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dc.contributor.authorHaram, Karin Margrete
dc.contributor.authorHansen, Rune
dc.contributor.authorBouget, David Nicolas Jean-Marie
dc.contributor.authorMyhre, Ola Finneng
dc.contributor.authorDavies, Catharina de Lange
dc.contributor.authorHofsli, Eva
dc.date.accessioned2024-05-31T08:29:07Z
dc.date.available2024-05-31T08:29:07Z
dc.date.created2023-08-23T10:49:37Z
dc.date.issued2023
dc.identifier.citationUltrasound in Medicine and Biology. 2023, 49 (9), 2081-2088.en_US
dc.identifier.issn0301-5629
dc.identifier.urihttps://hdl.handle.net/11250/3132070
dc.description.abstractObjective: Pre-clinical trials have obtained promising results that focused ultrasound (FUS) combined with microbubbles (MBs) increases tumor uptake and the therapeutic effect of drugs. The aims of the study described here were to investigate whether FUS and MBs could improve the effect of chemotherapy in patients with liver metastases from colorectal cancer and to investigate the safety and feasibility of using FUS + MBs. Methods: We included 17 patients with liver metastases from colorectal cancer, selected two lesions in each patient's liver and randomized the lesions for, respectively, treatment with FUS + MBs or control. After chemotherapy (FOLFIRI or FOLFOXIRI), the lesions were treated with FUS (frequency = 1.67 MHz, mechanical index = 0.5, pulse repetition frequency = 0.33 Hz, 33 oscillations, duty cycle = 0.2%–0.4% and MBs (SonoVue) for 35 min). Nine boluses of MBs were injected intravenously at 3.5 min intervals. Patients were scheduled for four cycles of treatment. Changes in the size of metastases were determined from computed tomography images. Results: Treatment with FUS + MBs is safe at the settings used. There was considerable variation in treatment response between lesions and mixed response between lesions receiving only chemotherapy. There is a tendency toward larger-volume reduction in lesions treated with FUS + MBs compared with control lesions, but a mixed response to chemotherapy and lesion heterogeneity make it difficult to interpret the results. Conclusion: The combination of FUS and MBs is a safe, feasible and available strategy for improving the effect of chemotherapy in cancer patients. Therapeutic effect was not demonstrated in this trial. Multicenter trials with standardized protocols should be performed.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleTreatment of Liver Metastases With Focused Ultrasound and Microbubbles in Patients With Colorectal Cancer Receiving Chemotherapyen_US
dc.title.alternativeTreatment of Liver Metastases With Focused Ultrasound and Microbubbles in Patients With Colorectal Cancer Receiving Chemotherapyen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber2081-2088en_US
dc.source.volume49en_US
dc.source.journalUltrasound in Medicine and Biologyen_US
dc.source.issue9en_US
dc.identifier.doi10.1016/j.ultrasmedbio.2023.05.013
dc.identifier.cristin2168943
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal