Blar i St. Olavs hospital på tittel

Viser treff 1427-1446 av 2460

    • MicroRNA profiling of psoriatic skin identifies 11 miRNAs associated with disease severity 

      Solvin, Åshild Øksnevad; Chawla, Konika; Olsen, Lene Christin; Hegre, Siv Anita; Danielsen, Kjersti; Jenssen, Marita; Furberg, Anne-Sofie; Saunes, Marit; Hveem, Kristian; Sætrom, Pål; Løset, Mari (Peer reviewed; Journal article, 2021)
      MicroRNAs (miRNAs) are small non-coding RNAs that have emerged as central regulators of gene expression and powerful biomarkers of disease. Much is yet unknown about their role in psoriasis pathology. To globally characterize ...

    • microRNA-451a prevents activation of matrix metalloproteinases 2 and 9 in human cardiomyocytes during pathological stress stimulation. 

      Scrimgeour, Nathan Robert; Wrobel, Aleksandra Zofia; Pinho, Maria; Høydal, Morten (Peer reviewed; Journal article, 2019)
      Matrix metalloproteinases (MMP) are important for cardiac remodeling. Recently, microRNA (miR)-451a has been found to inhibit the expression of both MMP-2 and MMP-9 in human malignancies, but its role in cardiomyocytes has ...

    • Microscale nuclear magnetic resonance gradient chip 

      Meissner, Markus V; While, Peter Thomas; Mager, Dario; Korvink, Jan G. (Peer reviewed; Journal article, 2022)
      We propose a design, micro fabrication process, and nuclear magnetic resonance (NMR) based evaluation, of a magnetic field gradient chip. The uni-axial linear z-gradient coil design was computed by a stream-function method, ...

    • A middle-out modeling strategy to extend a colon cancer logical model improves drug synergy predictions in epithelial-derived cancer cell lines 

      Tsirvouli, Eirini; Touré, Vasundra; Niederdorfer, Barbara; Vazquez Garcia, Miguel; Flobak, Åsmund; Kuiper, Martin (Peer reviewed; Journal article, 2020)
      Cancer is a heterogeneous and complex disease and one of the leading causes of death worldwide. The high tumor heterogeneity between individuals affected by the same cancer type is accompanied by distinct molecular and ...

    • Migraine and risk of stroke 

      Øie, Lise Rystad; Kurth, Tobias; Gulati, Sasha; Dodick, David W. (Peer reviewed; Journal article, 2020)
      Migraine and stroke are two common and heterogeneous neurovascular disorders responsible for a significant burden for those affected and a great economic cost for the society. There is growing evidence that migraine increases ...

    • Mild to Moderate Cognitive Impairment Does Not Affect the Ability to Self-Report Important Symptoms in Patients With Cancer: A Prospective Longitudinal Multinational Study (EPCCS) 

      Ekström, Magnus P.; Palmqvist, Sebastian; Currow, David C.; Sjøgren, Per; Kurita, Geana Paula; Jakobsen, Gunnhild; Kaasa, Stein; Hjermstad, Marianne Jensen (Peer reviewed; Journal article, 2020)
      Context Patients with advanced cancer commonly suffer from both distressing symptoms and cognitive impairment, but the effect of cognitive impairment on the reliability and validity of symptom self-report is unknown. ...

    • Mild to moderate partial sleep deprivation is associated with increased impulsivity and decreased positive affect in young adults 

      Saksvik-Lehouillier, Ingvild; Saksvik, Simen Berg; Dahlberg, Berit Johanna; Tanum, Tiril Kristine; Ringen, Heidi; Karlsen, Håvard Rudi; Smedbøl, Trine; Sørengaard, Torhild Anita; Stople, Mailen; Kallestad, Håvard; Olsen, Alexander (Peer reviewed; Journal article, 2020)
      The effects of mild–moderate partial sleep deprivation on affective and cognitive functioning were evaluated in a naturalistic home environment, mimicking short sleep typically caused by demands from work or society. A ...

    • The Minimum Information about a Molecular Interaction Causal Statement (MI2CAST) 

      Touré, Vasundra; Vercruysse, Steven; Acencio, Marcio Luis; Lovering, Ruth C.; Orchard, Sandra; Bradley, Glyn; Casals-Casas, Cristina; Chaouiya, Claudine; del-Toro, Noemi; Flobak, Åsmund; Gaudet, Pascale; Hermjakob, Henning; Hoyt, Charles Tapley; Licata, Luana; Lægreid, Astrid; Mungall, Christopher; Niknejad, Anne; Panni, Simona; Perfetto, Livia; Porras, Pablo; Pratt, Dexter; Saez-Rodriguez, Julio; Thieffry, Denis; Thomas, Paul; Türei, Dénes; Kuiper, Martin (Peer reviewed; Journal article, 2020)
      Motivation A large variety of molecular interactions occurs between biomolecular components in cells. When a molecular interaction results in a regulatory effect, exerted by one component onto a downstream component, a ...

    • miR-210 Regulates Apoptotic Cell Death during Cellular Hypoxia and Reoxygenation in a Diametrically Opposite Manner 

      Marwarha, Gurdeep; Røsand, Øystein; Scrimgeour, Nathan Robert; Slagsvold, Katrine Hordnes; Høydal, Morten (Peer reviewed; Journal article, 2021)
      Apoptotic cell death of cardiomyocytes is a characteristic hallmark of ischemia–reperfusion (I/R) injury. The master hypoxamiR, microRNA-210 (miR-210), is considered the primary driver of the cellular response to hypoxic ...

    • Missing Data in Prediction Research: A Five-Step Approach for Multiple Imputation, Illustrated in the CENTER-TBI Study 

      Gravesteijn, Benjamin; Sewalt, Charlie; Venema, Esmee; Nieboer, Daan; Steyerberg, Ewout W.; Andelic, Nada; Andreassen, Lasse; Anke, Audny Gabriele Wagner; Frisvold, Shirin; Helseth, Eirik; Røe, Cecilie; Røise, Olav; Skandsen, Toril; Vik, Anne; Åkerlund, Cecilia; Amrein, Krisztina; Antoni, Anna; Audibert, Gerard; Azouvi, Philippe; Azzolini, Maria luisa; Bartels, Ronald; Barzo, Pal; Beauvais, Romuald; Beer, Ronny; Bellander, Bo-michael; Belli, Antonio; Benali, Habib; Berardino, Maurizio; Beretta, Luigi; Blaabjerg, Morten; Bragge, Peter; Brazinova, Alexandra; Brinck, Vibeke; Brooker, Joanne; Brorsson, Camilla; Buki, Andras; Bullinger, Monika; Cabeleira, Manuel; Caccioppola, Alessio; Calappi, Emiliana; Calvi, Maria rosa; Cameron, Peter; Lozano, Guillermo carbayo; Carbonara, Marco; Chevallard, Giorgio; Chieregato, Arturo; Citerio, Giuseppe; Cnossen, Maryse; Coburn, Mark (Peer reviewed; Journal article, 2021)
      In medical research, missing data is common. In acute diseases, such as traumatic brain injury (TBI), even well-conducted prospective studies may suffer from missing data in baseline characteristics and outcomes. Statistical ...

    • Mitigating adolescent social anxiety symptoms: the effects of social support and social self-efficacy in findings from the Young-HUNT 3 study 

      Aune, Tore; Juul, Else Marie Lysfjord; Beidel, Deborah C.; Nordahl, Hans Morten; Dvorak, Robert D. (Peer reviewed; Journal article, 2020)
      Adolescents’ exposure to negative life events (NLEs) and potentially traumatic events is highly prevalent and increases their risk of developing psychological disorders considerably. NLE exposure has also been linked to ...

    • Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation 

      Niyonzima, Nathalie; Rahman, Jubayer; Kunz, Natalie; West, Erin; Freiwald, Tilo; Desai, Jigar V.; Merle, Nicolas; Gidon, Alexandre; Sporsheim, Bjørnar; Lionakis, Michail S.; Evensen, Kristin; Lindberg, Beate; Skagen, Karolina; Skjelland, Mona; Singh, Parul; Haug, Markus; Ruseva, Marieta M.; Kolev, Martin; Bibby, Jack; Marshall, Olivia; O’Brien, Brett; Deeks, Nigel; Afzali, Behdad; Clark, Richard J.; Woodruff, Trent M.; Pryor, Mylton; Yang, Zhi-Hong; Remaley, Alan T.; Mollnes, Tom Eirik; Hewitt, Stephen M.; Yan, Bingyu; Kazemian, Majid; Kiss, Mate G.; Binder, Christoph J.; Halvorsen, Bente; Espevik, Terje; Kemper, Claudia (Peer reviewed; Journal article, 2021)
      While serum-circulating complement destroys invading pathogens, intracellularly active complement, termed the “complosome,” functions as a vital orchestrator of cell-metabolic events underlying T cell effector responses. ...

    • Mitochondrial genome-wide association study of migraine – the HUNT Study 

      Børte, Sigrid; Zwart, John-Anker; Skogholt, Anne Heidi; Gabrielsen, Maiken Elvestad; Thomas, Laurent; Fritsche, Lars G; Surakke, Ida; Nielsen, Jonas B.; Zhou, Wei; Wolford, Brooke; Vigeland, Magnus Dehli; Hagen, Knut; Kristoffersen, Espen Saxhaug; Nyholt, Dale R; Chasman, Daniel I; Brumpton, Ben Michael; Willer, Christen; Winsvold, Bendik K S (Peer reviewed; Journal article, 2020)
      Background Variation in mitochondrial DNA (mtDNA) has been indicated in migraine pathogenesis, but genetic studies to date have focused on candidate variants, with sparse findings. We aimed to perform the first mitochondrial ...

    • Mitochondrial Mechanisms of LRRK2 G2019S Penetrance 

      Delcambre, Sylvie; Ghelfi, Jenny; Ouzren, Nazzima; Grandmougin, Lea; Delbrouck, Catherine; Seibler, Philip; Wasner, Kobi; Aasly, Jan; Klein, Christine; Trinh, Joanne; Pereira, Sandro L; Grünewald, Anne (Peer reviewed; Journal article, 2020)
      Several mutations in leucine-rich repeat kinase-2 (LRRK2) have been associated with Parkinson's disease (PD). The most common substitution, G2019S, interferes with LRRK2 kinase activity, which is regulated by autophosphorylation. ...

    • Mn-alginate gels as a novel system for controlled release of Mn2+ in manganese-enhanced MRI 

      Mørch, Yrr Asbjørg; Sandvig, Ioanna; Olsen, Øystein; Donati, Ivan; Thuen, Marte; Skjåk-Bræk, Gudmund; Haraldseth, Olav; Brekken, Christian (Journal article; Peer reviewed, 2012)
      The aim of the present study was to test alginate gels of different compositions as a system for controlled release of manganese ions (Mn2+) for application in manganese‐enhanced MRI (MEMRI), in order to circumvent the ...

    • Mobile Assessments of Mood, Cognition, Smartphone-Based Sensor Activity, and Variability in Craving and Substance Use in Patients With Substance Use Disorders in Norway: Prospective Observational Feasibility Study 

      Lauvsnes, Anders Dahlen Forsmo; Hansen, Tor Ivar; Ankill, Sebastian Øiungen; Bae, Sang Won; Gråwe, Rolf W.; Braund, Taylor A.; Larsen, Mark; Langaas, Mette (Peer reviewed; Journal article, 2023)
      Background: Patients with substance use disorders (SUDs) are at increased risk for symptom deterioration following treatment, with up to 60% resuming substance use within the first year posttreatment. Substance use craving ...

    • Mobile Sensing in Substance Use Research: A Scoping Review 

      Lauvsnes, Anders Dahlen Forsmo; Langaas, Mette; Toussaint, Pieter Jelle; Gråwe, Rolf W. (Peer reviewed; Journal article, 2020)
      Background:Addictive disorders and substance use are significant health challenges worldwide, and relapse is a core component of addictive disorders. The dynamics surrounding relapse and especially the immediate period ...

    • Mode of delivery of Cognitive Behavioral Therapy for Insomnia: a randomized controlled non-inferiority trial of digital and face-to-face therapy 

      Kallestad, Håvard; Scott, Janine Linda; Vedaa, Øystein; Lydersen, Stian; Vethe, Daniel; Morken, Gunnar; Stiles, Tore C; Sivertsen, Børge; Langsrud, Knut (Peer reviewed; Journal article, 2021)
      Study Objectives Digital Cognitive Behavioral Therapy for Insomnia (dCBT-I) has demonstrated efficacy in reducing insomnia severity in self-referred and community samples. It is unknown, however, how dCBT-I compares to ...

    • Modeling Obesity in Norway (The MOON Study): A Decision-Analytic Approach—Prevalence, Costs, and Years of Life Lost 

      Bjørnelv, Gudrun Maria Waaler; Halsteinli, Vidar; Kulseng, Bård Eirik; Sonntag, Diana; Ødegård, Rønnaug (Peer reviewed; Journal article, 2020)
      Background. Limited knowledge exists on the expected long-term effects and cost-effectiveness of initiatives aiming to reduce the burden of obesity. Aim. To develop a Norwegian obesity-focused disease-simulation model: the ...

    • Modeling the diffusion-weighted imaging signal for breast lesions in the b = 200 to 3000 s/mm 2 range: quality of fit and classification accuracy for different representations 

      Vidic, Igor; Egnell, Liv Elisabet; Jerome, Neil Peter; White, Nathan; Karunamuni, Roshan; Rakow-Penner, Rebecca; Dale, Anders M.; Bathen, Tone Frost; Goa, Pål Erik (Peer reviewed; Journal article, 2020)
      Purpose To evaluate different non‐Gaussian representations for the diffusion‐weighted imaging (DWI) signal in the b‐value range 200 to 3000 s/mm2 in benign and malignant breast lesions. Methods Forty‐three patients ...