Institutt for bioteknologi og matvitenskap
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Absolute Quantification of the Central Carbon Metabolome in Eight Commonly Applied Prokaryotic and Eukaryotic Model Systems
(Peer reviewed; Journal article, 2020)Absolute quantification of intracellular metabolite pools is a prerequisite for modeling and in-depth biological interpretation of metabolomics data. It is the final step of an elaborate metabolomics workflow, with challenges ... -
ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine
(Peer reviewed; Journal article, 2020)Recurrent somatic mutations in ETNK1 (Ethanolamine-Kinase-1) were identified in several myeloid malignancies and are responsible for a reduced enzymatic activity. Here, we demonstrate in primary leukemic cells and in cell ... -
Zwitterionic HILIC tandem mass spectrometry with isotope dilution for rapid, sensitive and robust quantification of pyridine nucleotides in biological extracts
(Peer reviewed; Journal article, 2020)The pyridine nucleotides nicotineamide adenine dinucleotide (NAD) and nicotineamide adenine dinucleotide phosphate (NADP) are conserved coenzymes across all domains of life, and are involved in more than 200 different ... -
Metabolic engineering of Bacillus methanolicus for production of recombinant proteins and acetoin from methanol
(Doctoral theses at NTNU;2020:339, Doctoral thesis, 2020)The use of methanol as a carbon source for industrial biotechnology is a tantalizing prospect. Methanol is highly abundant, and has a long history of efficient, large-scale production. It can be produced abiotically from ... -
Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling
(Peer reviewed; Journal article, 2020)Cell replacement therapies hold great therapeutic potential. Nevertheless, our knowledge of the mechanisms governing the developmental processes is limited, impeding the quality of differentiation protocols. Generating ... -
Metabolic Profiling of Glucose-Fed Metabolically Active Resting Zymomonas mobilis Strains
(Peer reviewed; Journal article, 2020)Zymomonas mobilis is the most efficient bacterial ethanol producer and its physiology is potentially applicable to industrial-scale bioethanol production. However, compared to other industrially important microorganisms, ... -
Increased salt tolerance in Zymomonas mobilis strain generated by adaptative evolution
(Peer reviewed; Journal article, 2020)Background Ethanologenic alphaproteobacterium Zymomonas mobilis has been acknowledged as a promising biofuel producer. There have been numerous efforts to engineer this species applicable for an industrial-scale bioethanol ... -
An assessment of serial co-cultivation approach for generating novel Zymomonas mobilis strains
(Peer reviewed; Journal article, 2020)Objective The alphaproteobacterium Zymomonas mobilis is an efficient ethanol producer, and Z. mobilis-based biorefinery shows great potential for biofuel production. Serial co-cultivation is an emerging approach that ... -
A comparison of two seawater adaptation strategies for Atlantic salmon post-smolt (Salmo salar) grown in recirculating aquaculture systems (RAS): Nitrification, water and gut microbiota, and performance of fish
(Peer reviewed; Journal article, 2021)The land-based production phase in Norwegian Atlantic salmon farming has the past years been extended to include post-smolt for an increasing number of farmers. Post-smolt production can involve introduction of brackish/seawater ... -
Bacterial community assembly in Atlantic cod larvae (Gadus morhua): Contributions of ecological processes and metacommunity structure
(Peer reviewed; Journal article, 2020)Many studies demonstrate the importance of the commensal microbiomes to animal health and development. However, the initial community assembly process is poorly understood. It is unclear to what extent the hosts select for ... -
Emerging Techniques for Differentiation of Fresh and Frozen–Thawed Seafoods: Highlighting the Potential of Spectroscopic Techniques
(Peer reviewed; Journal article, 2020)Fish and other seafood products have a limited shelf life due to favorable conditions for microbial growth and enzymatic alterations. Various preservation and/or processing methods have been developed for shelf-life extension ... -
A comparative study of Atlantic salmon chilled in refrigerated seawater versus on ice: from whole fish to cold-smoked fillets
(Peer reviewed; Journal article, 2020)Water and salt uptake, and water holding capacity (WHC) of whole gutted Atlantic salmon superchilled at sub-zero temperatures in refrigerated seawater (RSW) were compared to traditional ice storage. Following the entire ... -
Enzyme-Constrained Models and Omics Analysis of Streptomyces coelicolor Reveal Metabolic Changes that Enhance Heterologous Production
(Journal article; Peer reviewed, 2020)Many biosynthetic gene clusters (BGCs) require heterologous expression to realize their genetic potential, including silent and metagenomic BGCs. Although the engineered Streptomyces coelicolor M1152 is a widely used host ... -
Rheology of skin mucus from yolk-sac salmon fry
(Journal article; Peer reviewed, 2020)As part of our project “Microbial contributions to the Atlantic salmon (Salmo salar) skin mucosal barrier” we have explored techniques to investigate and characterise the rheological properties of the skin mucus of yolk-sac ... -
Effect of chilling technologies on water holding properties and other quality parameters throughout the whole value chain: From whole fish to cold-smoked fillets of Atlantic salmon (Salmo salar)
(Peer reviewed; Journal article, 2020)The effect of different chilling technologies on water holding and quality parameters was investigated on Atlantic salmon throughout the entire value chain. Chilling technologies of whole fish before filleting, included ... -
Potential of innovative pre-treatment technologies for the revalorisation of residual materials from the chicken industry through enzymatic hydrolysis
(Peer reviewed; Journal article, 2020)The effect of microwave, ultrasound and high-pressure pre-treatment prior to enzymatic hydrolysis of mechanically deboned chicken residuals was evaluated. Increased protein extraction yield was observed for high-pressure ... -
Effect of design geometry, exposure energy, cytophilic molecules, cell type and load in fabrication of single-cell arrays using micro-contact printing
(Journal article; Peer reviewed, 2020)In this study a range of factors influencing the fabrication of single-cell arrays (SCAs) are identified and investigated. Micro-contact printing was used to introduce spots coated with polyethyleneimine or Matrigel on ... -
Assessment of Astaxanthin Accumulation in Hepatocytes of Atlantic Salmon Fed Different Diets Using NMR Spectroscopy
(Journal article; Peer reviewed, 2020)This study aimed to assess the astaxanthin (Ax) accumulation in hepatocytes isolated from farmed Atlantic salmon fed different diets (rich marine, poor, poor with marine phospholipids (MPL) and poor with docosahexaenoic ... -
Study and Engineering of Gram- Negative Bacteria as Hosts for Production of Recombinant Proteins and Biopolymers
(Doctoral theses at NTNU;2020:173, Doctoral thesis, 2020)Gram-negative bacteria are a large group of prokaryotic organisms that thrive in diverse environments and differ in terms of structure and metabolism. They are capable of producing a variety of natural compounds and ... -
Modelling biodegradation of crude oil components at low temperatures
(Others, 2020)For oil spilled at sea, the main weathering processes are evaporation, emulsification, photo-oxidation, dispersion and biodegradation. Of these, only biodegradation may completely remove hydrocarbons from the environment ...
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