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dc.contributor.authorSolvin, Åshild Øksnevad
dc.contributor.authorChawla, Konika
dc.contributor.authorOlsen, Lene Christin
dc.contributor.authorHegre, Siv Anita
dc.contributor.authorDanielsen, Kjersti
dc.contributor.authorJenssen, Marita
dc.contributor.authorFurberg, Anne-Sofie
dc.contributor.authorSaunes, Marit
dc.contributor.authorHveem, Kristian
dc.contributor.authorSætrom, Pål
dc.contributor.authorLøset, Mari
dc.identifier.citationExperimental Dermatology. 2021, 1-14.en_US
dc.description.abstractMicroRNAs (miRNAs) are small non-coding RNAs that have emerged as central regulators of gene expression and powerful biomarkers of disease. Much is yet unknown about their role in psoriasis pathology. To globally characterize the miRNAome of psoriatic skin, skin biopsies were collected from psoriatic cases (n = 75) and non-psoriatic controls (n = 46) and RNA sequenced. Count data were meta-analysed with a previously published dataset (cases, n = 24, controls, n = 20), increasing the number of psoriatic cases fourfold from previously published studies. Differential gene expression analyses were performed comparing lesional psoriatic (PP), non-lesional psoriatic (PN) and control (NN) skin. Further, functional enrichment and cell-specific analyses were performed. Across all contrasts, we identified 439 significantly differentially expressed miRNAs (DEMs), of which 85 were novel for psoriasis and 11 were related to disease severity. Meta-analyses identified 20 DEMs between PN and NN, suggesting an inherent change in the constitution of all skin in psoriasis. By integrating the miRNA transcriptome with mRNA target interactions, we identified several functionally enriched terms, including “thyroid hormone signalling,” “insulin resistance” and various infectious diseases. Cell-specific expression analyses revealed that the upregulated DEMs were enriched in epithelial and immune cells. This study provides the most comprehensive overview of the miRNAome in psoriatic skin to date and identifies a miRNA signature related to psoriasis severity. Our results may represent molecular links between psoriasis and related comorbidities and have outlined potential directions for future functional studies to identify biomarkers and treatment targets.en_US
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.titleMicroRNA profiling of psoriatic skin identifies 11 miRNAs associated with disease severityen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalExperimental Dermatologyen_US

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Navngivelse-Ikkekommersiell 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse-Ikkekommersiell 4.0 Internasjonal