dc.contributor.author | Sun, Yi-Qian | |
dc.contributor.author | Brumpton, Ben Michael | |
dc.contributor.author | Bonilla, Carolina | |
dc.contributor.author | Lewis, Sarah J. | |
dc.contributor.author | Burgess, Stephen | |
dc.contributor.author | Skorpen, Frank | |
dc.contributor.author | Chen, Yue | |
dc.contributor.author | Nilsen, Tom Ivar Lund | |
dc.contributor.author | Romundstad, Pål Richard | |
dc.contributor.author | Mai, Xiao-Mei | |
dc.date.accessioned | 2019-07-01T12:00:53Z | |
dc.date.available | 2019-07-01T12:00:53Z | |
dc.date.created | 2018-05-16T15:32:47Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0903-1936 | |
dc.identifier.uri | http://hdl.handle.net/11250/2603040 | |
dc.description.abstract | We aimed to investigate potential causal associations between serum 25-hydroxyvitamin D [25(OH)D] levels and incidence of lung cancer overall and histologic types. We performed a Mendelian randomization (MR) analysis using a prospective cohort study in Norway, including 54580 individuals and 676 incident lung cancer cases. A 25(OH)D allele score was generated based on vitamin D-increasing alleles of rs2282679, rs12785878 and rs10741657. Hazard ratios (HRs) with 95% confidence intervals (CIs) for incidence of lung cancer and histologic types were estimated in relation to the allele score. Inverse-variance weighted method using summarized data of individual single-nucleotide polymorphisms was applied to calculate the MR estimates. The allele score accounted for 3.4% of the variation in serum 25(OH)D levels. There was no association between the allele score and lung cancer incidence overall, with HR being 0.99 (95% CI 0.93 to 1.06) per allele score. A 25 nmol/L increase in genetically determined 25(OH)D level was not associated with the incidence of lung cancer overall (MR estimate HR 0.96, 95% CI 0.54 to 1.69) or any histologic type. MR analysis did not suggest causal association between 25(OH)D levels and risk of lung cancer overall or histologic types in this population-based cohort study. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | European Respiratory Society: ERJ | nb_NO |
dc.title | Serum 25-hydroxyvitamin D levels and risk of lung cancer and histologic types: a Mendelian randomization analysis of the HUNT study | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | acceptedVersion | nb_NO |
dc.source.volume | 51 | nb_NO |
dc.source.journal | European Respiratory Journal | nb_NO |
dc.source.issue | 6 | nb_NO |
dc.identifier.doi | 10.1183/13993003.00329-2018 | |
dc.identifier.cristin | 1585461 | |
dc.relation.project | Kreftforeningen: 5769155- 2015 | nb_NO |
dc.relation.project | Samarbeidsorganet mellom Helse Midt-Norge og NTNU: #46055500-10 | nb_NO |
dc.description.localcode | © 2018. This is the authors' accepted and refereed manuscript to the article. The final authenticated version is available online at: 10.1183/13993003.00329-2018 | nb_NO |
cristin.unitcode | 194,65,15,0 | |
cristin.unitcode | 194,65,20,0 | |
cristin.unitname | Institutt for klinisk og molekylær medisin | |
cristin.unitname | Institutt for samfunnsmedisin og sykepleie | |
cristin.ispublished | true | |
cristin.fulltext | preprint | |
cristin.fulltext | postprint | |
cristin.qualitycode | 2 | |