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dc.contributor.authorJakola, Asgeir S
dc.contributor.authorBouget, David Nicolas Jean-Marie
dc.contributor.authorReinertsen, Ingerid
dc.contributor.authorSkjulsvik, Anne Jarstein
dc.contributor.authorSagberg, Lisa Millgård
dc.contributor.authorBø, Hans Kristian
dc.contributor.authorGulati, Sasha
dc.contributor.authorSjåvik, Kristin
dc.contributor.authorSolheim, Ole
dc.description.abstractBackground Malignant transformation represents the natural evolution of diffuse low-grade gliomas (LGG). This is a catastrophic event, causing neurocognitive symptoms, intensified treatment and premature death. However, little is known concerning the spatial distribution of malignant transformation in patients with LGG. Materials and methods Patients histopathological diagnosed with LGG and subsequent radiological malignant transformation were identified from two different institutions. We evaluated the spatial distribution of malignant transformation with (1) visual inspection and (2) segmentations of longitudinal tumor volumes. In (1) a radiological transformation site < 2 cm from the tumor on preceding MRI was defined local transformation. In (2) overlap with pretreatment volume after importation into a common space was defined as local transformation. With a centroid model we explored if there were particular patterns of transformations within relevant subgroups. Results We included 43 patients in the clinical evaluation, and 36 patients had MRIs scans available for longitudinal segmentations. Prior to malignant transformation, residual radiological tumor volumes were > 10 ml in 93% of patients. The transformation site was considered local in 91% of patients by clinical assessment. Patients treated with radiotherapy prior to transformation had somewhat lower rate of local transformations (83%). Based upon the segmentations, the transformation was local in 92%. We did not observe any particular pattern of transformations in examined molecular subgroups. Conclusion Malignant transformation occurs locally and within the T2w hyperintensities in most patients. Although LGG is an infiltrating disease, this data conceptually strengthens the role of loco-regional treatments in patients with LGG.en_US
dc.publisherSpringer Verlagen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleSpatial distribution of malignant transformation in patients with low-grade gliomaen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.source.journalJournal of Neuro-Oncologyen_US
dc.description.localcode© The Author(s) 2020 Open Access This chapter is licensed under the terms of the Creative Commons Attribution 4.0 International License (,en_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal