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dc.contributor.authorSkjulsvik, Anne Jarstein
dc.contributor.authorBø, Hans Kristian
dc.contributor.authorJakola, Asgeir S
dc.contributor.authorBerntsen, Erik Magnus
dc.contributor.authorBø, Lars Eirik
dc.contributor.authorReinertsen, Ingerid
dc.contributor.authorMyrmel, Kristin Smistad
dc.contributor.authorSjåvik, Kristin
dc.contributor.authorÅberg, Kristin
dc.contributor.authorBerg, Thomas
dc.contributor.authorHong, Yan Dai
dc.contributor.authorKloster, Roar
dc.contributor.authorTorp, Sverre Helge
dc.contributor.authorSolheim, Ole
dc.identifier.citationJournal of Neuro-Oncology. 2020, 147 147-157.en_US
dc.description.abstractIntroduction According to the stem cell theory, two neurogenic niches in the adult human brain may harbor cells that initiate the formation of gliomas: The larger subventricular zone (SVZ) and the subgranular zone (SGZ) in the hippocampus. We wanted to explore whether defining molecular markers in low-grade gliomas (LGG; WHO grade II) are related to distance to the neurogenic niches. Methods Patients treated at two Norwegian university hospitals with population-based referral were included. Eligible patients had histopathological verified supratentorial low-grade glioma. IDH mutational status and 1p19q co-deletion status was retrospectively assessed. 159 patients were included, and semi-automatic tumor segmentation was done from pre-treatment T2-weighted (T2W) or Fluid-Attenuated Inversion Recovery (FLAIR) images. 3D maps showing the anatomical distribution of the tumors were then created for each of the three molecular subtypes (IDH mutated/1p19q co-deleted, IDH mutated and IDH wild-type). Both distance from tumor center and tumor border to the neurogenic niches were recorded. Results In this population-based cohort of previously untreated low-grade gliomas, we found that low-grade gliomas are more often found closer to the SVZ than the SGZ, but IDH wild-type tumors are more often found near SGZ. Conclusion Our study suggests that the stem cell origin of IDH wild-type and IDH mutated low-grade gliomas may be different.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleIs the anatomical distribution of low-grade gliomas linked to regions of gliogenesis?en_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalJournal of Neuro-Oncologyen_US

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