convertase Subtilisin/Kexin Type 9 and Survival from Sepsis
(Peer reviewed; Journal article, 2023)OBJECTIVES: Treatments that prevent sepsis complications are needed. Circulating lipid and protein assemblies—lipoproteins play critical roles in clearing pathogens from the bloodstream. We investigated whether early ... -
Prevention of obstetric anal sphincter injuries with perineal support and lateral episiotomy: A historical cohort study
(Journal article; Peer reviewed, 2023)Introduction - There are many risk factors for obstetric anal sphincter injury (OASIS) and the interaction between these risk factors is complex and understudied. The many observational studies that have shown a reduction ... -
Initial management and survival of patients with primary metastatic bladder cancer before the immunotherapy era: a population-based study from Norway
(Peer reviewed; Journal article, 2023)Before immunotherapy became part of the management of metastatic bladder cancer (mBC), systemic anti-cancer treatment comprised primarily of platinum-based chemotherapy. The objective of this study was to describe the ... -
Randomised, placebo-controlled, double-blinded trial of fecal microbiota transplantation in severe obesity: a study protocol
(Peer reviewed; Journal article, 2023)Introduction - Obesity is one of the main threats to public health in western countries and increases the risk of several diseases, overall morbidity and mortality. Sustained weight loss will reduce risk factors and improve ... -
Mortality and subsequent healthcare use among older patients discharged to a municipality with excess demand for elderly care
(Peer reviewed; Journal article, 2023)There is limited knowledge on how excess demand for elderly care influences patient outcomes. We used a natural experiment to estimate the causal effect of discharging elderly patients from hospital to municipalities with ... -
Homologous Recombination Deficiency Across Subtypes of Primary Breast Cancer
(Peer reviewed; Journal article, 2023)Purpose Homologous recombination deficiency (HRD) is highly prevalent in triple-negative breast cancer (TNBC) and associated with response to PARP inhibition (PARPi). Here, we studied the prevalence of HRD in non-TNBC to ... -
Thinking strategies used by registered nurses during drug administration in nursing homes — An observational study
(Journal article; Peer reviewed, 2023)Aim: To explore registered nurses' thinking strategies during the drug administration process in nursing homes. Design: An exploratory qualitative design. Methods: Eight registered nurses, one male and seven female, in ... -
Chemotherapy for colorectal cancer - Physical exercise and quality of life
(Doctoral theses at NTNU;2024:34, Doctoral thesis, 2024)Colorectal cancer (CRC) is the third most common cancer worldwide, the second most common cancer in Norway, and the second leading cause of cancer deaths both globally and nationally. In Norway, 4745 new cases were diagnosed ... -
Activation of multiple stress responses in Staphylococcus aureus substantially lowers the minimal inhibitory concentration when combining two novel antibiotic drug candidates
(Peer reviewed; Journal article, 2023)The past few decades have been plagued by an increasing number of infections caused by antibiotic resistant bacteria. To mitigate the rise in untreatable infections, we need new antibiotics with novel targets and drug ... -
Irisin reduces orthodontic tooth movement in rats by promoting the osteogenic potential in the periodontal ligament
(Peer reviewed; Journal article, 2023)Objectives Positive effects of irisin on osteogenic differentiation of periodontal ligament (PDL) cells have been identified previously, this study aims to examine its effect on orthodontic tooth movement (OTM) in ... -
Multiple Myeloma: Cancer Cell Intrinsic- and Tumor Microenvironmental Factors
(Doctoral theses at NTNU;2024:33, Doctoral thesis, 2024)Myelomatose (MM) er en hematologisk kreftsykdom som skyldes ukontrollert vekst av maligne plasmaceller i beinmargen. Myelomatose utvikler seg via to asymptomatiske forstadier: monoklonal gammopati av usikker betydning ... -
Variation in antibiotic consumption in very preterm infants-a 10 year population-based study
(Peer reviewed; Journal article, 2023)Objectives Wide variations in antibiotic use in very preterm infants have been reported across centres despite similar rates of infection. We describe 10 year trends in use of antibiotics and regional variations among ... -
SARS-CoV-2 activates the TLR4/MyD88 pathway in human macrophages: A possible correlation with strong pro-inflammatory responses in severe COVID-19
(Peer reviewed; Journal article, 2023)Background Toll-like receptors (TLRs) play a pivotal role in the immunologic response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Exaggerated inflammatory response of innate immune cells, ... -
The central role of gastrin in gastric cancer
(Peer reviewed; Journal article, 2023)The prevalence of gastric cancer has markedly declined, but due to the high mortality rates associated with gastric cancer, it is still a serious disease. The preferred classification of gastric cancer is according to ...