Blar i St. Olavs hospital på tittel

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    • Cytokine Patterns in Maternal Serum From First Trimester to Term and Beyond 

      Jarmund, Anders Hagen; Giskeødegård, Guro F.; Ryssdal, Mariell; Steinkjer, Bjørg; Stokkeland, Live Marie; Madssen, Torfinn Støve; Stafne, Signe Nilssen; Stridsklev, Solhild; Moholdt, Trine; Heimstad, Runa Kristine; Vanky, Eszter; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2021)
      Pregnancy implies delicate immunological balance between two individuals, with constant changes and adaptions in response to maternal capacity and fetal demands. We performed cytokine profiling of 1149 longitudinal serum ...

    • Cytokines in agitated and non-agitated patients admitted to an acute psychiatric department: A cross-sectional study 

      Larsen, Jeanette Brun; Stunes, Astrid Kamilla; Vaaler, Arne; Reitan, Solveig Merete Klæbo (Journal article; Peer reviewed, 2019)
      Background:Different psychiatric diagnostic groups have been reported to have cytokine levels deviating from healthy controls. In acute clinical settings however, the specific challenging symptoms and signs are more important ...

    • Cytokines in Relation to Motor Activity in an Acute Psychiatric Population 

      Larsen, Jeanette Brun; Stunes, Astrid Kamilla; Iversen, Valentina Cabral; Vaaler, Arne; Reitan, Solveig Merete Klæbo (Peer reviewed; Journal article, 2019)
      Background: Deviations in motor activity are important clinical features of several psychiatric disorders in an acute state. Immune activity is associated with several psychiatric disorders and may affect motor activity. ...

    • Cytomegalovirus High-risk Kidney Transplant Recipients Show No Difference in Long-term Outcomes Following Preemptive Versus Prophylactic Management 

      Blom, Kjersti Benedicte; Kro, Grete Anette Birkeland; Midtvedt, Karsten; Jenssen, Trond; Reisæter, Anna Varberg; Rollag, Halvor; Hartmann, Anders; Sagedal, Solbjørg; Sjaastad, Ivar; Tylden, Garth Daryl; Njølstad, Gro; Nilsen, Einar; Christensen, Andreas; Åsberg, Anders; Birkeland, Jon Arne (Peer reviewed; Journal article, 2023)
      Background. Following kidney transplantation (KT), cytomegalovirus (CMV) infection remains an important challenge. Both prophylactic and preemptive antiviral protocols are used for CMV high-risk kidney recipients (donor ...

    • Cytotoxicity and effect on wound re-epithelialization after topical administration of tranexamic acid 

      Eikebrokk, Tuva; Vassmyr, Brita; Ausen, Kjersti; Gravastrand, Caroline S.; Spigset, Olav; Pukstad, Brita (Journal article; Peer reviewed, 2019)
      Background Topical administration of tranexamic acid (TXA) reduces bleeding from surgical wounds similarly to intravenous use, but with negligible risk of adverse systemic events. Topical use is expanding, but is ...

    • Data Adaptive 2-D Tracking Doppler for High-Resolution Spectral Estimation 

      Karabiyik, Yücel; Avdal, Jørgen; Ekroll, Ingvild Kinn; Fiorentini, Stefano; Torp, Hans; Løvstakken, Lasse (Peer reviewed; Journal article, 2019)
      Spectral broadening in pulsed-wave Doppler caused by the transit-time effect deteriorates the frequency resolution and may cause overestimation of maximum velocities in high-velocity blood flow regions and for large ...

    • Data quality of Glasgow Coma Scale and Systolic Blood Pressure in scientific studies involving physician-staffed emergency medical services: Systematic review 

      Tønsager, Kristin; Krüger, Andreas; Ringdal, Kjetil G.; Rehn, Marius (Peer reviewed; Journal article, 2020)
      Background: Emergency physicians on‐scene provide highly specialized care to severely sick or injured patients. High‐quality research relies on the quality of data, but no commonly accepted definition of EMS data quality ...

    • Deaf and hard-of-hearing children and adolescents’ mental health, Quality of Life and communication 

      Aanondsen, Chris Margaret; Jozefiak, Thomas; Lydersen, Stian; Heiling, Kerstin; Rimehaug, Tormod (Peer reviewed; Journal article, 2023)
      Mental health problems and lower Quality of Life (QoL) are more common in deaf and hard-of-hearing – (D)HH – children than in typically hearing (TH) children. Communication has been repeatedly linked to both mental health ...

    • Decidual and placental NOD1 is associated with inflammation in normal and preeclamptic pregnancies 

      Rakner, Johanne Johnsen; Silva, Gabriela; Mundal, Siv Boon; Thaning, Astrid Josefin; Elschot, Mattijs; Ostrop, Jenny; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Gierman, Lobke; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2021)
      Introduction: Inflammation is a normal physiological process that increases to harmful levels in preeclampsia. It affects the interaction between maternal immune cells and fetal trophoblasts at both sites of the maternal-fetal ...

    • Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations 

      Boer, Cindy G.; Hatzikotoulas, Konstantinos; Southam, Lorraine; Stefánsdóttir, Lilja; Almeida, Rodrigo Coutinho de; Zhang, Yanfei; Wu, Tian T.; Zheng, Jie; Hartley, April; Teder-Laving, Maris; Skogholt, Anne Heidi; Terao, Chikashi; Zengini, Eleni; Alexiadis, George; Barysenka, Andrei; Bjornsdottir, Gyda; Gabrielsen, Maiken Elvestad; Gilly, Arthur; Ingvarsson, Thorvaldur; Johnsen, Marianne Bakke; Jonsson, Helgi; Kloppenburg, Margreet; Luetge, Almut; Lund, Sigrun H; Magi, Reedik; Mangino, Massimo; Nelissen, Rob G.H.H.; Shivakumar, Manu; Steinberg, Julia; Takuwa, Hiroshi; Thomas, Laurent; Tuerlings, Margo; Babis, George C.; Cheung, Jason Pui Yin; Kang, Jae Hee; Kraft, Peter; Lietman, Steven A.; Samartzis, Dino; Slagboom, P. Eline; Stefansson, Kari; Thorsteinsdottir, Unnur; Tobias, Jonathan H.; Uitterlinden, André G.; Winsvold, Bendik K S; Zwart, John Anker Henrik; Smith, George Davey; Sham, Pak Chung; Thorleifsson, Gudmar; Hveem, Kristian; Zeggini, Eleftheria (Peer reviewed; Journal article, 2021)
      Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated ...

    • Decision support system and outcome prediction in a cohort of patients with necrotizing soft-tissue infections 

      Katz, Sonja; Suijker, Jaco; Hardt, Christopher; Madsen, Martin Bruun; Vries, Annebeth Meij-de; Pijpe, Anouk; Skrede, Steinar; Hyldegaard, Ole; Solligård, Erik; Norrby-Teglund, Anna; Saccenti, Edoardo; Martins dos Santos, Vitor A.P. (Peer reviewed; Journal article, 2022)
      Introduction: Necrotizing Soft Tissue Infections (NSTI) are severe infections with high mortality affecting a heterogeneous patient population. There is a need for a clinical decision support system which predicts ...

    • Decreased adiponectin/leptin ratio relates to insulin resistance in adults with obesity 

      Castela, Inês; Morais, Juliana; Barreiros-Mota, Inês; Silvestre, Marta P.; Marques, Cláudia; Rodrigues, Catarina; Ismael, Shámila; Araújo, João R; Ângelo-Dias, Miguel; Martins, Catarina; Borrego, Luís Miguel; Monteiro, Rosário; dos Santos Ribeiro F. Coutinho, Silvia; Calhau, Conceição; Alho Letra Martins, Catia Patricia; Faria, Ana; Pestana, Diogo; Teixeira, Diana (Journal article; Peer reviewed, 2023)
      Adiponectin/leptin ratio, triacylglycerols, and waist-to-hip ratio explained almost half of HOMA-IR variance in the context of obesity. This study provides evidence to support adipose tissue dysfunction as a central feature ...

    • Deep Learning for Improved Precision and Reproducibility of Left Ventricular Strain in Echocardiography: A Test-Retest Study 

      Salte, Ivar Mjåland; Østvik, Andreas; Olaisen, Sindre Hellum; Karlsen, Sigve; Dahlslett, Thomas; Smistad, Erik; Eriksen-Volnes, Torfinn Kirknes; Brunvand, Harald; Haugaa, Kristina Ingrid Helena Hermann; Edvardsen, Thor; Dalen, Håvard; Løvstakken, Lasse; Grenne, Bjørnar Leangen (Peer reviewed; Journal article, 2023)
      Aims Assessment of left ventricular (LV) function by echocardiography is hampered by modest test-retest reproducibility. A novel artificial intelligence (AI) method based on deep learning provides fully automated ...

    • Deep learning identify retinal nerve fibre and choroid layers as markers of age-related macular degeneration in the classification of macular spectral-domain optical coherence tomography volumes 

      Tvenning, Arnt-Ole; Hanssen, Stian Rikstad; Austeng, Dordi; Morken, Tora Sund (Peer reviewed; Journal article, 2022)
      Purpose Deep learning models excel in classifying medical image data but give little insight into the areas identified as pathology. Visualization of a deep learning model’s point of interest (POI) may reveal unexpected ...

    • Deep learning-based image analysis reveals significant differences in the number and distribution of mucosal CD3 and γδ T cells between Crohn's disease and ulcerative colitis 

      Røyset, Elin Synnøve; Pettersen, Henrik Sahlin; Xu, Weili; Larbi, Anis; Sandvik, Arne Kristian; Steigen, Sonja Eriksson; Catalan-Serra, Ignacio; Bakke, Ingunn (Peer reviewed; Journal article, 2022)
      Colon mucosae of ulcerative colitis (UC) and Crohn's disease (CD) display differences in the number and distribution of immune cells that are difficult to assess by eye. Deep learning-based analysis on whole slide images ...

    • Definitive radiotherapy for prostate cancer in Norway 2006-2015: Temporal trends, performance and survival 

      Fosså, Sophie Dorothea; Aas, Kirsti; Muller, Christoph Rainer; Jerm, Marianne Brenn; Tandstad, Torgrim; Lilleby, Wolfgang; Kvåle, Rune; Gulbrandsen, Johanne; Haug, Erik Skaaheim; Myklebust, Tor Åge (Peer reviewed; Journal article, 2020)
      Background: More studies are needed to document nation-wide use and effectiveness of curative definitive radiotherapy (Def-RT) in the treatment of prostate cancer (PCa). Patients and methods: For 38,960 men diagnosed with ...

    • Deletion of aquaporin-4 improves capillary blood flow distribution in brain edema 

      Bordoni, Luca; Thorén, Anna Elisabeth; Gutiérrez-Jiménez, Eugenio; Åbjørsbråten, Knut Sindre; Bjørnstad, Daniel Marelius; Tang, Wannan; Stern, Mette; Østergaard, Leif; Nagelhus, Erlend Arnulf; Frische, Sebastian; Ottersen, Ole Petter; Enger, Rune (Peer reviewed; Journal article, 2023)
      Brain edema is a feared complication to disorders and insults affecting the brain. It can be fatal if the increase in intracranial pressure is sufficiently large to cause brain herniation. Moreover, accruing evidence ...

    • Delirium og kognitiv svikt blant eldre i norske akuttmottak 

      Evensen, Sigurd; Saltvedt, Ingvild; Ranhoff, Anette Hylen; Myrstad, Marius; Myrstad, Christian; Mellingsæter, Marte; Wang-Hansen, Marte Sofie; Neerland, Bjørn Erik (Journal article; Peer reviewed, 2019)
      BAKGRUNN Delirium er vanlig og underdiagnostisert blant pasienter på sykehus og er assosiert med komplikasjoner, økt dødelighet, demensutvikling og behov for sykehjemsplass. Kognitiv svikt av andre årsaker er også vanlig ...

    • The delirium screening tool 4AT in routine clinical practice: prediction of mortality, sensitivity and specificity 

      Evensen, Sigurd; Hylen Ranhoff, Anette; Lydersen, Stian; Saltvedt, Ingvild (Peer reviewed; Journal article, 2021)
      Purpose Delirium is common and associated with poor outcomes, partly due to underdetection. We investigated if the delirium screening tool 4 A’s test (4AT) score predicts 1 year mortality and explored the sensitivity and ...

    • Demographical, personality, alcohol use, and mental health characteristics associated with different alcoholic beverage preferences among students 

      Erevik, Eilin K.; Torsheim, Torbjørn; Vedaa, Øystein; Andreassen, Cecilie Schou; Pallesen, Ståle (Peer reviewed; Journal article, 2020)
      The study investigates correlates (i.e. demographics, personality, alcohol use and alcohol-related harm, alcohol expectancies, and mental health) of different alcoholic beverage preferences (i.e. beer/alcopops/cider, wine, ...