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    • Active conventional treatment and three different biological treatments in early rheumatoid arthritis: Phase IV investigator initiated, randomised, observer blinded clinical trial 

      Hetland, Merete Lund; Haavardsholm, Espen A.; Rudin, Anna; Nordström, Dan C.; Nurmohamed, Michael; Gudbjornsson, Bjorn; Lampa, Jon; Hørslev-Petersen, Kim; Uhlig, Till; Grondal, Gerdur; Østergaard, Mikkel; Schrumpf, Marte; Twisk, Jos; Lend, Kristina; Krabbe, Simon; Hyldstrup, Lise; Lindqvist, Joakim; Hultgård Ekwall, Anna-Karin; Grøn, Kathrine Lederballe; Kapetanovic, Meliha C.; Faustini, Francesca; Tuompo, Riitta; Lorenzen, Tove; Cagnotto, Giovanni; Baecklund, Eva; Hendricks, Oliver; Vedder, Daisy; Sokka-Isler, Tuulikki; Husmark, Tomas; Ljoså, Maud-Kristine Aga; Brodin, Eli; Ellingsen, Torkell; Söderbergh, Annika; Rizk, Milad; Olsson, Åsa Reckner; Larsson, Per; Uhrenholt, Line; Just, Søren Andreas; Stevens, David John; Laurberg, Trine Bay; Bakland, Gunnstein; Olsen, Inge Christoffer; Vollenhoven, Ronald F. (Peer reviewed; Journal article, 2020)
      Objective To evaluate and compare benefits and harms of three biological treatments with different modes of action versus active conventional treatment in patients with early rheumatoid arthritis. Design Investigator ...

    • Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors 

      Olsen, Oddrun Elise; Hella, Hanne; Elsaadi, Samah; Jacobi, Carsten; Martinez-Hackert, Erik; Holien, Toril (Peer reviewed; Journal article, 2020)
      Activins belong to the transforming growth factor (TGF)-β family of multifunctional cytokines and signal via the activin receptors ALK4 or ALK7 to activate the SMAD2/3 pathway. In some cases, activins also signal via the ...

    • Acute Diffusion Tensor and Kurtosis Imaging and Outcome following Mild Traumatic Brain Injury 

      Stenberg, Jonas; Eikenes, Live; Moen, Kent Gøran; Vik, Anne; Håberg, Asta; Skandsen, Toril (Peer reviewed; Journal article, 2021)
      In this prospective cohort study, we investigated associations between acute diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) metrics and persistent post-concussion symptoms (PPCS) 3 months after mild ...

    • Acute effects of high intensity training on cardiac function: a pilot study comparing subjects with type 2 diabetes to healthy controls 

      Ness, Henning Ofstad; Ljones, Kristine; Gjelsvik, Randi H; Tjønna, Arnt Erik; Malmo, Vegard; Nilsen, Hans-Olav; Hollekim-Strand, Siri Marte; Dalen, Håvard; Høydal, Morten (Peer reviewed; Journal article, 2022)
      This study evaluated acute cardiac stress after a high-intensity interval training session in patients with type 2 diabetes (T2D) versus healthy controls. High intensity aerobic exercise was performed by 4 × 4-min intervals ...

    • Acute effects of strength and endurance training on bone turnover markers in young adults and elderly men 

      Stunes, Astrid Kamilla; Brobakken, Cathrine Langlie; Sujan, Md Abu Jafar; Aagård, Norun; Brevig, Martin Siksjø; Wang, Eivind; Syversen, Unni; Mosti, Mats Peder (Peer reviewed; Journal article, 2022)
      Context: Exercise is recognized as an important strategy to prevent bone loss, but its acute effects on bone turnover markers (BTMs) and related markers remain uncertain. Objective: To assess the acute effects of two ...

    • Acute flaccid myelitis and Guillain-Barré syndrome in children: A comparative study with evaluation of diagnostic criteria. 

      Helfferich, J; Roodbol, Joyce; de Wit, Marie-Claire; Brouwer, Oebele F; Jacobs, Bart C.; Aberle, Stephan W.; Popow-Kraupp, Theresia; Nikolaeva-Glomb, Lubomira; Rainetova, Petra; Midgley, Sofie; Fischer, Thea Kølsen; Simonlatser, Grethel; Savolainen-Kopra, Carita; Lina, Bruno; Schuffenecker, Isabelle; Aubart, Melodie; Gitiaux, Cyril; Antona, Denise; Eis-Hübinger, Anna Maria; Buderus, Stephan; Panning, Marcus; Nowotny, Markus; Kiechle, Lisa; Böttcher, Sindy; Takas, Maria; Farkas, Agnes; Löve, Arthur; Baldanti, Fausto; Capobianchi, Maria Rosaria; Valli, Maria Beatrice; Esposito, Susanna; Pariani, Elena; Binda, Sandro; Neuteboom, Rinze; Pas, Suzan; Benschop, Kimberley; Meijer, Adam; Nordbø, Svein Arne; Hafström, Maria; Dudman, Susanne Gjeruldsen; Pfeiffer, Helle Cecilie Viekilde; Guiomar, Raquel; Palminha, Paula; Costa, Ines; Dias, Andrea Sofia; Tecu, Cristina; Cherciu, Carmen Maria; Lazarevic, Ivana; Filipovic-Vignjevic, Svetlana; Berginc, Natasa (Peer reviewed; Journal article, 2021)
      Background and purpose Differentiation between acute flaccid myelitis (AFM) and Guillain–Barré syndrome (GBS) can be difficult, particularly in children. Our objective was to improve the diagnostic accuracy by giving ...

    • Acute kidney injury in intensive care patients: Incidence, time course, and risk factors 

      Mo, Skule; Bjelland, Thor Wilhelm; Nilsen, Tom Ivar Lund; Klepstad, Pål (Peer reviewed; Journal article, 2022)
      Background Acute kidney injury (AKI) is frequent and influences the prognosis of intensive care unit (ICU) patients. The aim of this study was to estimate the incidence, time-course, risk factors, and mortality of AKI ...

    • Acute kidney injury in patients with COVID-19 in the intensive care unit: Evaluation of risk factors and mortality in a national cohort 

      Aukland, Eirik Aasen; Klepstad, Pål; Aukland, Stein Magnus; Zamanzad Ghavidel, Fatemeh; Buanes, Eirik Alnes (Peer reviewed; Journal article, 2022)
      Objectives Acute kidney injury (AKI) is a frequent complication among critical ill patients with COVID-19, but the actual incidence is unknown as AKI-incidence varies from 25% to 89% in intensive care unit (ICU) populations. ...

    • Adhd and mental health symptoms in the identification of young adults with increased risk of alcohol dependency in the general population—the hunt4 population study 

      Lauvsnes, Anders Dahlen Forsmo; Langaas, Mette; Olsen, Alexander; Vassileva, Jasmin; Spigset, Olav; Gråwe, Rolf Wilhelm (Peer reviewed; Journal article, 2021)
      Symptoms of ADHD are strongly associated with alcohol use disorders, and mental health symptoms attenuate this relationship. There is limited knowledge about how specific symptoms of inattentiveness and hyperactivity/impulsivity ...

    • Adherence to clinical guidelines for Barrett’s esophagus 

      Holmberg, Dag; Ness-Jensen, Eivind; Mattsson, Fredrik; Lagergren, Jesper (Journal article; Peer reviewed, 2019)
      Background and aim: Clinical guidelines recommend endoscopy surveillance at given intervals or endoscopic therapy for Barrett’s esophagus with low-grade dysplasia (LGD) and high-grade dysplasia (HGD). Whether these guidelines ...

    • Adiposity and risk of decline in glomerular filtration rate: Meta-analysis of individual participant data in a global consortium 

      Chang, Alex R.; Grams, Morgan E.; Ballew, Shoshana H.; Bilo, Henk; Correa, Adolfo; Evans, Marie; Gutierrez, Orlando M.; Hosseinpanah, Farhad; Iseki, Kunitoshi; Kenealy, Timothy; Klein, Barbara; Kronenberg, Florian; Lee, Brian J.; Li, Yuanying; Miura, Katsuyuki; Navaneethan, Sankar D.; Roderick, Paul J.; Valdivielso, Jose M.; Visseren, Frank L.J.; Zhang, Luxia; Gansevoort, Ron T.; Hallan, Stein; Levey, Andrew S.; Matsushita, Kunihiro; Shalev, Varda; Woodward, Mark (Journal article; Peer reviewed, 2019)
      Objective To evaluate the associations between adiposity measures (body mass index, waist circumference, and waist-to-height ratio) with decline in glomerular filtration rate (GFR) and with all cause mortality.Design ...

    • Admissions and surgery as indicators of hospital functions in Sierra Leone during the west-African Ebola outbreak 

      Bolkan, Håkon Angell; van Duinen, Aalke Johan; Samai, Mohammed; Bash-Taqi, Donald Alpha; Gassama, Ibarahim; Waalewijn, Bart; Wibe, Arne; von Schreeb, Johan (Journal article; Peer reviewed, 2018)
      Background In an attempt to assess the effects of the Ebola viral disease (EVD) on hospital functions in Sierra Leone, the aim of this study was to evaluate changes in provisions of surgery and non-Ebola admissions during ...

    • Adolescent siblings of children with cancer: a qualitative study from a salutogenic health promotion perspective 

      Løkkeberg, Birgit; Sollesnes, Ragnhild; Hestvik, Jorun; Langeland, Eva (Peer reviewed; Journal article, 2020)
      Purpose: To explore the experiences of adolescents with a sibling suffering from cancer from a salutogenic health promotion perspective. Methods: Seven female siblings aged 13–17 years were interviewed. The interviews ...

    • Advancements in predicting outcomes in patients with glioma: a surgical perspective 

      Jakola, Asgeir S; Sagberg, Lisa Millgård; Gulati, Sasha; Solheim, Ole (Peer reviewed; Journal article, 2020)
      Introduction: Diffuse glioma is a challenging neurosurgical entity. Although surgery does not provide a cure, it may greatly influence survival, brain function, and quality of life. Surgical treatment is by nature highly ...

    • Adverse childhood experiences and their association with substance use disorders in adulthood: A general population study (Young-HUNT) 

      Broekhof, Rosalie; Nordahl, Hans Morten; Tanum, Lars Håkon Reiestad; Selvik, Sara Germans (Peer reviewed; Journal article, 2023)
      Aim To investigate the association of adverse childhood experiences (ACEs) and substance use disorders (alcohol and illicit drug use disorders), specifically by gender, in a large longitudinal non-clinical population ...

    • Adverse events of exercise therapy in randomised controlled trials: A systematic review and meta-analysis 

      Niemeijer, Andre; Lund, Hans; Stafne, Signe Nilssen; Ipsen, Thomas; Goldschmidt, Cathrine Luhaäär; Jørgensen, Claus Thomas; Juhl, Carsten B. (Journal article; Peer reviewed, 2019)
      Objective To evaluate the relative risk (RR) of serious and non-serious adverse events in patients treated with exercise therapy compared with those in a non-exercising control group. Design Systematic review and ...

    • Adverse events with fatal outcome associated with alemtuzumab treatment in multiple sclerosis 

      Holmøy, Trygve; Fevang, Børre; Olsen, David Benee; Spigset, Olav; Bø, Lars (Journal article; Peer reviewed, 2019)
      Objective Sporadic fatal adverse events have been reported during treatment of multiple sclerosis with alemtuzumab. To provide a systematic overview, we searched the centralized European Medicines Agency database of ...

    • Adverse pregnancy outcomes among women in Norway with gestational diabetes using three diagnostic criteria 

      Rai, Anam Shakil; Sletner, Line; Jenum, Anne Karen; Øverby, Nina Cecilie; Stafne, Signe Nilssen; Qvigstad, Elisabeth; Pripp, Are Hugo; Sagedal, Linda (Peer reviewed; Journal article, 2023)
      Introduction The aim of this study was to examine the risk of adverse perinatal outcomes in women diagnosed with GDM by the World Health Organization (WHO) 1999 criteria, and in those retrospectively identified by the ...

    • Aerobic and cardiovascular autonomic adaptations to moderate intensity endurance exercise in patients with fibromyalgia 

      Bardal, Ellen Marie; Roeleveld, Karin; Mork, Paul Jarle (Journal article; Peer reviewed, 2015)
      Objective: To investigate whether moderate intensity endurance exercise has similar effects on cardiovascular fitness and autonomic function in patients with fibromyalgia and healthy controls. Design: Case-control ...

    • Aerobic high-intensity intervals improve V̇O2max more than supramaximal sprint intervals in females, similar to males 

      Helgerud, Jan; Hov, Håkon; Mehus, Håkon Andre; Balto, Bård; Boye, Anders Johan Nesheim; Finsås, Lars; Hoff, Jan; Wang, Eivind (Journal article; Peer reviewed, 2023)
      Introduction: Maximal oxygen uptake (V̇O2max) is a pivotal factor for aerobic endurance performance. Recently, aerobic high-intensity interval training (HIIT) was documented to be superior to sprint interval training (SIT) ...