Vis enkel innførsel

dc.contributor.authorHjermstad, Marianne Jensen
dc.contributor.authorJakobsen, Gunnhild
dc.contributor.authorArends, Jann
dc.contributor.authorBalstad, Trude Rakel
dc.contributor.authorBrown, Leo R.
dc.contributor.authorBye, Asta
dc.contributor.authorCoats, Andrew J.S.
dc.contributor.authorDajani, Olav
dc.contributor.authorDolan, Ross D.
dc.contributor.authorFallon, Marie T.
dc.contributor.authorGreil, Christine
dc.contributor.authorGrzyb, Alexandra
dc.contributor.authorKaasa, Stein
dc.contributor.authorKoteng, Lisa Heide
dc.contributor.authorMay, Anne M.
dc.contributor.authorMcDonald, James
dc.contributor.authorOttestad, Inger
dc.contributor.authorPhilips, Iain
dc.contributor.authorRoeland, Eric J.
dc.contributor.authorSayers, Judith
dc.contributor.authorSimpson, Melanie Rae
dc.contributor.authorSkipworth, Richard J.E.
dc.contributor.authorSolheim, Tora S
dc.contributor.authorSousa, Mariana S.
dc.contributor.authorVagnildhaug, Ola Magne
dc.contributor.authorLaird, Barry J.A.
dc.date.accessioned2024-07-31T12:40:59Z
dc.date.available2024-07-31T12:40:59Z
dc.date.created2024-04-23T16:54:58Z
dc.date.issued2024
dc.identifier.citationJournal of Cachexia, Sarcopenia and Muscle. 2024, .en_US
dc.identifier.issn2190-5991
dc.identifier.urihttps://hdl.handle.net/11250/3143891
dc.description.abstractThe use of patient-reported outcomes (PROMs) of quality of life (QOL) is common in cachexia trials. Patients' self-report on health, functioning, wellbeing, and perceptions of care, represent important measures of efficacy. This review describes the frequency, variety, and reporting of QOL endpoints used in cancer cachexia clinical trials. Electronic literature searches were performed in Medline, Embase, and Cochrane (1990–2023). Seven thousand four hundred thirty-five papers were retained for evaluation. Eligibility criteria included QOL as a study endpoint using validated measures, controlled design, adults (>18 years), ≥40 participants randomized, and intervention exceeding 2 weeks. The Covidence software was used for review procedures and data extractions. Four independent authors screened all records for consensus. Papers were screened by titles and abstracts, prior to full-text reading. PRISMA guidance for systematic reviews was followed. The protocol was prospectively registered via PROSPERO (CRD42022276710). Fifty papers focused on QOL. Twenty-four (48%) were double-blind randomized controlled trials. Sample sizes varied considerably (n = 42 to 469). Thirty-nine trials (78%) included multiple cancer types. Twenty-seven trials (54%) featured multimodal interventions with various drugs and dietary supplements, 11 (22%) used nutritional interventions alone and 12 (24%) used a single pharmacological intervention only. The median duration of the interventions was 12 weeks (4–96). The most frequent QOL measure was the EORTC QLQ-C30 (60%), followed by different FACIT questionnaires (34%). QOL was a primary, secondary, or exploratory endpoint in 15, 31 and 4 trials respectively, being the single primary in six. Statistically significant results on one or more QOL items favouring the intervention group were found in 18 trials. Eleven of these used a complete multidimensional measure. Adjustments for multiple testing when using multicomponent QOL measures were not reported. Nine trials (18%) defined a statistically or clinically significant difference for QOL, five with QOL as a primary outcome, and four with QOL as a secondary outcome. Correlation statistics with other study outcomes were rarely performed. PROMs including QOL are important endpoints in cachexia trials. We recommend using well-validated QOL measures, including cachexia-specific items such as weight history, appetite loss, and nutritional intake. Appropriate statistical methods with definitions of clinical significance, adjustment for multiple testing and few co-primary endpoints are encouraged, as is an understanding of how interventions may relate to changes in QOL endpoints. A strategic and scientific-based approach to PROM research in cachexia trials is warranted, to improve the research base in this field and avoid the use of QOL as supplementary measures.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleQuality of life endpoints in cancer cachexia clinical trials: Systematic review 3 of the cachexia endpoints seriesen_US
dc.title.alternativeQuality of life endpoints in cancer cachexia clinical trials: Systematic review 3 of the cachexia endpoints seriesen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber0en_US
dc.source.journalJournal of Cachexia, Sarcopenia and Muscleen_US
dc.identifier.doi10.1002/jcsm.13453
dc.identifier.cristin2263907
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Navngivelse 4.0 Internasjonal
Med mindre annet er angitt, så er denne innførselen lisensiert som Navngivelse 4.0 Internasjonal