Blar i Institutt for bioteknologi og matvitenskap på tittel
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Metabolic Engineering of thermophilic Bacillus methanolicus for riboflavin overproduction from methanol
(Peer reviewed; Journal article, 2023)The growing need of next generation feedstocks for biotechnology spurs an intensification of research on the utilization of methanol as carbon and energy source for biotechnological processes. In this paper, we introduced ... -
Metabolic engineering to understand and control productionof l-glutamate from methanol by the methylotrophic thermotolerant bacterium Bacillus methanolicus
(Doktoravhandlinger ved NTNU, 1503-8181; 2013:337, Doctoral thesis, 2013)The production of L-glutamate and L-lysine together excides 3.5 million tons annually and are the most important amino acids in production volume. Their production is based on fermentation processes with the bacterium ... -
Metabolic memory underlying minimal residual disease in breast cancer
(Peer reviewed; Journal article, 2021)Tumor relapse from treatment-resistant cells (minimal residual disease, MRD) underlies most breast cancer-related deaths. Yet, the molecular characteristics defining their malignancy have largely remained elusive. Here, ... -
Metabolic network layout using biochemical coordinates
(Master thesis, 2022)De kjemiske egenskapene til molekyler er preget av numeriske verdier kjent som molekylære deskriptorer og beregnes fra molekylære representasjoner i kjeminformatiske verktøy. Ulike molekylære deskriptorer brukes for å ... -
Metabolic Profiling of Cisplatin and ATX-101 Induced Stress-responses in the Bladder Cancer Cell Line T24
(Master thesis, 2016)Proliferating cell nuclear antigen (PCNA) is a protein central in many cellular processes through its numerous protein interaction partners. Recently, it has been shown that several proteins involved in stress related ... -
Metabolic Profiling of Escherichia coli BL21 During Recombinant Protein Production with Varying Expression Vector Characteristics
(Master thesis, 2022)The production of recombinant proteins usingmicrobial cell factories such as Escherichia coli (E. coli) is both a high value industry and a growing area of interest for the field of metabolomics. While historical industrial ... -
Metabolic Profiling of Glucose-Fed Metabolically Active Resting Zymomonas mobilis Strains
(Peer reviewed; Journal article, 2020)Zymomonas mobilis is the most efficient bacterial ethanol producer and its physiology is potentially applicable to industrial-scale bioethanol production. However, compared to other industrially important microorganisms, ... -
Metabolic Profiling of Multiple Myeloma Cancer Cells During Exposure to Chemotherapeutic Drugs: A Study of the Effects of ATX-101
(Master thesis, 2014)This thesis investigates the metabolomic stress response induced in JJN-3 cells treated with the cell-penetrating peptide ATX-A, the anti-cancer drug ATX-101, the chemotherapeutic drug cisplatin, and combinations of these ... -
Metabolic Profiling of the Glioblastoma Cell Line U-87 MG in Response to Hypoxia and HIF-1alpha Inhibitors
(Master thesis, 2020)Glioblastom er en krefttype med høy dødelighet, og dens dødelighet har sammenheng med graden av hypoksi. Hypoksi, fraværet av nok oksygenering av vev, vil aktivere en rekke tilpasninger som fører til økning i behandlingsresistens ... -
Metabolic Responses to Colistin Sulfate and Trimethoprim Perturbation in Escherichia coli K12 MG1655
(Master thesis, 2022)Antibiotika er antibakterielle molekyler som brukes i behandling mot bakterieinfeksjoner, men grunnet overforbruk og feilbruk har antibiotikaresistens blitt et økende problem. Antibiotikaresistens regnes som en av de største ... -
Metabolic Stress Study of a Human Embryotic Kidney Cell Line exposed to Chemotherapeutic Drugs: Mass Spectrometry based Targeted and Non-targeted Approach
(Master thesis, 2014)Metabolomics, the study of metabolites in a cell, has proven as an applicable approach in cancer research to investigate the altered metabolism of cancer cells and to develop new selective chemotherapeutic drugs. ATX-101 ... -
Metabolism fingerprinting of the antibiotic- producing bacterium Streptomyces coelicolor
(Master thesis, 2010)The aim of this master thesis project was to do a metabolism fingerprinting of streptomyces coelicolor strain A3(2)M145 growing in a fermentation vessel on a phosphate dependent medium. Three biological replicates were ... -
Metabolite profiling and kinetic modeling of antibiotic producing Streptomyces coelicolor in response to metabolic switching triggered by nutrient depletion
(Master thesis, 2020)Rask framvekst av antibiotikaresistens i patogene bakteriar er ei global helsekrise. Handtering av denne krisa krev rask oppdaging og effektiv produksjon av nye antibiotiske biosyntetiske genklynger (BGC). Ein potensiell ... -
Metabolome Studies of Stress Responses in Saccharomyces Cerevisiae : - implementation of sampling and analytical protocols
(Master thesis, 2011)As a part of cancer research and therapy, it is important to study metabolic responses caused by DNA damaging agents. Whereas earlier studies have focused on changes at protein levels caused by DNA damaging agents, this ... -
Metabolsk Tilpasning til Hypoksi i Prostatakreftcellelinjen DU-145 og i Glioblastoma-Astrocytoma Kreftcellelinjen U-87 MG
(Master thesis, 2017)Regioner med lav oxygentensjon (hypoksiske regioner) er karakteristisk for solide tumorer. Hypoksiske forhold fremkommer når den raske cellulære prolifereringen begrenser oksygentilgangen. Proteinkomplekset proliferating ... -
Metagenomic mapping of bacterial microflora from salmon lice (Lepeophtheirus salmonis) with next-generation sequencing of the 16S ribosomal RNA gene
(Master thesis, 2019)Lakselusen (Lepeophtheirus salmonis) og fiskesykdommer er store utfordringer innen akvakultur. I denne studien ble den bakterielle mikrofloraen til L. salmonis, samlet fra åtte måneder, kartlagt for å finne informasjon om ... -
Methane monooxygenases: central enzymes in methanotrophy with promising biotechnological applications
(Peer reviewed; Journal article, 2021)Worldwide, the use of methane is limited to generating power, electricity, heating, and for production of chemicals. We believe this valuable gas can be employed more widely. Here we review the possibility of using methane ... -
Methanol as a carbon substrate in the bio-economy: metabolic engineering of aerobic methylotrophic bacteria for production of value-added chemicals
(Journal article; Peer reviewed, 2017)Bacteria are widely used as cell factories for production of enzymes and chemicals, mostly from sugars. Methylotrophic bacteria can utilize the one-carbon compound methanol as sole carbon source for growth, and metabolic ... -
Methanol-based acetoin production by genetically engineered Bacillus methanolicus
(Journal article; Peer reviewed, 2019)Methanol is an attractive alternative non-food feedstock for industrial fermentations that can be used instead of sugar-based raw materials. Here, the thermophilic and methylotrophic bacterium Bacillus methanolicus MGA3 ... -
Methanol-based cadaverine production by genetically engineered Bacillus methanolicus strains
(Journal article; Peer reviewed, 2015)Methanol is regarded as an attractive substrate for biotechnological production of value-added bulk products, such as amino acids and polyamines. In the present study, the methylotrophic and thermophilic bacterium Bacillus ...