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dc.contributor.authorGjellesvik, Tor Ivar
dc.contributor.authorBecker, Frank
dc.contributor.authorTjønna, Arnt Erik
dc.contributor.authorIndredavik, Bent
dc.contributor.authorNilsen, Halvard Knut
dc.contributor.authorBrurok, Berit
dc.contributor.authorTørhaug, Tom
dc.contributor.authorBusuladzic, Maja
dc.contributor.authorLydersen, Stian
dc.contributor.authorAskim, Torunn
dc.identifier.citationArchives of Physical Medicine and Rehabilitation. 2020, 101 (6), 939-947.en_US
dc.description.abstractObjective To examine if 8 weeks of high-intensity interval training (HIIT) in addition to standard care would increase and maintain peak oxygen uptake (Vo2peak) more than standard care alone in patients with stroke. Design This was a single-blind, multicenter, parallel group, randomized controlled trial. Setting Specialized rehabilitation units at 3 Norwegian hospitals. Participants Participants (N=70), 3 months to 5 years after first-ever stroke, were randomly assigned to the intervention group (n=36) or the control group (n=34); 42% were women, mean age was 57.6±9.3 years, mean time post stroke was 26.4±14.5 months. Intervention The intervention was 8 weeks: 3 times a week with HIIT treadmill training with work periods of 4 × 4 minutes at 85%-95% of peak heart rate interspersed with 3 minutes of active recovery at 50%-70% of peak heart rate. The control group received standard care according to national guidelines. Outcomes The primary outcome, analyzed by intention-to-treat, was Vo2peak measured as liters per minute 12 months after inclusion. Secondary outcome measures were blood pressure and blood profile. Results Mean baseline Vo2peak was 2.63±1.08 L·min−1 vs 2.87±0.71 L·min−1, while at 12 months Vo2peak was 2.70±1.00 L·min−1 vs 2.67±0.76 L·min−1 (P=.068) in the intervention and control groups, respectively. There was a significant and greater improvement in the intervention group compared with the control group at 12 months in 3 of 6 secondary outcomes from the peak test but no significant differences for blood pressure or blood profile. Conclusions The HIIT intervention, which was well-tolerated in this sample of well-functioning survivors of stroke, was not superior to standard care in improving and maintaining Vo2peak at the 12-month follow-up. However, secondary results from the peak test showed a significant improvement from before to immediately after the intervention.en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.titleEffects of High-Intensity Interval Training After Stroke (the HIIT-Stroke Study): A Multicenter Randomized Controlled Trialen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalArchives of Physical Medicine and Rehabilitationen_US
dc.description.localcode"© 2020. This is the authors’ accepted and refereed manuscript to the article. Locked until 4.3.2021 due to copyright restrictions. This manuscript version is made available under the CC-BY-NC-ND 4.0 license "en_US

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