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dc.contributor.authorStensvold, Dorthe
dc.contributor.authorViken, Hallgeir
dc.contributor.authorSteinshamn, Sigurd Loe
dc.contributor.authorDalen, Håvard
dc.contributor.authorStøylen, Asbjørn
dc.contributor.authorLoennechen, Jan Pål
dc.contributor.authorReitlo, Line Skarsem
dc.contributor.authorZisko, Nina
dc.contributor.authorBækkerud, Fredrik Hjulstad
dc.contributor.authorTari, Atefe R
dc.contributor.authorBucher Sandbakk, Silvana
dc.contributor.authorCarlsen, Trude
dc.contributor.authorIngebrigtsen, Jan Erik
dc.contributor.authorLydersen, Stian
dc.contributor.authorMattsson, Erney
dc.contributor.authorAnderssen, Sigmund Alfred
dc.contributor.authorSingh, Maria A. Fiatarone
dc.contributor.authorCoombes, Jeff S.
dc.contributor.authorSkogvoll, Eirik
dc.contributor.authorVatten, Lars Johan
dc.contributor.authorHelbostad, Jorunn L.
dc.contributor.authorRognmo, Øivind
dc.contributor.authorWisløff, Ulrik
dc.identifier.citationBMJ. British Medical Journal. 2020, 371 .en_US
dc.description.abstractObjective To evaluate the effect of five years of supervised exercise training compared with recommendations for physical activity on mortality in older adults (70-77 years). Design Randomised controlled trial. Setting General population of older adults in Trondheim, Norway. Participants 1567 of 6966 individuals born between 1936 and 1942. Intervention Participants were randomised to two sessions weekly of high intensity interval training at about 90% of peak heart rate (HIIT, n=400), moderate intensity continuous training at about 70% of peak heart rate (MICT, n=387), or to follow the national guidelines for physical activity (n=780; control group); all for five years. Main outcome measure All cause mortality. An exploratory hypothesis was that HIIT lowers mortality more than MICT. Results Mean age of the 1567 participants (790 women) was 72.8 (SD 2.1) years. Overall, 87.5% of participants reported to have overall good health, with 80% reporting medium or high physical activity levels at baseline. All cause mortality did not differ between the control group and combined MICT and HIIT group. When MICT and HIIT were analysed separately, with the control group as reference (observed mortality of 4.7%), an absolute risk reduction of 1.7 percentage points was observed after HIIT (hazard ratio 0.63, 95% confidence interval 0.33 to 1.20) and an absolute increased risk of 1.2 percentage points after MICT (1.24, 0.73 to 2.10). When HIIT was compared with MICT as reference group an absolute risk reduction of 2.9 percentage points was observed (0.51, 0.25 to 1.02) for all cause mortality. Control participants chose to perform more of their physical activity as HIIT than the physical activity undertaken by participants in the MICT group. This meant that the controls achieved an exercise dose at an intensity between the MICT and HIIT groups. Conclusion This study suggests that combined MICT and HIIT has no effect on all cause mortality compared with recommended physical activity levels. However, we observed a lower all cause mortality trend after HIIT compared with controls and MICT.en_US
dc.publisherBMJ Publishing Groupen_US
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.titleEffect of exercise training for five years on all cause mortality in older adults-The Generation 100 study: Randomised controlled trialen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalBMJ. British Medical Journalen_US
dc.description.localcodeThis is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:

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Navngivelse-Ikkekommersiell 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse-Ikkekommersiell 4.0 Internasjonal