Browsing St. Olavs hospital by Title
Now showing items 1792-1811 of 2579
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Physical function endpoints in cancer cachexia clinical trials: Systematic Review 1 of the cachexia endpoints series
(Peer reviewed; Journal article, 2023)In cancer cachexia trials, measures of physical function are commonly used as endpoints. For drug trials to obtain regulatory approval, efficacy in physical function endpoints may be needed alongside other measures. However, ... -
Physical Health Impairment and Exercise as Medicine in Severe Mental Disorders: A Narrative Review
(Peer reviewed; Journal article, 2022)Background: Individuals with severe mental disorders (SMDs; schizophrenia spectrum disorders, bipolar disorder, and major depressive disorder) are not only suffering from their mental conditions; they also have an attenuated ... -
Physical Performance and Cognition as Predictors of Instrumental Activities of Daily Living After Stroke: A Prospective Multicenter Cohort Study
(Journal article; Peer reviewed, 2022)Objective: To investigate whether cognition and physical performance, both separately and combined, 3 months post stroke predict change in instrumental activities of daily living (IADL) up to 18 months and whether different ... -
Physical rehabilitation in patients with head and neck cancer: Impact on health-related quality of life and suitability of a post-treatment program
(Peer reviewed; Journal article, 2020)Objective: Physical rehabilitation programs hold the potential to mitigate deterioration in health-related quality of life (HRQoL) in patients with head and neck cancer. The objective was to assess development in relevant ... -
Physical therapy intervention in patients with non-cardiac chest pain following a recent cardiac event: A randomized controlled trial
(Journal article; Peer reviewed, 2015)Objectives: To assess the effect of two different physical therapy interventions in patients with stable coronary heart disease and non-cardiac chest pain. Methods: A randomized controlled trial was carried out at a ... -
Physician Parents Attending Work Despite Own Sick Children: A Qualitative Study on Caregiver Presenteeism Among Norwegian Hospital Physicians
(Journal article; Peer reviewed, 2018)Background: Studies have shown that physicians manifest a clear duty to work, even in the face of personal risk, and despite their own symptoms of ill health; this is termed presenteeism. We lack knowledge on their ... -
Physicians' perceptions of patient participation and the involvement of family caregivers in the palliative care pathway
(Peer reviewed; Journal article, 2022)Introduction Patient participation is essential for quality palliative care, and physicians play a crucial role in promoting participation. This study explores physicians' perceptions of patients and family caregivers' ... -
Physicians’ Mental Health and Nationality Affect how Work Characteristics Influence Presenteeism
(Journal article; Peer reviewed, 2018)This study aimed to investigate how variations in mental health and nationality affect the influence of job demands and job resources on presenteeism among physicians. By differentiating between hindrances and challenging ... -
Physicians’ Recognition and Management of Kidney Disease: A Randomized Vignette Study Evaluating the Impact of the KDIGO 2012 CKD Classification System
(Peer reviewed; Journal article, 2020)Rationale & Objective The Kidney Disease Outcome Quality Initiative (KDOQI) and Kidney Disease: Improving Global Outcomes (KDIGO) chronic kidney disease (CKD) classification systems published in 2002 and 2012, respectively, ... -
Physiological and Perceptual Responses to Single-player vs. Multiplayer Exergaming
(Peer reviewed; Journal article, 2022)Rationale: Since many modern exergames include a multiplayer component, this study aimed to compare the physiological and perceptual responses between playing a cycling exergame alone or with others. Methods: In this ... -
Physiological effects of intraperitoneal versus subcutaneous insulin infusion in patients with diabetes mellitus type 1: A systematic review and meta-analysis
(Peer reviewed; Journal article, 2021)The intraperitoneal route of administration accounts for less than 1% of insulin treatment regimes in patients with diabetes mellitus type 1 (DM1). Despite being used for decades, a systematic review of various physiological ... -
Physiological hypoxia improves growth and functional differentiation of human intestinal epithelial organoids
(Peer reviewed; Journal article, 2023)Background: The epithelium in the colonic mucosa is implicated in the pathophysiology of various diseases, including inflammatory bowel diseases and colorectal cancer. Intestinal epithelial organoids from the colon (colonoids) ... -
Physiological responses during clinical spasticity evaluation in elbow flexors in children with cerebral palsy
(Journal article; Peer reviewed, 2018) -
Physiological significance of pre- and post-ejection left ventricular tissue velocities and relations to mitral and aortic valve closures
(Peer reviewed; Journal article, 2021)Background: Tissue Doppler shows short duration velocity spikes during pre- and post-ejection (protodiastole). They have been assumed to be isovolumic contraction and relaxation movements, but this is not in accordance ... -
Physiologically-based pharmacokinetic models for CYP1A2 drug-drug interaction prediction: A modeling network of fluvoxamine, theophylline, caffeine, rifampicin, and midazolam
(Journal article; Peer reviewed, 2019)This study provides whole‐body physiologically‐based pharmacokinetic models of the strong index cytochrome P450 (CYP)1A2 inhibitor and moderate CYP3A4 inhibitor fluvoxamine and of the sensitive CYP1A2 substrate theophylline. ... -
Picomolar FKBP inhibitors enabled by a single water-displacing methyl group in bicyclic [4.3.1] aza-amides
(Journal article; Peer reviewed, 2021)Methyl groups can have profound effects in drug discovery but the underlying mechanisms are diverse and incompletely understood. Here we report the stereospecific effect of a single, solvent-exposed methyl group in bicyclic ... -
Placental inflammation by HMGB1 activation of TLR4 at the syncytium
(Peer reviewed; Journal article, 2018)Introduction: Normal pregnancy is characterized by an elevated inflammatory state involving the placenta. The placental inflammation is further increased in preeclampsia, resulting in release of harmful danger signals ... -
Placental inflammation by HMGB1 activation of TLR4 at the syncytium
(Peer reviewed; Journal article, 2018)Normal pregnancy is characterized by an elevated inflammatory state involving the placenta. The placental inflammation is further increased in preeclampsia, resulting in release of harmful danger signals to the maternal ... -
Placental inflammation in pre-eclampsia by Nod-like receptor protein (NLRP)3 inflammasome activation in trophoblasts
(Journal article; Peer reviewed, 2018)Pre‐eclampsia is associated with increased levels of cholesterol and uric acid and an inflamed placenta expressing danger‐sensing pattern recognition receptors (PRRs). Crystalline cholesterol and uric acid activate the PRR ... -
Plasma apolipoprotein E levels in longitudinally followed patients with mild cognitive impairment and Alzheimer’s disease
(Peer reviewed; Journal article, 2022)Background Low levels of plasma apolipoprotein E (apoE) and presence of the APOE ε4 allele are associated with an increased risk of Alzheimer’s disease (AD). Although the increased risk of AD in APOE ε4-carriers is ...