Vis enkel innførsel

dc.contributor.authorHo, Kevin Kwan Ngai
dc.contributor.authorSkarpsno, Eivind S.
dc.contributor.authorNilsen, Kristian Bernhard
dc.contributor.authorFerreira, Paulo Herrique
dc.contributor.authorPinheiro, Marina
dc.contributor.authorHopstock, Laila Arnesdatter
dc.contributor.authorJohnsen, Marianne Bakke
dc.contributor.authorSteingrímsdóttir, Ólöf Anna
dc.contributor.authorNielsen, Christopher Sivert
dc.contributor.authorStubhaug, Audun
dc.contributor.authorSimic, Milena
dc.date.accessioned2023-04-18T13:44:00Z
dc.date.available2023-04-18T13:44:00Z
dc.date.created2022-04-14T14:13:44Z
dc.date.issued2022
dc.identifier.citationScandinavian Journal of Pain. 2022, 23 (1), 110-125.en_US
dc.identifier.issn1877-8860
dc.identifier.urihttps://hdl.handle.net/11250/3063631
dc.description.abstractObjectives - To examine the possible bidirectional association between insomnia and comorbid chronic low back pain (LBP) and lower limb pain and to explore whether high-sensitivity C-reactive protein (hsCRP) amplifies these associations. Methods - We calculated adjusted risk ratios (RR) with 95% confidence intervals (CI) for the development of insomnia and mild-to-severe chronic LBP and lower limb pain at 11 years follow-up in participants aged ≥32 years and with hsCRP ≤10 mg/L at baseline in 2007–2008: 3,714 without chronic LBP or lower limb pain (sample 1) and 7,892 without insomnia (sample 2). Results - Compared to participants without chronic pain, participants with comorbid chronic LBP and lower limb pain had a RR of insomnia of 1.37 (95% CI 1.12–1.66). Compared with participants without insomnia, participants with insomnia did not have an increased risk of comorbid chronic LBP and lower limb pain (RR: 1.06, 95% CI 0.76–1.46); however, participants with insomnia had a RR of chronic LBP of 1.20 (95% CI 1.02–1.42). There was no strong amplifying effect of elevated hsCRP (3.00–10.0 mg/L) on these associations. Conclusions - These findings suggest that elevated hsCRP does not amplify the associations between insomnia and mild-to-severe chronic LBP and lower limb pain. Further research using data on the temporal relation between insomnia, chronic pain, and inflammatory responses are required to fully understand the causal pathways.en_US
dc.language.isoengen_US
dc.publisherDe Gruyteren_US
dc.titleA bidirectional study of the association between insomnia, high-sensitivity C-reactive protein, and comorbid low back pain and lower limb painen_US
dc.title.alternativeA bidirectional study of the association between insomnia, high-sensitivity C-reactive protein, and comorbid low back pain and lower limb painen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionacceptedVersionen_US
dc.rights.holderAuthors accepted manuscript. © 2022 Walter de Gruyter GmbH, Berlin/Bostonen_US
dc.source.pagenumber110-125en_US
dc.source.volume23en_US
dc.source.journalScandinavian Journal of Painen_US
dc.source.issue1en_US
dc.identifier.doi10.1515/sjpain-2021-0197
dc.identifier.cristin2017304
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel